Bengt Winblad Dept of Neurobiology, Care Sciences and Society Karolinska Institutet Biography Publications Institution JoVE Articles Bengt Winblad Professor Bengt Winblad was until 2018 Head of the Division of Neurogeriatrics at Karolinska Institutet. He is currently leading his own research group in the same division, focusing on drug development. Bengt Winblad is Professor of Geriatric Medicine at Karolinska Institutet in Solna and Chief Physician at Karolinska University Hospital in Huddinge. 2001-2019, he chaired the European Alzheimer Disease Consortium (EADC), currently consisting of 71 clinical research centers across Europe. Since 2009, he is a member of the Senate for the German national network on neurodegenerative disorders, DZNE. He was PI of the first EU Joint Program project, BIOMARKAPD aiming at standardizing sampling and measurement of biomarkers in Alzheimer and Parkinson disease. He has been given numerous international and national awards for his research. He has founded a number of international conferences, eg the ”International Conference of Alzheimer’s Disease (ICAD, renamed AAIC) and the International PharmacoEconomic Conferences on AD (IPECAD). He was a member of the Nobel Assembly, Karolinska Institutet 1988 – 2010. In 2009, he was recognized the world’s most prolific researcher in AD by the Journal of Alzheimer’s Disease and in 2016, he was recognized as one (out of five from Karolinska Institutet) of the most cited scientists worldwide. Publications Distinctive Alteration of Presynaptic Proteins in the Outer Molecular Layer of the Dentate Gyrus in Alzheimer's Disease Brain Communications. Month, 2021 | Pubmed ID: 34013204 Harmonizing Neuropsychological Assessment for Mild Neurocognitive Disorders in Europe Alzheimer's & Dementia : the Journal of the Alzheimer's Association. May, 2021 | Pubmed ID: 33984176 Mortality After Ischemic Stroke in Patients with Alzheimer's Disease Dementia and Other Dementia Disorders Journal of Alzheimer's Disease : JAD. Month, 2021 | Pubmed ID: 33935077 Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons International Journal of Molecular Sciences. Apr, 2021 | Pubmed ID: 33926107 Identification of Undiagnosed Dementia Cases Using a Web-based Pre-screening Tool: The MOPEAD Project Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Apr, 2021 | Pubmed ID: 33860599 Biting the Bullet: Firearm Ownership in Persons with Dementia. A Registry-Based Observational Study Journal of Alzheimer's Disease : JAD. Month, 2021 | Pubmed ID: 33720891 The Strategic Biomarker Roadmap for the Validation of Alzheimer's Diagnostic Biomarkers: Methodological Update European Journal of Nuclear Medicine and Molecular Imaging. 07, 2021 | Pubmed ID: 33688996 General Practitioners' Attitude Toward Early and Pre-dementia Diagnosis of AD in Five European Countries-A MOPEAD Project Survey Alzheimer's & Dementia (Amsterdam, Netherlands). Month, 2021 | Pubmed ID: 33665337 Small Molecule Therapeutics for Tauopathy in Alzheimer's Disease: Walking on the Path of Most Resistance European Journal of Medicinal Chemistry. Jan, 2021 | Pubmed ID: 33139110 Statins, Risk of Death and Ischemic Stroke in Patients with Dementia: A Registry-Based Observational Cohort Study Current Alzheimer Research. Month, 2020 | Pubmed ID: 33327915 Huntingtin Levels Are Elevated in Hippocampal Post-Mortem Samples of Alzheimer's Disease Brain Current Alzheimer Research. Month, 2020 | Pubmed ID: 33272184 Are Neuropsychiatric Symptoms in Dementia Linked to CSF Biomarkers of Synaptic and Axonal Degeneration? Alzheimer's Research & Therapy. 11, 2020 | Pubmed ID: 33203439 Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL Frontiers in Genetics. Month, 2020 | Pubmed ID: 33101365 Regional Disconnection in Alzheimer Dementia and Amyloid-Positive Mild Cognitive Impairment: Association Between EEG Functional Connectivity and Brain Glucose Metabolism Brain Connectivity. 12, 2020 | Pubmed ID: 33073602 Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2020 | Pubmed ID: 32925049 Dementia Diagnosis Is Associated with Changes in Antidiabetic Drug Prescription: An Open-Cohort Study of ∼130,000 Swedish Subjects over 14 Years Journal of Alzheimer's Disease : JAD. Month, 2020 | Pubmed ID: 32741836 Quantifying and Describing the Natural History and Costs of Alzheimer's Disease and Effects of Hypothetical Interventions Journal of Alzheimer's Disease : JAD. Month, 2020 | Pubmed ID: 32390617 Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology Journal of Alzheimer's Disease : JAD. Month, 2020 | Pubmed ID: 32280097 Corrigendum to Quantitative EEG Power and Synchronization Correlate with Alzheimer's Disease CSF Biomarkers Neurobiology of Aging 63 (2018) 88-95 Neurobiology of Aging. 07, 2020 | Pubmed ID: 32280030 Proximity Ligation Assay Reveals Both Pre- and Postsynaptic Localization of the APP-processing Enzymes ADAM10 and BACE1 in Rat and Human Adult Brain BMC Neuroscience. 02, 2020 | Pubmed ID: 32019490 Glycan Biomarkers for Alzheimer Disease Correlate with T-tau and P-tau in Cerebrospinal Fluid in Subjective Cognitive Impairment The FEBS Journal. 