Cliona O'Farrelly School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute Trinity College Dublin Biography Publications Institution JoVE Articles Cliona O'Farrelly has not added a biography. If you are Cliona O'Farrelly and would like to personalize this page please email our Author Liaison for assistance. Publications The Hepatitis C Virus (HCV) Protein, P7, Suppresses Inflammatory Responses to Tumor Necrosis Factor (TNF)-α Signal Transducer and Activator of Transcription (STAT)3 and Extracellular Signal-regulated Kinase (ERK)-mediated Induction of Suppressor of Cytokine Signaling (SOCS)3 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2019 | Pubmed ID: 31163989 Non-canonical Inflammasome-Mediated IL-1β Production by Primary Endometrial Epithelial and Stromal Fibroblast Cells Is NLRP3 and Caspase-4 Dependent Frontiers in Immunology. 2019 | Pubmed ID: 30804935 Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis Cancer Immunology Research. Feb, 2019 | Pubmed ID: 30563827 β-Defensins: Farming the Microbiome for Homeostasis and Health Frontiers in Immunology. 2018 | Pubmed ID: 30761155 Metabolic Reprogramming of Natural Killer Cells in Obesity Limits Antitumor Responses Nature Immunology. 12, 2018 | Pubmed ID: 30420624 Cervico-vaginal Mucus (CVM) - an Accessible Source of Immunologically Informative Biomolecules Veterinary Research Communications. Dec, 2018 | Pubmed ID: 30117040 Innate Immunity in Stem Cell-derived Hepatocytes Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2018 | Pubmed ID: 29786555 Designer Human Tissue: Coming to a Lab Near You Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2018 | Pubmed ID: 29786548 HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction EBioMedicine. Apr, 2018 | Pubmed ID: 29580840 Depleted Polymorphonuclear Leukocytes in Human Metastatic Liver Reflect an Altered Immune Microenvironment Associated with Recurrent Metastasis Cancer Immunology, Immunotherapy : CII. 07, 2018 | Pubmed ID: 29572702 Uterine Natural Killer Cell Progenitor Populations Predict Successful Implantation in Women with Endometriosis-associated Infertility American Journal of Reproductive Immunology (New York, N.Y. : 1989). 03, 2018 | Pubmed ID: 29380456 Extratumoral PD-1 Blockade Does Not Perpetuate Obesity-associated Inflammation in Esophageal Adenocarcinoma Cancer Letters. 04, 2018 | Pubmed ID: 29339209 Disease Outcomes in a Cohort of Women in Ireland Infected by Hepatitis C-contaminated Anti-D Immunoglobulin During 1970s Journal of Hepatology. 12, 2017 | Pubmed ID: 28843656 Early Subretinal Allograft Rejection Is Characterized by Innate Immune Activity Cell Transplantation. 06, 2017 | Pubmed ID: 28105976 A Novel Anti-viral Role for STAT3 in IFN-α Signalling Responses Cellular and Molecular Life Sciences : CMLS. 05, 2017 | Pubmed ID: 27988795 Sex-specific Effects of TLR9 Promoter Variants on Spontaneous Clearance of HCV Infection Gut. 10, 2017 | Pubmed ID: 27196570 Immune Cell Profiling of IFN-λ Response Shows PDCs Express Highest Level of IFN-λR1 and Are Directly Responsive Via the JAK-STAT Pathway Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. 12, 2016 | Pubmed ID: 27617757 The CD4(+) T Cell Methylome Contributes to a Distinct CD4(+) T Cell Transcriptional Signature in Mycobacterium Bovis-infected Cattle Scientific Reports. 08, 2016 | Pubmed ID: 27507428 Tissue-resident Eomes(hi) T-bet(lo) CD56(bright) NK Cells with Reduced Proinflammatory Potential Are Enriched in the Adult Human Liver European Journal of Immunology. 09, 2016 | Pubmed ID: 27485474 The Microenvironment of Visceral Adipose Tissue and Liver Alter Natural Killer Cell Viability and Function Journal of Leukocyte Biology. 12, 2016 | Pubmed ID: 27365528 Liver Immunology and Its Role in Inflammation and Homeostasis Cellular & Molecular Immunology. 05, 2016 | Pubmed ID: 27063467 CCR1 Antagonism Attenuates T Cell Trafficking to Omentum and Liver in Obesity-associated Cancer Immunology and Cell Biology. 07, 2016 | Pubmed ID: 27046081 Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain Stem Cells and Development. Apr, 2016 | Pubmed ID: 26879149 Increased UNK Progenitor Cells in Women With Endometriosis and Infertility Are Associated With Low Levels of Endometrial Stem Cell Factor American Journal of Reproductive Immunology (New York, N.Y. : 1989). Apr, 2016 | Pubmed ID: 26791471 Natural Killer Cells: Key Players in Endometriosis American Journal of Reproductive Immunology (New York, N.Y. : 1989). Oct, 2015 | Pubmed ID: 26104509 Anxiety is Associated with Higher Levels of Global DNA Methylation and Altered Expression of Epigenetic and Interleukin-6 Genes Psychiatric Genetics. Apr, 2015 | Pubmed ID: 25350786 The Role of MicroRNAs in Bovine Infection and Immunity Frontiers in Immunology. 2014 | Pubmed ID: 25505900 Tissue-specific NK Cell Populations and Their Origin Journal of Leukocyte Biology. Dec, 2014 | Pubmed ID: 25246601 RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium Bovis Frontiers in Immunology. 