Brahm H. Segal Department of Medicine, School of Medicine and Biomedical Sciences University of Buffalo Biography Publications Institution JoVE Articles Brahm H. Segal has not added a biography. If you are Brahm H. Segal and would like to personalize this page please email our Author Liaison for assistance. Publications Dectin-1-Dependent LC3 Recruitment to Phagosomes Enhances Fungicidal Activity in Macrophages The Journal of Infectious Diseases. May, 2014 | Pubmed ID: 24842831 Prevention of Infection in Cancer Patients Cancer Treatment and Research. 2014 | Pubmed ID: 24706235 Nrf2 Amplifies Oxidative Stress Via Induction of Klf9 Molecular Cell. Mar, 2014 | Pubmed ID: 24613345 NADPH Oxidase Promotes Neutrophil Extracellular Trap Formation in Pulmonary Aspergillosis Infection and Immunity. May, 2014 | Pubmed ID: 24549323 NF-κB Inhibition After Cecal Ligation and Puncture Reduces Sepsis-associated Lung Injury Without Altering Bacterial Host Defense Mediators of Inflammation. 2013 | Pubmed ID: 24347827 Myeloid-derived Suppressor Cells Modulate Immune Responses Independently of NADPH Oxidase in the Ovarian Tumor Microenvironment in Mice PloS One. 2013 | Pubmed ID: 23922763 NADPH Oxidase Limits Lipopolysaccharide-induced Lung Inflammation and Injury in Mice Through Reduction-oxidation Regulation of NF-κB Activity Journal of Immunology (Baltimore, Md. : 1950). May, 2013 | Pubmed ID: 23530143 Monocyte- and Macrophage-targeted NADPH Oxidase Mediates Antifungal Host Defense and Regulation of Acute Inflammation in Mice Journal of Immunology (Baltimore, Md. : 1950). Apr, 2013 | Pubmed ID: 23509361 Identification of Myeloid Cell Subsets in Murine Lungs Using Flow Cytometry American Journal of Respiratory Cell and Molecular Biology. Aug, 2013 | Pubmed ID: 23492192 NETosis and NADPH Oxidase: at the Intersection of Host Defense, Inflammation, and Injury Frontiers in Immunology. 2013 | Pubmed ID: 23459634 NADPH Oxidase and Nrf2 Regulate Gastric Aspiration-induced Inflammation and Acute Lung Injury Journal of Immunology (Baltimore, Md. : 1950). Feb, 2013 | Pubmed ID: 23296708 Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung Cell Reports. Dec, 2012 | Pubmed ID: 23200858 Interferon Regulatory Factor-8 is Important for Histone Deacetylase Inhibitor-mediated Antitumor Activity PloS One. 2012 | Pubmed ID: 23028998 Elevating Body Temperature Enhances Hematopoiesis and Neutrophil Recovery After Total Body Irradiation in an IL-1-, IL-17-, and G-CSF-dependent Manner Blood. Sep, 2012 | Pubmed ID: 22806894 Regulation of Innate Immunity by NADPH Oxidase Free Radical Biology & Medicine. Jul, 2012 | Pubmed ID: 22583699 Reactive Oxygen Species Produced by the NADPH Oxidase 2 Complex in Monocytes Protect Mice from Bacterial Infections Journal of Immunology (Baltimore, Md. : 1950). May, 2012 | Pubmed ID: 22491245 Characterization of Vancomycin Pharmacokinetics in the Adult Acute Myeloid Leukemia Population Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners. Mar, 2012 | Pubmed ID: 21521799 Role of NADPH Oxidase Versus Neutrophil Proteases in Antimicrobial Host Defense PloS One. 2011 | Pubmed ID: 22163282 Thematic Issue: Immunity, Inflammation and Fungal Infections Immunological Investigations. 