08, 2020 | Pubmed ID: 31889402 Secondary Stroke Prevention After Ischemic Stroke in Patients with Alzheimer's Disease and Other Dementia Disorders Journal of Alzheimer's Disease : JAD. Month, 2020 | Pubmed ID: 31884483 Metal Binding by GMP-1 and Its Pyrimido [1, 2]benzimidazole Analogs Confirms Protection Against Amyloid-β Associated Neurotoxicity Journal of Alzheimer's Disease : JAD. Month, 2020 | Pubmed ID: 31839606 The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease Molecular & Cellular Proteomics : MCP. 01, 2020 | Pubmed ID: 31699905 Restoring Synaptic Function Through Multimodal Therapeutics Progress in Molecular Biology and Translational Science. Month, 2019 | Pubmed ID: 31699320 Erythrocyte Amyloid Beta Peptide Isoform Distributions in Alzheimer and Mild Cognitive Impairment Current Alzheimer Research. Month, 2019 | Pubmed ID: 31660827 Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies Frontiers in Aging Neuroscience. Month, 2019 | Pubmed ID: 31649526 Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products Journal of Alzheimer's Disease : JAD. Month, 2019 | Pubmed ID: 31609694 Prevention of Cognitive Decline in Old Age-varying Effects of Interventions in Different Populations Annals of Translational Medicine. Jul, 2019 | Pubmed ID: 31576349 A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2019 | Pubmed ID: 31524172 Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study Journal of Alzheimer's Disease : JAD. Month, 2019 | Pubmed ID: 31498125 Alzheimer's Disease: Erythrocyte 2,3-diphosphoglycerate Content and Circulating Erythropoietin Current Alzheimer Research. Month, 2019 | Pubmed ID: 31453787 The Thriving of Older People Assessment Scale: Psychometric Evaluation and Short-form Development Journal of Advanced Nursing. Dec, 2019 | Pubmed ID: 31441533 The MOPEAD Project: Advancing Patient Engagement for the Detection of "hidden" Undiagnosed Cases of Alzheimer's Disease in the Community Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 06, 2019 | Pubmed ID: 31076376 Antipsychotic Treatment Associated With Increased Mortality Risk in Patients With Dementia. A Registry-Based Observational Cohort Study Journal of the American Medical Directors Association. 03, 2019 | Pubmed ID: 30824220 Residing in Sheltered Housing Versus Ageing in Place - Population Characteristics, Health Status and Social Participation Health & Social Care in the Community. 07, 2019 | Pubmed ID: 30821865 Conformation-specific Antibodies Against Multiple Amyloid Protofibril Species from a Single Amyloid Immunogen Journal of Cellular and Molecular Medicine. 03, 2019 | Pubmed ID: 30663210 Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain Molecular Neurobiology. Jul, 2019 | Pubmed ID: 30361890 Phenotypic Variability and Neuropsychological Findings Associated with C9orf72 Repeat Expansions in a Bulgarian Dementia Cohort PloS One. Month, 2018 | Pubmed ID: 30550541 The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ and Alzheimer Amyloid Plaques Journal of Alzheimer's Disease Reports. Feb, 2018 | Pubmed ID: 30480246 Neuronal Aβ42 is Enriched in Small Vesicles at the Presynaptic Side of Synapses Life Science Alliance. Jun, 2018 | Pubmed ID: 30456353 Identification and Biochemical Characterization of the Human Dicarboxylate Clamp TPR Protein Interaction Network FEBS Open Bio. Nov, 2018 | Pubmed ID: 30410862 Stroke As a Cause of Death in Death Certificates of Patients with Dementia: A Cohort Study from the Swedish Dementia Registry Current Alzheimer Research. Month, 2018 | Pubmed ID: 30280666 Acute Stroke Care in Dementia: A Cohort Study from the Swedish Dementia and Stroke Registries Journal of Alzheimer's Disease : JAD. Month, 2018 | Pubmed ID: 30248059 Development of GMP-1 a Molecular Chaperone Network Modulator Protecting Mitochondrial Function and Its Assessment in Fly and Mice Models of Alzheimer's Disease Journal of Cellular and Molecular Medicine. 07, 2018 | Pubmed ID: 29704317 Apolipoprotein E Genotypes and Longevity Across Dementia Disorders Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 07, 2018 | Pubmed ID: 29548722 Synaptic Markers of Cognitive Decline in Neurodegenerative Diseases: a Proteomic Approach Brain : a Journal of Neurology. 02, 2018 | Pubmed ID: 29324989 Treatment of Atrial Fibrillation in Patients with Dementia: A Cohort Study from the Swedish Dementia Registry Journal of Alzheimer's Disease : JAD. Month, 2018 | Pubmed ID: 29286925 Quantitative EEG Power and Synchronization Correlate with Alzheimer's Disease CSF Biomarkers Neurobiology of Aging. 03, 2018 | Pubmed ID: 29245058 Cerebrospinal Fluid and Blood Biomarkers for Neurodegenerative Dementias: An Update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 06, 2018 | Pubmed ID: 29076399 Combined X-ray Crystallography and Computational Modeling Approach to Investigate the Hsp90 C-terminal Peptide Binding to FKBP51 Scientific Reports. 