Bernhard Bettler Dept. of Biomedicine, Pharmacenter University of Basel Biography Publications Institution JoVE Articles Bernhard Bettler has not added a biography. If you are Bernhard Bettler and would like to personalize this page please email our Author Liaison for assistance. Publications Presynaptic Excitation Via GABAB Receptors in Habenula Cholinergic Neurons Regulates Fear Memory Expression Cell. Jul, 2016 | Pubmed ID: 27426949 KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB Receptor-Mediated Inhibition in Cholecystokinin-Containing Interneurons Cerebral Cortex (New York, N.Y. : 1991). Apr, 2016 | Pubmed ID: 27073217 Presynaptic GABAB Receptors Regulate Hippocampal Synapses During Associative Learning in Behaving Mice PloS One. 2016 | Pubmed ID: 26848590 Modular Composition and Dynamics of Native GABAB Receptors Identified by High-resolution Proteomics Nature Neuroscience. Feb, 2016 | Pubmed ID: 26691831 Differential Roles of GABAB1 Subunit Isoforms on Locomotor Responses to Acute and Repeated Administration of Cocaine Behavioural Brain Research. Feb, 2016 | Pubmed ID: 26518330 A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes Cancer Cell. Dec, 2015 | Pubmed ID: 26669487 Trace Amine-associated Receptor 1 Activation Silences GSK3β Signaling of TAAR1 and D2R Heteromers European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. Nov, 2015 | Pubmed ID: 26372541 GABAB Receptor Deficiency Causes Failure of Neuronal Homeostasis in Hippocampal Networks Proceedings of the National Academy of Sciences of the United States of America. Jun, 2015 | Pubmed ID: 26056260 Glutamate Input in the Dorsal Raphe Nucleus As a Determinant of Escalated Aggression in Male Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2015 | Pubmed ID: 25904796 GABA Blocks Pathological but Not Acute TRPV1 Pain Signals Cell. Feb, 2015 | Pubmed ID: 25679765 Mechanisms of Fast Desensitization of GABA(B) Receptor-gated Currents Advances in Pharmacology (San Diego, Calif.). 2015 | Pubmed ID: 25637440 Lack of GABAB Receptors Modifies Behavioural and Biochemical Alterations Induced by Precipitated Nicotine Withdrawal Neuropharmacology. Mar, 2015 | Pubmed ID: 25479464 Pharmacological Characterization of GABAB Receptor Subtypes Assembled with Auxiliary KCTD Subunits Neuropharmacology. Jan, 2015 | Pubmed ID: 25196734 GABAB(1) Receptor Subunit Isoforms Differentially Regulate Stress Resilience Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25288769 Effect of Genetic and Pharmacological Blockade of GABA Receptors on the 5-HT2C Receptor Function During Stress Journal of Neurochemistry. Dec, 2014 | Pubmed ID: 25113583 GABAB Receptor Phosphorylation Regulates KCTD12-induced K⁺ Current Desensitization Biochemical Pharmacology. Oct, 2014 | Pubmed ID: 25065880 Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization Neuron. Jun, 2014 | Pubmed ID: 24836506 Involvement of GABAB Receptors in Biochemical Alterations Induced by Anxiety-related Responses to Nicotine in Mice: Genetic and Pharmacological Approaches Neuropharmacology. Jun, 2014 | Pubmed ID: 24486711 Deletion of GABA-B Receptor in Schwann Cells Regulates Remak Bundles and Small Nociceptive C-fibers Glia. Apr, 2014 | Pubmed ID: 24474699 Impaired GABAB Receptor Signaling Dramatically Up-regulates Kiss1 Expression Selectively in Nonhypothalamic Brain Regions of Adult but Not Prepubertal Mice Endocrinology. Mar, 2014 | Pubmed ID: 24424047 GABA Suppresses Neurogenesis in the Adult Hippocampus Through GABAB Receptors Development (Cambridge, England). Jan, 2014 | Pubmed ID: 24284211 GABA Type B Receptor Signaling in Proopiomelanocortin Neurons Protects Against Obesity, Insulin Resistance, and Hypothalamic Inflammation in Male Mice on a High-fat Diet The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2013 | Pubmed ID: 24155320 Lack of Functional GABAB Receptors Alters Kiss1 , Gnrh1 and Gad1 MRNA Expression in the Medial Basal Hypothalamus at Postnatal Day 4 Neuroendocrinology. 