Chwee Teck Lim Mechanobiology Institute National University of Singapore Biography Publications Institution JoVE Articles Chwee Teck Lim has not added a biography. If you are Chwee Teck Lim and would like to personalize this page please email our Author Liaison for assistance. Publications Rapid, High-Throughput Tracking of Bacterial Motility in 3D Via Phase-Contrast Holographic Video Microscopy Biophysical Journal. Mar, 2015 | Pubmed ID: 25762336 Corrigendum: Force-dependent Conformational Switch of α-catenin Controls Vinculin Binding Nature Communications. 2015 | Pubmed ID: 25735633 Preclinical Evaluation of Tegaderm™ Supported Nanofibrous Wound Matrix Dressing on Porcine Wound Healing Model Advances in Wound Care. Feb, 2015 | Pubmed ID: 25713753 Cell Surface Receptors: Rapid Quantification of Live Cell Receptors Using Bioluminescence in a Flow-based Microfluidic Device (small 8/2015) Small (Weinheim an Der Bergstrasse, Germany). Feb, 2015 | Pubmed ID: 25702895 Mechanics of Epithelial Closure over Non-adherent Environments Nature Communications. 2015 | Pubmed ID: 25608921 Actomyosin Bundles Serve As a Tension Sensor and a Platform for ERK Activation EMBO Reports. Feb, 2015 | Pubmed ID: 25550404 Malaria Detection Using Inertial Microfluidics Lab on a Chip. Feb, 2015 | Pubmed ID: 25537768 Biophysical Properties of Human Breast Cancer Cells Measured Using Silicon MEMS Resonators and Atomic Force Microscopy Lab on a Chip. Feb, 2015 | Pubmed ID: 25473785 Jetting Microfluidics with Size-sorting Capability for Single-cell Protease Detection Biosensors & Bioelectronics. Apr, 2015 | Pubmed ID: 25460876 Plasmodium Vivax: Restricted Tropism and Rapid Remodeling of CD71-positive Reticulocytes Blood. Feb, 2015 | Pubmed ID: 25414440 Bone Marrow Regeneration Promoted by Biophysically Sorted Osteoprogenitors from Mesenchymal Stromal Cells Stem Cells Translational Medicine. Jan, 2015 | Pubmed ID: 25411477 Rapid Quantification of Live Cell Receptors Using Bioluminescence in a Flow-based Microfluidic Device Small (Weinheim an Der Bergstrasse, Germany). Feb, 2015 | Pubmed ID: 25336403 Cell-assembled Graphene Biocomposite for Enhanced Chondrogenic Differentiation Small (Weinheim an Der Bergstrasse, Germany). Feb, 2015 | Pubmed ID: 25320042 Polysaccharide Nanofibers with Variable Compliance for Directing Cell Fate Journal of Biomedical Materials Research. Part A. Mar, 2015 | Pubmed ID: 24853353 Highly Sensitive Reduced Graphene Oxide Microelectrode Array Sensor Biosensors & Bioelectronics. Oct, 2014 | Pubmed ID: 25461168 Multivariate Biophysical Markers Predictive of Mesenchymal Stromal Cell Multipotency Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25298531 Actin Flow and Talin Dynamics Govern Rigidity Sensing in Actin-integrin Linkage Through Talin Extension Journal of the Royal Society, Interface / the Royal Society. Oct, 2014 | Pubmed ID: 25142525 Mechanistic Adaptability of Cancer Cells Strongly Affects Anti-migratory Drug Efficacy Journal of the Royal Society, Interface / the Royal Society. Oct, 2014 | Pubmed ID: 25100319 DEAD-box Helicase DP103 Defines Metastatic Potential of Human Breast Cancers The Journal of Clinical Investigation. Sep, 2014 | Pubmed ID: 25083991 Molecular Mechanisms Underlying the Force-dependent Regulation of Actin-to-ECM Linkage at the Focal Adhesions Progress in Molecular Biology and Translational Science. 2014 | Pubmed ID: 25081617 Force-dependent Conformational Switch of α-catenin Controls Vinculin Binding Nature Communications. 