Bernd Meibohm Department of Pharmaceutical Sciences, College of Pharmacy University of Tennessee Health Science Center Biography Publications Institution JoVE Articles Bernd Meibohm has not added a biography. If you are Bernd Meibohm and would like to personalize this page please email our Author Liaison for assistance. Publications The Inducible Prostaglandin E Synthase (mPGES-1) in Neuroinflammatory Disorders Experimental Biology and Medicine (Maywood, N.J.). May, 2023 | Pubmed ID: 37515545 Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics Pharmaceutics. Jun, 2023 | Pubmed ID: 37376207 Clinical and Translational Pharmacology Considerations for Anti-infectives Approved Under the FDA Animal Rule Clinical Pharmacokinetics. Jul, 2023 | Pubmed ID: 37326917 Use of Machine Learning for Dosage Individualization of Vancomycin in Neonates Clinical Pharmacokinetics. Aug, 2023 | Pubmed ID: 37300630 Characterization of Spectinamide 1599 Efficacy Against Different Mycobacterial Phenotypes Tuberculosis (Edinburgh, Scotland). May, 2023 | Pubmed ID: 37120915 Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives As Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo ACS Pharmacology & Translational Science. Apr, 2023 | Pubmed ID: 37082747 Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation and ACS Pharmacology & Translational Science. Apr, 2023 | Pubmed ID: 37082746 Efficacy of a Brain-penetrant Antiviral in Lethal Venezuelan and Eastern Equine Encephalitis Mouse Models Science Translational Medicine. Apr, 2023 | Pubmed ID: 37043558 TNX-1500, a Crystallizable Fragment-modified Anti-CD154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Aug, 2023 | Pubmed ID: 37030662 TNX-1500, a Crystallizable Fragment-modified Anti-CD154 Antibody, Prolongs Nonhuman Primate Renal Allograft Survival American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Aug, 2023 | Pubmed ID: 37019335 Barriers to Global Pharmacometrics: Educational Challenges and Opportunities Across the Globe CPT: Pharmacometrics & Systems Pharmacology. Jun, 2023 | Pubmed ID: 36960632 Spray Dried Tigecycline Dry Powder Aerosols for the Treatment of Nontuberculous Mycobacterial Pulmonary Infections Tuberculosis (Edinburgh, Scotland). Mar, 2023 | Pubmed ID: 36716525 SB226, an Inhibitor of Tubulin Polymerization, Inhibits Paclitaxel-resistant Melanoma Growth and Spontaneous Metastasis Cancer Letters. Feb, 2023 | Pubmed ID: 36596380 Alcohol Inhibits the Metabolism of Dimethyl Fumarate to the Active Metabolite Responsible for Decreasing Relapse Frequency in the Treatment of Multiple Sclerosis PloS One. 2022 | Pubmed ID: 36441753 Colchicine-Binding Site Agent CH-2-77 As a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer Molecular Cancer Therapeutics. Jul, 2022 | Pubmed ID: 35499388 Knowledge Gaps in the Pharmacokinetics of Therapeutic Proteins in Pediatric Patients Frontiers in Pharmacology. 2022 | Pubmed ID: 35222051 Drug Repurposing to Identify Nilotinib As a Potential SARS-CoV-2 Main Protease Inhibitor: Insights from a Computational and Study Journal of Chemical Information and Modeling. Nov, 2021 | Pubmed ID: 34666487 Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy Against Tuberculosis ACS Infectious Diseases. Oct, 2021 | Pubmed ID: 34546724 X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone As a Potent Tubulin Polymerization Inhibitor Journal of Medicinal Chemistry. Sep, 2021 | Pubmed ID: 34406768 Time to 'Mind the Gap' in Novel Small Molecule Drug Discovery for Direct-acting Antivirals for SARS-CoV-2 Current Opinion in Virology. Oct, 2021 | Pubmed ID: 34256351 Pediatric Dose Selection for