2013 | Pubmed ID: 24080944 Activation of Presynaptic GABA(B(1a,2)) Receptors Inhibits Synaptic Transmission at Mammalian Inhibitory Cholinergic Olivocochlear-hair Cell Synapses The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2013 | Pubmed ID: 24068816 Up-regulation of GABA(B) Receptor Signaling by Constitutive Assembly with the K+ Channel Tetramerization Domain-containing Protein 12 (KCTD12) The Journal of Biological Chemistry. Aug, 2013 | Pubmed ID: 23843457 Differential GABAB-receptor-mediated Effects in Perisomatic- and Dendrite-targeting Parvalbumin Interneurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2013 | Pubmed ID: 23637187 Postnatal Development of the Endocrine Pancreas in Mice Lacking Functional GABAB Receptors American Journal of Physiology. Endocrinology and Metabolism. May, 2013 | Pubmed ID: 23531612 Distinct Roles of GABAB1a- and GABAB1b-containing GABAB Receptors in Spontaneous and Evoked Termination of Persistent Cortical Activity The Journal of Physiology. Feb, 2013 | Pubmed ID: 23266934 GABAB Receptor Subtypes Differentially Modulate Synaptic Inhibition in the Dentate Gyrus to Enhance Granule Cell Output British Journal of Pharmacology. Apr, 2013 | Pubmed ID: 23186302 Constitutive Notch2 Signaling Induces Hepatic Tumors in Mice Hepatology (Baltimore, Md.). Apr, 2013 | Pubmed ID: 23175466 Opposite Effects of KCTD Subunit Domains on GABA(B) Receptor-mediated Desensitization The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 23035119 GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking but Not the Sleep-wake Switch or Propofol-induced Loss of Consciousness The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2012 | Pubmed ID: 22993424 Inhibition of Notch2 by Numb/Numblike Controls Myocardial Compaction in the Heart Cardiovascular Research. Nov, 2012 | Pubmed ID: 22865640 Acute Behavioural Responses to Nicotine and Nicotine Withdrawal Syndrome Are Modified in GABA(B1) Knockout Mice Neuropharmacology. Oct, 2012 | Pubmed ID: 22727822 Regulation of Neuronal GABA(B) Receptor Functions by Subunit Composition Nature Reviews. Neuroscience. Jun, 2012 | Pubmed ID: 22595784 Early-life Stress Induces Visceral Hypersensitivity in Mice Neuroscience Letters. Mar, 2012 | Pubmed ID: 22326388 A Modified RMCE-compatible Rosa26 Locus for the Expression of Transgenes from Exogenous Promoters PloS One. 2012 | Pubmed ID: 22253858 Compartmentalization of the GABAB Receptor Signaling Complex is Required for Presynaptic Inhibition at Hippocampal Synapses The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2011 | Pubmed ID: 21880914 The Oligomeric State Sets GABA(B) Receptor Signalling Efficacy The EMBO Journal. Jun, 2011 | Pubmed ID: 21552208 TAAR1 Activation Modulates Monoaminergic Neurotransmission, Preventing Hyperdopaminergic and Hypoglutamatergic Activity Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21525407 Distribution of the Auxiliary GABAB Receptor Subunits KCTD8, 12, 12b, and 16 in the Mouse Brain The Journal of Comparative Neurology. Jun, 2011 | Pubmed ID: 21452234 Differential Effects of GABAB Receptor Subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG Activity and Sleep Regulation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2010 | Pubmed ID: 20962240 Molecular Organization and Dynamics of the Melatonin MT₁ Receptor/RGS20/G(i) Protein Complex Reveal Asymmetry of Receptor Dimers for RGS and G(i) Coupling The EMBO Journal. Nov, 2010 | Pubmed ID: 20859254 GABAB Receptors: Physiological Functions and Mechanisms of Diversity Advances in Pharmacology (San Diego, Calif.). 