Francesco A. Aprile Centre for Misfolding Diseases, Department of Chemistry University of Cambridge Biography Publications Institution JoVE Articles Francesco A. Aprile has not added a biography. If you are Francesco A. Aprile and would like to personalize this page please email our Author Liaison for assistance. Publications Third Generation Antibody Discovery Methods: in Silico Rational Design Chemical Society Reviews. Oct, 2018 | Pubmed ID: 30298157 Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms International Journal of Molecular Sciences. Sep, 2018 | Pubmed ID: 30205618 Author Correction: The Molecular Chaperones DNAJB6 and Hsp70 Cooperate to Suppress α-synuclein Aggregation Scientific Reports. Aug, 2018 | Pubmed ID: 30068912 Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine ACS Chemical Biology. Aug, 2018 | Pubmed ID: 29953201 Cooperative Assembly of Hsp70 Subdomain Clusters Biochemistry. Jul, 2018 | Pubmed ID: 29763298 A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells International Journal of Molecular Sciences. May, 2018 | Pubmed ID: 29757200 Delivery of Native Proteins into C. Elegans Using a Transduction Protocol Based on Lipid Vesicles Scientific Reports. Nov, 2017 | Pubmed ID: 29118344 A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases Chem. Oct, 2017 | Pubmed ID: 29094109 The Molecular Chaperones DNAJB6 and Hsp70 Cooperate to Suppress α-synuclein Aggregation Scientific Reports. Aug, 2017 | Pubmed ID: 28831037 Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide Journal of Molecular Biology. Sep, 2017 | Pubmed ID: 28743590 Selective Targeting of Primary and Secondary Nucleation Pathways in Aβ42 Aggregation Using a Rational Antibody Scanning Method Science Advances. Jun, 2017 | Pubmed ID: 28691099 Methods of Probing the Interactions Between Small Molecules and Disordered Proteins Cellular and Molecular Life Sciences : CMLS. 09, 2017 | Pubmed ID: 28631009 Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation Molecular Cell. Mar, 2017 | Pubmed ID: 28306505 Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition Between α-Synuclein Species Biochemistry. 03, 2017 | Pubmed ID: 28230968 A Natural Product Inhibits the Initiation of α-synuclein Aggregation and Suppresses Its Toxicity Proceedings of the National Academy of Sciences of the United States of America. 02, 2017 | Pubmed ID: 28096355 Structure of a Low-population Binding Intermediate in Protein-RNA Recognition Proceedings of the National Academy of Sciences of the United States of America. 06, 2016 | Pubmed ID: 27286828 Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions Analytical Chemistry. Apr, 2016 | Pubmed ID: 26940224 Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins Under Native Solution Conditions ACS Nano. Jan, 2016 | Pubmed ID: 26678709 Biophysical Approaches for the Study of Interactions Between Molecular Chaperones and Protein Aggregates Chemical Communications (Cambridge, England). Oct, 2015 | Pubmed ID: 26328629 Cell Surface Localised Hsp70 is a Cancer Specific Regulator of Clathrin-independent Endocytosis FEBS Letters. Sep, 2015 | Pubmed ID: 26257049 Rational Design of Antibodies Targeting Specific Epitopes Within Intrinsically Disordered Proteins Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26216991 A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone Toward a Target Substrate Biochemistry. Aug, 2015 | Pubmed ID: 26192230 Structural Characterization of Toxic Oligomers That Are Kinetically Trapped During α-synuclein Fibril Formation Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25855634 Structure and Dynamics of the Integrin LFA-1 I-domain in the Inactive State Underlie Its Inside-out/outside-in Signaling and Allosteric Mechanisms Structure (London, England : 1993). Apr, 2015 | Pubmed ID: 25773142 Structure of a Low-population Intermediate State in the Release of an Enzyme Product ELife. Jan, 2015 | Pubmed ID: 25575179 The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility Journal of Molecular Biology. Jan, 2015 | Pubmed ID: 25451785 NMR Characterization of the Conformational Fluctuations of the Human Lymphocyte Function-associated Antigen-1 I-domain Protein Science : a Publication of the Protein Society. Nov, 2014 | Pubmed ID: 25147050 Hsp70 Oligomerization is Mediated by an Interaction Between the Interdomain Linker and the Substrate-binding Domain PloS One. Month, 2013 | Pubmed ID: 23840795 Nanobodies Raised Against Monomeric α-synuclein Distinguish Between Fibrils at Different Maturation Stages Journal of Molecular Biology. Jul, 2013 | Pubmed ID: 23557833 Direct Observation of the Interconversion of Normal and Toxic Forms of α-synuclein Cell. May, 2012 | Pubmed ID: 22632969 Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform Michele Perni1, Sam Casford1, Francesco A. Aprile1, Ellen A. Nollen2, Tuomas P.J. Knowles1, Michele Vendruscolo1, Christopher M. Dobson1 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2European Research Institute for the Biology of Aging, University Medical Centre Groningen JoVE 58643 Immunologie et Infection
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform Michele Perni1, Sam Casford1, Francesco A. Aprile1, Ellen A. Nollen2, Tuomas P.J. Knowles1, Michele Vendruscolo1, Christopher M. Dobson1 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2European Research Institute for the Biology of Aging, University Medical Centre Groningen JoVE 58643 Immunologie et Infection