Carl Nathan Departments of Microbiology & Immunology Weill Cornell Medical College Biography Publications Institution JoVE Articles Carl Nathan has not added a biography. If you are Carl Nathan and would like to personalize this page please email our Author Liaison for assistance. Publications Reconstitution of a Mycobacterium Tuberculosis Proteostasis Network Highlights Essential Cofactor Interactions with Chaperone DnaK Proceedings of the National Academy of Sciences of the United States of America. Nov, 2016 | Pubmed ID: 27872278 Macrophages' Choice: Take It In or Keep It Out Immunity. Oct, 2016 | Pubmed ID: 27760333 Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors ChemMedChem. Oct, 2016 | Pubmed ID: 27561172 Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond PLoS Pathogens. Jul, 2016 | Pubmed ID: 27467575 N-methylation of a Bactericidal Compound As a Resistance Mechanism in Mycobacterium Tuberculosis Proceedings of the National Academy of Sciences of the United States of America. Aug, 2016 | Pubmed ID: 27432954 Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium Tuberculosis Journal of Medicinal Chemistry. Jul, 2016 | Pubmed ID: 27144688 Human Studies at JEM: Immunology and Beyond The Journal of Experimental Medicine. Apr, 2016 | Pubmed ID: 26976629 Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library Against Nonreplicating Mycobacterium Tuberculosis ACS Infectious Diseases. Dec, 2015 | Pubmed ID: 27623055 Comparison of Transposon and Deletion Mutants in Mycobacterium Tuberculosis: The Case of Rv1248c, Encoding 2-hydroxy-3-oxoadipate Synthase Tuberculosis (Edinburgh, Scotland). Dec, 2015 | Pubmed ID: 26547230 IMMUNOLOGY. From Transient Infection to Chronic Disease Science (New York, N.Y.). Oct, 2015 | Pubmed ID: 26450196 E1 of α-ketoglutarate Dehydrogenase Defends Mycobacterium Tuberculosis Against Glutamate Anaplerosis and Nitroxidative Stress Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26430237 Cooperative Development of Antimicrobials: Looking Back to Look Ahead Nature Reviews. Microbiology. Oct, 2015 | Pubmed ID: 26373373 Rapid, Semiquantitative Assay To Discriminate Among Compounds with Activity Against Replicating or Nonreplicating Mycobacterium Tuberculosis Antimicrobial Agents and Chemotherapy. Oct, 2015 | Pubmed ID: 26239979 Identification of Rv3852 As an Agrimophol-Binding Protein in Mycobacterium Tuberculosis PloS One. 2015 | Pubmed ID: 25978362 A Multi-stress Model for High Throughput Screening Against Non-replicating Mycobacterium Tuberculosis Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25779324 TB Drug Development: Immunology at the Table Immunological Reviews. Mar, 2015 | Pubmed ID: 25703568 What Can Immunology Contribute to the Control of the World's Leading Cause of Death from Bacterial Infection? Immunological Reviews. Mar, 2015 | Pubmed ID: 25703548 Video Podcast: Tuberculosis Immunological Reviews. Mar, 2015 | Pubmed ID: 25703547 Stressed Mycobacteria Use the Chaperone ClpB to Sequester Irreversibly Oxidized Proteins Asymmetrically Within and Between Cells Cell Host & Microbe. Feb, 2015 | Pubmed ID: 25620549 Target-based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial PH Homeostasis in Mycobacterium Tuberculosis ACS Chemical Biology. Feb, 2015 | Pubmed ID: 25457457 Antibiotic Resistance--problems, Progress, and Prospects The New England Journal of Medicine. Nov, 2014 | Pubmed ID: 25271470 Isocitrate Lyase Mediates Broad Antibiotic Tolerance in Mycobacterium Tuberculosis Nature Communications. Jun, 2014 | Pubmed ID: 24978671 Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome ACS Medicinal Chemistry Letters. Apr, 2014 | Pubmed ID: 24900849 Synthetic Calanolides with Bactericidal Activity Against Replicating and Nonreplicating Mycobacterium Tuberculosis