2014 | Pubmed ID: 25077739 Clinical Validation of an Ultra High-throughput Spiral Microfluidics for the Detection and Enrichment of Viable Circulating Tumor Cells PloS One. 2014 | Pubmed ID: 24999991 Single Cell Kinase Signaling Assay Using Pinched Flow Coupled Droplet Microfluidics Biomicrofluidics. May, 2014 | Pubmed ID: 24926389 An Ultra-high-throughput Spiral Microfluidic Biochip for the Enrichment of Circulating Tumor Cells The Analyst. Jul, 2014 | Pubmed ID: 24840240 Substrate Topography Determines the Fate of Chondrogenesis from Human Mesenchymal Stem Cells Resulting in Specific Cartilage Phenotype Formation Nanomedicine : Nanotechnology, Biology, and Medicine. Oct, 2014 | Pubmed ID: 24768908 Mesenchymal Stem Cells Reduce Intervertebral Disc Fibrosis and Facilitate Repair Stem Cells (Dayton, Ohio). Aug, 2014 | Pubmed ID: 24737495 Force-dependent Vinculin Binding to Talin in Live Cells: a Crucial Step in Anchoring the Actin Cytoskeleton to Focal Adhesions American Journal of Physiology. Cell Physiology. Mar, 2014 | Pubmed ID: 24452377 Effect of Ultrasound on Cyprid Footprint and Juvenile Barnacle Adhesion on a Fouling Release Material Colloids and Surfaces. B, Biointerfaces. Mar, 2014 | Pubmed ID: 24333559 High-throughput Synchronization of Mammalian Cell Cultures by Spiral Microfluidics Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24297405 Epithelial Bridges Maintain Tissue Integrity During Collective Cell Migration Nature Materials. Jan, 2014 | Pubmed ID: 24292420 Slanted Spiral Microfluidics for the Ultra-fast, Label-free Isolation of Circulating Tumor Cells Lab on a Chip. Jan, 2014 | Pubmed ID: 23949794 Collective Cell Migration: a Mechanistic Perspective Physiology (Bethesda, Md.). Nov, 2013 | Pubmed ID: 24186932 Significant Biochemical, Biophysical and Metabolic Diversity in Circulating Human Cord Blood Reticulocytes PloS One. 2013 | Pubmed ID: 24116088 Nanomechanics Insights into the Performance of Healthy and Osteoporotic Bones Nano Letters. Nov, 2013 | Pubmed ID: 24063581 Stretching and Relaxation of Malaria-infected Red Blood Cells Biophysical Journal. Sep, 2013 | Pubmed ID: 24010653 Guidance of Collective Cell Migration by Substrate Geometry Integrative Biology : Quantitative Biosciences from Nano to Macro. Aug, 2013 | Pubmed ID: 23784144 Adhesion of B. Subtilis Spores and Vegetative Cells Onto Stainless Steel--DLVO Theories and AFM Spectroscopy Journal of Colloid and Interface Science. Sep, 2013 | Pubmed ID: 23777862 Geometrical Constraints and Physical Crowding Direct Collective Migration of Fibroblasts Communicative & Integrative Biology. Mar, 2013 | Pubmed ID: 23750300 Probing the Cytoadherence of Malaria Infected Red Blood Cells Under Flow PloS One. 2013 | Pubmed ID: 23724092 Cycle De Vie-dépendante Du Cytosquelette Modifications Dans Les érythrocytes Infectés Par Plasmodium Falciparum PloS One. 2013 | Pubmed ID: 23585879 Tumor Dissemination: an EMT Affair Cancer Cell. Mar, 2013 | Pubmed ID: 23518345 Molecular Mechanism of Transglutaminase-2 in Corneal Epithelial Migration and Adhesion Biochimica Et Biophysica Acta. Jun, 2013 | Pubmed ID: 23466867 Isoporous Micro/nanoengineered Membranes ACS Nano. Mar, 2013 | Pubmed ID: 23442009 Isolation and Retrieval of Circulating Tumor Cells Using Centrifugal Forces Scientific Reports. 