Herbert Gaisano Department of Medicine University of Toronto Biography Publications Institution JoVE Articles Herbert Gaisano has not added a biography. If you are Herbert Gaisano and would like to personalize this page please email our Author Liaison for assistance. Publications Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction Diabetes. Jul, 2017 | Pubmed ID: 28607108 The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1 Diabetes. Sep, 2017 | Pubmed ID: 28596237 Association Between Indices of Body Composition and Abnormal Metabolic Phenotype in Normal-Weight Chinese Adults International Journal of Environmental Research and Public Health. Apr, 2017 | Pubmed ID: 28387701 Ex Vivo Human Pancreatic Slice Preparations Offer a Valuable Model for Studying Pancreatic Exocrine Biology The Journal of Biological Chemistry. Apr, 2017 | Pubmed ID: 28242761 Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis EBioMedicine. Feb, 2017 | Pubmed ID: 28163042 Syntaxin 2 Acts As Inhibitory SNARE for Insulin Granule Exocytosis Diabetes. Apr, 2017 | Pubmed ID: 28115395 Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke Journal of the American Heart Association. Jan, 2017 | Pubmed ID: 28108466 Palmitic Acid Increases Invasiveness of Pancreatic Cancer Cells AsPC-1 Through TLR4/ROS/NF-κB/MMP-9 Signaling Pathway Biochemical and Biophysical Research Communications. Feb, 2017 | Pubmed ID: 28088520 New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment The Journal of Biological Chemistry. Feb, 2017 | Pubmed ID: 28031464 Cell Polarity Defines Three Distinct Domains in Pancreatic β-cells Journal of Cell Science. Jan, 2017 | Pubmed ID: 26919978 Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells Diabetes. Jul, 2016 | Pubmed ID: 27207520 Association of Diabetes and Prognosis of Minor Stroke and Its Subtypes: A Prospective Observational Study PloS One. 2016 | Pubmed ID: 27070309 Changes in Beta Cell Function Occur in Prediabetes and Early Disease in the Lepr (db) Mouse Model of Diabetes Diabetologia. Jun, 2016 | Pubmed ID: 27048248 Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells PloS One. 2016 | Pubmed ID: 26848587 Erratum To: Association of KCNB1 Polymorphisms with Lipid Metabolisms and Insulin Resistance: a Case-control Design of Population-based Cross-sectional Study in Chinese Han Population Lipids in Health and Disease. Nov, 2015 | Pubmed ID: 26545729 Cell-to-Cell Communication and the Regulation of Pancreatic Function Pancreas. Nov, 2015 | Pubmed ID: 26465945 Association of KCNB1 Polymorphisms with Lipid Metabolisms and Insulin Resistance: a Case-control Design of Population-based Cross-sectional Study in Chinese Han Population Lipids in Health and Disease. Sep, 2015 | Pubmed ID: 26377690 Spatial and Temporal Coordination of Insulin Granule Exocytosis in Intact Human Pancreatic Islets Diabetologia. Dec, 2015 | Pubmed ID: 26376795 A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells The Journal of Biological Chemistry. Oct, 2015 | Pubmed ID: 26272612 ER Stress-associated CTRC Mutants Decrease Stimulated Pancreatic Zymogen Secretion Through SIRT2-mediated Microtubule Dysregulation Biochemical and Biophysical Research Communications. Jul, 2015 | Pubmed ID: 26022124 Munc18c Mediates Exocytosis of Pre-docked and Newcomer Insulin Granules Underlying Biphasic Glucose Stimulated Insulin Secretion in Human Pancreatic Beta-cells Molecular Metabolism. May, 2015 | Pubmed ID: 25973389 Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION The Journal of Biological Chemistry. Jul, 2015 | Pubmed ID: 25969539 The Expression of Dominant Negative TCF7L2 in Pancreatic Beta Cells During the Embryonic Stage Causes Impaired Glucose Homeostasis Molecular Metabolism. Apr, 2015 | Pubmed ID: 25830097 Chaperoning of Closed Syntaxin-3 Through Lys46 and Glu59 in Domain 1 of Munc18 Proteins is Indispensable for Mast Cell Exocytosis Journal of Cell Science. May, 2015 | Pubmed ID: 25795302 Syntaxin-4 Mediates Exocytosis of Pre-docked and Newcomer Insulin Granules Underlying Biphasic Glucose-stimulated Insulin Secretion in Human Pancreatic Beta Cells Diabetologia. Jun, 2015 | Pubmed ID: 25762204 PTEN Deletion in Pancreatic α-cells Protects Against High-fat Diet-induced Hyperglucagonemia and Insulin Resistance Diabetes. Jan, 2015 | Pubmed ID: 25092678 Vesicle Associated Membrane Protein 8 (VAMP8)-mediated Zymogen Granule Exocytosis is Dependent on Endosomal Trafficking Via the Constitutive-like Secretory Pathway The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25138214 Phosphatidylinositol 4,5-biphosphate (PIP2) Modulates Syntaxin-1A Binding to Sulfonylurea Receptor 2A to Regulate Cardiac ATP-sensitive Potassium (KATP) Channels Journal of Molecular and Cellular Cardiology. Oct, 2014 | Pubmed ID: 25073062 Progesterone Receptor Membrane Component 1 is a Functional Part of the Glucagon-like Peptide-1 (GLP-1) Receptor Complex in Pancreatic β Cells Molecular & Cellular Proteomics : MCP. Nov, 2014 | Pubmed ID: 25044020 Dichotomous Role of Pancreatic HUWE1/MULE/ARF-BP1 in Modulating Beta Cell Apoptosis in Mice Under Physiological and Genotoxic Conditions Diabetologia. Sep, 2014 | Pubmed ID: 24981769 α/β-Hydrolase Domain-6-accessible Monoacylglycerol Controls Glucose-stimulated Insulin Secretion Cell Metabolism. Jun, 2014 | Pubmed ID: 24814481 Insulin Secretion from Beta Cells in Intact Mouse Islets is Targeted Towards the Vasculature Diabetologia. Aug, 2014 | Pubmed ID: 24795086 Here Come the Newcomer Granules, Better Late Than Never Trends in Endocrinology and Metabolism: TEM. Aug, 2014 | Pubmed ID: 24746186 The Secretory Deficit in Islets from Db/db Mice is Mainly Due to a Loss of Responding Beta Cells Diabetologia. Jul, 2014 | Pubmed ID: 24705605 Biliopancreatic Route for Effective Viral Transduction of Pancreatic Islets Pancreas. Mar, 2014 | Pubmed ID: 24518502 Phosphatidylinositol 4,5-biphosphate (PIP2) Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic β-cell ATP-sensitive Potassium Channels The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24429282 Role of Vesicle-associated Membrane Protein 2 in Exocytosis of Glucagon-like Peptide-1 from the Murine Intestinal L Cell Diabetologia. Apr, 2014 | Pubmed ID: 24356748 Glucose Principally Regulates Insulin Secretion in Mouse Islets by Controlling the Numbers of Granule Fusion Events Per Cell Diabetologia. Dec, 2013 | Pubmed ID: 23995471 Exocyst Sec5 Regulates Exocytosis of Newcomer Insulin Granules Underlying Biphasic Insulin Secretion PloS One. 2013 | Pubmed ID: 23844030 Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats Diabetes. Aug, 2013 | Pubmed ID: 23630299 UCP2 Regulates the Glucagon Response to Fasting and Starvation Diabetes. May, 2013 | Pubmed ID: 23434936 An Exploratory Study of the Association Between KCNB1 Rs1051295 and Type 2 Diabetes and Its Related Traits in Chinese Han Population PloS One. 2013 | Pubmed ID: 23431371 Munc18b is a Major Mediator of Insulin