Therapeutic Proteins Journal of Clinical Pharmacology. Jun, 2021 | Pubmed ID: 34185910 Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction Clinical Pharmacokinetics. Nov, 2021 | Pubmed ID: 34041714 Use of Real-World Data and Pharmacometric Modeling in Support of Lacosamide Dosing in Pediatric Patients Under 4 Years of Age Journal of Clinical Pharmacology. Jul, 2021 | Pubmed ID: 33599301 Discovery of -(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-]quinoline-8-sulfonamide As a Potent Dual MDM2/XIAP Inhibitor Journal of Medicinal Chemistry. Feb, 2021 | Pubmed ID: 33556244 Pharmacological Principles Guiding Prolonged Glucocorticoid Treatment in ARDS Intensive Care Medicine. Dec, 2020 | Pubmed ID: 33150472 Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients Pharmaceutics. Sep, 2020 | Pubmed ID: 32977559 Pharmacokinetics and Clinical Pharmacology of Monoclonal Antibodies in Pediatric Patients Paediatric Drugs. Apr, 2020 | Pubmed ID: 32052309 Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis Clinical Pharmacokinetics. Jun, 2020 | Pubmed ID: 32020532 Immunogenicity in Clinical Practice and Drug Development: When is It Significant? Clinical and Translational Science. Mar, 2020 | Pubmed ID: 31762152 Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence ACS Applied Materials & Interfaces. Oct, 2019 | Pubmed ID: 31553876 Sterilization of Mycobacterium Tuberculosis Infected Samples Using Methanol Preserves Anti-tuberculosis Drugs for Subsequent Pharmacological Testing Studies Tuberculosis (Edinburgh, Scotland). Jul, 2019 | Pubmed ID: 31378268 Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599 Pharmaceutical Research. Jul, 2019 | Pubmed ID: 31321552 Population Pharmacokinetic Meta-analysis of Individual Data to Design the First Randomized Efficacy Trial of Vancomycin in Neonates and Young Infants The Journal of Antimicrobial Chemotherapy. Aug, 2019 | Pubmed ID: 31049551 Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Common Problem Drugs and How to Prescribe Them Journal of Clinical Pharmacology. Jul, 2019 | Pubmed ID: 30768795 Comparative Pharmacokinetics of Spectinamide 1599 After Subcutaneous and Intrapulmonary Aerosol Administration in Mice Tuberculosis (Edinburgh, Scotland). Jan, 2019 | Pubmed ID: 30711150 Dynamic Time-kill Curve Characterization of Spectinamide Antibiotics 1445 and 1599 for the Treatment of Tuberculosis European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2019 | Pubmed ID: 30419293 Tannic Acid-inspired Paclitaxel Nanoparticles for Enhanced Anticancer Effects in Breast Cancer Cells Journal of Colloid and Interface Science. Feb, 2019 | Pubmed ID: 30292104 The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360 The AAPS Journal. Nov, 2018 | Pubmed ID: 30392015 The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360 AAPS PharmSciTech. Nov, 2018 | Pubmed ID: 30390237 Pharmacometric Applications and Challenges in the Development of Therapeutic Antibodies in Immuno-Oncology Current Pharmacology Reports. Aug, 2018 | Pubmed ID: 30319936 Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular Frontiers in Microbiology. 