2014 | Pubmed ID: 25206354 In Vitro Blood Cell Responsiveness to IFN-α Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients Journal of Translational Medicine. Jul, 2014 | Pubmed ID: 25048205 IFNL Cytokines Do Not Modulate Human or Murine NK Cell Functions Human Immunology. Sep, 2014 | Pubmed ID: 24994459 Hepatitis C Virus (HCV)-induced Suppressor of Cytokine Signaling (SOCS) 3 Regulates Proinflammatory TNF-α Responses Journal of Leukocyte Biology. Aug, 2014 | Pubmed ID: 24659790 Characterisation and Expression Profile of the Bovine Cathelicidin Gene Repertoire in Mammary Tissue BMC Genomics. Feb, 2014 | Pubmed ID: 24524771 Endogenous Oils Derived from Human Adipocytes Are Potent Adjuvants That Promote IL-1α-dependent Inflammation Diabetes. Jun, 2014 | Pubmed ID: 24458363 Reply To: "Dendritic Cell Subset Composition in the Human Liver is More Complex Than It Seems" Journal of Hepatology. May, 2014 | Pubmed ID: 24418016 CD141⁺ Myeloid Dendritic Cells Are Enriched in Healthy Human Liver Journal of Hepatology. Jan, 2014 | Pubmed ID: 23968887 Hepatitis C Virus Targets the Interferon-α JAK/STAT Pathway by Promoting Proteasomal Degradation in Immune Cells and Hepatocytes FEBS Letters. May, 2013 | Pubmed ID: 23587486 Global Endometrial Transcriptomic Profiling: Transient Immune Activation Precedes Tissue Proliferation and Repair in Healthy Beef Cows BMC Genomics. 2012 | Pubmed ID: 22985206 Adipose Tissue Invariant NKT Cells Protect Against Diet-induced Obesity and Metabolic Disorder Through Regulatory Cytokine Production Immunity. Sep, 2012 | Pubmed ID: 22981538 Genome-wide Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium Bovis Reveals Suppression of Host Immune Genes BMC Genomics. 2011 | Pubmed ID: 22182502 Ribavirin Enhances IFN-α Signalling and MxA Expression: a Novel Immune Modulation Mechanism During Treatment of HCV PloS One. 2011 | Pubmed ID: 22114715 Preparation of Pre-confluent Retinal Cells Increases Graft Viability in Vitro and in Vivo: a Mouse Model PloS One. 2011 | Pubmed ID: 21738643 Risk Factors for the Development of Depression in Patients with Hepatitis C Taking Interferon-α Neuropsychiatric Disease and Treatment. 2011 | Pubmed ID: 21654873 Activation of Human Invariant Natural Killer T Cells with a Thioglycoside Analogue of α-galactosylceramide Clinical Immunology (Orlando, Fla.). Aug, 2011 | Pubmed ID: 21493160 Hepatitis C Virus Targets the T Cell Secretory Machinery As a Mechanism of Immune Evasion Hepatology (Baltimore, Md.). Jun, 2011 | Pubmed ID: 21452285 Experimental Staphylococcus Aureus Infection of the Mammary Gland Induces Region-specific Changes in Innate Immune Gene Expression Veterinary Immunology and Immunopathology. Apr, 2011 | Pubmed ID: 21292330 Clinical Anxiety, Cortisol and Interleukin-6: Evidence for Specificity in Emotion-biology Relationships Brain, Behavior, and Immunity. Oct, 2010 | Pubmed ID: 20227485 Natural Killer Cells in Obesity: Impaired Function and Increased Susceptibility to the Effects of Cigarette Smoke PloS One. Jan, 2010 | Pubmed ID: 20107494 Differential Antimicrobial Peptide Gene Expression Patterns During Early Chicken Embryological Development Developmental and Comparative Immunology. Apr, 2009 | Pubmed ID: 19007808 Toll-like Receptor and Antimicrobial Peptide Expression in the Bovine Endometrium Reproductive Biology and Endocrinology : RB&E. Nov, 2008 | Pubmed ID: 19017375 Antigen Stimulation of Peripheral Blood Mononuclear Cells from Mycobacterium Bovis Infected Cattle Yields Evidence for a Novel Gene Expression Program BMC Genomics. Sep, 2008 | Pubmed ID: 18823559 Hepatitis C Virus-specific Th17 Cells Are Suppressed by Virus-induced TGF-beta Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18802051 Evolution, Expression and Effectiveness in a Cluster of Novel Bovine Beta-defensins Immunogenetics. Apr, 2008 | Pubmed ID: 18369613 Induction of a Novel Chicken Toll-like Receptor Following Salmonella Enterica Serovar Typhimurium Infection Infection and Immunity. Mar, 2006 | Pubmed ID: 16495540 Producción libre de suero de heferas humanas tridimensionales a partir de células madre pluripotentes Balta Lucendo-Villarin1, Hassan Rashidi1,2, Sharmin Alhaque1,3, Lena Fischer1,4, Jose Meseguer-Ripolles1, Yu Wang1, Cliona O'Farrelly4, Michael Themis3, David C. Hay1 1MRC Centre for Regenerative Medicine, University of Edinburgh, 2UCL Great Ormond Street Institute of Child Health, University College London, 3Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, 4School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin JoVE 59965 Biologie du développement
Producción libre de suero de heferas humanas tridimensionales a partir de células madre pluripotentes Balta Lucendo-Villarin1, Hassan Rashidi1,2, Sharmin Alhaque1,3, Lena Fischer1,4, Jose Meseguer-Ripolles1, Yu Wang1, Cliona O'Farrelly4, Michael Themis3, David C. Hay1 1MRC Centre for Regenerative Medicine, University of Edinburgh, 2UCL Great Ormond Street Institute of Child Health, University College London, 3Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, 4School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin JoVE 59965 Biologie du développement