Exocytosis in Rat Pancreatic β-cells Diabetes. Jul, 2013 | Pubmed ID: 23423569 RalA GTPase Tethers Insulin Granules to L- and R-type Calcium Channels Through Binding α2 δ-1 Subunit Traffic (Copenhagen, Denmark). Apr, 2013 | Pubmed ID: 23346930 Role of the SNARE Protein SNAP23 on CAMP-stimulated Renin Release in Mouse Juxtaglomerular Cells American Journal of Physiology. Renal Physiology. Mar, 2013 | Pubmed ID: 23269646 In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion Diabetes. Feb, 2013 | Pubmed ID: 23043159 Glucagon Secretion and Signaling in the Development of Diabetes Frontiers in Physiology. 2012 | Pubmed ID: 22969729 Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth Cell Metabolism. Jul, 2012 | Pubmed ID: 22841572 Effects of Ethanol Metabolites on Exocytosis of Pancreatic Acinar Cells in Rats Gastroenterology. Jun, 2012 | Pubmed ID: 22710192 In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking Diabetes. Jul, 2012 | Pubmed ID: 22498697 Molecular Control of Compound Exocytosis: A Key Role for VAMP8 Communicative & Integrative Biology. Jan, 2012 | Pubmed ID: 22482012 Pancreatic GLP-1 Receptor Activation is Sufficient for Incretin Control of Glucose Metabolism in Mice The Journal of Clinical Investigation. Jan, 2012 | Pubmed ID: 22182839 Syntaxin-1A Inhibits KATP Channels by Interacting with Specific Conserved Motifs Within Sulfonylurea Receptor 2A Journal of Molecular and Cellular Cardiology. Nov, 2011 | Pubmed ID: 21884702 Vesicle-associated Membrane Protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21733851 Electrophysiological Identification of Mouse Islet α-cells: from Isolated Single α-cells to in Situ Assessment Within Pancreas Slices Islets. Jul-Aug, 2011 | Pubmed ID: 21623173 Syntaxin-1A Interacts with Distinct Domains Within Nucleotide-binding Folds of Sulfonylurea Receptor 1 to Inhibit Beta-cell ATP-sensitive Potassium Channels The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21540180 Live Pancreatic Acinar Imaging of Exocytosis Using Syncollin-pHluorin American Journal of Physiology. Cell Physiology. Jun, 2011 | Pubmed ID: 21307342 SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans Diabetes. Mar, 2011 | Pubmed ID: 21266332 TGF-β1 Increases Invasiveness of SW1990 Cells Through Rac1/ROS/NF-κB/IL-6/MMP-2 Biochemical and Biophysical Research Communications. Feb, 2011 | Pubmed ID: 21219858 Syntaxin 1A Regulates Surface Expression of Beta-cell ATP-sensitive Potassium Channels American Journal of Physiology. Cell Physiology. Mar, 2011 | Pubmed ID: 21209369 ATP Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic Beta-cell KATP Channels The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21173146 SNARE Protein Regulation of Cardiac Potassium Channels and Atrial Natriuretic Factor Secretion Journal of Molecular and Cellular Cardiology. Mar, 2011 | Pubmed ID: 21129378 Unperturbed Islet α-cell Function Examined in Mouse Pancreas Tissue Slices The Journal of Physiology. Jan, 2011 | Pubmed ID: 21078586 Nitric Oxide Activation of a Potassium Channel (BK(Ca)) in Feline Lower Esophageal Sphincter World Journal of Gastroenterology. Dec, 2010 | Pubmed ID: 21155007 Erythropoietin Protects Against Diabetes Through Direct Effects on Pancreatic Beta Cells The Journal of Experimental Medicine. Dec, 2010 | Pubmed ID: 21149549 Deletion of Pten in Pancreatic ß-cells Protects Against Deficient ß-cell Mass and Function in Mouse Models of Type 2 Diabetes Diabetes. Dec, 2010 | Pubmed ID: 