Devesh Kumar Department of Pharmacology and Toxicology University of Saarland School of Medicine Biography Publications Institution JoVE Articles Devesh Kumar has not added a biography. If you are Devesh Kumar and would like to personalize this page please email our Author Liaison for assistance. Publications Long-Range Electron Transfer Triggers Mechanistic Differences Between Iron(IV)-Oxo and Iron(IV)-Imido Oxidants Journal of the American Chemical Society. Dec, 2014 | Pubmed ID: 25392052 Specialized Subpopulations of Kisspeptin Neurons Communicate with GnRH Neurons in Female Mice Endocrinology. Oct, 2014 | Pubmed ID: 25337655 Properties and Reactivities of Nonheme Iron(IV)-oxo Versus Iron(V)-oxo: Long-range Electron Transfer Versus Hydrogen Atom Abstraction Physical Chemistry Chemical Physics : PCCP. Nov, 2014 | Pubmed ID: 25231726 Thioether-ligated Iron(II) and Iron(III)-hydroperoxo/alkylperoxo Complexes with an H-bond Donor in the Second Coordination Sphere Dalton Transactions (Cambridge, England : 2003). May, 2014 | Pubmed ID: 24705907 Murine Arcuate Nucleus Kisspeptin Neurons Communicate with GnRH Neurons in Utero The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2014 | Pubmed ID: 24599473 Quantum Mechanics/molecular Mechanics Study on the Oxygen Binding and Substrate Hydroxylation Step in AlkB Repair Enzymes Chemistry (Weinheim an Der Bergstrasse, Germany). Jan, 2014 | Pubmed ID: 24339041 Comparison of the Reactivity of Nonheme Iron(IV)-oxo Versus Iron(IV)-imido Complexes: Which is the Better Oxidant? Angewandte Chemie (International Ed. in English). Nov, 2013 | Pubmed ID: 24222577 Mechanistic Insight into Halide Oxidation by Non-heme Iron Complexes. Haloperoxidase Versus Halogenase Activity Chemical Communications (Cambridge, England). Dec, 2013 | Pubmed ID: 24136302 Synthesis and Ligand Non-innocence of Thiolate-ligated (N4S) Iron(II) and Nickel(II) Bis(imino)pyridine Complexes Inorganic Chemistry. Sep, 2013 | Pubmed ID: 23992096 Genetic Dissection of Puberty in Mice Experimental Physiology. Nov, 2013 | Pubmed ID: 23955307 Three-dimensional Echocardiographic Delineation of an Acquired Aorto-left Atrial Fistula Complicating Native Aortic Valve Endocarditis - "advantage of Three Dimensions" Echocardiography (Mount Kisco, N.Y.). Nov, 2013 | Pubmed ID: 23931072 Inversion of Enantioselectivity of a Mononuclear Non-heme Iron(II)-dependent Hydroxylase by Tuning the Interplay of Metal-center Geometry and Protein Structure Angewandte Chemie (International Ed. in English). Sep, 2013 | Pubmed ID: 23881738 Rationalization of the Barrier Height for P-Z-styrene Epoxidation by Iron(IV)-oxo Porphyrin Cation Radicals with Variable Axial Ligands Inorganic Chemistry. Jul, 2013 | Pubmed ID: 23822112 The Serum C Peptide Levels Among the Offsprings of the People with Type 2 Diabetes Journal of Clinical and Diagnostic Research : JCDR. May, 2013 | Pubmed ID: 23814721 Generation of a High-valent Iron Imido Corrolazine Complex and NR Group Transfer Reactivity Inorganic Chemistry. Apr, 2013 | Pubmed ID: 23527920 Axial and Equatorial Ligand Effects on Biomimetic Cysteine Dioxygenase Model Complexes Organic & Biomolecular Chemistry. Jul, 2012 | Pubmed ID: 22714822 Axial Ligand Effect on the Rate Constant of Aromatic Hydroxylation by Iron(IV)-oxo Complexes Mimicking Cytochrome P450 Enzymes The Journal of Physical Chemistry. B. Jan, 2012 | Pubmed ID: 