10, 2017 | Pubmed ID: 29079741 Tau Hyperphosphorylation Induces Oligomeric Insulin Accumulation and Insulin Resistance in Neurons Brain : a Journal of Neurology. Dec, 2017 | Pubmed ID: 29053786 Thrombolysis in Acute Ischemic Stroke in Patients with Dementia: A Swedish Registry Study Neurology. Oct, 2017 | Pubmed ID: 28986410 CSF/serum Albumin Ratio in Dementias: a Cross-sectional Study on 1861 Patients Neurobiology of Aging. 11, 2017 | Pubmed ID: 28779628 APP Mouse Models for Alzheimer's Disease Preclinical Studies The EMBO Journal. 09, 2017 | Pubmed ID: 28768718 Monoamine Oxidase B is Elevated in Alzheimer Disease Neurons, is Associated with γ-secretase and Regulates Neuronal Amyloid β-peptide Levels Alzheimer's Research & Therapy. Aug, 2017 | Pubmed ID: 28764767 Strategic Roadmap for an Early Diagnosis of Alzheimer's Disease Based on Biomarkers The Lancet. Neurology. Aug, 2017 | Pubmed ID: 28721928 Subclinical White Matter Lesions and Medial Temporal Lobe Atrophy Are Associated with EEG Slowing in a Memory Clinic Cohort Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 09, 2017 | Pubmed ID: 28709123 Diabetes in a Large Dementia Cohort: Clinical Characteristics and Treatment From the Swedish Dementia Registry Diabetes Care. 09, 2017 | Pubmed ID: 28655740 Consensus Guidelines for Lumbar Puncture in Patients with Neurological Diseases Alzheimer's & Dementia (Amsterdam, Netherlands). Month, 2017 | Pubmed ID: 28603768 Living Alone with Alzheimer's Disease: Data from SveDem, the Swedish Dementia Registry Journal of Alzheimer's Disease : JAD. Month, 2017 | Pubmed ID: 28550260 Recommendations for Cerebrospinal Fluid Alzheimer's Disease Biomarkers in the Diagnostic Evaluation of Mild Cognitive Impairment Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Mar, 2017 | Pubmed ID: 28341066 Recommendations for CSF AD Biomarkers in the Diagnostic Evaluation of Dementia Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Mar, 2017 | Pubmed ID: 28341065 The Biomarker-based Diagnosis of Alzheimer's Disease. 2-lessons from Oncology Neurobiology of Aging. Apr, 2017 | Pubmed ID: 28317645 The Biomarker-based Diagnosis of Alzheimer's Disease. 1-ethical and Societal Issues Neurobiology of Aging. 04, 2017 | Pubmed ID: 28317644 Alzheimer's Disease Biomarker Development: a Call to Funding Bodies Neurobiology of Aging. Apr, 2017 | Pubmed ID: 28317642 Long-Term Cognitive Decline in Dementia with Lewy Bodies in a Large Multicenter, International Cohort Journal of Alzheimer's Disease : JAD. Month, 2017 | Pubmed ID: 28304294 Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid Journal of Alzheimer's Disease : JAD. Feb, 2017 | Pubmed ID: 28269767 Predicting Progression to Dementia in Persons with Mild Cognitive Impairment Using Cerebrospinal Fluid Markers Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Feb, 2017 | Pubmed ID: 28216393 27-Hydroxycholesterol Impairs Neuronal Glucose Uptake Through an IRAP/GLUT4 System Dysregulation The Journal of Experimental Medicine. 03, 2017 | Pubmed ID: 28213512 Maturation and Processing of the Amyloid Precursor Protein is Regulated by the Potassium/sodium Hyperpolarization-activated Cyclic Nucleotide-gated Ion Channel 2 (HCN2) Biochemical and Biophysical Research Communications. 01, 2017 | Pubmed ID: 28017718 BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, And Mindfulness: Associations With Working Memory Function Journal of Alzheimer's Disease : JAD. Month, 2017 | Pubmed ID: 27716670 Management of Acute Myocardial Infarction in Patients With Dementia: Data From SveDem, the Swedish Dementia Registry Journal of the American Medical Directors Association. 01, 2017 | Pubmed ID: 27639334 The Worldwide Costs of Dementia 2015 and Comparisons with 2010 Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 01, 2017 | Pubmed ID: 27583652 Perforin Promotes Amyloid Beta Internalisation in Neurons Molecular Neurobiology. 03, 2017 | Pubmed ID: 26780457 Exploring the Prevalence and Variance of Cognitive Impairment, Pain, Neuropsychiatric Symptoms and ADL Dependency Among Persons Living in Nursing Homes; a Cross-sectional Study BMC Geriatrics. 08, 2016 | Pubmed ID: 27549203 Evidence-based Prevention and Treatment of Dementia - Authors' Reply The Lancet. Neurology. 09, 2016 | Pubmed ID: 27450477 Targeted Delivery of Nerve Growth Factor to the Cholinergic Basal Forebrain of Alzheimer's Disease Patients: Application of a Second-generation Encapsulated Cell Biodelivery Device Alzheimer's Research & Therapy. 07, 2016 | Pubmed ID: 27389402 Assessment and Reporting of Driving Fitness in Patients with Dementia in Clinical Practice: Data from SveDem, the Swedish Dementia Registry Journal of Alzheimer's Disease : JAD. 05, 2016 | Pubmed ID: 27163829 Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 05, 2016 | Pubmed ID: 27163814 Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers Journal of Alzheimer's Disease : JAD. 05, 2016 | Pubmed ID: 27163811 CAIDE Dementia Risk Score and Biomarkers of Neurodegeneration in Memory Clinic Patients Without Dementia Neurobiology of Aging. 