Journal of Medicinal Chemistry. May, 2014 | Pubmed ID: 24694175 Benzimidazole-based Compounds Kill Mycobacterium Tuberculosis European Journal of Medicinal Chemistry. Mar, 2014 | Pubmed ID: 24556148 Drug-resistant Tuberculosis: a New Shot on Goal Nature Medicine. Feb, 2014 | Pubmed ID: 24504402 Lipoamide Channel-binding Sulfonamides Selectively Inhibit Mycobacterial Lipoamide Dehydrogenase Biochemistry. Dec, 2013 | Pubmed ID: 24251446 Genetic Regulation of Vesiculogenesis and Immunomodulation in Mycobacterium Tuberculosis Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013 | Pubmed ID: 24248369 Nitrite Produced by Mycobacterium Tuberculosis in Human Macrophages in Physiologic Oxygen Impacts Bacterial ATP Consumption and Gene Expression Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013 | Pubmed ID: 24145454 Perspective: Graduation Time Nature. Oct, 2013 | Pubmed ID: 24108080 A Journey in Science: Promise, Purpose, Privilege Molecular Medicine (Cambridge, Mass.). Oct, 2013 | Pubmed ID: 24089245 Nitrite Impacts the Survival of Mycobacterium Tuberculosis in Response to Isoniazid and Hydrogen Peroxide MicrobiologyOpen. Dec, 2013 | Pubmed ID: 24019302 Whole Cell Screen for Inhibitors of PH Homeostasis in Mycobacterium Tuberculosis PloS One. 2013 | Pubmed ID: 23935911 N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets Journal of the American Chemical Society. Jul, 2013 | Pubmed ID: 23782398 Influence of Allosteric Regulators on Individual Steps in the Reaction Catalyzed by Mycobacterium Tuberculosis 2-hydroxy-3-oxoadipate Synthase The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23760263 SARM Is Required for Neuronal Injury and Cytokine Production in Response to Central Nervous System Viral Infection Journal of Immunology (Baltimore, Md. : 1950). Jun, 2013 | Pubmed ID: 23749635 Beyond Oxidative Stress: an Immunologist's Guide to Reactive Oxygen Species Nature Reviews. Immunology. May, 2013 | Pubmed ID: 23618831 Efficacy of Nitazoxanide Against Clinical Isolates of Mycobacterium Tuberculosis Antimicrobial Agents and Chemotherapy. Jun, 2013 | Pubmed ID: 23507275 Nonsteroidal Anti-inflammatory Drug Sensitizes Mycobacterium Tuberculosis to Endogenous and Exogenous Antimicrobials Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23012453 Fresh Approaches to Anti-infective Therapies Science Translational Medicine. Jun, 2012 | Pubmed ID: 22745440 DSarm/Sarm1 is Required for Activation of an Injury-induced Axon Death Pathway Science (New York, N.Y.). Jul, 2012 | Pubmed ID: 22678360 Secretory Products of Macrophages: Twenty-five Years On The Journal of Clinical Investigation. Apr, 2012 | Pubmed ID: 22570864 Improved Control of Tuberculosis and Activation of Macrophages in Mice Lacking Protein Kinase R PloS One. 2012 | Pubmed ID: 22359543 Remembering Ralph Steinman The Journal of Experimental Medicine. Nov, 2011 | Pubmed ID: 22216461 Nitazoxanide Disrupts Membrane Potential and Intrabacterial PH Homeostasis of Mycobacterium Tuberculosis ACS Medicinal Chemistry Letters. 2011 | Pubmed ID: 22096616 Is INOS Beginning to Smoke? Cell. Oct, 2011 | Pubmed ID: 22000003 In Vitro Differentiation of Human Macrophages with Enhanced Antimycobacterial Activity The Journal of Clinical Investigation. Oct, 2011 | Pubmed ID: 21911939 Mycobacterium Tuberculosis Gene Rv2136c is Dispensable for Acid Resistance and Virulence in Mice Tuberculosis (Edinburgh, Scotland). Sep, 2011 | Pubmed ID: 21778115 Identification of New Inhibitors of Protein Kinase R Guided by Statistical Modeling Bioorganic & Medicinal Chemistry Letters. Jul, 2011 | Pubmed ID: 21632247 Making Space for Anti-infective Drug Discovery Cell Host & Microbe. May, 2011 | Pubmed ID: 21575903 Central Carbon Metabolism in Mycobacterium Tuberculosis: an Unexpected Frontier