2011 | Pubmed ID: 21985300 Transmission of Resistant Bacteria in Intensive Care The New England Journal of Medicine. Aug, 2011 | Pubmed ID: 21864175 Nrf2 Regulates Chronic Lung Inflammation and B-cell Responses to Nontypeable Haemophilus Influenzae American Journal of Respiratory Cell and Molecular Biology. Sep, 2011 | Pubmed ID: 21216970 Chronic Granulomatous Disease: Lessons from a Rare Disorder Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Jan, 2011 | Pubmed ID: 21195301 Proceedings from the 4th Advances Against Aspergillosis Conference, February 4-6, 2010, Rome, Italy Medical Mycology : Official Publication of the International Society for Human and Animal Mycology. Apr, 2011 | Pubmed ID: 21108577 Role of NADPH Oxidase in Host Defense Against Aspergillosis Medical Mycology : Official Publication of the International Society for Human and Animal Mycology. Apr, 2011 | Pubmed ID: 20560866 Antifungal Prophylaxis and Therapy in Patients with Hematological Malignancies and Hematopoietic Stem Cell Transplant Recipients Expert Review of Anti-infective Therapy. Dec, 2010 | Pubmed ID: 21133669 Pulmonary Aspergillosis: Clinical Presentation, Diagnostic Tests, Management and Complications Current Opinion in Pulmonary Medicine. May, 2010 | Pubmed ID: 20375786 NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice PloS One. 2010 | Pubmed ID: 20300512 Altered Eosinophil Profile in Mice with ST6Gal-1 Deficiency: an Additional Role for ST6Gal-1 Generated by the P1 Promoter in Regulating Allergic Inflammation Journal of Leukocyte Biology. Mar, 2010 | Pubmed ID: 20007243 Editorial: Special Issue, "invasive Fungal Diseases in Allogeneic Hematopoietic Stem Cell Transplant Recipients" Mycopathologia. Dec, 2009 | Pubmed ID: 19937130 Infection Control Measures to Prevent Invasive Mould Diseases in Hematopoietic Stem Cell Transplant Recipients Mycopathologia. Dec, 2009 | Pubmed ID: 19859825 Prevention and Treatment of Invasive Fungal Diseases in Neutropenic Patients Current Opinion in Infectious Diseases. Aug, 2009 | Pubmed ID: 19506476 Aspergillosis The New England Journal of Medicine. Apr, 2009 | Pubmed ID: 19403905 Invasive Aspergillosis in Chronic Granulomatous Disease Medical Mycology : Official Publication of the International Society for Human and Animal Mycology. 2009 | Pubmed ID: 19296367 Antifungal Agents in Hematopoietic Stem Cell Transplantation Current Pharmaceutical Design. 2008 | Pubmed ID: 18691111 Defining Responses to Therapy and Study Outcomes in Clinical Trials of Invasive Fungal Diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer Consensus Criteria Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Sep, 2008 | Pubmed ID: 18637757 Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jun, 2008 | Pubmed ID: 18462102 Broad-spectrum Antifungal Prophylaxis in Patients with Cancer at High Risk for Invasive Mold Infections: Point Journal of the National Comprehensive Cancer Network : JNCCN. Feb, 2008 | Pubmed ID: 18319049 Prevention and Treatment of Cancer-related Infections Journal of the National Comprehensive Cancer Network : JNCCN. Feb, 2008 | Pubmed ID: 18319048 Defective Tryptophan Catabolism Underlies Inflammation in Mouse Chronic Granulomatous Disease Nature. Jan, 2008 | Pubmed ID: 18185592 Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Feb, 2008 | Pubmed ID: 18177225 Role of Macrophages in Host Defense Against Aspergillosis and Strategies for Immune Augmentation The Oncologist. 