06, 2016 | Pubmed ID: 27143429 Super-resolution Microscopy Reveals γ-secretase at Both Sides of the Neuronal Synapse Acta Neuropathologica Communications. Mar, 2016 | Pubmed ID: 27036709 Amyloid-Related Imaging Abnormalities (ARIA) in Immunotherapy Trials for Alzheimer's Disease: Need for Prognostic Biomarkers? Journal of Alzheimer's Disease : JAD. 03, 2016 | Pubmed ID: 27031492 Defeating Alzheimer's Disease and Other Dementias: a Priority for European Science and Society The Lancet. Neurology. Apr, 2016 | Pubmed ID: 26987701 Comparison of Different Matrices As Potential Quality Control Samples for Neurochemical Dementia Diagnostics Journal of Alzheimer's Disease : JAD. Mar, 2016 | Pubmed ID: 26967210 BRICHOS Binds to a Designed Amyloid-forming β-protein and Reduces Proteasomal Inhibition and Aggresome Formation The Biochemical Journal. Jan, 2016 | Pubmed ID: 26578816 Mitochondrial Dysfunction in a Transgenic Mouse Model Expressing Human Amyloid Precursor Protein (APP) with the Arctic Mutation Journal of Neurochemistry. Feb, 2016 | Pubmed ID: 26500157 Same Ages, Same Genes: Same Brains, Same Pathologies?: Dementia Timings, Co-Occurring Brain Pathologies, ApoE Genotypes in Identical and Fraternal Age-matched Twins at Autopsy Alzheimer Disease and Associated Disorders. Apr-Jun, 2016 | Pubmed ID: 26492328 The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases Frontiers in Neurology. Month, 2015 | Pubmed ID: 26528237 The Need for Thorough Phase II Studies in Medicines Development for Alzheimer's Disease Alzheimer's Research & Therapy. Oct, 2015 | Pubmed ID: 26503107 Feelings of Hopelessness in Midlife and Cognitive Health in Later Life: A Prospective Population-Based Cohort Study PloS One. Month, 2015 | Pubmed ID: 26460971 Cardiovascular Diseases in ~30,000 Patients in the Swedish Dementia Registry Journal of Alzheimer's Disease : JAD. Month, 2015 | Pubmed ID: 26402118 Autoantibodies Toward the Angiotensin 2 Type 1 Receptor: A Novel Autoantibody in Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2015 | Pubmed ID: 26401573 A Practical Guide to Immunoassay Method Validation Frontiers in Neurology. Month, 2015 | Pubmed ID: 26347708 Brain Health: the Importance of Recognizing Cognitive Impairment: an IAGG Consensus Conference Journal of the American Medical Directors Association. Sep, 2015 | Pubmed ID: 26315321 ADAM10 and BACE1 Are Localized to Synaptic Vesicles Journal of Neurochemistry. Nov, 2015 | Pubmed ID: 26296617 Loss of Neprilysin Alters Protein Expression in the Brain of Alzheimer's Disease Model Mice Proteomics. Oct, 2015 | Pubmed ID: 26194619 HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study PLoS Medicine. Jul, 2015 | Pubmed ID: 26173052 Brain Health: a Primary Health Care Viewpoint Journal of the American Medical Directors Association. Sep, 2015 | Pubmed ID: 26170039 Cerebrospinal Fluid Tau and Amyloid-β1-42 in Patients with Dementia Brain : a Journal of Neurology. Sep, 2015 | Pubmed ID: 26133663 Proton Myo-inositol Cotransporter is a Novel γ-secretase Associated Protein That Regulates Aβ Production Without Affecting Notch Cleavage The FEBS Journal. Sep, 2015 | Pubmed ID: 26094765 Benchmarking Biomarker-based Criteria for Alzheimer's Disease: Data from the Swedish Dementia Registry, SveDem Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Dec, 2015 | Pubmed ID: 26079415 Long-term Treatment with Active Aβ Immunotherapy with CAD106 in Mild Alzheimer's Disease Alzheimer's Research & Therapy. Month, 2015 | Pubmed ID: 25918556 Human Brain Proteins Showing Neuron-specific Interactions with γ-secretase The FEBS Journal. Jul, 2015 | Pubmed ID: 25893612 Dissociation of a BRICHOS Trimer into Monomers Leads to Increased Inhibitory Effect on Aβ42 Fibril Formation Biochimica Et Biophysica Acta. Aug, 2015 | Pubmed ID: 25891900 Mild Cognitive Impairment and Deficits in Instrumental Activities of Daily Living: a Systematic Review Alzheimer's Research & Therapy. Month, 2015 | Pubmed ID: 25815063 MTor Mediates Tau Localization and Secretion: Implication for Alzheimer's Disease Biochimica Et Biophysica Acta. Jul, 2015 | Pubmed ID: 25791428 SveDem, the Swedish Dementia Registry - a Tool for Improving the Quality of Diagnostics, Treatment and Care of Dementia Patients in Clinical Practice PloS One. Month, 2015 | Pubmed ID: 25695768 Heart Failure and Dementia: Survival in Relation to Types of Heart Failure and Different Dementia Disorders European Journal of Heart Failure. Jun, 2015 | Pubmed ID: 25581033 Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells Molecular Neurobiology. Dec, 2015 | Pubmed ID: 25288153 Medial Temporal Lobe Atrophy and Depressive Symptoms in Elderly Patients with and Without Alzheimer Disease Journal of Geriatric Psychiatry and Neurology. Mar, 2015 | Pubmed ID: 25080472 Subjective Cognitive Impairment Subjects in Our Clinical Practice Dementia and Geriatric Cognitive Disorders Extra. Sep, 2014 | Pubmed ID: 25538726 Erratum To: Cardiovascular Medication Burden in Dementia Disorders: a Nationwide Study of 19, 743 Dementia