Trends in Microbiology. Jul, 2011 | Pubmed ID: 21561773 Virulence of Mycobacterium Tuberculosis Depends on Lipoamide Dehydrogenase, a Member of Three Multienzyme Complexes Cell Host & Microbe. Jan, 2011 | Pubmed ID: 21238944 Identification of a Chemical That Inhibits the Mycobacterial UvrABC Complex in Nucleotide Excision Repair Biochemistry. Mar, 2011 | Pubmed ID: 21235228 Genome-wide Screen for Mycobacterium Tuberculosis Genes That Regulate Host Immunity PloS One. Dec, 2010 | Pubmed ID: 21170273 Metabolomics of Mycobacterium Tuberculosis Reveals Compartmentalized Co-catabolism of Carbon Substrates Chemistry & Biology. Oct, 2010 | Pubmed ID: 21035735 A Protecting Group-free Synthesis of Deazathiamine: a Step Toward Inhibitor Design Bioorganic & Medicinal Chemistry Letters. Nov, 2010 | Pubmed ID: 20943392 Induction of ER Stress in Macrophages of Tuberculosis Granulomas PloS One. Sep, 2010 | Pubmed ID: 20856677 Behavioral Deficits and Progressive Neuropathology in Progranulin-deficient Mice: a Mouse Model of Frontotemporal Dementia FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2010 | Pubmed ID: 20667979 Fellutamide B is a Potent Inhibitor of the Mycobacterium Tuberculosis Proteasome Archives of Biochemistry and Biophysics. Sep, 2010 | Pubmed ID: 20558127 Killing of Non-replicating Mycobacterium Tuberculosis by 8-hydroxyquinoline The Journal of Antimicrobial Chemotherapy. Jul, 2010 | Pubmed ID: 20435781 Activity-based Metabolomic Profiling of Enzymatic Function: Identification of Rv1248c As a Mycobacterial 2-hydroxy-3-oxoadipate Synthase Chemistry & Biology. Apr, 2010 | Pubmed ID: 20416504 SnapShot: Reactive Oxygen Intermediates (ROI) Cell. Mar, 2010 | Pubmed ID: 20303882 Nonresolving Inflammation Cell. Mar, 2010 | Pubmed ID: 20303877 Triazaspirodimethoxybenzoyls As Selective Inhibitors of Mycobacterial Lipoamide Dehydrogenase Biochemistry. Mar, 2010 | Pubmed ID: 20078138 Exaggerated Inflammation, Impaired Host Defense, and Neuropathology in Progranulin-deficient Mice The Journal of Experimental Medicine. Jan, 2010 | Pubmed ID: 20026663 N-iminoethyl-L-lysine Improves Memory and Reduces Amyloid Pathology in a Transgenic Mouse Model of Amyloid Deposition Neurochemistry International. Jan, 2010 | Pubmed ID: 19914323 Structural Insights on the Mycobacterium Tuberculosis Proteasomal ATPase Mpa Structure (London, England : 1993). Oct, 2009 | Pubmed ID: 19836337 Inhibitors Selective for Mycobacterial Versus Human Proteasomes Nature. Oct, 2009 | Pubmed ID: 19759536 Nitazoxanide Kills Replicating and Nonreplicating Mycobacterium Tuberculosis and Evades Resistance Journal of Medicinal Chemistry. Oct, 2009 | Pubmed ID: 19736929 Acid Resistance in Mycobacterium Tuberculosis Journal of Bacteriology. Aug, 2009 | Pubmed ID: 19465648 Taming Tuberculosis: a Challenge for Science and Society Cell Host & Microbe. Mar, 2009 | Pubmed ID: 19286131 Triterpenoid CDDO-methylamide Improves Memory and Decreases Amyloid Plaques in a Transgenic Mouse Model of Alzheimer's Disease Journal of Neurochemistry. Apr, 2009 | Pubmed ID: 19200343 Mycobacterium Tuberculosis Expresses Methionine Sulphoxide Reductases A and B That Protect from Killing by Nitrite and Hypochlorite Molecular Microbiology. Feb, 2009 | Pubmed ID: 19040639 Acid-susceptible Mutants of Mycobacterium Tuberculosis Share Hypersusceptibility to Cell Wall and Oxidative Stress and to the Host Environment Journal of Bacteriology. Jan, 2009 | Pubmed ID: 19011036 Microbiology. An Antibiotic Mimics Immunity Science (New York, N.Y.). Nov, 2008 | Pubmed ID: 19039126 Distinct Specificities of Mycobacterium Tuberculosis and Mammalian Proteasomes for N-acetyl Tripeptide Substrates The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18829465 A Philosophy of Anti-infectives As a Guide in the Search