Dobromir Dobrev Institute of Pharmacology University of Duisburg-Essen Biography Publications Institution JoVE Articles Dobromir Dobrev has not added a biography. If you are Dobromir Dobrev and would like to personalize this page please email our Author Liaison for assistance. Publications Phosphodiesterase-2 is Upregulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes Journal of the American College of Cardiology. Jun, 2013 | Pubmed ID: 23810893 Safety and Efficacy of Vernakalant for Acute Cardioversion of Atrial Fibrillation: an Update Vascular Health and Risk Management. 2013 | Pubmed ID: 23637539 KCNQ1 Autoantibodies: Another Way to Regulate IKs Cardiovascular Research. Jun, 2013 | Pubmed ID: 23615563 Atrial Fibrillation Promotion by Endurance Exercise: Demonstration and Mechanistic Exploration in an Animal Model Journal of the American College of Cardiology. Jul, 2013 | Pubmed ID: 23583240 Pleiotropic Actions of Amiodarone: Still Puzzling After Half a Century Naunyn-Schmiedeberg's Archives of Pharmacology. Jul, 2013 | Pubmed ID: 23568552 Impaired Na(+)-dependent Regulation of Acetylcholine-activated Inward-rectifier K(+) Current Modulates Action Potential Rate Dependence in Patients with Chronic Atrial Fibrillation Journal of Molecular and Cellular Cardiology. Mar, 2013 | Pubmed ID: 23531443 MicroRNA29: a Mechanistic Contributor and Potential Biomarker in Atrial Fibrillation Circulation. Apr, 2013 | Pubmed ID: 23459615 Electrical Storm: Recent Pathophysiological Insights and Therapeutic Consequences Basic Research in Cardiology. Mar, 2013 | Pubmed ID: 23429935 New Directions in Antiarrhythmic Drug Therapy for Atrial Fibrillation Future Cardiology. Jan, 2013 | Pubmed ID: 23259476 The Biology of Human Pulmonary Veins: Does It Help Us to Better Understand AF Pathophysiology in Patients? Heart Rhythm : the Official Journal of the Heart Rhythm Society. Mar, 2013 | Pubmed ID: 23237913 Cellular and Molecular Correlates of Ectopic Activity in Patients with Atrial Fibrillation Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Nov, 2012 | Pubmed ID: 23104921 Voltage-gated Na⺠Channels: Novel Players in Fibroblast-to-myofibroblast Transition with a Potential Role in Atrial Arrhythmogenesis? The Journal of Physiology. Oct, 2012 | Pubmed ID: 23082023 Transient Receptor Potential Canonical-3 Channel-dependent Fibroblast Regulation in Atrial Fibrillation Circulation. Oct, 2012 | Pubmed ID: 22992321 Palmitoylation and Membrane Association of the Stress Axis Regulated Insert (STREX) Controls BK Channel Regulation by Protein Kinase C The Journal of Biological Chemistry. Sep, 2012 | Pubmed ID: 22843729 Is Altered Atrial MicroRNA-ome a Critical Contributor to the Pathophysiology of Atrial Fibrillation? Basic Research in Cardiology. Sep, 2012 | Pubmed ID: 22802051 Systems Approaches to Post-operative Atrial Fibrillation - Do They Help Us to Better Understand the Ionic Basis of the Arrhythmogenic Substrate? Journal of Molecular and Cellular Cardiology. Sep, 2012 | Pubmed ID: 22742961 Calcium Handling and Atrial Fibrillation Wiener Medizinische Wochenschrift (1946). Jul, 2012 | Pubmed ID: 22695810 Role of RyR2 Phosphorylation at S2814 During Heart Failure Progression Circulation Research. May, 2012 | Pubmed ID: 22511749 The Multidimensional Role of Calcium in Atrial Fibrillation Pathophysiology: Mechanistic Insights and Therapeutic Opportunities European Heart Journal. Aug, 2012 | Pubmed ID: 22507975 Novel Molecular Targets for Atrial Fibrillation Therapy Nature Reviews. Drug Discovery. Apr, 2012 | Pubmed ID: 22460122 Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients with Chronic Atrial Fibrillation Circulation. May, 2012 | Pubmed ID: 22456474 Proarrhythmic Atrial Calcium Cycling in the Diseased Heart Advances in Experimental Medicine and Biology. 