2018 | Pubmed ID: 30186246 Sustained Plasma Hepcidin Suppression and Iron Elevation by Anticalin-derived Hepcidin Antagonist in Cynomolgus Monkey British Journal of Pharmacology. Apr, 2018 | Pubmed ID: 29329501 Comparison of Caffeine Disposition Following Administration by Oral Solution (energy Drink) and Inspired Powder (AeroShot) in Human Subjects British Journal of Clinical Pharmacology. Dec, 2017 | Pubmed ID: 28758694 Pharmacokinetics of Monoclonal Antibodies CPT: Pharmacometrics & Systems Pharmacology. Sep, 2017 | Pubmed ID: 28653357 Influence of Ethanol on Darunavir Hepatic Clearance and Intracellular PK/PD in HIV-Infected Monocytes, and CYP3A4-Darunavir Interactions Using Inhibition and in Silico Binding Studies Pharmaceutical Research. Sep, 2017 | Pubmed ID: 28616684 Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Biologics Journal of Clinical Pharmacology. Aug, 2017 | Pubmed ID: 28614591 Regulatory and Ethical Issues in Pediatric Clinical Research: Recommendations From a Panel Discussion Journal of Clinical Pharmacology. Aug, 2017 | Pubmed ID: 28513861 A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter Baumannii Journal of Medicinal Chemistry. Apr, 2017 | Pubmed ID: 28291943 Alterations in Cellular Pharmacokinetics and Pharmacodynamics of Elvitegravir in Response to Ethanol Exposure in HIV-1 Infected Monocytic (U1) Cells PloS One. 2017 | Pubmed ID: 28231276 Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions ACS Infectious Diseases. Jan, 2017 | Pubmed ID: 28081607 Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure The AAPS Journal. Mar, 2017 | Pubmed ID: 28070711 Translational PK/PD of Anti-infective Therapeutics Drug Discovery Today. Technologies. 2016 | Pubmed ID: 27978987 Drug Development of Therapeutic Monoclonal Antibodies BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. Aug, 2016 | Pubmed ID: 27342605 Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jul, 2016 | Pubmed ID: 27098745 Phase II Metabolic Pathways of Spectinamide Antitubercular Agents: A Comparative Study of the Reactivity of 4-Substituted Pyridines to Glutathione Conjugation MedChemComm. Jan, 2016 | Pubmed ID: 27042286 Tissue Penetration of a Novel Spectinamide Antibiotic for the Treatment of Tuberculosis The AAPS Journal. May, 2016 | Pubmed ID: 26984832 Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method PloS One. 2016 | Pubmed ID: 26872388 Pattern Recognition in Pharmacokinetic Data Analysis The AAPS Journal. Jan, 2016 | Pubmed ID: 26338231 In Vitro and in Vivo Evaluation of Synergism Between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics Scientific Reports. Sep, 2015 | Pubmed ID: 26365087 Preclinical Evaluation of SMM-189, a Cannabinoid Receptor 2-specific Inverse Agonist Pharmacology Research & Perspectives. Aug, 2015 | Pubmed ID: 26196013 Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group Clinical Pharmacology and Therapeutics. Sep, 2015 | Pubmed ID: 26088472 Aminomethyl Spectinomycins As Therapeutics for Drug-resistant Respiratory Tract and Sexually Transmitted Bacterial Infections Science Translational Medicine. May, 2015 | Pubmed ID: 25995221 Clinical Pharmacology of Bispecific Antibody Constructs Journal of Clinical Pharmacology. Mar, 2015 | Pubmed ID: 25707960 Ethanol Lock Therapy: a Pilot Infusion Study in Infants The Annals of Pharmacotherapy. Apr, 2015 | Pubmed ID: 25632063 Effects of Alcohol on Human Carboxylesterase Drug Metabolism Clinical Pharmacokinetics. Jun, 2015 | Pubmed ID: 25511794 Protein Engineering for Improved Pharmacologic Characteristics of Established Monoclonal Antibody-based Therapeutics Clinical Pharmacokinetics. Oct, 2014 | Pubmed ID: 25212704 Large-scale Genome-wide Association Studies and Meta-analyses of Longitudinal Change in Adult Lung Function PloS One. 2014 | Pubmed ID: 24983941 Pentacyclic Nitrofurans with in Vivo Efficacy and Activity Against Nonreplicating Mycobacterium Tuberculosis PloS One. 2014 | Pubmed ID: 24505329 Novel Endogenous Glycan Therapy for Retinal Diseases: Safety, in Vitro Stability, Ocular Pharmacokinetic Modeling, and Biodistribution The AAPS Journal. Mar, 2014 | Pubmed