Patients in the Swedish Dementia Registry Alzheimer's Research & Therapy. Month, 2014 | Pubmed ID: 25476876 Cerebral ABC Transporter-common Mechanisms May Modulate Neurodegenerative Diseases and Depression in Elderly Subjects Archives of Medical Research. Nov, 2014 | Pubmed ID: 25446622 CSF Neurofilament Light Differs in Neurodegenerative Diseases and Predicts Severity and Survival Neurology. Nov, 2014 | Pubmed ID: 25339208 Amyloid-β-induced Action Potential Desynchronization and Degradation of Hippocampal Gamma Oscillations is Prevented by Interference with Peptide Conformation Change and Aggregation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2014 | Pubmed ID: 25143621 Alzheimer and Platelets: Low-density Platelet Populations Reveal Increased Serotonin Content in Alzheimer Type Dementia Clinical Biochemistry. Oct, 2014 | Pubmed ID: 25041722 Cardiovascular Medication Burden in Dementia Disorders: a Nationwide Study of 19,743 Dementia Patients in the Swedish Dementia Registry Alzheimer's Research & Therapy. Month, 2014 | Pubmed ID: 25024749 The Battle of Alzheimer's Disease - the Beginning of the Future Unleashing the Potential of Academic Discoveries Frontiers in Pharmacology. Month, 2014 | Pubmed ID: 24847271 MTor is a Signaling Hub in Cell Survival: a Mass-spectrometry-based Proteomics Investigation Journal of Proteome Research. May, 2014 | Pubmed ID: 24694195 The Chaperone Domain BRICHOS Prevents CNS Toxicity of Amyloid-β Peptide in Drosophila Melanogaster Disease Models & Mechanisms. Jun, 2014 | Pubmed ID: 24682783 Clinical Trials and Late-stage Drug Development for Alzheimer's Disease: an Appraisal from 1984 to 2014 Journal of Internal Medicine. Mar, 2014 | Pubmed ID: 24605808 Activity-independent Release of the Amyloid β-peptide from Rat Brain Nerve Terminals Neuroscience Letters. Apr, 2014 | Pubmed ID: 24602978 Long-term Metformin Usage and Cognitive Function Among Older Adults with Diabetes Journal of Alzheimer's Disease : JAD. Month, 2014 | Pubmed ID: 24577463 Vitamin D in Relation to Cognitive Impairment, Cerebrospinal Fluid Biomarkers, and Brain Volumes The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Sep, 2014 | Pubmed ID: 24568931 Lesion of the Subiculum Reduces the Spread of Amyloid Beta Pathology to Interconnected Brain Regions in a Mouse Model of Alzheimer's Disease Acta Neuropathologica Communications. Feb, 2014 | Pubmed ID: 24517102 Active Immunotherapy Options for Alzheimer's Disease Alzheimer's Research & Therapy. Month, 2014 | Pubmed ID: 24476230 Neuropathologic Assessment of Dementia Markers in Identical and Fraternal Twins Brain Pathology (Zurich, Switzerland). Jul, 2014 | Pubmed ID: 24450926 The Role of Protein Glycosylation in Alzheimer Disease The FEBS Journal. Jan, 2014 | Pubmed ID: 24279329 VEGF Significantly Restores Impaired Memory Behavior in Alzheimer's Mice by Improvement of Vascular Survival Scientific Reports. Month, 2013 | Pubmed ID: 23792494 Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation--application on γ-secretase PloS One. Month, 2013 | Pubmed ID: 23717518 Modulation of the Endoplasmic Reticulum-mitochondria Interface in Alzheimer's Disease and Related Models Proceedings of the National Academy of Sciences of the United States of America. May, 2013 | Pubmed ID: 23620518 Twenty-year Changes in Dementia Occurrence Suggest Decreasing Incidence in Central Stockholm, Sweden Neurology. May, 2013 | Pubmed ID: 23596063 Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis: Implication for Alzheimer Disease The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23585566 The Pathogenic Aβ43 is Enriched in Familial and Sporadic Alzheimer Disease PloS One. Month, 2013 | Pubmed ID: 23409063 Abnormal Platelet Amyloid-β Protein Precursor (AβPP) Metabolism in Alzheimer's Disease: Identification and Characterization of a New AβPP Isoform As Potential Biomarker Journal of Alzheimer's Disease : JAD. Month, 2013 | Pubmed ID: 23388171 The Worldwide Economic Impact of Dementia 2010 Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jan, 2013 | Pubmed ID: 23305821 Accelerated Progression from Mild Cognitive Impairment to Dementia Among APOE ε4ε4 Carriers Journal of Alzheimer's Disease : JAD. Month, 2013 | Pubmed ID: 23247007 Application of Resource Utilization in Dementia (RUD) Instrument in a Global Setting Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jul, 2013 | Pubmed ID: 23142433 Mortality and Treatment Costs Have a Great Impact on the Cost-effectiveness of Disease Modifying Treatment in Alzheimer's Disease--a Simulation Study Current Alzheimer Research. Feb, 2013 | Pubmed ID: 23036018 How Can Elderly Apolipoprotein E ε4 Carriers Remain Free from Dementia? Neurobiology of Aging. Jan, 2013 | Pubmed ID: 22503000 Thioredoxin-80 is a Product of Alpha-secretase Cleavage That Inhibits Amyloid-beta Aggregation and is Decreased in Alzheimer's Disease Brain EMBO Molecular Medicine. Oct, 2012 | Pubmed ID: 22933306 Erlin-2 is Associated with Active γ-secretase in Brain and Affects Amyloid β-peptide