2012 | Pubmed ID: 22453988 Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice Circulation Research. Feb, 2012 | Pubmed ID: 22158709 Comprehensive Risk Reduction in Patients with Atrial Fibrillation: Emerging Diagnostic and Therapeutic Options--a Report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association Consensus Conference Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Jan, 2012 | Pubmed ID: 21791573 The Impact of Rapid Atrial Pacing on ADMA and Endothelial NOS International Journal of Cardiology. Jan, 2012 | Pubmed ID: 20926145 Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation Circulation Research. Oct, 2011 | Pubmed ID: 21921263 Differential Protein Kinase C Isoform Regulation and Increased Constitutive Activity of Acetylcholine-regulated Potassium Channels in Atrial Remodeling Circulation Research. Oct, 2011 | Pubmed ID: 21903936 Defects in Ankyrin-based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation Circulation. Sep, 2011 | Pubmed ID: 21859974 Recent Advances in the Molecular Pathophysiology of Atrial Fibrillation The Journal of Clinical Investigation. Aug, 2011 | Pubmed ID: 21804195 Oxidized CaMKII Causes Cardiac Sinus Node Dysfunction in Mice The Journal of Clinical Investigation. Aug, 2011 | Pubmed ID: 21785215 Role of T-type Calcium Channel Subunits in Post-myocardial Infarction Remodelling Probed with Genetically Engineered Mice Cardiovascular Research. Aug, 2011 | Pubmed ID: 21622683 No Evidence for an Association Between the Rs2824292 Variant at Chromosome 21q21 and Ventricular Fibrillation During Acute Myocardial Infarction in a German Population Clinical Chemistry and Laboratory Medicine : CCLM / FESCC. Jul, 2011 | Pubmed ID: 21574885 Ca(2+)-related Signaling and Protein Phosphorylation Abnormalities Play Central Roles in a New Experimental Model of Electrical Storm Circulation. May, 2011 | Pubmed ID: 21555709 Prevention of Atrial Fibrillation Complications with Antiarrhythmic Drugs: Still an Unmet Need in Clinical Practice Expert Opinion on Pharmacotherapy. Jun, 2011 | Pubmed ID: 21548721 Atrial-selective Sodium Channel Block by Dronedarone: Sufficient to Terminate Atrial Fibrillation? Naunyn-Schmiedeberg's Archives of Pharmacology. Aug, 2011 | Pubmed ID: 21541758 Phosphatase-1 Inhibitor-1 in Physiological and Pathological β-adrenoceptor Signalling Cardiovascular Research. Aug, 2011 | Pubmed ID: 21354993 New Insights into the Molecular Basis of Atrial Fibrillation: Mechanistic and Therapeutic Implications Cardiovascular Research. Mar, 2011 | Pubmed ID: 21296897 Mechanisms of Atrial Tachyarrhythmias Associated with Coronary Artery Occlusion in a Chronic Canine Model Circulation. Jan, 2011 | Pubmed ID: 21200008 Enhanced Myofilament Responsiveness Upon β-adrenergic Stimulation in Post-infarct Remodeled Myocardium Journal of Molecular and Cellular Cardiology. Mar, 2011 | Pubmed ID: 21156182 The Ryanodine Receptor Channel As a Molecular Motif in Atrial Fibrillation: Pathophysiological and Therapeutic Implications Cardiovascular Research. Mar, 2011 | Pubmed ID: 20943673 Vernakalant Nature Reviews. Drug Discovery. Dec, 2010 | Pubmed ID: 21119728 Voltage-clamp-based Methods for the Detection of Constitutively Active Acetylcholine-gated I(K,ACh) Channels in the Diseased Heart Methods in Enzymology. 