Armin Buschauer Institute of Pharmacy University of Regensburg Biography Publications Institution JoVE Articles Armin Buschauer has not added a biography. If you are Armin Buschauer and would like to personalize this page please email our Author Liaison for assistance. Publications Basal Histamine H Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif Chemistry (Weinheim an Der Bergstrasse, Germany). Nov, 2019 | Pubmed ID: 31498478 [H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H Receptors Journal of Medicinal Chemistry. Sep, 2019 | Pubmed ID: 31469288 Split Luciferase-based Assay for Simultaneous Analyses of the Ligand Concentration- and Time-dependent Recruitment of β-arrestin2 Analytical Biochemistry. 05, 2019 | Pubmed ID: 30853375 Alkyl Derivatives of 1,3,5-triazine As Histamine H Receptor Ligands Bioorganic & Medicinal Chemistry. 04, 2019 | Pubmed ID: 30792106 A Split Luciferase-based Probe for Quantitative Proximal Determination of Gα Signalling in Live Cells Scientific Reports. 11, 2018 | Pubmed ID: 30464299 Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H Receptor Agonists ACS Omega. Mar, 2018 | Pubmed ID: 30221224 Tariquidar-Related Chalcones and Ketones As ABCG2 Modulators ACS Medicinal Chemistry Letters. Aug, 2018 | Pubmed ID: 30128080 Structural Basis of Ligand Binding Modes at the Neuropeptide Y Y Receptor Nature. 04, 2018 | Pubmed ID: 29670288 Structural Basis of Small-molecule Inhibition of Human Multidrug Transporter ABCG2 Nature Structural & Molecular Biology. Apr, 2018 | Pubmed ID: 29610494 Molecular Mechanisms of Biased and Probe-Dependent Signaling at CXC-Motif Chemokine Receptor CXCR3 Induced by Negative Allosteric Modulators Molecular Pharmacology. 04, 2018 | Pubmed ID: 29343553 In Search of NPY YR Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or D-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists ACS Omega. Jul, 2017 | Pubmed ID: 30023699 Fluorescence- and Radiolabeling of [Lys,Nle]hPP Yields Molecular Tools for the NPY Y Receptor Bioconjugate Chemistry. 04, 2017 | Pubmed ID: 28345900 Prototypic F-Labeled Argininamide-Type Neuropeptide Y YR Antagonists As Tracers for PET Imaging of Mammary Carcinoma ACS Medicinal Chemistry Letters. Mar, 2017 | Pubmed ID: 28337321 High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and Radiolabeling Journal of Medicinal Chemistry. 07, 2016 | Pubmed ID: 27223253 Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H4 Receptor Agonists Journal of Medicinal Chemistry. Apr, 2016 | Pubmed ID: 27007611 BK K+ Channel Blockade Inhibits Radiation-induced Migration/brain Infiltration of Glioblastoma Cells Oncotarget. Mar, 2016 | Pubmed ID: 26893360 Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples Journal of Medicinal Chemistry. Mar, 2016 | Pubmed ID: 26824643 Flavonoid Derivatives As Selective ABCC1 Modulators: Synthesis and Functional Characterization European Journal of Medicinal Chemistry. Feb, 2016 | Pubmed ID: 26774038 Histamine H(1)- and H(4)-receptor Signaling Cooperatively Regulate MAPK Activation Biochemical Pharmacology. Dec, 2015 | Pubmed ID: 26385311 Esters of Bendamustine Are by Far More Potent Cytotoxic Agents Than the Parent Compound Against Human Sarcoma and Carcinoma Cells PloS One. 2015 | Pubmed ID: 26196503 Topotecan-induced ABCG2 Expression in MCF-7 Cells is Associated with Decreased CD24 and EpCAM Expression and a Loss of Tumorigenicity Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Aug, 2015 | Pubmed ID: 25892097 Toward Labeled Argininamide-Type NPY Y1 Receptor Antagonists: Identification of a Favorable Propionylation Site in BIBO3304 Archiv Der Pharmazie. Jun, 2015 | Pubmed ID: 25884646 High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection (HPAEC-PAD) for the Sensitive Determination of Hyaluronan Oligosaccharides Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Apr, 2015 | Pubmed ID: 25768984 M2 Subtype Preferring Dibenzodiazepinone-type Muscarinic Receptor Ligands: Effect of Chemical Homo-dimerization on Orthosteric (and Allosteric?) Binding Bioorganic & Medicinal Chemistry. Jul, 2015 | Pubmed ID: 25650309 Dimeric Carbamoylguanidine-type Histamine H2 Receptor Ligands: A New Class of Potent and Selective Agonists Bioorganic & Medicinal Chemistry. Jul, 2015 | Pubmed ID: 25639885 The Extracellular Loop 2 (ECL2) of the Human Histamine H4 Receptor Substantially Contributes to Ligand Binding and Constitutive Activity PloS One. 2015 | Pubmed ID: 25629160 No Evidence for Histamine H4 Receptor in Human Monocytes