2007 | Pubmed ID: 18039634 Immunotherapy for Fungal Infections with Special Emphasis on Central Nervous System Infections Neurology India. Jul-Sep, 2007 | Pubmed ID: 17921655 Combination Antifungals: an Update Expert Review of Anti-infective Therapy. Oct, 2007 | Pubmed ID: 17914921 Ganciclovir Inhibits Lymphocyte Proliferation by Impairing DNA Synthesis Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Jul, 2007 | Pubmed ID: 17580254 Antibacterial Prophylaxis in Patients with Neutropenia Journal of the National Comprehensive Cancer Network : JNCCN. Feb, 2007 | Pubmed ID: 17335692 Modeling the Combination of Amphotericin B, Micafungin, and Nikkomycin Z Against Aspergillus Fumigatus in Vitro Using a Novel Response Surface Paradigm Antimicrobial Agents and Chemotherapy. May, 2007 | Pubmed ID: 17325217 Prevention and Early Treatment of Invasive Fungal Infection in Patients with Cancer and Neutropenia and in Stem Cell Transplant Recipients in the Era of Newer Broad-spectrum Antifungal Agents and Diagnostic Adjuncts Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Feb, 2007 | Pubmed ID: 17205448 Treatment of Invasive Aspergillosis with Posaconazole in Patients Who Are Refractory to or Intolerant of Conventional Therapy: an Externally Controlled Trial Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jan, 2007 | Pubmed ID: 17143808 Acid Aspiration-induced Lung Inflammation and Injury Are Exacerbated in NADPH Oxidase-deficient Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2007 | Pubmed ID: 17114280 Multicenter, Noncomparative Study of Caspofungin in Combination with Other Antifungals As Salvage Therapy in Adults with Invasive Aspergillosis Cancer. Dec, 2006 | Pubmed ID: 17103444 Issues Related to the Design and Interpretation of Clinical Trials of Salvage Therapy for Invasive Mold Infection Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Dec, 2006 | Pubmed ID: 17083020 Clinical Research in the Lay Press: Irresponsible Journalism Raises a Huge Dose of Doubt Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Oct, 2006 | Pubmed ID: 16983616 Altered Granulopoietic Profile and Exaggerated Acute Neutrophilic Inflammation in Mice with Targeted Deficiency in the Sialyltransferase ST6Gal I Blood. Nov, 2006 | Pubmed ID: 16849643 Review of Epidemiology, Diagnosis, and Treatment of Invasive Mould Infections in Allogeneic Hematopoietic Stem Cell Transplant Recipients Mycopathologia. Jul, 2006 | Pubmed ID: 16830186 Aspergillus Fumigatus Extract Differentially Regulates Antigen-specific CD4+ and CD8+ T Cell Responses to Promote Host Immunity Journal of Leukocyte Biology. Sep, 2006 | Pubmed ID: 16793916 Heat Shock Proteins As Vaccine Adjuvants in Infections and Cancer Drug Discovery Today. Jun, 2006 | Pubmed ID: 16713905 Dapsone-induced Methemoglobinemia After Hematopoietic Stem Cell Transplantation Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Feb, 2006 | Pubmed ID: 16443522 Effect of Amphotericin B and Micafungin Combination on Survival, Histopathology, and Fungal Burden in Experimental Aspergillosis in the P47phox-/- Mouse Model of Chronic Granulomatous Disease Antimicrobial Agents and Chemotherapy. Feb, 2006 | Pubmed ID: 16436692 Immunotherapy for Fungal Infections Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Feb, 2006 | Pubmed ID: 16421795 Antibacterial Prophylaxis in Patients with Cancer and Neutropenia The New England Journal of Medicine. Jan, 2006 | Pubmed ID: 16395832 Current Approaches to Diagnosis and Treatment of Invasive Aspergillosis American Journal of Respiratory and Critical Care Medicine. Apr, 2006 | Pubmed ID: 16387806 Long-term Use of Oral Beclomethasone Dipropionate for the Treatment of Gastrointestinal Graft-versus-host Disease Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Aug, 2005 | Pubmed ID: 16041308 Posaconazole As Salvage Therapy in Patients with Chronic Granulomatous Disease and