2010 | Pubmed ID: 21036255 Calmodulin Kinase II, Sarcoplasmic Reticulum Ca2+ Leak, and Atrial Fibrillation Trends in Cardiovascular Medicine. Jan, 2010 | Pubmed ID: 20685575 Multiple Potential Molecular Contributors to Atrial Hypocontractility Caused by Atrial Tachycardia Remodeling in Dogs Circulation. Arrhythmia and Electrophysiology. Oct, 2010 | Pubmed ID: 20660541 Left-to-right Atrial Inward Rectifier Potassium Current Gradients in Patients with Paroxysmal Versus Chronic Atrial Fibrillation Circulation. Arrhythmia and Electrophysiology. Oct, 2010 | Pubmed ID: 20657029 Aldosterone-receptor Antagonism As a Potential Therapeutic Option for Atrial Fibrillation British Journal of Pharmacology. Apr, 2010 | Pubmed ID: 20388187 New Antiarrhythmic Drugs for Treatment of Atrial Fibrillation Lancet. Apr, 2010 | Pubmed ID: 20334907 Constitutively Active Phosphatase Inhibitor-1 Improves Cardiac Contractility in Young Mice but is Deleterious After Catecholaminergic Stress and with Aging The Journal of Clinical Investigation. Feb, 2010 | Pubmed ID: 20071777 Animal Models for Atrial Fibrillation: Clinical Insights and Scientific Opportunities Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Feb, 2010 | Pubmed ID: 19875395 Atrial Ca2+ Signaling in Atrial Fibrillation As an Antiarrhythmic Drug Target Naunyn-Schmiedeberg's Archives of Pharmacology. Mar, 2010 | Pubmed ID: 19784635 Inhibition of IK,ACh Current May Contribute to Clinical Efficacy of Class I and Class III Antiarrhythmic Drugs in Patients with Atrial Fibrillation Naunyn-Schmiedeberg's Archives of Pharmacology. Mar, 2010 | Pubmed ID: 19760273 Stroke Prevention Versus Bleeding Risk of Vitamin-K Antagonists: a Double-edged Sword in Patients with Atrial Fibrillation Who Require Surgery Cardiovascular Therapeutics. 2009 | Pubmed ID: 19903184 Calmodulin Kinase II-mediated Sarcoplasmic Reticulum Ca2+ Leak Promotes Atrial Fibrillation in Mice The Journal of Clinical Investigation. Jul, 2009 | Pubmed ID: 19603549 Ion Channel Portrait of the Human Sinus Node: Useful for a Better Understanding of Sinus Node Function and Dysfunction in Humans? Circulation. Mar, 2009 | Pubmed ID: 19332478 Acute Atrial Tachyarrhythmia Induces Angiotensin II Type 1 Receptor-mediated Oxidative Stress and Microvascular Flow Abnormalities in the Ventricles European Heart Journal. Jun, 2009 | Pubmed ID: 19269986 Distinct Contractile and Molecular Differences Between Two Goat Models of Atrial Dysfunction: AV Block-induced Atrial Dilatation and Atrial Fibrillation Journal of Molecular and Cellular Cardiology. Mar, 2009 | Pubmed ID: 19100271 Remodelling of Cardiac Repolarization: How Homeostatic Responses Can Lead to Arrhythmogenesis Cardiovascular Research. Feb, 2009 | Pubmed ID: 18826964 Calcium-handling Abnormalities Underlying Atrial Arrhythmogenesis and Contractile Dysfunction in Dogs with Congestive Heart Failure Circulation. Arrhythmia and Electrophysiology. Jun, 2008 | Pubmed ID: 19808399 Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications Circulation. Arrhythmia and Electrophysiology. Apr, 2008 | Pubmed ID: 19808395 The German Competence Network on Atrial Fibrillation (AFNET) Herz. Dec, 2008 | Pubmed ID: 19137244 Calcium Handling Abnormalities in Atrial Fibrillation As a Target for Innovative Therapeutics Journal of Cardiovascular Pharmacology. Oct, 2008 | Pubmed ID: 18791467 