The Journal of Pharmacology and Experimental Therapeutics. Dec, 2014 | Pubmed ID: 25273276 Synthesis and Functional Characterization of Imbutamine Analogs As Histamine H3 and H4 Receptor Ligands Archiv Der Pharmazie. Feb, 2014 | Pubmed ID: 24493592 Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators ACS Medicinal Chemistry Letters. Apr, 2013 | Pubmed ID: 24900683 Synthesis and Dual Histamine H₁ and H₂ Receptor Antagonist Activity of Cyanoguanidine Derivatives Molecules (Basel, Switzerland). Nov, 2013 | Pubmed ID: 24248146 Replacement of Thr32 and Gln34 in the C-terminal Neuropeptide Y Fragment 25-36 by Cis-cyclobutane and Cis-cyclopentane β-amino Acids Shifts Selectivity Toward the Y(4) Receptor Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24090364 Dimeric Argininamide-type Neuropeptide Y Receptor Antagonists: Chiral Discrimination Between Y1 and Y4 Receptors Bioorganic & Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24074877 Luciferase Reporter Gene Assay on Human, Murine and Rat Histamine H4 Receptor Orthologs: Correlations and Discrepancies Between Distal and Proximal Readouts PloS One. 2013 | Pubmed ID: 24023919 Dissociations in the Effects of β2-adrenergic Receptor Agonists on CAMP Formation and Superoxide Production in Human Neutrophils: Support for the Concept of Functional Selectivity PloS One. 2013 | Pubmed ID: 23741338 Molecular and Cellular Analysis of Human Histamine Receptor Subtypes Trends in Pharmacological Sciences. Jan, 2013 | Pubmed ID: 23254267 Species-dependent Activities of G-protein-coupled Receptor Ligands: Lessons from Histamine Receptor Orthologs Trends in Pharmacological Sciences. Jan, 2013 | Pubmed ID: 23228711 The Neuropeptide Y Y(1) Receptor: a Diagnostic Marker? Expression in Mcf-7 Breast Cancer Cells is Down-regulated by Antiestrogens in Vitro and in Xenografts PloS One. 2012 | Pubmed ID: 23236424 The Bivalent Ligand Approach Leads to Highly Potent and Selective Acylguanidine-type Histamine H₂ Receptor Agonists Journal of Medicinal Chemistry. Feb, 2012 | Pubmed ID: 22216892 Fast Counter-electroosmotic Capillary Electrophoresis-time-of-flight Mass Spectrometry of Hyaluronan Oligosaccharides Analytical and Bioanalytical Chemistry. Mar, 2012 | Pubmed ID: 21800126 Synthesis and Histamine H(3) and H(4) Receptor Activity of Conformationally Restricted Cyanoguanidines Related to UR-PI376 Archiv Der Pharmazie. Dec, 2011 | Pubmed ID: 21987304 Design of Benzimidazole- and Benzoxazole-2-thione Derivatives As Inhibitors of Bacterial Hyaluronan Lyase European Journal of Medicinal Chemistry. Sep, 2011 | Pubmed ID: 21803461 Role of the Second and Third Extracellular Loops of the Histamine H(4) Receptor in Receptor Activation Naunyn-Schmiedeberg's Archives of Pharmacology. Sep, 2011 | Pubmed ID: 21800093 Functional Reconstitution of Human Neuropeptide Y (NPY) Y(2) and Y(4) Receptors in Sf9 Insect Cells Journal of Receptor and Signal Transduction Research. Aug, 2011 | Pubmed ID: 21745157 Expression and Functional Properties of Canine, Rat, and Murine Histamine H₄ Receptors in Sf9 Insect Cells Naunyn-Schmiedeberg's Archives of Pharmacology. May, 2011 | Pubmed ID: 21359967 Histamine H4 Receptor Agonists Bioorganic & Medicinal Chemistry Letters. Dec, 2010 | Pubmed ID: 21044842 G Protein-coupled Receptors Function As Logic Gates for Nanoparticle Binding and Cell Uptake Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20498042 Chiral NG-acylated Hetarylpropylguanidine-type Histamine H2 Receptor Agonists Do Not Show Significant Stereoselectivity Bioorganic & Medicinal Chemistry Letters. May, 2010 | Pubmed ID: 20409707 Synthesis and Structure-activity Relationships of Cyanoguanidine-type and Structurally Related Histamine H4 Receptor Agonists Journal of Medicinal Chemistry. Oct, 2009 | Pubmed ID: 19791743 N(G)-acylated Imidazolylpropylguanidines As Potent Histamine H4 Receptor Agonists: Selectivity by Variation of the N(G)-substituent Journal of Medicinal Chemistry. Apr, 2009 | Pubmed ID: 19317445 Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from the P-glycoprotein (ABCB1) Modulator Tariquidar Journal of Medicinal Chemistry. Feb, 2009 | Pubmed ID: 19170519 Guanidine-acylguanidine Bioisosteric Approach in the Design of Radioligands: Synthesis of a Tritium-labeled N(G)-propionylargininamide ([3H]-UR-MK114) As a Highly Potent and Selective Neuropeptide Y Y1 Receptor Antagonist Journal of Medicinal Chemistry. Dec, 2008 | Pubmed ID: 19053784 Acylguanidines As Bioisosteres of Guanidines: NG-acylated