Christine L. Mummery Department of Anatomy and Embryology Leiden University Medical Center Biography Publications Institution JoVE Articles Christine L. Mummery has not added a biography. If you are Christine L. Mummery and would like to personalize this page please email our Author Liaison for assistance. Publications Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts Current Protocols in Human Genetics. Oct, 2018 | Pubmed ID: 30253059 Advanced in Vitro Models of Vascular Biology: Human Induced Pluripotent Stem Cells and Organ-on-chip Technology Advanced Drug Delivery Reviews. Jun, 2018 | Pubmed ID: 29944904 Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Stem Cell Reports. May, 2018 | Pubmed ID: 29657098 NKX2-5 Regulates Human Cardiomyogenesis Via a HEY2 Dependent Transcriptional Network Nature Communications. 04, 2018 | Pubmed ID: 29636455 Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives Biomacromolecules. Apr, 2018 | Pubmed ID: 29528623 MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo Circulation Research. Feb, 2018 | Pubmed ID: 29282212 Executive Summary of the 12th HHT International Scientific Conference Angiogenesis. Feb, 2018 | Pubmed ID: 29147802 Interpretation of Field Potentials Measured on a Multi Electrode Array in Pharmacological Toxicity Screening on Primary and Human Pluripotent Stem Cell-derived Cardiomyocytes Biochemical and Biophysical Research Communications. 03, 2018 | Pubmed ID: 28153730 Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells Stem Cell Reports. 12, 2017 | Pubmed ID: 29173898 A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes Stem Cell Reports. 12, 2017 | Pubmed ID: 29173897 Co-Differentiation of Human Pluripotent Stem Cells-Derived Cardiomyocytes and Endothelial Cells from Cardiac Mesoderm Provides a Three-Dimensional Model of Cardiac Microtissue Current Protocols in Human Genetics. 10, 2017 | Pubmed ID: 29044469 DNA Methylation and Transcriptional Trajectories During Human Development and Reprogramming of Isogenic Pluripotent Stem Cells Nature Communications. 10, 2017 | Pubmed ID: 29030611 Human Pluripotent Stem Cell Models of Cardiac Disease: from Mechanisms to Therapies Disease Models & Mechanisms. 09, 2017 | Pubmed ID: 28883014 FANTOM5 CAGE Profiles of Human and Mouse Samples Scientific Data. 08, 2017 | Pubmed ID: 28850106 Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays Stem Cell Reports. 05, 2017 | Pubmed ID: 28494940 Three-dimensional Cardiac Microtissues Composed of Cardiomyocytes and Endothelial Cells Co-differentiated from Human Pluripotent Stem Cells Development (Cambridge, England). Mar, 2017 | Pubmed ID: 28279973 Subtype-specific Promoter-driven Action Potential Imaging for Precise Disease Modelling and Drug Testing in HiPSC-derived Cardiomyocytes European Heart Journal. Jan, 2017 | Pubmed ID: 28182242 Small Molecule Absorption by PDMS in the Context of Drug Response Bioassays Biochemical and Biophysical Research Communications. Jan, 2017 | Pubmed ID: 27856254 Cytostretch, an Organ-on-Chip Platform Micromachines. Jul, 2016 | Pubmed ID: 30404293 TECRL, a New Life-threatening Inherited Arrhythmia Gene Associated with Overlapping Clinical Features of Both LQTS and CPVT EMBO Molecular Medicine. 12, 2016 | Pubmed ID: 27861123 Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A Circulation. Arrhythmia and Electrophysiology. Nov, 2016 | Pubmed ID: 27784737 Integrating Cardiomyocytes from Human Pluripotent Stem Cells in Safety Pharmacology: Has the Time Come? British Journal of Pharmacology. Sep, 2016 | Pubmed ID: 27641943 A New HERG Allosteric Modulator Rescues Genetic and Drug-induced Long-QT Syndrome Phenotypes in Cardiomyocytes from Isogenic Pairs of Patient Induced Pluripotent Stem Cells EMBO Molecular Medicine. 