for New Drugs for Tuberculosis Tuberculosis (Edinburgh, Scotland). Aug, 2008 | Pubmed ID: 18762150 Identification of a Copper-binding Metallothionein in Pathogenic Mycobacteria Nature Chemical Biology. Oct, 2008 | Pubmed ID: 18724363 A Membrane Protein Preserves Intrabacterial PH in Intraphagosomal Mycobacterium Tuberculosis Nature Medicine. Aug, 2008 | Pubmed ID: 18641659 Metchnikoff's Legacy in 2008 Nature Immunology. Jul, 2008 | Pubmed ID: 18563074 Epidemic Inflammation: Pondering Obesity Molecular Medicine (Cambridge, Mass.). Jul-Aug, 2008 | Pubmed ID: 18431463 Selective Killing of Nonreplicating Mycobacteria Cell Host & Microbe. Mar, 2008 | Pubmed ID: 18329613 Pulmonary Nodules in an Infliximab-treated Rheumatoid Arthritis Patient: a Clinical Pathology Conference Held by the Division of Rheumatology at Hospital for Special Surgery HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery. Feb, 2007 | Pubmed ID: 18751782 New Approaches to Filling the Gap in Tuberculosis Drug Discovery PLoS Medicine. Nov, 2007 | Pubmed ID: 17988169 MyD88-5 Links Mitochondria, Microtubules, and JNK3 in Neurons and Regulates Neuronal Survival The Journal of Experimental Medicine. Sep, 2007 | Pubmed ID: 17724133 Aligning Pharmaceutical Innovation with Medical Need Nature Medicine. Mar, 2007 | Pubmed ID: 17342145 Man is Not a Mouse: Reply Journal of Leukocyte Biology. Mar, 2007 | Pubmed ID: 17332374 Role of INOS in Human Host Defense Science (New York, N.Y.). Jun, 2006 | Pubmed ID: 16809512 Neutrophils and Immunity: Challenges and Opportunities Nature Reviews. Immunology. Mar, 2006 | Pubmed ID: 16498448 Cytosolic Phospholipase A2 Enzymes Are Not Required by Mouse Bone Marrow-derived Macrophages for the Control of Mycobacterium Tuberculosis in Vitro Infection and Immunity. Mar, 2006 | Pubmed ID: 16495548 Structure of the Mycobacterium Tuberculosis Proteasome and Mechanism of Inhibition by a Peptidyl Boronate Molecular Microbiology. Mar, 2006 | Pubmed ID: 16468986 Mycobacterium Tuberculosis PrcBA Genes Encode a Gated Proteasome with Broad Oligopeptide Specificity Molecular Microbiology. Mar, 2006 | Pubmed ID: 16468985 Abrupt Expression of TLR4 in TLR4-deficient Macrophages Imposes a Selective Disadvantage: Genetic Evidence for TLR4-dependent Responses to Endogenous, Nonmicrobial Stimuli Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16394008 Chemical Inhibitors of TNF Signal Transduction in Human Neutrophils Point to Distinct Steps in Cell Activation Journal of Leukocyte Biology. Jan, 2006 | Pubmed ID: 16275893 Protection from Alzheimer's-like Disease in the Mouse by Genetic Ablation of Inducible Nitric Oxide Synthase The Journal of Experimental Medicine. Nov, 2005 | Pubmed ID: 16260491 Outlook: the Profit Problem in Antibiotic R&D Nature Reviews. Drug Discovery. Nov, 2005 | Pubmed ID: 16247440 Progress and New Directions in Genetics of Tuberculosis: an NHLBI Working Group Report American Journal of Respiratory and Critical Care Medicine. Dec, 2005 | Pubmed ID: 16192449 Crystal Structure and Functional Analysis of Lipoamide Dehydrogenase from Mycobacterium Tuberculosis The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16093239 Mycobacterium Tuberculosis Appears to Lack Alpha-ketoglutarate Dehydrogenase and Encodes Pyruvate Dehydrogenase in Widely Separated Genes Molecular Microbiology. Aug, 2005 | Pubmed ID: 16045627 Calcium-sensing Soluble Adenylyl Cyclase Mediates TNF Signal Transduction in Human Neutrophils The Journal of Experimental Medicine. Aug, 2005 | Pubmed ID: 16043520 Role for Nucleotide Excision Repair in Virulence of Mycobacterium Tuberculosis Infection and Immunity. Aug, 2005 | Pubmed ID: 16040969 Variant Tricarboxylic Acid Cycle in Mycobacterium Tuberculosis: Identification of Alpha-ketoglutarate