Production Biochemical and Biophysical Research Communications. Aug, 2012 | Pubmed ID: 22771797 An Active Lifestyle Postpones Dementia Onset by More Than One Year in Very Old Adults Journal of Alzheimer's Disease : JAD. Month, 2012 | Pubmed ID: 22751170 Safety, Tolerability, and Antibody Response of Active Aβ Immunotherapy with CAD106 in Patients with Alzheimer's Disease: Randomised, Double-blind, Placebo-controlled, First-in-human Study The Lancet. Neurology. Jul, 2012 | Pubmed ID: 22677258 Cerebrospinal Fluid Alzheimer Markers in Depressed Elderly Subjects with and Without Alzheimer's Disease Dementia and Geriatric Cognitive Disorders Extra. Jan, 2012 | Pubmed ID: 22649429 Practical Lessons from Amyloid Immunotherapy Trials in Alzheimer Disease Current Alzheimer Research. Dec, 2012 | Pubmed ID: 22631442 Identification of Two Novel Synaptic γ-secretase Associated Proteins That Affect Amyloid β-peptide Levels Without Altering Notch Processing Neurochemistry International. Jul, 2012 | Pubmed ID: 22521230 Dementia Diagnosis Differs in Men and Women and Depends on Age and Dementia Severity: Data from SveDem, the Swedish Dementia Quality Registry Dementia and Geriatric Cognitive Disorders. Month, 2012 | Pubmed ID: 22433665 Psychosocial Stress at Work is Associated with Increased Dementia Risk in Late Life Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Month, 2012 | Pubmed ID: 22404853 Encapsulated Cell Biodelivery of Nerve Growth Factor to the Basal Forebrain in Patients with Alzheimer's Disease Dementia and Geriatric Cognitive Disorders. Month, 2012 | Pubmed ID: 22377499 A Novel Approach for Aβ₁₋₄₀ Quantification Using Immuno-PCR Journal of Neuroscience Methods. Apr, 2012 | Pubmed ID: 22327103 Identification of Novel γ-secretase-associated Proteins in Detergent-resistant Membranes from Brain The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22315232 Side-chain-oxidized Oxysterols Upregulate ACE2 and Mas Receptor in Rat Primary Neurons Neuro-degenerative Diseases. Month, 2012 | Pubmed ID: 22236548 Overexpression of Apolipoprotein E4 Increases Kainic-acid-induced Hippocampal Neurodegeneration Experimental Neurology. Jan, 2012 | Pubmed ID: 22079154 Analysis of Microdissected Neurons by 18O Mass Spectrometry Reveals Altered Protein Expression in Alzheimer's Disease Journal of Cellular and Molecular Medicine. Aug, 2012 | Pubmed ID: 21883897 Amyloid Neuropathology in the Single Arctic APP Transgenic Model Affects Interconnected Brain Regions Neurobiology of Aging. Apr, 2012 | Pubmed ID: 21880397 Depression in Dementia: Epidemiology, Mechanisms, and Treatment Current Opinion in Psychiatry. Nov, 2011 | Pubmed ID: 21926624 Validation of the Relevant Outcome Scale for Alzheimer's Disease: a Novel Multidomain Assessment for Daily Medical Practice Alzheimer's Research & Therapy. Jul, 2011 | Pubmed ID: 21914212 Mutations in Nicastrin Protein Differentially Affect Amyloid Beta-peptide Production and Notch Protein Processing The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21768095 Dementia Management Programme in a Community Setting and the Use of Psychotropic Drugs in the Elderly Population Scandinavian Journal of Primary Health Care. Sep, 2011 | Pubmed ID: 21740344 Liposomes Functionalized with Acidic Lipids Rescue Aβ-induced Toxicity in Murine Neuroblastoma Cells Nanomedicine : Nanotechnology, Biology, and Medicine. Oct, 2011 | Pubmed ID: 21703989 Predictors of Costs of Care in Alzheimer's Disease: a Multinational Sample of 1222 Patients Alzheimer's & Dementia : the Journal of the Alzheimer's Association. May, 2011 | Pubmed ID: 21575872 Interplay Between Glycogen Synthase Kinase-3β and Tau in the Cerebellum of Hsp27 Transgenic Mouse Journal of Neuroscience Research. Aug, 2011 | Pubmed ID: 21544852 Marked Accumulation of 27-hydroxycholesterol in the Brains of Alzheimer's Patients with the Swedish APP 670/671 Mutation Journal of Lipid Research. May, 2011 | Pubmed ID: 21335619 Upregulation of Brain Renin Angiotensin System by 27-hydroxycholesterol in Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2011 | Pubmed ID: 21297254 Linkage Analysis of Autopsy-confirmed Familial Alzheimer Disease Supports an Alzheimer Disease Locus in 8q24 Dementia and Geriatric Cognitive Disorders. Month, 2011 | Pubmed ID: 21273770 Morphological and Behavioral Changes Induced by Transgenic Overexpression of Interleukin-1ra in the Brain Journal of Neuroscience Research. Feb, 2011 | Pubmed ID: 21162122 Minor Contribution of Presenilin 2 for γ-secretase Activity in Mouse Embryonic Fibroblasts and Adult Mouse Brain Biochemical and Biophysical Research Communications. Jan, 2011 | Pubmed ID: 21146496 The Obesity Related Gene, FTO, Interacts with APOE, and is Associated with Alzheimer's Disease Risk: a Prospective Cohort Study Journal of Alzheimer's Disease : JAD. Month, 2011 | Pubmed ID: 21098976 Linkage to the 8p21.1 Region Including the CLU Gene in Age at Onset Stratified Alzheimer's Disease Families Journal of Alzheimer's Disease : JAD. Month, 2011 | Pubmed ID: 20930273 