20852026 Insulin Treatment and High-fat Diet Feeding Reduces the Expression of Three Tcf Genes in Rodent Pancreas The Journal of Endocrinology. Oct, 2010 | Pubmed ID: 20675304 Hypoxia-reoxygenation Increase Invasiveness of PANC-1 Cells Through Rac1/MMP-2 Biochemical and Biophysical Research Communications. Mar, 2010 | Pubmed ID: 20153729 Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction Between Munc18 and Closed Syntaxin in PC12 Cells Molecular Biology of the Cell. Dec, 2009 | Pubmed ID: 19812250 Deletion of Fas in the Pancreatic Beta-cells Leads to Enhanced Insulin Secretion American Journal of Physiology. Endocrinology and Metabolism. Dec, 2009 | Pubmed ID: 19755672 Characterization of Erg K+ Channels in Alpha- and Beta-cells of Mouse and Human Islets The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19690348 Functional Characterization of Hyperpolarization-activated Cyclic Nucleotide-gated Channels in Rat Pancreatic Beta Cells The Journal of Endocrinology. Oct, 2009 | Pubmed ID: 19654142 POU Homeodomain Protein Oct-1 Functions As a Sensor for Cyclic AMP The Journal of Biological Chemistry. Sep, 2009 | Pubmed ID: 19617623 Truncation of SNAP-25 Reduces the Stimulatory Action of CAMP on Rapid Exocytosis in Insulin-secreting Cells American Journal of Physiology. Endocrinology and Metabolism. Aug, 2009 | Pubmed ID: 19509185 Cab45b, a Munc18b-interacting Partner, Regulates Exocytosis in Pancreatic Beta-cells The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19487699 New Insights into the Mechanisms of Pancreatitis Gastroenterology. Jun, 2009 | Pubmed ID: 19379751 High Beta-cell Mass Prevents Streptozotocin-induced Diabetes in Thioredoxin-interacting Protein-deficient Mice American Journal of Physiology. Endocrinology and Metabolism. Jun, 2009 | Pubmed ID: 19223654 Rescuing the Subprime Meltdown in Insulin Exocytosis in Diabetes Annals of the New York Academy of Sciences. Jan, 2009 | Pubmed ID: 19161386 Epac is Involved in CAMP-stimulated Proglucagon Expression and Hormone Production but Not Hormone Secretion in Pancreatic Alpha- and Intestinal L-cell Lines American Journal of Physiology. Endocrinology and Metabolism. Jan, 2009 | Pubmed ID: 18854429 Syntaxin-1A Inhibition of P-1075, Cromakalim, and Diazoxide Actions on Mouse Cardiac ATP-sensitive Potassium Channel Cardiovascular Research. Dec, 2008 | Pubmed ID: 18703534 Inhibition of Cholesterol Biosynthesis Impairs Insulin Secretion and Voltage-gated Calcium Channel Function in Pancreatic Beta-cells Endocrinology. Oct, 2008 | Pubmed ID: 18599549 Inhibition of Rac1 Decreases the Severity of Pancreatitis and Pancreatitis-associated Lung Injury in Mice Experimental Physiology. Oct, 2008 | Pubmed ID: 18567599 VAMP8 is the V-SNARE That Mediates Basolateral Exocytosis in a Mouse Model of Alcoholic Pancreatitis The Journal of Clinical Investigation. Jul, 2008 | Pubmed ID: 18535671 Pancreatic Islet Alpha Cell Commands Itself: Secrete More Glucagon! Cell Metabolism. Jun, 2008 | Pubmed ID: 18522828 The RalA GTPase is a Central Regulator of Insulin Exocytosis from Pancreatic Islet Beta Cells The Journal of Biological Chemistry. Jun, 2008 | Pubmed ID: 18426794 Munc18/SNARE Proteins' Regulation of Exocytosis in Guinea Pig Duodenal Brunner's Gland Acini World Journal of Gastroenterology. Apr, 2008 | Pubmed ID: 18416456 Elevation in Intracellular Long-chain Acyl-coenzyme A Esters Lead to Reduced Beta-cell Excitability Via Activation of Adenosine 5'-triphosphate-sensitive