2010 | Pubmed ID: 20655485 NMDA Receptor-dependent GABAB Receptor Internalization Via CaMKII Phosphorylation of Serine 867 in GABAB1 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20643921 Native GABA(B) Receptors Are Heteromultimers with a Family of Auxiliary Subunits Nature. May, 2010 | Pubmed ID: 20400944 The Sushi Domains of GABAB Receptors Function As Axonal Targeting Signals The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2010 | Pubmed ID: 20107064 Lack of Functional GABA(B) Receptors Alters GnRH Physiology and Sexual Dimorphic Expression of GnRH and GAD-67 in the Brain American Journal of Physiology. Endocrinology and Metabolism. Mar, 2010 | Pubmed ID: 20009027 Conditional Gene Deletion Reveals Functional Redundancy of GABAB Receptors in Peripheral Nociceptors in Vivo Molecular Pain. 2009 | Pubmed ID: 19925671 The Selective Antagonist EPPTB Reveals TAAR1-mediated Regulatory Mechanisms in Dopaminergic Neurons of the Mesolimbic System Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19892733 A Mouse Model for Visualization of GABA(B) Receptors Genesis (New York, N.Y. : 2000). Sep, 2009 | Pubmed ID: 19603512 Subcellular Compartment-specific Molecular Diversity of Pre- and Post-synaptic GABA-activated GIRK Channels in Purkinje Cells Journal of Neurochemistry. Aug, 2009 | Pubmed ID: 19558451 Notch2 Signaling Promotes Biliary Epithelial Cell Fate Specification and Tubulogenesis During Bile Duct Development in Mice Hepatology (Baltimore, Md.). Sep, 2009 | Pubmed ID: 19551907 Selective Loss of GABA(B) Receptors in Orexin-producing Neurons Results in Disrupted Sleep/wakefulness Architecture Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19246384 The GABAB1a Isoform Mediates Heterosynaptic Depression at Hippocampal Mossy Fiber Synapses The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2009 | Pubmed ID: 19193888 No Evidence for a Bone Phenotype in GPRC6A Knockout Mice Under Normal Physiological Conditions Journal of Molecular Endocrinology. Mar, 2009 | Pubmed ID: 19103720 Loss of GABAB Receptors in Cochlear Neurons: Threshold Elevation Suggests Modulation of Outer Hair Cell Function by Type II Afferent Fibers Journal of the Association for Research in Otolaryngology : JARO. Mar, 2009 | Pubmed ID: 18925381 The Sushi Domains of Secreted GABA(B1) Isoforms Selectively Impair GABA(B) Heteroreceptor Function The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18765663 Altered Peripheral Myelination in Mice Lacking GABAB Receptors Molecular and Cellular Neurosciences. Mar, 2008 | Pubmed ID: 18206390 Trace Amine-associated Receptor 1 Modulates Dopaminergic Activity The Journal of Pharmacology and Experimental Therapeutics. Mar, 2008 | Pubmed ID: 18083911 The Pros of Not Being Competitive Current Neuropharmacology. Sep, 2007 | Pubmed ID: 19305796 Functional Mapping of GABA(B)-receptor Subtypes in the Thalamus Journal of Neurophysiology. Dec, 2007 | Pubmed ID: 17881477 GluR7 is an Essential Subunit of Presynaptic Kainate Autoreceptors at Hippocampal Mossy Fiber Synapses Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17620617 Type B Gamma-aminobutyric Acid Receptors Modulate the Function of the Extracellular Ca2+-sensing Receptor and Cell Differentiation in Murine Growth Plate Chondrocytes Endocrinology. Oct, 2007 | Pubmed ID: 17615148 Synapse Loss in Cortex of Agrin-deficient Mice After Genetic Rescue of Perinatal Death The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2007 | Pubmed ID: 17611272 Complex Formation with the Type B Gamma-aminobutyric Acid Receptor Affects the Expression and Signal Transduction of the Extracellular Calcium-sensing Receptor. Studies with HEK-293 Cells and Neurons The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17591780 Specific Roles of GABA(B(1)) Receptor Isoforms in Cognition Behavioural Brain Research. Jul, 