Invasive Filamentous Fungal Infection Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jun, 2005 | Pubmed ID: 15889369 Invasive Filamentous Fungal Infections in Allogeneic Hematopoietic Stem Cell Transplant Recipients After Recovery from Neutropenia: Clinical, Radiologic, and Pathologic Characteristics Mycopathologia. Feb, 2005 | Pubmed ID: 15770441 Prevention, Diagnosis, and Treatment of Invasive Fungal Infections in Patients with Cancer and Neutropenia Journal of the National Comprehensive Cancer Network : JNCCN. Sep, 2004 | Pubmed ID: 19780254 Linezolid-resistant Enterococcus Faecalis Isolated from a Cord Blood Transplant Recipient Journal of Clinical Microbiology. Apr, 2004 | Pubmed ID: 15071066 P47phox Deficiency Impairs NF-kappa B Activation and Host Defense in Pseudomonas Pneumonia Journal of Immunology (Baltimore, Md. : 1950). Feb, 2004 | Pubmed ID: 14734763 Deficiency of NADPH Oxidase Components P47phox and Gp91phox Caused Granulomatous Synovitis and Increased Connective Tissue Destruction in Experimental Arthritis Models The American Journal of Pathology. Oct, 2003 | Pubmed ID: 14507659 Phagocyte NADPH Oxidase, but Not Inducible Nitric Oxide Synthase, is Essential for Early Control of Burkholderia Cepacia and Chromobacterium Violaceum Infection in Mice Infection and Immunity. Jan, 2003 | Pubmed ID: 12496167 Fungal Infections in Nontransplant Patients with Hematologic Malignancies Infectious Disease Clinics of North America. Dec, 2002 | Pubmed ID: 12512188 Efficacy of High-efficiency Particulate Air Filtration in Preventing Aspergillosis in Immunocompromised Patients with Hematologic Malignancies Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America. Sep, 2002 | Pubmed ID: 12269451 Invasive Pulmonary Filamentous Fungal Infection in a Patient Receiving Inhaled Corticosteroid Therapy Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Sep, 2002 | Pubmed ID: 12173150 Thioglycollate Peritonitis in Mice Lacking C5, 5-lipoxygenase, or P47(phox): Complement, Leukotrienes, and Reactive Oxidants in Acute Inflammation Journal of Leukocyte Biology. Mar, 2002 | Pubmed ID: 11867678 Assessing Anti-fungal Activity of Isolated Alveolar Macrophages by Confocal Microscopy Melissa J. Grimm1, Anthony C. D'Auria1, Brahm H. Segal2 1Department of Medicine, Roswell Park Cancer Institute, 2Department of Medicine, School of Medicine and Biomedical Sciences, University of Buffalo JoVE 51678 Immunologie et Infection Bioluminescence Imaging of NADPH Oxidase Activity in Different Animal Models Wei Han1, Hui Li1, Brahm H. Segal2,3, Timothy S. Blackwell1 1Department of Medicine, Vanderbilt University School of Medicine, 2Departments of Medicine and Immunology, Roswell Park Cancer Institute, 3Department of Medicine, University at Buffalo School of Medicine JoVE 3925 Immunologie et Infection
Assessing Anti-fungal Activity of Isolated Alveolar Macrophages by Confocal Microscopy Melissa J. Grimm1, Anthony C. D'Auria1, Brahm H. Segal2 1Department of Medicine, Roswell Park Cancer Institute, 2Department of Medicine, School of Medicine and Biomedical Sciences, University of Buffalo JoVE 51678 Immunologie et Infection
Bioluminescence Imaging of NADPH Oxidase Activity in Different Animal Models Wei Han1, Hui Li1, Brahm H. Segal2,3, Timothy S. Blackwell1 1Department of Medicine, Vanderbilt University School of Medicine, 2Departments of Medicine and Immunology, Roswell Park Cancer Institute, 3Department of Medicine, University at Buffalo School of Medicine JoVE 3925 Immunologie et Infection