Potassium Channels Endocrinology. Jul, 2008 | Pubmed ID: 18372336 Botulinum Neurotoxin A and Neurotoxin E Cleavage Products of Synaptosome-associated Protein of 25 Kd Exhibit Distinct Actions on Pancreatic Islet Beta-cell Kv2.1 Channel Gating Pancreas. Jan, 2008 | Pubmed ID: 18192874 Munc18-1 is Critical for Plasma Membrane Localization of Syntaxin1 but Not of SNAP-25 in PC12 Cells Molecular Biology of the Cell. Feb, 2008 | Pubmed ID: 18077557 Activation of Exchange Protein Directly Activated by Cyclic Adenosine Monophosphate and Protein Kinase A Regulate Common and Distinct Steps in Promoting Plasma Membrane Exocytic and Granule-to-granule Fusions in Rat Islet Beta Cells Pancreas. Oct, 2007 | Pubmed ID: 17895835 SNAREing Voltage-gated K+ and ATP-sensitive K+ Channels: Tuning Beta-cell Excitability with Syntaxin-1A and Other Exocytotic Proteins Endocrine Reviews. Oct, 2007 | Pubmed ID: 17878408 Dynamin is Functionally Coupled to Insulin Granule Exocytosis The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17848579 Interaction of Syntaxin 1A with the N-terminus of Kv4.2 Modulates Channel Surface Expression and Gating Biochemistry. Sep, 2007 | Pubmed ID: 17725325 Interaction Between Munc13-1 and RIM is Critical for Glucagon-like Peptide-1 Mediated Rescue of Exocytotic Defects in Munc13-1 Deficient Pancreatic Beta-cells Diabetes. Oct, 2007 | Pubmed ID: 17639022 Distinct in Vivo Roles of Caspase-8 in Beta-cells in Physiological and Diabetes Models Diabetes. Sep, 2007 | Pubmed ID: 17563067 Ca2+-dependent Activator Protein for Secretion 1 is Critical for Constitutive and Regulated Exocytosis but Not for Loading of Transmitters into Dense Core Vesicles The Journal of Biological Chemistry. Jul, 2007 | Pubmed ID: 17540763 Modulation of the K(v)4.3 Channel by Syntaxin 1A Biochemical and Biophysical Research Communications. Jul, 2007 | Pubmed ID: 17506992 The Actions of a Novel Potent Islet Beta-cell Specific ATP-sensitive K+ Channel Opener Can Be Modulated by Syntaxin-1A Acting on Sulfonylurea Receptor 1 Diabetes. Aug, 2007 | Pubmed ID: 17496234 Alcohol Redirects CCK-mediated Apical Exocytosis to the Acinar Basolateral Membrane in Alcoholic Pancreatitis Traffic (Copenhagen, Denmark). May, 2007 | Pubmed ID: 17451559 A Cytosolic Splice Variant of Cab45 Interacts with Munc18b and Impacts on Amylase Secretion by Pancreatic Acini Molecular Biology of the Cell. Jul, 2007 | Pubmed ID: 17442889 Effects of Palmitate on Insulin Secretion and Exocytotic Proteins in Islets of Diabetic Goto-Kakizaki Rats Pancreas. Apr, 2007 | Pubmed ID: 17414060 Alcohol-induced Protein Kinase Calpha Phosphorylation of Munc18c in Carbachol-stimulated Acini Causes Basolateral Exocytosis Gastroenterology. Apr, 2007 | Pubmed ID: 17408632 Alcohol/cholecystokinin-evoked Pancreatic Acinar Basolateral Exocytosis is Mediated by Protein Kinase C Alpha Phosphorylation of Munc18c The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17324928 Targeting of Voltage-gated K+ and Ca2+ Channels and Soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins to Cholesterol-rich Lipid Rafts in Pancreatic Alpha-cells: Effects on Glucagon Stimulus-secretion Coupling Endocrinology. May, 2007 | Pubmed ID: 17303668 Distinct Modulation of Kv1.2 Channel Gating by Wild Type, but Not Open Form, of Syntaxin-1A American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2007 | Pubmed ID: 17234891 Recent Insights into the Cellular Mechanisms of Acute