2007 | Pubmed ID: 17498817 GABA(B) Receptors: Synaptic Functions and Mechanisms of Diversity Current Opinion in Neurobiology. Jun, 2007 | Pubmed ID: 17433877 Behavioral Evaluation of Mice Deficient in GABA(B(1)) Receptor Isoforms in Tests of Unconditioned Anxiety Psychopharmacology. Mar, 2007 | Pubmed ID: 17171558 GABAB1 Receptor Subunit Isoforms Exert a Differential Influence on Baseline but Not GABAB Receptor Agonist-induced Changes in Mice The Journal of Pharmacology and Experimental Therapeutics. Dec, 2006 | Pubmed ID: 16990508 GABA(B(1)) Receptor Isoforms Differentially Mediate the Acquisition and Extinction of Aversive Taste Memories The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2006 | Pubmed ID: 16928868 Generalization of Amygdala LTP and Conditioned Fear in the Absence of Presynaptic Inhibition Nature Neuroscience. Aug, 2006 | Pubmed ID: 16819521 WITHDRAWN: Type B Gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes Endocrinology. Sep, 2006 | Pubmed ID: 16728489 The GABAB1b Isoform Mediates Long-lasting Inhibition of Dendritic Ca2+ Spikes in Layer 5 Somatosensory Pyramidal Neurons Neuron. May, 2006 | Pubmed ID: 16701210 Differential Compartmentalization and Distinct Functions of GABAB Receptor Variants Neuron. May, 2006 | Pubmed ID: 16701209 Molecular Diversity, Trafficking and Subcellular Localization of GABAB Receptors Pharmacology & Therapeutics. Jun, 2006 | Pubmed ID: 16644017 Compartment-dependent Colocalization of Kir3.2-containing K+ Channels and GABAB Receptors in Hippocampal Pyramidal Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2006 | Pubmed ID: 16624949 Hyperdopaminergia and Altered Locomotor Activity in GABAB1-deficient Mice Journal of Neurochemistry. May, 2006 | Pubmed ID: 16606363 Adenohypophyseal and Hypothalamic GABA B Receptor Subunits Are Downregulated by Estradiol in Adult Female Rats Life Sciences. Jun, 2006 | Pubmed ID: 16516242 GABA(B1) Knockout Mice Reveal Alterations in Prolactin Levels, Gonadotropic Axis, and Reproductive Function Neuroendocrinology. 2005 | Pubmed ID: 16682806 Expression of Gamma-aminobutyric Acid B Receptor Subunits in Hypothalamus of Male and Female Developing Rats Brain Research. Developmental Brain Research. Dec, 2005 | Pubmed ID: 16297450 Subtype-selective Interaction with the Transcription Factor CCAAT/enhancer-binding Protein (C/EBP) Homologous Protein (CHOP) Regulates Cell Surface Expression of GABA(B) Receptors The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 16081421 The RXR-type Endoplasmic Reticulum-retention/retrieval Signal of GABAB1 Requires Distant Spacing from the Membrane to Function Molecular Pharmacology. Jul, 2005 | Pubmed ID: 15805225 Altered Anxiety and Depression-related Behaviour in Mice Lacking GABAB(2) Receptor Subunits Neuroreport. Feb, 2005 | Pubmed ID: 15706241 Determination of the Minimal Functional Ligand-binding Domain of the GABAB1b Receptor The Biochemical Journal. Mar, 2005 | Pubmed ID: 15482257 Effect of Androgens on Sexual Differentiation of Pituitary Gamma-aminobutyric Acid Receptor Subunit GABA(B) Expression Neuroendocrinology. 2004 | Pubmed ID: 15591793 Ca2+ Activity at GABAB Receptors Constitutively Promotes Metabotropic Glutamate Signaling in the Absence of GABA Proceedings of the National Academy of Sciences of the United States of America. Nov, 2004 | Pubmed ID: 15550547 Floxed Allele for Conditional Inactivation of the GABAB(1) Gene Genesis (New York, N.Y. : 2000). Nov, 2004 | Pubmed ID: 15493018 Altered Hippocampal Expression of Calbindin-D-28k and Calretinin in GABA(B(1))-deficient Mice Biochemical Pharmacology. Oct, 2004 | Pubmed ID: 15451404 Independent Maturation of the GABA(B) Receptor Subunits GABA(B1) and GABA(B2) During Postnatal Development in Rodent Brain The Journal of Comparative Neurology. Sep, 