22132821 Mechanism of S-oxygenation by a Cysteine Dioxygenase Model Complex The Journal of Physical Chemistry. A. Jan, 2012 | Pubmed ID: 22091701 Nonheme Ferric Hydroperoxo Intermediates Are Efficient Oxidants of Bromide Oxidation Chemical Communications (Cambridge, England). Oct, 2011 | Pubmed ID: 21904759 Oxidative Properties of a Nonheme Ni(II)(O2) Complex: Reactivity Patterns for C-H Activation, Aromatic Hydroxylation and Heteroatom Oxidation Chemical Communications (Cambridge, England). Oct, 2011 | Pubmed ID: 21892444 Study of Occupational Stress Among Railway Engine Pilots Indian Journal of Occupational and Environmental Medicine. Jan, 2011 | Pubmed ID: 21808497 Effect of the Axial Ligand on Substrate Sulfoxidation Mediated by Iron(IV)-oxo Porphyrin Cation Radical Oxidants Chemistry (Weinheim an Der Bergstrasse, Germany). May, 2011 | Pubmed ID: 21469227 Comparison of Computational Methods to Model DNA Minor Groove Binders Journal of Chemical Information and Modeling. Mar, 2011 | Pubmed ID: 21375336 Theoretical Study on the Mechanism of the Oxygen Activation Process in Cysteine Dioxygenase Enzymes Journal of the American Chemical Society. Mar, 2011 | Pubmed ID: 21344861 Water As Biocatalyst in Cytochrome P450 Faraday Discussions. 2011 | Pubmed ID: 21322494 Fattori Sterico Ignorare Termodinamico Forza Trainante in Regioselettività Di Idrossilazione Di Prolina Enzimi Prolil-4-idrossilasi The Journal of Physical Chemistry. A. Dec, 2010 | Pubmed ID: 21114303 Quali Fattori Influenzano La Costante Di Velocità Di Substrato Epossidazione Di Composto I Del Citocromo P450 E Analoga Ferro (IV)-oxo Ossidanti? Journal of the American Chemical Society. Jun, 2010 | Pubmed ID: 20481499 Coupling and Uncoupling Mechanisms in the Methoxythreonine Mutant of Cytochrome P450cam: a Quantum Mechanical/molecular Mechanical Study Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Mar, 2010 | Pubmed ID: 20225401 P450 Enzymes: Their Structure, Reactivity, and Selectivity-modeled by QM/MM Calculations Chemical Reviews. Feb, 2010 | Pubmed ID: 19813749 Electronic Properties of Pentacoordinated Heme Complexes in Cytochrome P450 Enzymes: Search for an Fe(I) Oxidation State Physical Chemistry Chemical Physics : PCCP. Nov, 2009 | Pubmed ID: 19865780 Effect of Porphyrin Ligands on the Regioselective Dehydrogenation Versus Epoxidation of Olefins by Oxoiron(IV) Mimics of Cytochrome P450 The Journal of Physical Chemistry. A. Oct, 2009 | Pubmed ID: 19658379 QM/MM Study of the Second Proton Transfer in the Catalytic Cycle of the D251N Mutant of Cytochrome P450cam The Journal of Physical Chemistry. B. Jul, 2009 | Pubmed ID: 19537775 How is the Reactivity of Cytochrome P450cam Affected by Thr252X Mutation? A QM/MM Study for X = Serine, Valine, Alanine, Glycine Journal of the American Chemical Society. Apr, 2009 | Pubmed ID: 19281168 A Tribute to Sason Shaik The Journal of Physical Chemistry. A. Dec, 2008 | Pubmed ID: 19072248 A Valence Bond Modeling of Trends in Hydrogen Abstraction Barriers and Transition States of Hydroxylation Reactions Catalyzed by Cytochrome P450 Enzymes Journal of the American Chemical Society. Aug, 2008 | Pubmed ID: 18616242 Multireference Ab Initio Quantum Mechanics/molecular Mechanics Study on Intermediates in the Catalytic Cycle of Cytochrome P450(cam) The Journal of Physical Chemistry. A. Dec, 2008 | Pubmed ID: 18543897 Theoretical Study of