Cholinergic Hypofunction Impairs Memory Acquisition Possibly Through Hippocampal Arc and BDNF Downregulation Hippocampus. Sep, 2011 | Pubmed ID: 20865740 Mitochondrial γ-secretase Participates in the Metabolism of Mitochondria-associated Amyloid Precursor Protein FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2011 | Pubmed ID: 20833873 Atrial Fibrillation, Stroke and Dementia in the Very Old: a Population-based Study Neurobiology of Aging. Jul, 2011 | Pubmed ID: 19732992 Progressive Neuropathology and Cognitive Decline in a Single Arctic APP Transgenic Mouse Model Neurobiology of Aging. Feb, 2011 | Pubmed ID: 19329229 Memantine Benefits Functional Abilities in Moderate to Severe Alzheimer's Disease The Journal of Nutrition, Health & Aging. Nov, 2010 | Pubmed ID: 21085908 Phenserine Efficacy in Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2010 | Pubmed ID: 20930279 A DNA Methylation Study of the Amyloid Precursor Protein Gene in Several Brain Regions from Patients with Familial Alzheimer Disease Journal of Neurogenetics. Dec, 2010 | Pubmed ID: 20919856 HPA Axis Dysregulation Associated to Apolipoprotein E4 Genotype in Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2010 | Pubmed ID: 20858975 Insulin Levels Are Decreased in the Cerebrospinal Fluid of Women with Prodomal Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2010 | Pubmed ID: 20847404 Review of Alzheimer's Disease Scales: is There a Need for a New Multi-domain Scale for Therapy Evaluation in Medical Practice? Alzheimer's Research & Therapy. Aug, 2010 | Pubmed ID: 20796301 Accelerated Progression from Mild Cognitive Impairment to Dementia in People with Diabetes Diabetes. Nov, 2010 | Pubmed ID: 20713684 Association of Omi/HtrA2 with γ-secretase in Mitochondria Neurochemistry International. Nov, 2010 | Pubmed ID: 20705111 Impaired Behavior of Female Tg-ArcSwe APP Mice in the IntelliCage: A Longitudinal Study Behavioural Brain Research. Dec, 2010 | Pubmed ID: 20615433 Alzheimer's Disease: Clinical Trials and Drug Development The Lancet. Neurology. Jul, 2010 | Pubmed ID: 20610346 Linkage to 20p13 Including the ANGPT4 Gene in Families with Mixed Alzheimer's Disease and Vascular Dementia Journal of Human Genetics. Oct, 2010 | Pubmed ID: 20596041 Dimebon (latrepirdine) Enhances Mitochondrial Function and Protects Neuronal Cells from Death Journal of Alzheimer's Disease : JAD. Month, 2010 | Pubmed ID: 20555134 Rethinking Alzheimer's Disease Therapy: Are Mitochondria the Key? Journal of Alzheimer's Disease : JAD. Month, 2010 | Pubmed ID: 20463405 High Plasma Levels of Vitamin E Forms and Reduced Alzheimer's Disease Risk in Advanced Age Journal of Alzheimer's Disease : JAD. Month, 2010 | Pubmed ID: 20413888 Gamma-Secretase Dependent Production of Intracellular Domains is Reduced in Adult Compared to Embryonic Rat Brain Membranes PloS One. Mar, 2010 | Pubmed ID: 20333303 The Worldwide Societal Costs of Dementia: Estimates for 2009 Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Mar, 2010 | Pubmed ID: 20298969 Analysis of Microdissected Human Neurons by a Sensitive ELISA Reveals a Correlation Between Elevated Intracellular Concentrations of Abeta42 and Alzheimer's Disease Neuropathology Acta Neuropathologica. May, 2010 | Pubmed ID: 20198479 Vascular Risk Profiles for Dementia and Alzheimer's Disease in Very Old People: a Population-based Longitudinal Study Journal of Alzheimer's Disease : JAD. Month, 2010 | Pubmed ID: 20164587 Synaptic and Endosomal Localization of Active Gamma-secretase in Rat Brain PloS One. Jan, 2010 | Pubmed ID: 20126630 The Large Hydrophilic Loop of Presenilin 1 is Important for Regulating Gamma-secretase Complex Assembly and Dictating the Amyloid Beta Peptide (Abeta) Profile Without Affecting Notch Processing The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 20106965 Biomarkers for Alzheimer's Disease and Other Forms of Dementia: Clinical Needs, Limitations and Future Aspects Experimental Gerontology. Jan, 2010 | Pubmed ID: 19796673 Affinity Pulldown of γ-secretase and Associated Proteins from Human and Rat Brain Journal of Cellular and Molecular Medicine. Nov, 2010 | Pubmed ID: 19754663 CD147, a Gamma-secretase Associated Protein is Upregulated in Alzheimer's Disease Brain and Its Cellular Trafficking is Affected by Presenilin-2 Neurochemistry International. Jan, 2010 | Pubmed ID: 19751784 Cognitive Impairment in the Tg6590 Transgenic Rat Model of Alzheimer's Disease Journal of Cellular and Molecular Medicine. Jun, 2010 | Pubmed ID: 19538474 Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations Journal of Neuropathology and Experimental Neurology. Dec, 2009 | Pubmed ID: 19915487 Low Diastolic Pressure and Risk of Dementia in Very Old People: a Longitudinal Study Dementia and Geriatric Cognitive Disorders. Month, 2009 | Pubmed ID: 19752556 Donepezil Treatment in Severe Alzheimer's Disease: a Pooled Analysis of Three Clinical Trials Current Medical Research and Opinion. Nov, 2009 | Pubmed ID: 19735164 Leisure Activities in Late Life in Relation to