Cellular Signaling Underlying Atrial Tachycardia Remodeling of L-type Calcium Current Circulation Research. Oct, 2008 | Pubmed ID: 18723446 Phosphatase Inhibitor-1-deficient Mice Are Protected from Catecholamine-induced Arrhythmias and Myocardial Hypertrophy Cardiovascular Research. Dec, 2008 | Pubmed ID: 18689792 Intracellular Calcium Leak Due to FKBP12.6 Deficiency in Mice Facilitates the Inducibility of Atrial Fibrillation Heart Rhythm : the Official Journal of the Heart Rhythm Society. Jul, 2008 | Pubmed ID: 18598963 Digital Lock-in Techniques for Adaptive Power-line Interference Extraction Physiological Measurement. Jul, 2008 | Pubmed ID: 18560061 Four and a Half LIM Protein 1: a Novel Chaperone for Atrium-specific Kv1.5 Channels with a Potential Role in Atrial Arrhythmogenesis Cardiovascular Research. Jun, 2008 | Pubmed ID: 18390898 New Concepts in Understanding and Modulating Atrial Repolarisation in Patients with Atrial Fibrillation Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing. Aug, 2008 | Pubmed ID: 18330686 Bootstrapped Two-electrode Biosignal Amplifier Medical & Biological Engineering & Computing. Jun, 2008 | Pubmed ID: 18266016 Changes in I K, ACh Single-channel Activity with Atrial Tachycardia Remodelling in Canine Atrial Cardiomyocytes Cardiovascular Research. Jan, 2008 | Pubmed ID: 18006448 Cardiomyocyte Ca2+ Overload in Atrial Tachycardia: is Blockade of L-type Ca2+ Channels a Promising Approach to Prevent Electrical Remodeling and Arrhythmogenesis? Naunyn-Schmiedeberg's Archives of Pharmacology. Dec, 2007 | Pubmed ID: 17999053 Vascular Large Conductance Calcium-activated Potassium Channels: Functional Role and Therapeutic Potential Naunyn-Schmiedeberg's Archives of Pharmacology. Nov, 2007 | Pubmed ID: 17932654 Pharmacological Evidence for Altered Src Kinase Regulation of I (Ca,L) in Patients with Chronic Atrial Fibrillation Naunyn-Schmiedeberg's Archives of Pharmacology. Aug, 2007 | Pubmed ID: 17593353 Decreased Phosphorylation Levels of Cardiac Myosin-binding Protein-C in Human and Experimental Heart Failure Journal of Molecular and Cellular Cardiology. Aug, 2007 | Pubmed ID: 17560599 Differential Phosphorylation-dependent Regulation of Constitutively Active and Muscarinic Receptor-activated IK,ACh Channels in Patients with Chronic Atrial Fibrillation Cardiovascular Research. Jun, 2007 | Pubmed ID: 17362895 Novel Anti-arrhythmic Agents for the Treatment of Atrial Fibrillation Current Opinion in Pharmacology. Apr, 2007 | Pubmed ID: 17303472 5-hydroxytryptamine and Atrial Arrhythmogenesis: a "culprit Mechanism" or Bystander in Patients with Chronic Atrial Fibrillation? Journal of Molecular and Cellular Cardiology. Jan, 2007 | Pubmed ID: 17064728 Molecular Determinants of Altered Ca2+ Handling in Human Chronic Atrial Fibrillation Circulation. Aug, 2006 | Pubmed ID: 16894034 Role of Calcineurin and Protein Phosphatase-2A in the Regulation of Phosphatase Inhibitor-1 in Cardiac Myocytes Biochemical and Biophysical Research Communications. Aug, 2006 | Pubmed ID: 16774736 Do Genetics Help to Better Understand the Underlying Mechanisms of Atrial Fibrillation? European Heart Journal. Jul, 2006 | Pubmed ID: 16760202 Electrical Remodeling in Atrial Fibrillation Herz. Apr, 2006 | Pubmed ID: 16738832 Human Atrial Ion Channel and Transporter Subunit Gene-expression Remodeling Associated with Valvular Heart Disease and Atrial Fibrillation Circulation. Jul, 2005 | Pubmed ID: 16027256 Comparing the Global MRNA Expression Profile of Human Atrial and Ventricular Myocardium with High-density Oligonucleotide Arrays The Journal of Thoracic and Cardiovascular Surgery. Jun, 2005 | Pubmed ID: 15942582 Effects of Immunoglobulin G from Patients with Dilated Cardiomyopathy on Rat Cardiomyocytes Basic & Clinical Pharmacology & Toxicology. Jun, 2005 | Pubmed ID: 15910408 Quantification of G Protein Gaalphas Subunit Splice Variants in Different Human Tissues and Cells Using Pyrosequencing Gene Expression. 