Eugene C. Butcher Laboratory of Immunology and Vascular Biology, Department of Pathology Stanford University School of Medicine Biography Publications Institution JoVE Articles Eugene C. Butcher has not added a biography. If you are Eugene C. Butcher and would like to personalize this page please email our Author Liaison for assistance. Publications Role and Species-specific Expression of Colon T Cell Homing Receptor GPR15 in Colitis Nature Immunology. Feb, 2015 | Pubmed ID: 25531831 Leukocyte Chemoattractant Receptors in Human Disease Pathogenesis Annual Review of Pathology. 2015 | Pubmed ID: 25387059 A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease PloS One. 2014 | Pubmed ID: 25437209 Absence of Nkx2-3 Homeodomain Transcription Factor Reprograms the Endothelial Addressin Preference for Lymphocyte Homing in Peyer's Patches Journal of Immunology (Baltimore, Md. : 1950). Nov, 2014 | Pubmed ID: 25320278 Transcriptional Programs of Lymphoid Tissue Capillary and High Endothelium Reveal Control Mechanisms for Lymphocyte Homing Nature Immunology. Oct, 2014 | Pubmed ID: 25173345 Comparative Transcriptional and Functional Profiling Defines Conserved Programs of Intestinal DC Differentiation in Humans and Mice Nature Immunology. Jan, 2014 | Pubmed ID: 24292363 Canonical and Noncanonical Wnt Proteins Program Dendritic Cell Responses for Tolerance Journal of Immunology (Baltimore, Md. : 1950). Jun, 2013 | Pubmed ID: 23677472 Plasmacytoid Dendritic Cells Promote Rotavirus-induced Human and Murine B Cell Responses The Journal of Clinical Investigation. Jun, 2013 | Pubmed ID: 23635775 Thymus-homing Dendritic Cells in Central Tolerance European Journal of Immunology. Jun, 2013 | Pubmed ID: 23616226 Chemerin is an Antimicrobial Agent in Human Epidermis PloS One. 2013 | Pubmed ID: 23527010 The Chemoattractant Chemerin Suppresses Melanoma by Recruiting Natural Killer Cell Antitumor Defenses The Journal of Experimental Medicine. Jul, 2012 | Pubmed ID: 22753924 Janus-like Opposing Roles of CD47 in Autoimmune Brain Inflammation in Humans and Mice The Journal of Experimental Medicine. Jul, 2012 | Pubmed ID: 22734047 Expression, Regulation, and Function of Atypical Chemerin Receptor CCRL2 on Endothelial Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2012 | Pubmed ID: 22696441 Plasmablast Frequency and Trafficking Receptor Expression Are Altered in Pediatric Ulcerative Colitis Inflammatory Bowel Diseases. Dec, 2012 | Pubmed ID: 22488927 Chemokine-like Receptor 1 Regulates Skeletal Muscle Cell Myogenesis American Journal of Physiology. Cell Physiology. Jun, 2012 | Pubmed ID: 22460713 Plasmacytoid Dendritic Cells Transport Peripheral Antigens to the Thymus to Promote Central Tolerance Immunity. Mar, 2012 | Pubmed ID: 22444632 Disruption of the Chemokine-like Receptor-1 (CMKLR1) Gene is Associated with Reduced Adiposity and Glucose Intolerance Endocrinology. Feb, 2012 | Pubmed ID: 22186410 A Disintegrin and Metalloproteinase 10 Regulates Antibody Production and Maintenance of Lymphoid Architecture Journal of Immunology (Baltimore, Md. : 1950). Nov, 2011 | Pubmed ID: 21998451 Regulation of Chemerin Chemoattractant and Antibacterial Activity by Human Cysteine Cathepsins Journal of Immunology (Baltimore, Md. : 1950). Aug, 2011 | Pubmed ID: 21715684 Absence of Keratin 8 Confers a Paradoxical Microflora-dependent Resistance to Apoptosis in the Colon Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21220329 Panhematin Provides a Therapeutic Benefit in Experimental Pancreatitis Gut. May, 2011 | Pubmed ID: 21159893 Heme Oxygenase-1 is Induced in Peripheral Blood Mononuclear Cells of Patients with Acute Pancreatitis: a Potential Therapeutic Target American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2011 | Pubmed ID: 20966033 IL-17 Regulates Adipogenesis, Glucose Homeostasis, and Obesity Journal of Immunology (Baltimore, Md. : 1950). Dec, 2010 | Pubmed ID: 21037091 Synovial Tissue-infiltrating Natural Killer Cells in Osteoarthritis and Periprosthetic Inflammation Arthritis and Rheumatism. Dec, 2010 | Pubmed ID: 20848566 Chemoattractant Receptors and Lymphocyte Egress from Extralymphoid Tissue: Changing Requirements During the Course of Inflammation Journal of Immunology (Baltimore, Md. : 1950). Oct, 2010 | Pubmed ID: 20833836 Dynamic T Cell Migration Program Provides Resident Memory Within Intestinal Epithelium The Journal of Experimental Medicine. Mar, 2010 | Pubmed ID: 20156972 Chemokine-like Receptor-1 Expression by Central Nervous System-infiltrating Leukocytes and Involvement in a Model of Autoimmune Demyelinating Disease Journal of Immunology (Baltimore, Md. : 1950). Nov, 2009 | Pubmed ID: 19864606 Chemerin and the Recruitment of NK Cells to Diseased Skin Acta Biochimica Polonica. 2009 | Pubmed ID: 19543554 Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 19010784 Modeling the Role of Homologous Receptor Desensitization in Cell Gradient Sensing Journal of Immunology (Baltimore, Md. : 1950). Dec, 2008 | Pubmed ID: 19050250 A Role for Leukocyte-endothelial Adhesion Mechanisms in Epilepsy Nature Medicine. Dec, 2008 | Pubmed ID: 19029985 An Indispensable Role for the Chemokine Receptor CCR10 in IgA Antibody-secreting Cell Accumulation Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008 | Pubmed ID: 18941222 CCR9 Expression Defines Tolerogenic Plasmacytoid Dendritic Cells Able to Suppress Acute Graft-versus-host Disease Nature Immunology. Nov, 2008 | Pubmed ID: 18836452 Mast Cell-expressed Orphan Receptor CCRL2 Binds Chemerin and is Required for Optimal Induction of IgE-mediated Passive Cutaneous Anaphylaxis The Journal of Experimental Medicine. Sep, 2008 | Pubmed ID: 18794339 Environmental Cues, Dendritic Cells and the Programming of Tissue-selective Lymphocyte Trafficking Nature Immunology. Sep, 2008 | Pubmed ID: 18711435 Lymphocyte Electrotaxis in Vitro and in Vivo Journal of Immunology (Baltimore, Md. : 1950). Aug, 2008 | Pubmed ID: 18684937 Critical Role for the Chemokine Receptor CXCR6 in Homeostasis and Activation of CD1d-restricted NKT Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2008 | Pubmed ID: 18566372 Prevention of Acute Graft-versus-host Disease by Blocking T-cell Entry to Secondary Lymphoid Organs Blood. Mar, 2008 | Pubmed ID: 17989315 NMR Assignment of Human Chemerin, a Novel Chemoattractant Biomolecular NMR Assignments. Dec, 2007 | Pubmed ID: 19636857 INKT Cells Require CCR4 to Localize to the Airways and to Induce Airway Hyperreactivity Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007 | Pubmed ID: 17878364 Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17635925 Lack of Lymphoid Chemokines CCL19 and CCL21 Enhances Allergic Airway Inflammation in Mice International Immunology. Jun, 2007 | Pubmed ID: 17513879 Staphylococcus Aureus-derived Staphopain B, a Potent Cysteine Protease Activator of Plasma Chemerin Journal of Immunology (Baltimore, Md. : 1950). Mar, 2007 | Pubmed ID: 17339469 DCs Metabolize Sunlight-induced Vitamin D3 to 'program' T Cell Attraction to the Epidermal Chemokine CCL27 Nature Immunology. Mar, 2007 | Pubmed ID: 17259988 The Germinal Center Response is Impaired in the Absence of T Cell-expressed CXCR5 European Journal of Immunology. Jan, 2007 | Pubmed ID: 17171760 Selectin, Platelet Plays a Critical Role in Granulocyte Access to the Pregnant