2004 | Pubmed ID: 15305362 Molecular Structure and Physiological Functions of GABA(B) Receptors Physiological Reviews. Jul, 2004 | Pubmed ID: 15269338 Redistribution of GABAB(1) Protein and Atypical GABAB Responses in GABAB(2)-deficient Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2004 | Pubmed ID: 15240800 Behavioral Characterization of the Novel GABAB Receptor-positive Modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-like Activity Without Side Effects Associated with Baclofen or Benzodiazepines The Journal of Pharmacology and Experimental Therapeutics. Sep, 2004 | Pubmed ID: 15113848 Glioblastomas on the Move Science's STKE : Signal Transduction Knowledge Environment. Apr, 2004 | Pubmed ID: 15100429 Specific Gamma-hydroxybutyrate-binding Sites but Loss of Pharmacological Effects of Gamma-hydroxybutyrate in GABA(B)(1)-deficient Mice The European Journal of Neuroscience. Nov, 2003 | Pubmed ID: 14656321 Recognition Molecule Associated Carbohydrate Inhibits Postsynaptic GABA(B) Receptors: a Mechanism for Homeostatic Regulation of GABA Release in Perisomatic Synapses Molecular and Cellular Neurosciences. Oct, 2003 | Pubmed ID: 14572452 GABA(B) Receptors As Potential Therapeutic Targets Current Drug Targets. CNS and Neurological Disorders. Aug, 2003 | Pubmed ID: 12871035 Altered Expression of GABAB Receptors in the Hippocampus After Kainic-acid-induced Seizures in Rats Brain Research. Molecular Brain Research. May, 2003 | Pubmed ID: 12750012 Ligands for Expression Cloning and Isolation of GABA(B) Receptors Farmaco (Società Chimica Italiana : 1989). Mar, 2003 | Pubmed ID: 12620413 The Intracellular Loops of the GB2 Subunit Are Crucial for G-protein Coupling of the Heteromeric Gamma-aminobutyrate B Receptor Molecular Pharmacology. Aug, 2002 | Pubmed ID: 12130687 The Anticonvulsant Gabapentin (neurontin) Does Not Act Through Gamma-aminobutyric Acid-B Receptors Molecular Pharmacology. Jun, 2002 | Pubmed ID: 12021399 Distinct Localization of GABA(B) Receptors Relative to Synaptic Sites in the Rat Cerebellum and Ventrobasal Thalamus The European Journal of Neuroscience. Jan, 2002 | Pubmed ID: 11849296 A Single Subunit (GB2) is Required for G-protein Activation by the Heterodimeric GABA(B) Receptor The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11711539 An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery Martin H. M. Sailer1, Durga Sarvepalli2, Catherine Brégère3, Urs Fisch3, Marin Guentchev4, Michael Weller6, Raphael Guzman3, Bernhard Bettler1, Arkasubhra Ghosh*2, Gregor Hutter*5 1Dept. of Biomedicine, Pharmacenter, University of Basel, 2Molecular Signalling and Gene Therapy, Narayana Nethralaya Foundation, Narayana Health City, 3Brain Ischemia and Regeneration, Department of Biomedicine, University Hospital Basel, 4Department of Neurosurgery, Klinikum Idar-Oberstein, 5Department of Neurosurgery and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 6Department of Neurology, Laboratory of Molecular Neuro Oncology, University Hospital of Zurich JoVE 54018 Biologie du développement
An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery Martin H. M. Sailer1, Durga Sarvepalli2, Catherine Brégère3, Urs Fisch3, Marin Guentchev4, Michael Weller6, Raphael Guzman3, Bernhard Bettler1, Arkasubhra Ghosh*2, Gregor Hutter*5 1Dept. of Biomedicine, Pharmacenter, University of Basel, 2Molecular Signalling and Gene Therapy, Narayana Nethralaya Foundation, Narayana Health City, 3Brain Ischemia and Regeneration, Department of Biomedicine, University Hospital Basel, 4Department of Neurosurgery, Klinikum Idar-Oberstein, 5Department of Neurosurgery and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 6Department of Neurology, Laboratory of Molecular Neuro Oncology, University Hospital of Zurich JoVE 54018 Biologie du développement