2005 | Pubmed ID: 15892449 Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation Circulation. Apr, 2005 | Pubmed ID: 15851612 Recording Atrial Monophasic Action Potentials Using Standard Pacemaker Leads: an Alternative Way to Study Electrophysiology Properties of the Human Atrium in Vivo? Pacing and Clinical Electrophysiology : PACE. Dec, 2004 | Pubmed ID: 15613126 An Aqueous Extract of the Marine Sponge Ectyoplasia Ferox Stimulates L-type Ca2+-current by Direct Interaction with the Cav1.2 Subunit Naunyn-Schmiedeberg's Archives of Pharmacology. Dec, 2004 | Pubmed ID: 15599709 Role of IKur in Controlling Action Potential Shape and Contractility in the Human Atrium: Influence of Chronic Atrial Fibrillation Circulation. Oct, 2004 | Pubmed ID: 15477405 Muscarinic Subtype-2 Receptor Autoantibodies: Actors or Bystanders in Human Atrial Fibrillation? European Heart Journal. Jul, 2004 | Pubmed ID: 15231365 Mechanisms of Beta-adrenergic Receptor-mediated Venodilation in Humans Clinical Pharmacology and Therapeutics. Jan, 2004 | Pubmed ID: 14749691 Decreased ATP-sensitive K(+) Current Density During Chronic Human Atrial Fibrillation Journal of Molecular and Cellular Cardiology. Dec, 2003 | Pubmed ID: 14654366 Transcription Factors for Ion Channels: Active or Passive Players in Cardiac Remodeling? Cardiovascular Research. Nov, 2003 | Pubmed ID: 14613850 Remodeling of Cardiomyocyte Ion Channels in Human Atrial Fibrillation Basic Research in Cardiology. May, 2003 | Pubmed ID: 12883831 Cardiac Sympathetic Innervation and Control of Potassium Channel Function Journal of Molecular and Cellular Cardiology. Feb, 2003 | Pubmed ID: 12606253 Therapeutically Relevant Concentrations of Neomycin Selectively Inhibit P-type Ca2+ Channels in Rat Striatum European Journal of Pharmacology. Feb, 2003 | Pubmed ID: 12586205 Rate-adaptive Pacing Using Intracardiac Impedance Shows No Evidence for Positive Feedback During Dobutamine Stress Test Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Jul, 2002 | Pubmed ID: 12134978 What is a Good Tutorial from the Student's Point of View? Evaluation of Tutorials in a Newly Established PBL Block Course "Basics of Drug Therapy" Naunyn-Schmiedeberg's Archives of Pharmacology. Jul, 2002 | Pubmed ID: 12107636 Human Inward Rectifier Potassium Channels in Chronic and Postoperative Atrial Fibrillation Cardiovascular Research. May, 2002 | Pubmed ID: 12062344 Problem-based Learning: a New Pathway to Competence? Trends in Pharmacological Sciences. Apr, 2002 | Pubmed ID: 11931987 בידוד של myocytes פרוזדורי אדם למדידות בו זמנית של Ca Niels Voigt*1,2, Xiao-Bo Zhou*2, Dobromir Dobrev1,2 1Institute of Pharmacology, University of Duisburg-Essen, 2Division of Experimental Cardiology, University of Heidelberg JoVE 50235 Biologie
בידוד של myocytes פרוזדורי אדם למדידות בו זמנית של Ca Niels Voigt*1,2, Xiao-Bo Zhou*2, Dobromir Dobrev1,2 1Institute of Pharmacology, University of Duisburg-Essen, 2Division of Experimental Cardiology, University of Heidelberg JoVE 50235 Biologie