Mouse Uterus Under Physiological and Pathological Conditions Biology of Reproduction. Apr, 2007 | Pubmed ID: 17151351 T Cell Chemotaxis in a Simple Microfluidic Device Lab on a Chip. Nov, 2006 | Pubmed ID: 17066171 Chemokine-like Receptor 1 Expression by Macrophages in Vivo: Regulation by TGF-beta and TLR Ligands Experimental Hematology. Aug, 2006 | Pubmed ID: 16863918 Chemoattractants, Extracellular Proteases, and the Integrated Host Defense Response Experimental Hematology. Aug, 2006 | Pubmed ID: 16863908 A Cell-surface Molecule Involved in Organ-specific Homing of Lymphocytes. 1983 Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16785489 Redundant Role of Chemokines CCL25/TECK and CCL28/MEC in IgA+ Plasmablast Recruitment to the Intestinal Lamina Propria After Rotavirus Infection Journal of Immunology (Baltimore, Md. : 1950). May, 2006 | Pubmed ID: 16670280 CD8+ Recent Thymic Emigrants Home to and Efficiently Repopulate the Small Intestine Epithelium Nature Immunology. May, 2006 | Pubmed ID: 16582913 RabGEF1 Regulates Stem Cell Factor/c-Kit-mediated Signaling Events and Biological Responses in Mast Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16533754 Hemin-activated Macrophages Home to the Pancreas and Protect from Acute Pancreatitis Via Heme Oxygenase-1 Induction The Journal of Clinical Investigation. Nov, 2005 | Pubmed ID: 16239966 Chemokine Receptor CCR7 Required for T Lymphocyte Exit from Peripheral Tissues Nature Immunology. Sep, 2005 | Pubmed ID: 16116468 Chemerin Activation by Serine Proteases of the Coagulation, Fibrinolytic, and Inflammatory Cascades The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16096270 Surface Phenotype of Peyer's Patch Germinal Center Cells: Implications for the Role of Germinal Centers in B Cell Differentiation. 1982 Journal of Immunology (Baltimore, Md. : 1950). Aug, 2005 | Pubmed ID: 16034071 Chemoattractant Induces LFA-1 Associated PI 3K Activity and Cell Migration That Are Dependent on Fyn Signaling FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2005 | Pubmed ID: 15955842 Can Cell Systems Biology Rescue Drug Discovery? Nature Reviews. Drug Discovery. Jun, 2005 | Pubmed ID: 15915152 Keratin-8-deficient Mice Develop Chronic Spontaneous Th2 Colitis Amenable to Antibiotic Treatment Journal of Cell Science. May, 2005 | Pubmed ID: 15840656 Modified Representational Difference Analysis: Isolation of Differentially Expressed MRNAs from Rare Cell Populations Analytical Biochemistry. Jan, 2005 | Pubmed ID: 15620887 Role for CXCR6 in Recruitment of Activated CD8+ Lymphocytes to Inflamed Liver Journal of Immunology (Baltimore, Md. : 1950). Jan, 2005 | Pubmed ID: 15611250 Chemokine-like Receptor 1 Expression and Chemerin-directed Chemotaxis Distinguish Plasmacytoid from Myeloid Dendritic Cells in Human Blood Journal of Immunology (Baltimore, Md. : 1950). Jan, 2005 | Pubmed ID: 15611246 Functional Involvement of P-selectin and MAdCAM-1 in the Recruitment of Alpha4beta7-integrin-expressing Monocyte-like Cells to the Pregnant Mouse Uterus European Journal of Immunology. Dec, 2004 | Pubmed ID: 15484189 Systems Biology in Drug Discovery Nature Biotechnology. Oct, 2004 | Pubmed ID: 15470465 Maturation and Trafficking Markers on Rotavirus-specific B Cells During Acute Infection and Convalescence in Children Journal of Virology. Oct, 2004 | Pubmed ID: 15452217 CCL28 Controls Immunoglobulin (Ig)A Plasma Cell Accumulation in the Lactating Mammary Gland and IgA Antibody Transfer to the Neonate The Journal of Experimental Medicine. Sep, 2004 | Pubmed ID: 15381732 Rapid Structure-activity and Selectivity Analysis of Kinase Inhibitors by BioMAP Analysis in Complex