2013 | Pubmed ID: 23405273 Microfluidic Cell Trap Array for Controlled Positioning of Single Cells on Adhesive Micropatterns Lab on a Chip. Feb, 2013 | Pubmed ID: 23282845 Biophysical Responses Upon the Interaction of Nanomaterials with Cellular Interfaces Accounts of Chemical Research. Mar, 2013 | Pubmed ID: 23194178 Atomic Force Microscopy of Plasmodium-infected Red Blood Cells: Detecting and Localizing Single Molecular Recognition Events Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 22990787 Biominéralisation Contrôlée Des Fibres électrofilées Poly Pour Améliorer Leurs Propriétés Mécaniques Acta Biomaterialia. Nov, 2012 | Pubmed ID: 23131385 CD80 Et CD86 Différentiellement Régulent Les Interactions Mécaniques Des Lymphocytes T Avec Les Cellules Dendritiques Présentatrices D'antigène Et Les Lymphocytes B PloS One. 2012 | Pubmed ID: 23024807 High-performance Graphene-titania Platform for Detection of Phosphopeptides in Cancer Cells Analytical Chemistry. Aug, 2012 | Pubmed ID: 22839352 Emerging Modes of Collective Cell Migration Induced by Geometrical Constraints Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22814373 Fluorinated Graphene for Promoting Neuro-induction of Stem Cells Advanced Materials (Deerfield Beach, Fla.). Aug, 2012 | Pubmed ID: 22689093 Estradiol Influences the Mechanical Properties of Human Fetal Osteoblasts Through Cytoskeletal Changes Biochemical and Biophysical Research Communications. Jul, 2012 | Pubmed ID: 22683634 A Microfluidics Approach Towards High-throughput Pathogen Removal from Blood Using Margination Biomicrofluidics. Jun, 2012 | Pubmed ID: 22655023 Microfluidic Technologies Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer. 2012 | Pubmed ID: 22527494 Host Cell Deformability is Linked to Transmission in the Human Malaria Parasite Plasmodium Falciparum Cellular Microbiology. Jul, 2012 | Pubmed ID: 22417683 3D Coupling of Fibronectin Fibril Arrangement with Topology of Ventral Plasma Membrane Cell Communication & Adhesion. Apr, 2012 | Pubmed ID: 22409236 TPPP Acts Downstream of RhoA-ROCK-LIMK2 to Regulate Astral Microtubule Organization and Spindle Orientation Journal of Cell Science. Mar, 2012 | Pubmed ID: 22328514 Mussel Inspired Protein-mediated Surface Modification to Electrospun Fibers and Their Potential Biomedical Applications Journal of Biomedical Materials Research. Part A. Apr, 2012 | Pubmed ID: 22275174 Highly Wrinkled Cross-linked Graphene Oxide Membranes for Biological and Charge-storage Applications Small (Weinheim an Der Bergstrasse, Germany). Feb, 2012 | Pubmed ID: 22162356 Fabrication of Large Pores in Electrospun Nanofibrous Scaffolds for Cellular Infiltration: a Review Tissue Engineering. Part B, Reviews. Apr, 2012 | Pubmed ID: 21902623 Flow Sensing of Single Cell by Graphene Transistor in a Microfluidic Channel Nano Letters. Dec, 2011 | Pubmed ID: 22077950 The Malaria Parasite Progressively Dismantles the Host Erythrocyte Cytoskeleton for Efficient Egress Molecular & Cellular Proteomics : MCP. Dec, 2011 | Pubmed ID: 21903871 Origin of Enhanced Stem Cell Growth and Differentiation on Graphene and Graphene Oxide ACS Nano. Sep, 2011 | Pubmed ID: 21793541 Biophysical Methods to Probe Claudin-mediated Adhesion at the Cellular and Molecular Level Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21717350 Biophysics of Malarial Parasite Exit from Infected Erythrocytes PloS One. 2011 | Pubmed ID: 21698115 Mechanical Interactions Between Dendritic Cells and T Cells Correlate with T Cell Responsiveness Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21622857 Pinched Flow Coupled Shear-modulated Inertial Microfluidics for High-throughput Rare Blood Cell Separation Lab on a Chip. Jun, 2011 | Pubmed ID: 21505682 Molecular Mechanistic Insights into the Endothelial Receptor Mediated Cytoadherence of Plasmodium Falciparum-infected Erythrocytes PloS One. 2011 | Pubmed ID: 21437286 Margination of Red Blood Cells Infected by Plasmodium Falciparum in a Microvessel Journal of Biomechanics. May, 