Dementia Risk: Principal Component Analysis Dementia and Geriatric Cognitive Disorders. Month, 2009 | Pubmed ID: 19690416 Interactions Between Glycogen Synthase Kinase 3beta, Protein Kinase B, and Protein Phosphatase 2A in Tau Phosphorylation in Mouse N2a Neuroblastoma Cells Journal of Alzheimer's Disease : JAD. Month, 2009 | Pubmed ID: 19542610 Abeta43 is More Frequent Than Abeta40 in Amyloid Plaque Cores from Alzheimer Disease Brains Journal of Neurochemistry. Jul, 2009 | Pubmed ID: 19457079 Mentally Stimulating Activities at Work During Midlife and Dementia Risk After Age 75: Follow-up Study from the Kungsholmen Project The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry. Mar, 2009 | Pubmed ID: 19454849 The Rat As an Animal Model of Alzheimer's Disease Journal of Cellular and Molecular Medicine. Jun, 2009 | Pubmed ID: 19432812 Donepezil in Severe Alzheimer's Disease American Journal of Alzheimer's Disease and Other Dementias. Jun-Jul, 2009 | Pubmed ID: 19246572 Use of Rivastigmine Transdermal Patch in the Treatment of Alzheimer's Disease Expert Opinion on Drug Delivery. Dec, 2008 | Pubmed ID: 19040398 The Amyloid Beta-peptide is Imported into Mitochondria Via the TOM Import Machinery and Localized to Mitochondrial Cristae Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18757748 Therapeutic Use of Nicergoline Clinical Drug Investigation. Month, 2008 | Pubmed ID: 18666801 The Pilot European Alzheimer's Disease Neuroimaging Initiative of the European Alzheimer's Disease Consortium Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jul, 2008 | Pubmed ID: 18631976 Prevalence of Chronic Diseases and Multimorbidity Among the Elderly Population in Sweden American Journal of Public Health. Jul, 2008 | Pubmed ID: 18511722 Apolipoprotein E Epsilon4 Magnifies Lifestyle Risks for Dementia: a Population-based Study Journal of Cellular and Molecular Medicine. Dec, 2008 | Pubmed ID: 18318693 IDEAL: a 6-month, Double-blind, Placebo-controlled Study of the First Skin Patch for Alzheimer Disease Neurology. Jul, 2007 | Pubmed ID: 17646619 Occludin is Overexpressed in Alzheimer's Disease and Vascular Dementia Journal of Cellular and Molecular Medicine. May-Jun, 2007 | Pubmed ID: 17635647 Caregiver Preference for Rivastigmine Patch Relative to Capsules for Treatment of Probable Alzheimer's Disease International Journal of Geriatric Psychiatry. May, 2007 | Pubmed ID: 17407176 A Six-month Double-blind, Randomized, Placebo-controlled Study of a Transdermal Patch in Alzheimer's Disease--rivastigmine Patch Versus Capsule International Journal of Geriatric Psychiatry. May, 2007 | Pubmed ID: 17380489 Donepezil in Patients with Severe Alzheimer's Disease: Double-blind, Parallel-group, Placebo-controlled Study Lancet (London, England). Apr, 2006 | Pubmed ID: 16581404 3-year Study of Donepezil Therapy in Alzheimer's Disease: Effects of Early and Continuous Therapy Dementia and Geriatric Cognitive Disorders. Month, 2006 | Pubmed ID: 16508298 A Unique Gene Expression Signature Discriminates Familial Alzheimer's Disease Mutation Carriers from Their Wild-type Siblings Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005 | Pubmed ID: 16199521 Piracetam: a Review of Pharmacological Properties and Clinical Uses CNS Drug Reviews. Month, 2005 | Pubmed ID: 16007238 Alcohol Drinking in Middle Age and Subsequent Risk of Mild Cognitive Impairment and Dementia in Old Age: a Prospective Population Based Study BMJ (Clinical Research Ed.). Sep, 2004 | Pubmed ID: 15304383 Okadaic-acid-induced Inhibition of Protein Phosphatase 2A Produces Activation of Mitogen-activated Protein Kinases ERK1/2, MEK1/2, and P70 S6, Similar to That in Alzheimer's Disease The American Journal of Pathology. Sep, 2003 | Pubmed ID: 12937126 Up-regulation of Phosphorylated/activated P70 S6 Kinase and Its Relationship to Neurofibrillary Pathology in Alzheimer's Disease The American Journal of Pathology. Aug, 2003 | Pubmed ID: 12875979 Cingulate Cortex Hypoperfusion Predicts Alzheimer's Disease in Mild Cognitive Impairment BMC Neurology. Sep, 2002 | Pubmed ID: 12227833 The Antidepressant and Antiinflammatory Effects of Rolipram in the Central Nervous System CNS Drug Reviews. Month, 2001 | Pubmed ID: 11830756 Homojen Boncuk Bazlı Test Kullanılarak Chaperone-Cochaperone Etkileşimleri Çalışmaları Lisha Wang1, Liza Bergkvist1, Rajnish Kumar1,2, Bengt Winblad1,3, Pavel F. Pavlov1 1Department of Neuroscience Care and Society, Division of Neurogeriatrics, Karolinska Institutet, 2Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), 3Theme Inflammation and Aging, Karolinska University Hospital JoVE 62762 Biochimie
Homojen Boncuk Bazlı Test Kullanılarak Chaperone-Cochaperone Etkileşimleri Çalışmaları Lisha Wang1, Liza Bergkvist1, Rajnish Kumar1,2, Bengt Winblad1,3, Pavel F. Pavlov1 1Department of Neuroscience Care and Society, Division of Neurogeriatrics, Karolinska Institutet, 2Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), 3Theme Inflammation and Aging, Karolinska University Hospital JoVE 62762 Biochimie