Christopher Aiken Department of Pathology, Microbiology and Immunology Vanderbilt University School of Medicine Biography Publications Institution JoVE Articles Christopher Aiken has not added a biography. If you are Christopher Aiken and would like to personalize this page please email our Author Liaison for assistance. Publications RING Domain Mutations Uncouple TRIM5α Restriction of HIV-1 from Inhibition of Reverse Transcription and Acceleration of Uncoating Journal of Virology. Feb, 2012 | Pubmed ID: 22114335 Maturation-induced Cloaking of Neutralization Epitopes on HIV-1 Particles PLoS Pathogens. Sep, 2011 | Pubmed ID: 21931551 Nature. Apr, 2011 | Pubmed ID: 21512569 Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter-hexamer Interfaces PLoS Pathogens. Mar, 2011 | Pubmed ID: 21455494 Structure of the HIV-1 Full-length Capsid Protein in a Conformationally Trapped Unassembled State Induced by Small-molecule Binding Journal of Molecular Biology. Feb, 2011 | Pubmed ID: 21146540 Small-molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization Journal of Virology. Jan, 2011 | Pubmed ID: 20962083 HIV Nuclear Entry: Clearing the Fog Viruses. May, 2010 | Pubmed ID: 21994675 TRIM5alpha Disrupts the Structure of Assembled HIV-1 Capsid Complexes in Vitro Journal of Virology. Jul, 2010 | Pubmed ID: 20410272 Anti-HIV Activity of Defective Cyanovirin-N Mutants is Restored by Dimerization The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20147291 Structural Convergence Between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function Cell. Nov, 2009 | Pubmed ID: 19914170 Cell-free Assays for HIV-1 Uncoating Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19020817 Cyclophilin A-dependent Restriction of Human Immunodeficiency Virus Type 1 Capsid Mutants for Infection of Nondividing Cells Journal of Virology. Dec, 2008 | Pubmed ID: 18829762 Biochemical Characterization of a Recombinant TRIM5alpha Protein That Restricts Human Immunodeficiency Virus Type 1 Replication Journal of Virology. Dec, 2008 | Pubmed ID: 18799573 Proteasomal Degradation of TRIM5alpha During Retrovirus Restriction PLoS Pathogens. May, 2008 | Pubmed ID: 18497858 Nef Enhances HIV-1 Infectivity Via Association with the Virus Assembly Complex Virology. Apr, 2008 | Pubmed ID: 18191978 Escape from the Dominant HLA-B27-restricted Cytotoxic T-lymphocyte Response in Gag is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication Journal of Virology. Nov, 2007 | Pubmed ID: 17804494 Analysis of Human Cell Heterokaryons Demonstrates That Target Cell Restriction of Cyclosporine-resistant Human Immunodeficiency Virus Type 1 Mutants is Genetically Dominant Journal of Virology. Nov, 2007 | Pubmed ID: 17715216 Maturation-dependent Human Immunodeficiency Virus Type 1 Particle Fusion Requires a Carboxyl-terminal Region of the Gp41 Cytoplasmic Tail Journal of Virology. Sep, 2007 | Pubmed ID: 17609279 A Mutation in Alpha Helix 3 of CA Renders Human Immunodeficiency Virus Type 1 Cyclosporin A Resistant and Dependent: Rescue by a Second-site Substitution in a Distal Region of CA Journal of Virology. Apr, 2007 | Pubmed ID: 17267487 Selective Restriction of Nef-defective Human Immunodeficiency Virus Type 1 by a Proteasome-dependent Mechanism Journal of Virology. Feb, 2007 | Pubmed ID: 17108041 Analysis of HIV-1-X4 Fusion with Immature Dendritic Cells Identifies a Specific Restriction That is Independent of CXCR4 Levels The Journal of Investigative Dermatology. Feb, 2007 | Pubmed ID: 16917492 Viral and Cellular Factors That Regulate HIV-1 Uncoating Current Opinion in HIV and AIDS. May, 2006 | Pubmed ID: 19372808 Human Immunodeficiency Virus Type 1 