Imidazolylpropylguanidines, a New Class of Histamine H2 Receptor Agonists Journal of Medicinal Chemistry. Nov, 2008 | Pubmed ID: 18950149 Frontiers in Medicinal Chemistry in Regensburg ChemMedChem. Aug, 2008 | Pubmed ID: 18655207 Effect of the ABCB1 Modulators Elacridar and Tariquidar on the Distribution of Paclitaxel in Nude Mice Journal of Cancer Research and Clinical Oncology. May, 2008 | Pubmed ID: 17932689 Isoenzyme-specific Differences in the Degradation of Hyaluronic Acid by Mammalian-type Hyaluronidases Glycoconjugate Journal. Feb, 2008 | Pubmed ID: 17620008 Mutations of Cys-17 and Ala-271 in the Human Histamine H2 Receptor Determine the Species Selectivity of Guanidine-type Agonists and Increase Constitutive Activity The Journal of Pharmacology and Experimental Therapeutics. Jun, 2007 | Pubmed ID: 17347323 Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and Canine Histamine H2 Receptors The Journal of Pharmacology and Experimental Therapeutics. Jun, 2007 | Pubmed ID: 17332265 Inhibitors of Kinesin Eg5: Antiproliferative Activity of Monastrol Analogues Against Human Glioblastoma Cells Cancer Chemotherapy and Pharmacology. Feb, 2007 | Pubmed ID: 16703323 Fluorescence- and Luminescence-based Methods for the Determination of Affinity and Activity of Neuropeptide Y2 Receptor Ligands European Journal of Pharmacology. Dec, 2006 | Pubmed ID: 17027743 Novel 6-O-acylated Vitamin C Derivatives As Hyaluronidase Inhibitors with Selectivity for Bacterial Lyases Bioorganic & Medicinal Chemistry Letters. Oct, 2006 | Pubmed ID: 16908142 A Simple and Powerful Flow Cytometric Method for the Simultaneous Determination of Multiple Parameters at G Protein-coupled Receptor Subtypes Chembiochem : a European Journal of Chemical Biology. Sep, 2006 | Pubmed ID: 16888730 Platelet-derived Growth Factor Receptor Independent Proliferation of Human Glioblastoma Cells: Selective Tyrosine Kinase Inhibitors Lack Antiproliferative Activity Journal of Cancer Research and Clinical Oncology. Sep, 2006 | Pubmed ID: 16736141 Design of New Benzoxazole-2-thione-derived Inhibitors of Streptococcus Pneumoniae Hyaluronan Lyase: Structure of a Complex with a 2-phenylindole Glycobiology. Aug, 2006 | Pubmed ID: 16638841 Sulphated Oligosaccharides As Inhibitors of Hyaluronidases from Bovine Testis, Bee Venom and Streptococcus Agalactiae Planta Medica. Aug, 2005 | Pubmed ID: 16142636 Construction and Validation of a Microprocessor Controlled Extracorporal Circuit in Rats for the Optimization of Isolated Limb Perfusion Archiv Der Pharmazie. Dec, 2004 | Pubmed ID: 15597400 Structure-activity Relationships of Histamine H2 Receptor Ligands Mini Reviews in Medicinal Chemistry. Nov, 2004 | Pubmed ID: 15544555 L-Ascorbic Acid 6-hexadecanoate, a Potent Hyaluronidase Inhibitor. X-ray Structure and Molecular Modeling of Enzyme-inhibitor Complexes The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15322107 Functional Expression of the Interleukin-11 Receptor Alpha-chain and Evidence of Antiapoptotic Effects in Human Colonic Epithelial Cells The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14701802 Transport of Paclitaxel (Taxol) Across the Blood-brain Barrier in Vitro and in Vivo The Journal of Clinical Investigation. Nov, 2002 | Pubmed ID: 12417570 Polyamine Levels of Human Colorectal Adenocarcinomas Are Correlated with Tumor Stage and Grade International Journal of Colorectal Disease. Nov, 2002 | Pubmed ID: 12355213 Stegvis doseringsprotokoll för ökat dataflöde i etikettfria Impedansbaserade GPCR-analyser Judith A. Stolwijk1, Anne-Kathrin Mildner1, Christian Kade1, Michael Skiba1, Guenther Bernhardt2, Armin Buschauer2, Harald Huebner3, Peter Gmeiner3, Joachim Wegener1,4 1Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 2Institute of Pharmacy, University of Regensburg, 3Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nuernberg, 4Fraunhofer Research Institution for Microsystems and Solid State Technologies EMFT JoVE 60686 Biochimie
Stegvis doseringsprotokoll för ökat dataflöde i etikettfria Impedansbaserade GPCR-analyser Judith A. Stolwijk1, Anne-Kathrin Mildner1, Christian Kade1, Michael Skiba1, Guenther Bernhardt2, Armin Buschauer2, Harald Huebner3, Peter Gmeiner3, Joachim Wegener1,4 1Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 2Institute of Pharmacy, University of Regensburg, 3Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nuernberg, 4Fraunhofer Research Institution for Microsystems and Solid State Technologies EMFT JoVE 60686 Biochimie