ID: 24470212 Spectinamides: a New Class of Semisynthetic Antituberculosis Agents That Overcome Native Drug Efflux Nature Medicine. Feb, 2014 | Pubmed ID: 24464186 Pharmacokinetic Profile of Spectinomycin in Rats Die Pharmazie. Aug, 2013 | Pubmed ID: 24020122 Pharmacokinetics and Pharmacokinetic-pharmacodynamic Correlations of Therapeutic Peptides Clinical Pharmacokinetics. Oct, 2013 | Pubmed ID: 23719681 Applications of Pharmacometrics in the Clinical Development and Pharmacotherapy of Anti-infectives Expert Review of Clinical Pharmacology. Mar, 2013 | Pubmed ID: 23473593 Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants The AAPS Journal. Apr, 2013 | Pubmed ID: 23334978 Simple and Sensitive Assay for Quantification of Oseltamivir and Its Active Metabolite Oseltamivir Carboxylate in Human Plasma Using High-performance Liquid Chromatography Coupled with Electrospray Ionization Tandem Mass Spectrometry: Improved Applicability to Pharmacokinetic Study Journal of Pharmaceutical and Biomedical Analysis. Jan, 2013 | Pubmed ID: 23000242 Genome-wide Joint Meta-analysis of SNP and SNP-by-smoking Interaction Identifies Novel Loci for Pulmonary Function PLoS Genetics. 2012 | Pubmed ID: 23284291 Antitubercular Nitrofuran Isoxazolines with Improved Pharmacokinetic Properties Bioorganic & Medicinal Chemistry. Oct, 2012 | Pubmed ID: 22995771 Developing a Gene Expression Model for Predicting Ventilator-associated Pneumonia in Trauma Patients: a Pilot Study PloS One. 2012 | Pubmed ID: 22916119 Estudios De Asociación Amplia Del Genoma Identifican CHRNA5/3 Y HTR4 En El Desarrollo De La Obstrucción Del Flujo De Aire American Journal of Respiratory and Critical Care Medicine. Jul, 2012 | Pubmed ID: 22837378 The Influence of Abdominal Visceral Fat on Inflammatory Pathways and Mortality Risk in Obstructive Lung Disease The American Journal of Clinical Nutrition. Sep, 2012 | Pubmed ID: 22811442 Genetic Ancestry-smoking Interactions and Lung Function in African Americans: a Cohort Study PloS One. 2012 | Pubmed ID: 22737244 Evaluation of Vancomycin Dosing Regimens in Preterm and Term Neonates Using Monte Carlo Simulations Pharmacotherapy. May, 2012 | Pubmed ID: 22488303 Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy The AAPS Journal. Jun, 2012 | Pubmed ID: 22407289 Characterizing the Impact of Renal Impairment on the Clinical Pharmacology of Biologics Journal of Clinical Pharmacology. Jan, 2012 | Pubmed ID: 22232754 Population Pharmacokinetic/pharmacodynamic Analyses As the Basis for Dosing of Therapeutic Monoclonal Antibodies Clinical Pharmacokinetics. Dec, 2011 | Pubmed ID: 22087868 Comparative Performance of Cell Life Span and Cell Transit Models for Describing Erythropoietic Drug Effects The AAPS Journal. Dec, 2011 | Pubmed ID: 22005901 Genome-wide Association and Large-scale Follow Up Identifies 16 New Loci Influencing Lung Function Nature Genetics. Sep, 2011 | Pubmed ID: 21946350 Is Age-related Decline in Lean Mass and Physical Function Accelerated by Obstructive Lung Disease or Smoking? Thorax. Nov, 2011 | Pubmed ID: 21724748 Pharmacokinetics of a Combination of Δ9-tetrahydro-cannabinol and Celecoxib in a Porcine Model of Hemorrhagic Shock Biopharmaceutics & Drug Disposition. Mar, 2011 | Pubmed ID: 21341278 The Current Role of Model-based Drug Development Expert Opinion on Drug Discovery. Apr, 2010 | Pubmed ID: 22823084 In Vitro Pharmacokinetic/pharmacodynamic Models in Anti-infective Drug Development: Focus on TB Future Medicinal Chemistry. Aug, 2010 | Pubmed ID: 21359155 Discovery of Novel 2-aryl-4-benzoyl-imidazoles Targeting the Colchicines Binding Site in Tubulin As