09, 2016 | Pubmed ID: 27470144 Inherited Heart Disease - What Can We Expect from the Second Decade of Human IPS Cell Research? FEBS Letters. Aug, 2016 | Pubmed ID: 27391414 Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease Stem Cells (Dayton, Ohio). Aug, 2016 | Pubmed ID: 27250776 Stem Cells: The Cancer's Gone, but Did Chemotherapy Damage Your Heart? Nature Reviews. Cardiology. Jul, 2016 | Pubmed ID: 27226155 Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: Cell-based Therapies for Myocardial Repair and Regeneration in Ischemic Heart Disease and Heart Failure European Heart Journal. Apr, 2016 | Pubmed ID: 27055812 Complex Tissue and Disease Modeling Using HiPSCs Cell Stem Cell. Mar, 2016 | Pubmed ID: 26942851 The Avian Embryo to Study Development of the Cardiac Conduction System Differentiation; Research in Biological Diversity. Apr-Jun, 2016 | Pubmed ID: 26856662 Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2016 | Pubmed ID: 26821948 The Composition and Differentiation Potential of the Duodenal Intraepithelial Innate Lymphocyte Compartment is Altered in Coeliac Disease Gut. Aug, 2016 | Pubmed ID: 25966995 Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 25626427 Advantages of the Avian Model for Human Ovarian Cancer Molecular and Clinical Oncology. Nov, 2015 | Pubmed ID: 26807219 Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva Stem Cell Reports. Dec, 2015 | Pubmed ID: 26626181 Contractile Defect Caused by Mutation in MYBPC3 Revealed Under Conditions Optimized for Human PSC-Cardiomyocyte Function Cell Reports. Oct, 2015 | Pubmed ID: 26489474 Altered Calcium Handling and Increased Contraction Force in Human Embryonic Stem Cell Derived Cardiomyocytes Following Short Term Dexamethasone Exposure Biochemical and Biophysical Research Communications. Nov, 2015 | Pubmed ID: 26456652 Transcriptome of Human Foetal Heart Compared with Cardiomyocytes from Pluripotent Stem Cells Development (Cambridge, England). Sep, 2015 | Pubmed ID: 26209647 Expansion and Patterning of Cardiovascular Progenitors Derived from Human Pluripotent Stem Cells Nature Biotechnology. Sep, 2015 | Pubmed ID: 26192318 KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas Stem Cell Reports. Jun, 2015 | Pubmed ID: 26028532 What Endothelial Cells from Patient IPSCs Can Tell Us About Aortic Valve Disease Cell Stem Cell. May, 2015 | Pubmed ID: 25957898 Reply to Christ Et Al.: LQT1 and JLNS Phenotypes in HiPSC-derived Cardiomyocytes Are Due to KCNQ1 Mutations Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25795241 Functional Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes in Vitro--correlation Between Contraction Force and Electrophysiology Biomaterials. May, 2015 | Pubmed ID: 25771005 Atrial-like Cardiomyocytes from Human Pluripotent Stem Cells Are a Robust Preclinical Model for Assessing Atrial-selective Pharmacology EMBO Molecular Medicine. Apr, 2015 | Pubmed ID: 25700171 Pluripotent Stem Cell Derived Cardiovascular Progenitors--a Developmental Perspective Developmental Biology. Apr, 2015 | Pubmed ID: 25624264 Lymphangiogenesis and Angiogenesis During Human Fetal Pancreas Development Vascular Cell. 2014 | Pubmed ID: 25785186 Recessive Cardiac Phenotypes in Induced Pluripotent Stem Cell Models of Jervell and Lange-Nielsen Syndrome: Disease Mechanisms and Pharmacological Rescue Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014 | Pubmed ID: 25453094 A Case for Crowd Sourcing in Stem Cell Research Stem Cells Translational Medicine. Nov, 2014 | Pubmed ID: 25232185 Assessment of Functional Competence of Endothelial Cells from Human Pluripotent Stem Cells in Zebrafish Embryos Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25173378 Cell Replacement Therapies: is It Time to Reprogram? Human Gene Therapy. Oct, 2014 | Pubmed ID: 25141889 Serum Supplemented Culture Medium Masks Hypertrophic Phenotypes in Human Pluripotent Stem Cell Derived Cardiomyocytes Journal of Cellular and Molecular Medicine. Aug, 2014 | Pubmed ID: 24981391 SIRPA, VCAM1 and CD34 Identify Discrete Lineages During Early Human Cardiovascular Development Stem Cell Research. Jul, 2014 | Pubmed ID: 24968096 Generation, Expansion and Functional Analysis of Endothelial Cells and Pericytes Derived from Human Pluripotent Stem Cells Nature Protocols. 