Pancreatitis Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. Jan, 2007 | Pubmed ID: 17225878 Characterization of VAMP-2 Gene from Marine Teleostean, Lateolabrax Japonicus Science in China. Series C, Life Sciences. Dec, 2006 | Pubmed ID: 17312998 Target Soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptors (t-SNAREs) Differently Regulate Activation and Inactivation Gating of Kv2.2 and Kv2.1: Implications on Pancreatic Islet Cell Kv Channels Molecular Pharmacology. Sep, 2006 | Pubmed ID: 16754785 The Neuronal Ca2+ Sensor Protein Visinin-like Protein-1 is Expressed in Pancreatic Islets and Regulates Insulin Secretion The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16731532 Two Populations of Pancreatic Islet Alpha-cells Displaying Distinct Ca2+ Channel Properties Biochemical and Biophysical Research Communications. Jun, 2006 | Pubmed ID: 16678791 Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic PH-induced Cardiac K(ATP) Channel Activation The Journal of Biological Chemistry. Jul, 2006 | Pubmed ID: 16672225 Role of the Exchange Protein Directly Activated by Cyclic Adenosine 5'-monophosphate (Epac) Pathway in Regulating Proglucagon Gene Expression in Intestinal Endocrine L Cells Endocrinology. Aug, 2006 | Pubmed ID: 16644915 Munc13-1 Deficiency Reduces Insulin Secretion and Causes Abnormal Glucose Tolerance Diabetes. May, 2006 | Pubmed ID: 16644700 Involvement of VAMP-2 in Exocytosis of IL-1 Beta in Turbot (Scophthalmus Maximus) Leukocytes After Vibrio Anguillarum Infection Biochemical and Biophysical Research Communications. Apr, 2006 | Pubmed ID: 16487935 Modulation of Kv2.1 Channel Gating and TEA Sensitivity by Distinct Domains of SNAP-25 The Biochemical Journal. Jun, 2006 | Pubmed ID: 16478442 Insulin Regulates Islet Alpha-cell Function by Reducing KATP Channel Sensitivity to Adenosine 5'-triphosphate Inhibition Endocrinology. May, 2006 | Pubmed ID: 16455778 Impaired Gene and Protein Expression of Exocytotic Soluble N-ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients Diabetes. Feb, 2006 | Pubmed ID: 16443778 Feline Lower Esophageal Sphincter Sling and Circular Muscles Have Different Functional Inhibitory Neuronal Responses American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2006 | Pubmed ID: 16166343 Transgenic Mouse Overexpressing Syntaxin-1A As a Diabetes Model Diabetes. Sep, 2005 | Pubmed ID: 16123365 Glucagon-like Peptide 1 Regulates Sequential and Compound Exocytosis in Pancreatic Islet Beta-cells Diabetes. Sep, 2005 | Pubmed ID: 16123364 Electrophysiological Characterization of Pancreatic Islet Cells in the Mouse Insulin Promoter-green Fluorescent Protein Mouse Endocrinology. Nov, 2005 | Pubmed ID: 16109783 Caspase-3-dependent Beta-cell Apoptosis in the Initiation of Autoimmune Diabetes Mellitus Molecular and Cellular Biology. May, 2005 | Pubmed ID: 15831467 Regional Differences in Cholinergic Regulation of Potassium Current in Feline Esophageal Circular Smooth Muscle American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2005 | Pubmed ID: 15691872 Open Form of Syntaxin-1A is a More Potent Inhibitor Than Wild-type Syntaxin-1A of Kv2.1 Channels The Biochemical Journal. Apr, 2005 | Pubmed ID: 15518587 H3 Domain of Syntaxin 1A Inhibits KATP Channels by Its Actions on the Sulfonylurea Receptor 1 Nucleotide-binding Folds-1 and -2 The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15485808 Syntaxin-1A Inhibits Cardiac KATP Channels by Its Actions on Nucleotide Binding Folds 1 and 2 