Decarboxylase Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005 | Pubmed ID: 16027371 Mycobacterium Tuberculosis and the Host Response The Journal of Experimental Medicine. Jun, 2005 | Pubmed ID: 15939785 A Glutamate-alanine-leucine (EAL) Domain Protein of Salmonella Controls Bacterial Survival in Mice, Antioxidant Defence and Killing of Macrophages: Role of Cyclic DiGMP Molecular Microbiology. Jun, 2005 | Pubmed ID: 15882417 Characterization of a Mycobacterium Tuberculosis Proteasomal ATPase Homologue Molecular Microbiology. Jan, 2005 | Pubmed ID: 15659170 S-nitroso Proteome of Mycobacterium Tuberculosis: Enzymes of Intermediary Metabolism and Antioxidant Defense Proceedings of the National Academy of Sciences of the United States of America. Jan, 2005 | Pubmed ID: 15626759 The Moving Frontier in Nitric Oxide-dependent Signaling Science's STKE : Signal Transduction Knowledge Environment. Nov, 2004 | Pubmed ID: 15523044 Antibiotics at the Crossroads Nature. Oct, 2004 | Pubmed ID: 15496893 Identification of Mycobacterium Tuberculosis Counterimmune (cim) Mutants in Immunodeficient Mice by Differential Screening Infection and Immunity. Sep, 2004 | Pubmed ID: 15322028 The Proteasome of Mycobacterium Tuberculosis is Required for Resistance to Nitric Oxide Science (New York, N.Y.). Dec, 2003 | Pubmed ID: 14671303 MyD88 Primes Macrophages for Full-scale Activation by Interferon-gamma Yet Mediates Few Responses to Mycobacterium Tuberculosis The Journal of Experimental Medicine. Oct, 2003 | Pubmed ID: 14517275 Transcriptional Adaptation of Mycobacterium Tuberculosis Within Macrophages: Insights into the Phagosomal Environment The Journal of Experimental Medicine. Sep, 2003 | Pubmed ID: 12953091 Immunology: Oxygen and the Inflammatory Cell Nature. Apr, 2003 | Pubmed ID: 12700748 Specificity of a Third Kind: Reactive Oxygen and Nitrogen Intermediates in Cell Signaling The Journal of Clinical Investigation. Mar, 2003 | Pubmed ID: 12639979 Critical Role of the Carboxyl Terminus of Proline-rich Tyrosine Kinase (Pyk2) in the Activation of Human Neutrophils by Tumor Necrosis Factor: Separation of Signals for the Respiratory Burst and Degranulation The Journal of Experimental Medicine. Jan, 2003 | Pubmed ID: 12515814 Conversion of Proepithelin to Epithelins: Roles of SLPI and Elastase in Host Defense and Wound Repair Cell. Dec, 2002 | Pubmed ID: 12526812 Points of Control in Inflammation Nature. Dec 19-26, 2002 | Pubmed ID: 12490957 Immunology. Catalytic Antibody Bridges Innate and Adaptive Immunity Science (New York, N.Y.). Dec, 2002 | Pubmed ID: 12481124 Inducible Nitric Oxide Synthase in the Tuberculous Human Lung American Journal of Respiratory and Critical Care Medicine. Jul, 2002 | Pubmed ID: 12119220 Nonredundant Antioxidant Defense by Multiple Two-cysteine Peroxiredoxins in Human Prostate Cancer Cells Molecular Medicine (Cambridge, Mass.). Feb, 2002 | Pubmed ID: 12080185 Peptide Methionine Sulfoxide Reductase: Structure, Mechanism of Action, and Biological Function Archives of Biochemistry and Biophysics. Jan, 2002 | Pubmed ID: 11795868 Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria Ben Gold1, Julia Roberts*1, Yan Ling*1, Landys Lopez Quezada1, Jou Glasheen1, Elaine Ballinger1, Selin Somersan-Karakaya2, Thulasi Warrier1, Carl Nathan1 1Departments of Microbiology & Immunology, Weill Cornell Medical College, 2Medicine, Weill Cornell Medical College JoVE 54690 Immunologie et Infection
Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria Ben Gold1, Julia Roberts*1, Yan Ling*1, Landys Lopez Quezada1, Jou Glasheen1, Elaine Ballinger1, Selin Somersan-Karakaya2, Thulasi Warrier1, Carl Nathan1 1Departments of Microbiology & Immunology, Weill Cornell Medical College, 2Medicine, Weill Cornell Medical College JoVE 54690 Immunologie et Infection