N-demethylation of Substituted N,N-dimethylanilines by Cytochrome P450: the Mechanistic Significance of Kinetic Isotope Effect Profiles The Journal of Physical Chemistry. B. Jul, 2007 | Pubmed ID: 17559261 Reactivity Patterns of Cytochrome P450 Enzymes: Multifunctionality of the Active Species, and the Two States-two Oxidants Conundrum Natural Product Reports. Jun, 2007 | Pubmed ID: 17534529 Reactivity of High-valent Iron-oxo Species in Enzymes and Synthetic Reagents: a Tale of Many States Accounts of Chemical Research. Jul, 2007 | Pubmed ID: 17488054 Singlet Diradical Character of an Oxidized Ruthenium Trithiolate: Electronic Structure and Reactivity Angewandte Chemie (International Ed. in English). 2007 | Pubmed ID: 17450515 Formation of the Active Species of Cytochrome P450 by Using Iodosylbenzene: a Case for Spin-selective Reactivity Chemistry (Weinheim an Der Bergstrasse, Germany). 2007 | Pubmed ID: 17367100 Proton-shuffle Mechanism of O-O Activation for Formation of a High-valent Oxo-iron Species of Bleomycin Journal of the American Chemical Society. Dec, 2006 | Pubmed ID: 17165768 Characterization of Manganese(V)-oxo Polyoxometalate Intermediates and Their Properties in Oxygen-transfer Reactions Journal of the American Chemical Society. Dec, 2006 | Pubmed ID: 17132012 On the Identity and Reactivity Patterns of the "second Oxidant" of the T252A Mutant of Cytochrome P450cam in the Oxidation of 5-methylenenylcamphor Journal of Inorganic Biochemistry. Dec, 2006 | Pubmed ID: 17084458 Catalysts for Monooxygenations Made from Polyoxometalate: an Iron(V)-oxo Derivative of the Lindqvist Anion Inorganic Chemistry. Oct, 2006 | Pubmed ID: 17029376 Ferromagnetic Bonding: High Spin Copper Clusters (n+1)Cu(n); N = 2-14) Devoid of Electron Pairs but Possessing Strong Bonding The Journal of Physical Chemistry. A. Jul, 2006 | Pubmed ID: 16821835 Two-state Reactivity in Alkane Hydroxylation by Non-heme Iron-oxo Complexes Journal of the American Chemical Society. Jul, 2006 | Pubmed ID: 16802826 In Silico Design of a Mutant of Cytochrome P450 Containing Selenocysteine Journal of the American Chemical Society. Mar, 2006 | Pubmed ID: 16492051 Gauging the Relative Oxidative Powers of Compound I, Ferric-hydroperoxide, and the Ferric-hydrogen Peroxide Species of Cytochrome P450 Toward C-H Hydroxylation of a Radical Clock Substrate Journal of the American Chemical Society. Jan, 2006 | Pubmed ID: 16402834 Kinetic Isotope Effect is a Sensitive Probe of Spin State Reactivity in C-H Hydroxylation of N,N-dimethylaniline by Cytochrome P450 Journal of the American Chemical Society. Jan, 2006 | Pubmed ID: 16402810 New Features in the Catalytic Cycle of Cytochrome P450 During the Formation of Compound I from Compound 0 The Journal of Physical Chemistry. B. Oct, 2005 | Pubmed ID: 16853579 The High-valent Iron-oxo Species of Polyoxometalate, if It Can Be Made, Will Be a Highly Potent Catalyst for C-H Hydroxylation and Double-bond Epoxidation Journal of the American Chemical Society. Dec, 2005 | Pubmed ID: 16351100 Two States and Two More in the Mechanisms of Hydroxylation and Epoxidation by Cytochrome P450 Journal of the American Chemical Society. Sep, 2005 | Pubmed ID: 16159296 Theoretical Perspective on the Structure and Mechanism of Cytochrome P450 Enzymes Chemical Reviews. Jun, 2005 | Pubmed ID: 15941215 Theory Favors a Stepwise Mechanism of Porphyrin Degradation by a