Resistance to the Small Molecule Maturation Inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic Acid is Conferred by a Variety of Single Amino Acid Substitutions at the CA-SP1 Cleavage Site in Gag Journal of Virology. Dec, 2006 | Pubmed ID: 17035324 Saturation of TRIM5 Alpha-mediated Restriction of HIV-1 Infection Depends on the Stability of the Incoming Viral Capsid Virology. Jul, 2006 | Pubmed ID: 16624363 Evidence for a Functional Link Between Uncoating of the Human Immunodeficiency Virus Type 1 Core and Nuclear Import of the Viral Preintegration Complex Journal of Virology. Apr, 2006 | Pubmed ID: 16571788 A Mutation in the Human Immunodeficiency Virus Type 1 Gag Protein Destabilizes the Interaction of the Envelope Protein Subunits Gp120 and Gp41 Journal of Virology. Mar, 2006 | Pubmed ID: 16474147 Maturation of the Viral Core Enhances the Fusion of HIV-1 Particles with Primary Human T Cells and Monocyte-derived Macrophages Virology. Mar, 2006 | Pubmed ID: 16375941 Inhibition of HIV-1 Maturation Via Drug Association with the Viral Gag Protein in Immature HIV-1 Particles The Journal of Biological Chemistry. Dec, 2005 | Pubmed ID: 16251182 Antimicrobial Peptides from Amphibian Skin Potently Inhibit Human Immunodeficiency Virus Infection and Transfer of Virus from Dendritic Cells to T Cells Journal of Virology. Sep, 2005 | Pubmed ID: 16140737 Betulinic Acid Derivatives As HIV-1 Antivirals Trends in Molecular Medicine. Jan, 2005 | Pubmed ID: 15649820 Structural Requirements for Recognition of the Human Immunodeficiency Virus Type 1 Core During Host Restriction in Owl Monkey Cells Journal of Virology. Jan, 2005 | Pubmed ID: 15613315 The Sequence of the CA-SP1 Junction Accounts for the Differential Sensitivity of HIV-1 and SIV to the Small Molecule Maturation Inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic Acid Retrovirology. 2004 | Pubmed ID: 15225375 Nef Stimulates Human Immunodeficiency Virus Type 1 Replication in Primary T Cells by Enhancing Virion-associated Gp120 Levels: Coreceptor-dependent Requirement for Nef in Viral Replication Journal of Virology. Jun, 2004 | Pubmed ID: 15163722 Coupling of Human Immunodeficiency Virus Type 1 Fusion to Virion Maturation: a Novel Role of the Gp41 Cytoplasmic Tail Journal of Virology. Apr, 2004 | Pubmed ID: 15016865 Assembly Properties of the Human Immunodeficiency Virus Type 1 CA Protein Journal of Virology. Mar, 2004 | Pubmed ID: 14963157 Bifunctional Anti-human Immunodeficiency Virus Type 1 Small Molecules with Two Novel Mechanisms of Action Antimicrobial Agents and Chemotherapy. Feb, 2004 | Pubmed ID: 14742233 Small-molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation Journal of Virology. Jan, 2004 | Pubmed ID: 14694123 Nef Does Not Affect the Efficiency of Human Immunodeficiency Virus Type 1 Fusion with Target Cells Journal of Virology. Oct, 2003 | Pubmed ID: 12970449 Disassembly of Human Immunodeficiency Virus Type 1 Cores in Vitro Reveals Association of Nef with the Subviral Ribonucleoprotein Complex Journal of Virology. Apr, 2003 | Pubmed ID: 12634398 Formation of a Human Immunodeficiency Virus Type 1 Core of Optimal Stability is Crucial for Viral Replication Journal of Virology. Jun, 2002 | Pubmed ID: 11991995 Nef-mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes Journal of Virology. May, 2002 | Pubmed ID: 11932428 ב Uncoating במבחנה של HIV-1 ליבות Vaibhav B. Shah1, Christopher Aiken1 1Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine JoVE 3384 Immunologie et Infection
ב Uncoating במבחנה של HIV-1 ליבות Vaibhav B. Shah1, Christopher Aiken1 1Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine JoVE 3384 Immunologie et Infection