of Sulfonylurea Receptor 2A The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15339904 Regional Differences in L-type Ca2+ Channel Expression in Feline Lower Esophageal Sphincter American Journal of Physiology. Gastrointestinal and Liver Physiology. Oct, 2004 | Pubmed ID: 15178551 Alcoholic Chronic Pancreatitis Involves Displacement of Munc18c from the Pancreatic Acinar Basal Membrane Surface Pancreas. May, 2004 | Pubmed ID: 15097857 Disruption of Pancreatic Beta-cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 15073181 Syntaxin-1A Binds the Nucleotide-binding Folds of Sulphonylurea Receptor 1 to Regulate the KATP Channel The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14645230 Calcium Source Diversity in Feline Lower Esophageal Sphincter Circular and Sling Muscle American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2004 | Pubmed ID: 14563670 Regulation of Insulin Exocytosis by Munc13-1 The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12871971 Direct Interaction of Target SNAREs with the Kv2.1 Channel. Modal Regulation of Channel Activation and Inactivation Gating The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12807875 SNAP-25 Inhibits L-type Ca2+ Channels in Feline Esophagus Smooth Muscle Cells Biochemical and Biophysical Research Communications. Jun, 2003 | Pubmed ID: 12788104 Syntaxin 1A Binds to the Cytoplasmic C Terminus of Kv2.1 to Regulate Channel Gating and Trafficking The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12621036 Effects of Selective Endocrine or Exocrine Induction of AR42J on SNARE and Munc18 Protein Expression Pancreas. Nov, 2002 | Pubmed ID: 12409842 Synaptosome-associated Protein of 25 Kilodaltons Modulates Kv2.1 Voltage-dependent K(+) Channels in Neuroendocrine Islet Beta-cells Through an Interaction with the Channel N Terminus Molecular Endocrinology (Baltimore, Md.). Nov, 2002 | Pubmed ID: 12403834 Abnormal Expression of Pancreatic Islet Exocytotic Soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptors in Goto-Kakizaki Rats is Partially Restored by Phlorizin Treatment and Accentuated by High Glucose Treatment Endocrinology. Nov, 2002 | Pubmed ID: 12399415 Modulation of L-type Ca(2+) Channels by Distinct Domains Within SNAP-25 Diabetes. May, 2002 | Pubmed ID: 11978639 Visualization of Sequential Exocytosis in Rat Pancreatic Islet Beta Cells Biochemical and Biophysical Research Communications. Apr, 2002 | Pubmed ID: 11944911 The 25-kDa Synaptosome-associated Protein (SNAP-25) Binds and Inhibits Delayed Rectifier Potassium Channels in Secretory Cells The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11925439 SNAP-25, a SNARE Protein, Inhibits Two Types of K Channels in Esophageal Smooth Muscle Gastroenterology. Apr, 2002 | Pubmed ID: 11910352 Confocal da imagem latente do Neuropeptide Y-pHluorin: uma técnica para visualizar a exocitose de grânulo de insulina em ilhotas murino e humanas intactas Madina Makhmutova1, Tao Liang2, Herbert Gaisano2, Alejandro Caicedo1, Joana Almaça1 1Department of Medicine, University of Miami, 2Department of Medicine, University of Toronto JoVE 56089 Biologie
Confocal da imagem latente do Neuropeptide Y-pHluorin: uma técnica para visualizar a exocitose de grânulo de insulina em ilhotas murino e humanas intactas Madina Makhmutova1, Tao Liang2, Herbert Gaisano2, Alejandro Caicedo1, Joana Almaça1 1Department of Medicine, University of Miami, 2Department of Medicine, University of Toronto JoVE 56089 Biologie