Chuan-ju Liu Department of Orthopaedic Surgery & Department of Cell Biology NYU School of Medicine Biography Publications Institution JoVE Articles Chuan-ju LiuProfessor of Orthopaedic Surgery and Cell Biology Dr. Chuanju Liu held a dual appointment as an Assistant Professor from Department of Orthopaedic Surgery and Department of Cell Biology at NYU School of Medicine since 2002, and was promoted to Associate Professor with Tenure and Professor with Tenure in 2007 and 2013, respectively. He is the current Editor-in-Chief of Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders and Rheumatology Research and Review, and serves on a number of Editorial Boards. He is also an active participant in peer review of grant applications to various agencies (NIH, DOD, VA, etc.). His current research focuses on inflammatory and degenerative arthritis, cartilage/bone regeneration, and autoimmune diseases. He has published over 140 papers in prestigious journals, including Science, ARD, EMBO J, and PNAS. He is the recipient of numerous awards, including the ASBMR's Harold M. Frost Award, the Arthritis Foundation's Dorothy W. Goldstein Award, the NIH Career Development Award, the Kappa Delta Award from the ORS and AAOS, the Innovative Research Award from the American College of Rheumatology, and the STAR Award from NIH/NIAMS. Publications Progranulin Promotes Diabetic Fracture Healing in Mice with Type 1 Diabetes Annals of the New York Academy of Sciences. Aug, 2019 | Pubmed ID: 31423598 Fexofenadine Inhibits TNF Signaling Through Targeting to Cytosolic Phospholipase A2 and is Therapeutic Against Inflammatory Arthritis Annals of the Rheumatic Diseases. Jul, 2019 | Pubmed ID: 31302596 Progranulin: A Conductor of Receptors Orchestra, a Chaperone of Lysosomal Enzymes and a Therapeutic Target for Multiple Diseases Cytokine & Growth Factor Reviews. 02, 2019 | Pubmed ID: 30733059 Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review JBJS Reviews. Jan, 2019 | Pubmed ID: 30694878 Targeting Tumor Necrosis Factor Receptors in Ankylosing Spondylitis Annals of the New York Academy of Sciences. Apr, 2019 | Pubmed ID: 30008173 Brain-penetrant Heat Shock Protein Amplifier Arimoclomol Enhances GCase Activity in in Vitro Gaucher Disease Models EBioMedicine. 12, 2018 | Pubmed ID: 30522930 Progranulin Associates with Hexosaminidase A and Ameliorates GM2 Ganglioside Accumulation and Lysosomal Storage in Tay-Sachs Disease Journal of Molecular Medicine (Berlin, Germany). Dec, 2018 | Pubmed ID: 30341570 Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29956284 Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor Arthritis & Rheumatology (Hoboken, N.J.). 11, 2018 | Pubmed ID: 29750395 Molecular Regulations and Therapeutic Targets of Gaucher Disease Cytokine & Growth Factor Reviews. 06, 2018 | Pubmed ID: 29699937 P204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice EBioMedicine. Mar, 2018 | Pubmed ID: 29472103 Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease EBioMedicine. Feb, 2018 | Pubmed ID: 29396296 Multifunctional Molecule ERp57: From Cancer to Neurodegenerative Diseases Pharmacology & Therapeutics. 01, 2018 | Pubmed ID: 28723413 Progranulin: A Key Player in Autoimmune Diseases Cytokine. 01, 2018 | Pubmed ID: 27527809 Progranulin Derivative Atsttrin Protects Against Early Osteoarthritis in Mouse and Rat Models Arthritis Research & Therapy. Dec, 2017 | Pubmed ID: 29258611 Progranulin Acts As a Shared Chaperone and Regulates Multiple Lysosomal Enzymes Genes & Diseases. Sep, 2017 | Pubmed ID: 28944282 Foxo4- and Stat3-dependent IL-10 Production by Progranulin in Regulatory T Cells Restrains Inflammatory Arthritis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2017 | Pubmed ID: 28011648 Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease EBioMedicine. Nov, 2016 | Pubmed ID: 27789271 Association Between Progranulin and Gaucher Disease EBioMedicine. Sep, 2016 | Pubmed ID: 27515686 Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling Arthritis & Rheumatology (Hoboken, N.J.). 