Human Primary Cell-based Models Assay and Drug Development Technologies. Aug, 2004 | Pubmed ID: 15357924 Antigen-specific Lymphocyte Sequestration in Lymphoid Organs: Lack of Essential Roles for AlphaL and Alpha4 Integrin-dependent Adhesion or Galphai Protein-coupled Receptor Signaling Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004 | Pubmed ID: 15240673 Unique Gene Expression Program of Human Germinal Center T Helper Cells Blood. Oct, 2004 | Pubmed ID: 15213097 An Integrative Biology Approach for Analysis of Drug Action in Models of Human Vascular Inflammation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2004 | Pubmed ID: 15208272 Murine CD8+ Recent Thymic Emigrants Are AlphaE Integrin-positive and CC Chemokine Ligand 25 Responsive Journal of Immunology (Baltimore, Md. : 1950). Jun, 2004 | Pubmed ID: 15187103 Method for Analyzing Signaling Networks in Complex Cellular Systems Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14745015 RhoA and Zeta PKC Control Distinct Modalities of LFA-1 Activation by Chemokines: Critical Role of LFA-1 Affinity Triggering in Lymphocyte in Vivo Homing Immunity. Jan, 2004 | Pubmed ID: 14738762 Targeting T Cell Responses by Selective Chemokine Receptor Expression Seminars in Immunology. Oct, 2003 | Pubmed ID: 15001177 Plasma-cell Homing Nature Reviews. Immunology. Oct, 2003 | Pubmed ID: 14523388 Chemokines in the Systemic Organization of Immunity Immunological Reviews. Oct, 2003 | Pubmed ID: 12969310 Differential Chemokine Responses and Homing Patterns of Murine TCR Alpha Beta NKT Cell Subsets Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003 | Pubmed ID: 12960320 Motility Analysis of Pancreatic Adenocarcinoma Cells Reveals a Role for the Atypical Zeta Isoform of Protein Kinase C in Cancer Cell Movement Laboratory Investigation; a Journal of Technical Methods and Pathology. Aug, 2003 | Pubmed ID: 12920244 Chemokines in Lymphocyte Trafficking and Intestinal Immunity Microcirculation (New York, N.Y. : 1994). Jun, 2003 | Pubmed ID: 12851648 Dendritic Cells Support Sequential Reprogramming of Chemoattractant Receptor Profiles During Naive to Effector T Cell Differentiation Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003 | Pubmed ID: 12816993 Lymphocyte Homing to Bronchus-associated Lymphoid Tissue (BALT) is Mediated by L-selectin/PNAd, Alpha4beta1 Integrin/VCAM-1, and LFA-1 Adhesion Pathways The Journal of Experimental Medicine. May, 2003 | Pubmed ID: 12756264 CCR10 Expression is a Common Feature of Circulating and Mucosal Epithelial Tissue IgA Ab-secreting Cells The Journal of Clinical Investigation. Apr, 2003 | Pubmed ID: 12671049 A Common Mucosal Chemokine (mucosae-associated Epithelial Chemokine/CCL28) Selectively Attracts IgA Plasmablasts Journal of Immunology (Baltimore, Md. : 1950). Apr, 2003 | Pubmed ID: 12646646 CD8+ T Cells from Patients with Acute Multiple Sclerosis Display Selective Increase of Adhesiveness in Brain Venules: a Critical Role for P-selectin Glycoprotein Ligand-1 Blood. Jun, 2003 | Pubmed ID: 12595306 Lectin-like Oxidized LDL Receptor-1 is a Cell-adhesion Molecule Involved in Endotoxin-induced Inflammation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2003 | Pubmed ID: 12538855 Rotavirus-specific B Cells Induced by Recent Infection in Adults and Children Predominantly Express the Intestinal Homing Receptor Alpha4beta7 Virology. Jan, 2003 | Pubmed ID: 12504544 Liver-infiltrating Lymphocytes in End-stage Hepatitis C Virus: Subsets, Activation Status, and Chemokine Receptor Phenotypes Journal of Hepatology. Jan, 2003 | Pubmed ID: 12480562 Distinct Subsets of Human Valpha24-invariant NKT Cells: Cytokine Responses