2014 | Pubmed ID: 24874816 Strategies for Rapidly Mapping Proviral Integration Sites and Assessing Cardiogenic Potential of Nascent Human Induced Pluripotent Stem Cell Clones Experimental Cell Research. Oct, 2014 | Pubmed ID: 24836851 Functionality of Endothelial Cells and Pericytes from Human Pluripotent Stem Cells Demonstrated in Cultured Vascular Plexus and Zebrafish Xenografts Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2014 | Pubmed ID: 24158517 PGC-1α and Reactive Oxygen Species Regulate Human Embryonic Stem Cell-derived Cardiomyocyte Function Stem Cell Reports. 2013 | Pubmed ID: 24371810 Isogenic Human Pluripotent Stem Cell Pairs Reveal the Role of a KCNH2 Mutation in Long-QT Syndrome The EMBO Journal. Dec, 2013 | Pubmed ID: 24213244 Direct Cardiomyocyte Reprogramming: a New Direction for Cardiovascular Regenerative Medicine Cold Spring Harbor Perspectives in Medicine. Sep, 2013 | Pubmed ID: 24003244 Generation of Induced Pluripotent Stem Cells from Human Foetal Fibroblasts Using the Sleeping Beauty Transposon Gene Delivery System Differentiation; Research in Biological Diversity. Jul-Sep, 2013 | Pubmed ID: 23933400 Conversion of Mature Human β-cells into Glucagon-producing α-cells Diabetes. Jul, 2013 | Pubmed ID: 23569174 Is Heart Regeneration on the Right Track? Nature Medicine. Apr, 2013 | Pubmed ID: 23558629 Model Systems for Cardiovascular Regenerative Biology Cold Spring Harbor Perspectives in Medicine. Apr, 2013 | Pubmed ID: 23545574 Induced Pluripotent Stem Cells: the New Patient? Nature Reviews. Molecular Cell Biology. Nov, 2012 | Pubmed ID: 23034453 Cardiomyocytes Derived from Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease Circulation. Jun, 2012 | Pubmed ID: 22647976 Smooth Muscle Diversity from Human Pluripotent Cells Nature Biotechnology. Feb, 2012 | Pubmed ID: 22318032 New Perspectives on Regeneration of the Heart Circulation Research. Sep, 2011 | Pubmed ID: 21960722 Human Embryonic and Fetal Mesenchymal Stem Cells Differentiate Toward Three Different Cardiac Lineages in Contrast to Their Adult Counterparts PloS One. 2011 | Pubmed ID: 21931658 Shedding New Light on the Mechanism Underlying Stem Cell Therapy for the Heart Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2011 | Pubmed ID: 21720378 Pluripotent Stem Cell Models of Cardiac Disease and Their Implication for Drug Discovery and Development Trends in Molecular Medicine. Sep, 2011 | Pubmed ID: 21703926 Cardiomyocyte Differentiation of Pluripotent Stem Cells and Their Use As Cardiac Disease Models The Biochemical Journal. Feb, 2011 | Pubmed ID: 21269276 Challenges in Using Stem Cells for Cardiac Repair Science Translational Medicine. Apr, 2010 | Pubmed ID: 20393186 Extracellular Matrix Formation After Transplantation of Human Embryonic Stem Cell-derived Cardiomyocytes Cellular and Molecular Life Sciences : CMLS. Jan, 2010 | Pubmed ID: 19844658 Prospects for Pluripotent Stem Cell-derived Cardiomyocytes in Cardiac Cell Therapy and As Disease Models Journal of Cellular Biochemistry. Jul, 2009 | Pubmed ID: 19449339 SOST Ausdruck Beschränkt Sich Auf Die Großen Arterien Während Der Embryonalen Und Neonatale Herz-Kreislauf-Entwicklung Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2007 | Pubmed ID: 17195180 Mikrofluidische Assay für die Beurteilung der Leukozyten Adhäsion an humanen induzierten pluripotenten Stammzellen abgeleitet Endothelzellen (HiPSC-ECs) Oleh V. Halaidych1, Francijna van den Hil1, Christine L. Mummery1,2, Valeria V. Orlova1 1Department of Anatomy and Embryology, Leiden University Medical Center, 2Department of Applied Stem Cell Technologies, University of Twente JoVE 58678 Biologie du développement
Mikrofluidische Assay für die Beurteilung der Leukozyten Adhäsion an humanen induzierten pluripotenten Stammzellen abgeleitet Endothelzellen (HiPSC-ECs) Oleh V. Halaidych1, Francijna van den Hil1, Christine L. Mummery1,2, Valeria V. Orlova1 1Department of Anatomy and Embryology, Leiden University Medical Center, 2Department of Applied Stem Cell Technologies, University of Twente JoVE 58678 Biologie du développement