2011 | Pubmed ID: 21420683 Atomic Force Microscope Imaging of Chromatin Assembled in Xenopus Laevis Egg Extract Chromosoma. Jun, 2011 | Pubmed ID: 21369955 Cycle Cellulaire Haut Débit De Synchronisation Utilisant Inertie Forces En Spirale Microcanaux Lab on a Chip. Apr, 2011 | Pubmed ID: 21336340 Modeling Cell Entry into a Micro-channel Biomechanics and Modeling in Mechanobiology. Oct, 2011 | Pubmed ID: 21104422 Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease MRS Bulletin / Materials Research Society. May, 2010 | Pubmed ID: 21151848 Chondroitin Sulfate A-adhering Plasmodium Falciparum-infected Erythrocytes Express Functionally Important Antibody Epitopes Shared by Multiple Variants Journal of Immunology (Baltimore, Md. : 1950). Dec, 2010 | Pubmed ID: 21078904 A Bioelectronic Platform Using a Graphene-lipid Bilayer Interface ACS Nano. Dec, 2010 | Pubmed ID: 21067155 Thickness Sensing of HMSCs on Collagen Gel Directs Stem Cell Fate Biochemical and Biophysical Research Communications. Oct, 2010 | Pubmed ID: 20851103 Micro and Nanotechnology for Biological and Biomedical Applications Medical & Biological Engineering & Computing. Oct, 2010 | Pubmed ID: 20844973 Manipulation and Isolation of Single Cells and Nuclei Methods in Cell Biology. 2010 | Pubmed ID: 20816231 Versatile Label Free Biochip for the Detection of Circulating Tumor Cells from Peripheral Blood in Cancer Patients Biosensors & Bioelectronics. Dec, 2010 | Pubmed ID: 20719496 Deformability Based Cell Margination--a Simple Microfluidic Design for Malaria-infected Erythrocyte Separation Lab on a Chip. Oct, 2010 | Pubmed ID: 20689864 Rapid Construction of Mechanically- Confined Multi- Cellular Structures Using Dendrimeric Intercellular Linker Biomaterials. Oct, 2010 | Pubmed ID: 20599265 Microfluidics for Cell Separation Medical & Biological Engineering & Computing. Oct, 2010 | Pubmed ID: 20414811 Mechanobiology Journal of the Royal Society, Interface / the Royal Society. Jun, 2010 | Pubmed ID: 20375041 Computational Model of Cell Positioning: Directed and Collective Migration in the Intestinal Crypt Epithelium Journal of the Royal Society, Interface / the Royal Society. Jun, 2010 | Pubmed ID: 20356873 Modeling of Hemodynamics Arising from Malaria Infection Journal of Biomechanics. May, 2010 | Pubmed ID: 20176360 Use of Atomic Force Microscopy As a Tool to Understand the Action of Antimicrobial Peptides on Bacteria Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20094868 Enhanced Biomineralization in Osteoblasts on a Novel Electrospun Biocomposite Nanofibrous Substrate of Hydroxyapatite/collagen/chitosan Tissue Engineering. Part A. Jun, 2010 | Pubmed ID: 20088700 Nanostructure of Collagen Fibrils in Human Nucleus Pulposus and Its Correlation with Macroscale Tissue Mechanics Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Apr, 2010 | Pubmed ID: 19862800 Effet De L'orientation Moléculaire Sur Les Propriétés Mécaniques Des Fibres électrofilées Unique Du Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate] The Journal of Physical Chemistry. B. Oct, 2009 | Pubmed ID: 19761245 Cationic Polyrotaxanes As Gene Carriers: Physicochemical Properties and Real-time Observation of DNA Complexation, and Gene Transfection in Cancer Cells The Journal of Physical Chemistry. B. Jun, 2009 | Pubmed ID: 19422177 Microdevice for the Isolation and Enumeration of Cancer Cells from Blood Biomedical Microdevices. Aug, 2009 | Pubmed ID: 19387837 Versatile Transfer of Aligned Carbon Nanotubes with Polydimethylsiloxane As the Intermediate Nanotechnology. Aug, 2008 | Pubmed ID: 21828811 Structure-mechanical