and Chemokine Receptor Expression Trends in Immunology. Nov, 2002 | Pubmed ID: 12401396 Intestinal Attraction: CCL25 Functions in Effector Lymphocyte Recruitment to the Small Intestine The Journal of Clinical Investigation. Oct, 2002 | Pubmed ID: 12393843 Bovine Gamma Delta T Cell Subsets Express Distinct Patterns of Chemokine Responsiveness and Adhesion Molecules: a Mechanism for Tissue-specific Gamma Delta T Cell Subset Accumulation Journal of Immunology (Baltimore, Md. : 1950). Nov, 2002 | Pubmed ID: 12391210 Tropism of Varicella-zoster Virus for Human Tonsillar CD4(+) T Lymphocytes That Express Activation, Memory, and Skin Homing Markers Journal of Virology. Nov, 2002 | Pubmed ID: 12388703 Cytokine Control of Memory B Cell Homing Machinery Journal of Immunology (Baltimore, Md. : 1950). Aug, 2002 | Pubmed ID: 12165486 Trafficking Machinery of NKT Cells: Shared and Differential Chemokine Receptor Expression Among V Alpha 24(+)V Beta 11(+) NKT Cell Subsets with Distinct Cytokine-producing Capacity Blood. Jul, 2002 | Pubmed ID: 12070001 Vascular Morphogenesis and Differentiation After Adoptive Transfer of Human Endothelial Cells to Immunodeficient Mice The American Journal of Pathology. May, 2002 | Pubmed ID: 12000715 Hematopoietic Stem Cells Are Uniquely Selective in Their Migratory Response to Chemokines The Journal of Experimental Medicine. May, 2002 | Pubmed ID: 11994419 Chemokines in Rapid Leukocyte Adhesion Triggering and Migration Seminars in Immunology. Apr, 2002 | Pubmed ID: 11978080 Correlation of Tissue Distribution, Developmental Phenotype, and Intestinal Homing Receptor Expression of Antigen-specific B Cells During the Murine Anti-rotavirus Immune Response Journal of Immunology (Baltimore, Md. : 1950). Mar, 2002 | Pubmed ID: 11859103 Chemokines and the Tissue-specific Migration of Lymphocytes Immunity. Jan, 2002 | Pubmed ID: 11825560 Molecular Mechanisms Involved in Lymphocyte Recruitment in Inflamed Brain Microvessels: Critical Roles for P-selectin Glycoprotein Ligand-1 and Heterotrimeric G(i)-linked Receptors Journal of Immunology (Baltimore, Md. : 1950). Feb, 2002 | Pubmed ID: 11823530 The Intestinal Chemokine Thymus-expressed Chemokine (CCL25) Attracts IgA Antibody-secreting Cells The Journal of Experimental Medicine. Jan, 2002 | Pubmed ID: 11805153 Alterations in the Expression of Homing-associated Molecules at the Maternal/fetal Interface During the Course of Pregnancy Biology of Reproduction. Feb, 2002 | Pubmed ID: 11804946 Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-infiltrating Lymphocytes The American Journal of Pathology. Jan, 2002 | Pubmed ID: 11786428 Rapid Acquisition of Tissue-specific Homing Phenotypes by CD4(+) T Cells Activated in Cutaneous or Mucosal Lymphoid Tissues The Journal of Experimental Medicine. Jan, 2002 | Pubmed ID: 11781372 Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model Russell K. Pachynski1, Alexander Scholz3, Justin Monnier2,3, Eugene C. Butcher3, Brian A. Zabel2 1Division of Oncology, Department of Medicine, Washington University School of Medicine, 2Palo Alto Institute for Research and Education, Veterans Affairs Palo Alto Health Care System, 3Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine JoVE 52657 Médecine
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model Russell K. Pachynski1, Alexander Scholz3, Justin Monnier2,3, Eugene C. Butcher3, Brian A. Zabel2 1Division of Oncology, Department of Medicine, Washington University School of Medicine, 2Palo Alto Institute for Research and Education, Veterans Affairs Palo Alto Health Care System, 3Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine JoVE 52657 Médecine