Ferric Hydroperoxide Model of the Active Species of Heme Oxygenase Journal of the American Chemical Society. Jun, 2005 | Pubmed ID: 15926850 Theoretical Investigation of C--H Hydroxylation by (N4Py)Fe(IV)=O(2+): an Oxidant More Powerful Than P450? Journal of the American Chemical Society. Jun, 2005 | Pubmed ID: 15926822 Sulfoxidation Mechanisms Catalyzed by Cytochrome P450 and Horseradish Peroxidase Models: Spin Selection Induced by the Ligand Biochemistry. Jun, 2005 | Pubmed ID: 15924434 Multistate Reactivity in Styrene Epoxidation by Compound I of Cytochrome P450: Mechanisms of Products and Side Products Formation Chemistry (Weinheim an Der Bergstrasse, Germany). Apr, 2005 | Pubmed ID: 15744771 The Intrinsic Axial Ligand Effect on Propene Oxidation by Horseradish Peroxidase Versus Cytochrome P450 Enzymes Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Mar, 2005 | Pubmed ID: 15723206 Computer-generated High-valent Iron--oxo and Manganese--oxo Species with Polyoxometalate Ligands: How Do They Compare with the Iron--oxo Active Species of Heme Enzymes? Angewandte Chemie (International Ed. in English). Oct, 2004 | Pubmed ID: 15495193 External Electric Field Will Control the Selectivity of Enzymatic-like Bond Activations Journal of the American Chemical Society. Sep, 2004 | Pubmed ID: 15366922 One Oxidant, Many Pathways: a Theoretical Perspective of Monooxygenation Mechanisms by Cytochrome P450 Enzymes Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry. Sep, 2004 | Pubmed ID: 15365903 A Predictive Pattern of Computed Barriers for C-h Hydroxylation by Compound I of Cytochrome P450 Journal of the American Chemical Society. Jul, 2004 | Pubmed ID: 15237977 How Do Aldehyde Side Products Occur During Alkene Epoxidation by Cytochrome P450? Theory Reveals a State-specific Multi-state Scenario Where the High-spin Component Leads to All Side Products Journal of Inorganic Biochemistry. Jul, 2004 | Pubmed ID: 15219984 Oxygen Economy of Cytochrome P450: What is the Origin of the Mixed Functionality As a Dehydrogenase-oxidase Enzyme Compared with Its Normal Function? Journal of the American Chemical Society. Apr, 2004 | Pubmed ID: 15099082 Porphyrin Traps Its Terminator! Concerted and Stepwise Porphyrin Degradation Mechanisms Induced by Heme-oxygenase and Cytochrome P450 Angewandte Chemie (International Ed. in English). Feb, 2004 | Pubmed ID: 14983454 Radical Clock Substrates, Their C-H Hydroxylation Mechanism by Cytochrome P450, and Other Reactivity Patterns: What Does Theory Reveal About the Clocks' Behavior? Journal of the American Chemical Society. Feb, 2004 | Pubmed ID: 14871124 Active Species of Horseradish Peroxidase (HRP) and Cytochrome P450: Two Electronic Chameleons Journal of the American Chemical Society. Dec, 2003 | Pubmed ID: 14677968 How Does Product Isotope Effect Prove the Operation of a Two-state "rebound" Mechanism in C-H Hydroxylation by Cytochrome P450? Journal of the American Chemical Society. Oct, 2003 | Pubmed ID: 14570465 Condizionale genetica Transsynaptic Tracing nel cervello embrionali di topo Devesh Kumar1, Ulrich Boehm1 1Department of Pharmacology and Toxicology, University of Saarland School of Medicine Neurosciences
Condizionale genetica Transsynaptic Tracing nel cervello embrionali di topo Devesh Kumar1, Ulrich Boehm1 1Department of Pharmacology and Toxicology, University of Saarland School of Medicine Neurosciences