12, 2016 | Pubmed ID: 27428882 Extracellular Matrix Protein 1, a Direct Targeting Molecule of Parathyroid Hormone-related Peptide, Negatively Regulates Chondrogenesis and Endochondral Ossification Via Associating with Progranulin Growth Factor FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 08, 2016 | Pubmed ID: 27075243 Progranulin Suppresses Titanium Particle Induced Inflammatory Osteolysis by Targeting TNFα Signaling Scientific Reports. Feb, 2016 | Pubmed ID: 26864916 Does Progranulin Account for the Opposite Effects of Etanercept and Infliximab/adalimumab in Osteoarthritis?: Comment on Olson Et Al.: "Therapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis After Articular Fracture" Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jan, 2016 | Pubmed ID: 26519939 Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice Scientific Reports. Mar, 2015 | Pubmed ID: 25777988 Overexpression of ADAMTS-7 Leads to Accelerated Initiation and Progression of Collagen-induced Arthritis in Mice Molecular and Cellular Biochemistry. Jun, 2015 | Pubmed ID: 25742929 Progranulin Protects Against Osteoarthritis Through Interacting with TNF-α and β-Catenin Signalling Annals of the Rheumatic Diseases. Dec, 2015 | Pubmed ID: 25169730 Progranulin Facilitates Conversion and Function of Regulatory T Cells Under Inflammatory Conditions PloS One. 2014 | Pubmed ID: 25393765 PGRN Protects Against Colitis Progression in Mice in an IL-10 and TNFR2 Dependent Manner Scientific Reports. Nov, 2014 | Pubmed ID: 25387791 ADAMTS-18: a Metalloproteinase with Multiple Functions Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896365 Three TNFR-binding Domains of PGRN Act Independently in Inhibition of TNF-alpha Binding and Activity Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896343 Progranulin Inhibition of TNFα Immunology and Cell Biology. Feb, 2014 | Pubmed ID: 24518982 Progranulin Directly Binds to the CRD2 and CRD3 of TNFR Extracellular Domains FEBS Letters. Nov, 2013 | Pubmed ID: 24070898 ADAMTS-7 Forms a Positive Feedback Loop with TNF-α in the Pathogenesis of Osteoarthritis Annals of the Rheumatic Diseases. Dec, 2013 | Pubmed ID: 23928557 The Promotion of Bone Healing by Progranulin, a Downstream Molecule of BMP-2, Through Interacting with TNF/TNFR Signaling Biomaterials. Sep, 2013 | Pubmed ID: 23746860 Progranulin Deficiency Exaggerates, Whereas Progranulin-derived Atsttrin Attenuates, Severity of Dermatitis in Mice FEBS Letters. Jun, 2013 | Pubmed ID: 23669357 Prevention of Atrophic Nonunion by the Systemic Administration of Parathyroid Hormone (PTH 1-34) in an Experimental Animal Model Journal of Orthopaedic Trauma. Dec, 2012 | Pubmed ID: 22932751 Progranulin: a Growth Factor, a Novel TNFR Ligand and a Drug Target Pharmacology & Therapeutics. Jan, 2012 | Pubmed ID: 22008260 GEP Constitutes a Negative Feedback Loop with MyoD and Acts As a Novel Mediator in Controlling Skeletal Muscle Differentiation Cellular and Molecular Life Sciences : CMLS. Dec, 2011 | Pubmed ID: 22179841 Progranulin: a Promising Therapeutic Target for Rheumatoid Arthritis FEBS Letters. Dec, 2011 | Pubmed ID: 21550343 The Growth Factor Progranulin Binds to TNF Receptors and is Therapeutic Against Inflammatory Arthritis in Mice Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21393509 Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting with Bone Morphogenetic Protein-2 Circulation Research. Apr, 2011 | Pubmed ID: 21350216 The Role of ADAMTSs in Arthritis Protein & Cell. Jan, 2010 | Pubmed ID: 21203996 GEP, a Local Growth Factor, is Critical for Odontogenesis and Amelogenesis International Journal of Biological Sciences. 2010 | Pubmed ID: 21152114 Matrix Metalloproteinases That Associate with and Cleave Bone Morphogenetic Protein-2 in Vitro Are Elevated in Hypertrophic Fracture Nonunion Tissue Journal of Orthopaedic Trauma. Sep, 2010 | Pubmed ID: 20736794 Interaction Between Cartilage Oligomeric Matrix Protein and Extracellular Matrix Protein 1 Mediates Endochondral Bone Growth Matrix Biology : Journal of the International Society for Matrix Biology. May, 2010 | Pubmed ID: 20138147 Granulin Epithelin Precursor: a Bone Morphogenic Protein 2-inducible Growth Factor That Activates Erk1/2 Signaling and JunB Transcription Factor in Chondrogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2010 | Pubmed ID: 20124436 Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting with Alpha(7)beta(1) Integrin Circulation Research. Feb, 2010 | Pubmed ID: 20019333 Levels of Expression for BMP-7 and Several BMP Antagonists May Play an Integral Role in a Fracture Nonunion: a Pilot Study Clinical Orthopaedics and Related Research. Dec, 2009 | Pubmed ID: 19597895 ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor Molecular and Cellular Biology. Aug, 2009 | Pubmed ID: 19487464 MicroRNAs in Skeletogenesis Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19273234 MiR-199a, a Bone Morphogenic Protein 2-responsive MicroRNA, Regulates Chondrogenesis Via Direct Targeting to Smad1 