Potential Anticancer Agents Journal of Medicinal Chemistry. Oct, 2010 | Pubmed ID: 20919720 Population Pharmacokinetics of Therapeutic Monoclonal Antibodies Clinical Pharmacokinetics. Oct, 2010 | Pubmed ID: 20818831 Genetic Ancestry in Lung-function Predictions The New England Journal of Medicine. Jul, 2010 | Pubmed ID: 20647190 Predictors of Mortality in Elderly Subjects with Obstructive Airway Disease: the PILE Score Annals of Epidemiology. Mar, 2010 | Pubmed ID: 20159492 A Simple in Vitro PK/PD Model System to Determine Time-kill Curves of Drugs Against Mycobacteria Tuberculosis (Edinburgh, Scotland). Sep, 2009 | Pubmed ID: 19748318 Concepts and Challenges in Quantitative Pharmacology and Model-based Drug Development The AAPS Journal. Dec, 2008 | Pubmed ID: 19003542 A Tandem Mass Spectrometry Assay for the Simultaneous Determination of Acetaminophen, Caffeine, Phenytoin, Ranitidine, and Theophylline in Small Volume Pediatric Plasma Specimens Clinica Chimica Acta; International Journal of Clinical Chemistry. Dec, 2008 | Pubmed ID: 18796299 A Microbiological Assessment of Novel Nitrofuranylamides As Anti-tuberculosis Agents The Journal of Antimicrobial Chemotherapy. Nov, 2008 | Pubmed ID: 18693235 Pharmacokinetically-guided Lead Optimization of Nitrofuranylamide Anti-tuberculosis Agents The AAPS Journal. 2008 | Pubmed ID: 18446516 Biopharmaceutics, Pharmacokinetics and Pharmacodynamics of Antituberculosis Drugs Current Medicinal Chemistry. 2008 | Pubmed ID: 18393850 Population Pharmacokinetics of Cetuximab in Patients with Squamous Cell Carcinoma of the Head and Neck Journal of Clinical Pharmacology. Mar, 2008 | Pubmed ID: 18218786 Discovery of Novel Isoxazolines As Anti-tuberculosis Agents Bioorganic & Medicinal Chemistry Letters. Dec, 2007 | Pubmed ID: 17937983 G2677T and C3435T Genotype and Haplotype Are Associated with Hepatic ABCB1 (MDR1) Expression Journal of Clinical Pharmacology. Mar, 2006 | Pubmed ID: 16490813 LC/MS/MS in Drug Development: Targeting the Brain BioTechniques. Jun, 2005 | Pubmed ID: 16528912 Population Pharmacokinetic Studies in Pediatrics: Issues in Design and Analysis The AAPS Journal. Oct, 2005 | Pubmed ID: 16353925 The Clinical Pharmacokinetics of Phosphodiesterase-5 Inhibitors for Erectile Dysfunction Journal of Clinical Pharmacology. Sep, 2005 | Pubmed ID: 16100293 SYBR Green-based Real-time PCR Allelic Discrimination Assay for Beta2-adrenergic Receptor Polymorphisms Analytical Biochemistry. Sep, 2005 | Pubmed ID: 16026755 Pharmacokinetic Aspects of Biotechnology Products Journal of Pharmaceutical Sciences. Sep, 2004 | Pubmed ID: 15295780 Real-time PCR-based Genotyping Assay for CXCR2 Polymorphisms Clinica Chimica Acta; International Journal of Clinical Chemistry. Mar, 2004 | Pubmed ID: 14967163 The Effect of CYP3A5 and MDR1 Polymorphic Expression on Cyclosporine Oral Disposition in Renal Transplant Patients Journal of Clinical Pharmacology. Jun, 2003 | Pubmed ID: 12817518 Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models (Video) | JoVE Sara E. Maloney1, Ian E. Stewart1, Jeffrey B. Mecham1, Mercedes Gonzalez-Juarrero2, Bernd Meibohm3, Anthony J. Hickey1 1Technology Advancement and Commercialization, RTI International, 2Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center JoVE 65756 Médecine
Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models (Video) | JoVE Sara E. Maloney1, Ian E. Stewart1, Jeffrey B. Mecham1, Mercedes Gonzalez-Juarrero2, Bernd Meibohm3, Anthony J. Hickey1 1Technology Advancement and Commercialization, RTI International, 2Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center JoVE 65756 Médecine