Property of Individual Cobalt Oxide Nanowires Nano Letters. Oct, 2008 | Pubmed ID: 18759488 Electrospun Biomimetic Nanocomposite Nanofibers of Hydroxyapatite/chitosan for Bone Tissue Engineering Biomaterials. Nov, 2008 | Pubmed ID: 18715637 Kinetics of Adhesion Mediated by Extracellular Loops of Claudin-2 As Revealed by Single-molecule Force Spectroscopy Journal of Molecular Biology. Sep, 2008 | Pubmed ID: 18635194 Probing Effects of PH Change on Dynamic Response of Claudin-2 Mediated Adhesion Using Single Molecule Force Spectroscopy Experimental Cell Research. Aug, 2008 | Pubmed ID: 18602630 Influence of Irrigation Regimens on the Adherence of Enterococcus Faecalis to Root Canal Dentin Journal of Endodontics. Jul, 2008 | Pubmed ID: 18570994 A Comparative Molecular Force Spectroscopy Study of Homophilic JAM-A Interactions and JAM-A Interactions with Reovirus Attachment Protein Sigma1 Journal of Molecular Recognition : JMR. Jul-Aug, 2008 | Pubmed ID: 18446885 Single-molecular-level Study of Claudin-1-mediated Adhesion Langmuir : the ACS Journal of Surfaces and Colloids. Jan, 2008 | Pubmed ID: 18095722 Molecular Force Spectroscopy of Homophilic Nectin-1 Interactions Biochemical and Biophysical Research Communications. Nov, 2007 | Pubmed ID: 17822670 Cell Adhesion Properties on Photochemically Functionalized Diamond Langmuir : the ACS Journal of Surfaces and Colloids. May, 2007 | Pubmed ID: 17407337 Propriétés Mécaniques Des Nanofibres De Médicaments Encapsulés électrofilées Unique Nanotechnology. Aug, 2006 | Pubmed ID: 19079553 Substrate-friendly Synthesis of Metal Oxide Nanostructures Using a Hotplate Small (Weinheim an Der Bergstrasse, Germany). Jan, 2006 | Pubmed ID: 17193559 Synthesis, Characterization, and Morphology Studies of Biodegradable Amphiphilic Poly[(R)-3-hydroxybutyrate]-alt-poly(ethylene Glycol) Multiblock Copolymers Biomacromolecules. Nov, 2006 | Pubmed ID: 17096539 Size Selective Assembly of Colloidal Particles on a Template by Directed Self-assembly Technique Langmuir : the ACS Journal of Surfaces and Colloids. Sep, 2006 | Pubmed ID: 16952269 Recent Development of Polymer Nanofibers for Biomedical and Biotechnological Applications Journal of Materials Science. Materials in Medicine. Oct, 2005 | Pubmed ID: 16167102 Phénomènes Micellisation Des Copolymères à Trois Blocs Amphiphiles Biodégradable Consistant En Poly (acide Bêta-hydroxyalcanoiques) Et Poly (oxyde D'éthylène) Langmuir : the ACS Journal of Surfaces and Colloids. Sep, 2005 | Pubmed ID: 16142948 Electrospinning of Gelatin Fibers and Gelatin/PCL Composite Fibrous Scaffolds Journal of Biomedical Materials Research. Part B, Applied Biomaterials. Jan, 2005 | Pubmed ID: 15389493 Measurement of Poisson's Ratio of Dental Composite Restorative Materials Biomaterials. Jun, 2004 | Pubmed ID: 14751729 Système de Gel concentrique à étudier le rôle biophysique de Matrix microenvironnement sur 3D migration cellulaire Nicholas Agung Kurniawan1, Parthiv Kant Chaudhuri2, Chwee Teck Lim2,3 1Systems Biophysics Department, FOM Institute AMOLF, 2Mechanobiology Institute, National University of Singapore, 3Department of Biomedical Engineering, National University of Singapore JoVE 52735 Bio-ingénierie
Système de Gel concentrique à étudier le rôle biophysique de Matrix microenvironnement sur 3D migration cellulaire Nicholas Agung Kurniawan1, Parthiv Kant Chaudhuri2, Chwee Teck Lim2,3 1Systems Biophysics Department, FOM Institute AMOLF, 2Mechanobiology Institute, National University of Singapore, 3Department of Biomedical Engineering, National University of Singapore JoVE 52735 Bio-ingénierie