The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19251704 ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-injured Rat Arteries Circulation Research. Mar, 2009 | Pubmed ID: 19168437 The Role of ADAMTS-7 and ADAMTS-12 in the Pathogenesis of Arthritis Nature Clinical Practice. Rheumatology. Jan, 2009 | Pubmed ID: 19098927 P204, a P200 Family Protein, As a Multifunctional Regulator of Cell Proliferation and Differentiation Cytokine & Growth Factor Reviews. Oct-Dec, 2008 | Pubmed ID: 19027346 Inhibition of ADAMTS-7 and ADAMTS-12 Degradation of Cartilage Oligomeric Matrix Protein by Alpha-2-macroglobulin Osteoarthritis and Cartilage. Nov, 2008 | Pubmed ID: 18485748 P204 Protein Overcomes the Inhibition of Core Binding Factor Alpha-1-mediated Osteogenic Differentiation by Id Helix-loop-helix Proteins Molecular Biology of the Cell. May, 2008 | Pubmed ID: 18287524 RbAp48 is a Critical Mediator Controlling the Transforming Activity of Human Papillomavirus Type 16 in Cervical Cancer The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17616526 IFI16 Inhibits Tumorigenicity and Cell Proliferation of Bone and Cartilage Tumor Cells Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17569615 Transcriptional Activation of Cartilage Oligomeric Matrix Protein by Sox9, Sox5, and Sox6 Transcription Factors and CBP/p300 Coactivators Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17485346 The Retinoblastoma Protein is an Essential Mediator of Osteogenesis That Links the P204 Protein to the Cbfa1 Transcription Factor Thereby Increasing Its Activity The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17439944 Protein-protein Interactions and Membrane Localization of the Human Organic Solute Transporter American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2007 | Pubmed ID: 17332473 Cartilage Oligomeric Matrix Protein Associates with Granulin-epithelin Precursor (GEP) and Potentiates GEP-stimulated Chondrocyte Proliferation The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17307734 ADAMTS-12 Associates with and Degrades Cartilage Oligomeric Matrix Protein The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16611630 ADAMTS-7: a Metalloproteinase That Directly Binds to and Degrades Cartilage Oligomeric Matrix Protein FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2006 | Pubmed ID: 16585064 P204 Protein Overcomes the Inhibition of the Differentiation of P19 Murine Embryonal Carcinoma Cells to Beating Cardiac Myocytes by Id Proteins The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556596 P204 is Required for the Differentiation of P19 Murine Embryonal Carcinoma Cells to Beating Cardiac Myocytes: Its Expression is Activated by the Cardiac Gata4, Nkx2.5, and Tbx5 Proteins The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556595 Serum Interleukin-6 As a Marker of Periprosthetic Infection Following Total Hip and Knee Arthroplasty The Journal of Bone and Joint Surgery. American Volume. Sep, 2005 | Pubmed ID: 16140805 The Interferon-inducible P204 Protein Acts As a Transcriptional Coactivator of Cbfa1 and Enhances Osteoblast Differentiation The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15557274 Leukemia/lymphoma-related Factor, a POZ Domain-containing Transcriptional Repressor, Interacts with Histone Deacetylase-1 and Inhibits Cartilage Oligomeric Matrix Protein Gene Expression and Chondrogenesis The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15337766 A Silencer Element in the Cartilage Oligomeric Matrix Protein Gene Regulates Chondrocyte-specific Expression Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jul, 2004 | Pubmed ID: 15183430 Association of the 16-kDa Subunit C of Vacuolar Proton Pump with the Ileal Na+-dependent Bile Acid Transporter: Protein-protein Interaction and Intracellular Trafficking The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14752118 Modulation of the Cardiac Sodium Channel Nav1.5 by Fibroblast Growth Factor Homologous Factor 1B The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12401812 The MyoD-inducible P204 Protein Overcomes the Inhibition of Myoblast Differentiation by Id Proteins Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940648 A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochimie Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bio-ingénierie Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biologie
A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochimie
Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bio-ingénierie
Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biologie