I. Jolanda de Vries Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences Radboud University Medical Center Biography Publications Institution JoVE Articles I. Jolanda de Vries has not added a biography. If you are I. Jolanda de Vries and would like to personalize this page please email our Author Liaison for assistance. Publications Tumoricidal Activity of Human Dendritic Cells Trends in Immunology. Nov, 2013 | Pubmed ID: 24262387 Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-presentation and Robust Type I IFN Secretion Journal of Immunology (Baltimore, Md. : 1950). Nov, 2013 | Pubmed ID: 24127556 Reducing Cell Number Improves the Homing of Dendritic Cells to Lymph Nodes Upon Intradermal Vaccination Oncoimmunology. Jul, 2013 | Pubmed ID: 24073362 An Altered Gp100 Peptide Ligand with Decreased Binding by TCR and CD8α Dissects T Cell Cytotoxicity from Production of Cytokines and Activation of NFAT Frontiers in Immunology. 2013 | Pubmed ID: 24027572 Importance of Helper T-cell Activation in Dendritic Cell-based Anticancer Immunotherapy Oncoimmunology. Jun, 2013 | Pubmed ID: 23894702 Naturally Circulating Dendritic Cells to Vaccinate Cancer Patients Oncoimmunology. Mar, 2013 | Pubmed ID: 23802086 The Nature of Activatory and Tolerogenic Dendritic Cell-derived Signal II Frontiers in Immunology. 2013 | Pubmed ID: 23450201 Targeting of 111In-labeled Dendritic Cell Human Vaccines Improved by Reducing Number of Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2013 | Pubmed ID: 23382117 Natural Human Plasmacytoid Dendritic Cells Induce Antigen-specific T-cell Responses in Melanoma Patients Cancer Research. Feb, 2013 | Pubmed ID: 23345163 Human Plasmacytoid Dendritic Cells Efficiently Cross-present Exogenous Ags to CD8+ T Cells Despite Lower Ag Uptake Than Myeloid Dendritic Cell Subsets Blood. Jan, 2013 | Pubmed ID: 23212525 Targeting CD4(+) T-helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell-based Vaccination Cancer Research. Jan, 2013 | Pubmed ID: 23087058 Interleukin-15-induced CD56(+) Myeloid Dendritic Cells Combine Potent Tumor Antigen Presentation with Direct Tumoricidal Potential PloS One. 2012 | Pubmed ID: 23284789 Humoral and Cellular Immune Responses After Influenza Vaccination in Patients with Chronic Fatigue Syndrome BMC Immunology. 2012 | Pubmed ID: 23244635 Potential Applications for Plasmacytoid Dendritic Cells in Cancer Immunotherapy Immunotherapy. Oct, 2012 | Pubmed ID: 23148748 In Vivo Tracking Techniques for Cellular Regeneration, Replacement, and Redirection Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Dec, 2012 | Pubmed ID: 23143090 In Vivo Imaging of Therapy-induced Anti-cancer Immune Responses in Humans Cellular and Molecular Life Sciences : CMLS. Oct, 2012 | Pubmed ID: 23052208 Skin-test Infiltrating Lymphocytes Early Predict Clinical Outcome of Dendritic Cell-based Vaccination in Metastatic Melanoma Cancer Research. Dec, 2012 | Pubmed ID: 23010076 Human Plasmacytoid Dendritic Cells Are Equipped with Antigen-presenting and Tumoricidal Capacities Blood. Nov, 2012 | Pubmed ID: 22966165 Labeling Cells for in Vivo Tracking Using (19)F MRI Biomaterials. Dec, 2012 | Pubmed ID: 22959182 Insight into the Dynamics, Localization and Magnitude of Antigen-specific Immune Responses by [(18)F]FLT PET Imaging Oncoimmunology. Aug, 2012 | Pubmed ID: 22934268 Vaccination with MRNA-electroporated Dendritic Cells Induces Robust Tumor Antigen-specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2012 | Pubmed ID: 22896657 STATing the Importance of Immune Modulation by Platinum Chemotherapeutics Oncoimmunology. Mar, 2012 | Pubmed ID: 22720254 Functional T Cells Targeting NY-ESO-1 or Melan-A Are Predictive for Survival of Patients with Distant Melanoma Metastasis Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2012 | Pubmed ID: 22529253 Humoral Anti-KLH Responses in Cancer Patients Treated with Dendritic Cell-based Immunotherapy Are Dictated by Different Vaccination Parameters Cancer Immunology, Immunotherapy : CII. Nov, 2012 | Pubmed ID: 22527252 Targeted Delivery of CpG ODN to CD32 on Human and Monkey Plasmacytoid Dendritic Cells Augments IFNα Secretion Immunobiology. Oct, 2012 | Pubmed ID: 22349518 Harnessing Human Plasmacytoid Dendritic Cells As Professional APCs Cancer Immunology, Immunotherapy : CII. Aug, 2012 | Pubmed ID: 22294456 The C-type Lectin Receptor CLEC9A Mediates Antigen Uptake and (cross-)presentation by Human Blood BDCA3+ Myeloid Dendritic Cells Blood. Mar, 2012 | Pubmed ID: 22234694 Regulatory T Cells in Melanoma: the Final Hurdle Towards Effective Immunotherapy? The Lancet Oncology. Jan, 2012 | Pubmed ID: 22225723 The Chemotherapeutic Drug Oxaliplatin Differentially Affects Blood DC Function Dependent on Environmental Cues Cancer Immunology, Immunotherapy : CII. Jul, 2012 | Pubmed ID: 22193989 Unraveling the Human Dendritic Cell Phagosome Proteome by Organellar Enrichment Ranking Journal of Proteomics. Feb, 2012 | Pubmed ID: 22146474 Early Identification of Antigen-specific Immune Responses in Vivo by [18F]-labeled 3'-fluoro-3'-deoxy-thymidine ([18F]FLT) PET Imaging Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22025695 Route of Administration Modulates the Induction of Dendritic Cell Vaccine-induced Antigen-specific T Cells in Advanced Melanoma Patients Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2011 | Pubmed ID: 21771874 Platinum-based Drugs Disrupt STAT6-mediated Suppression of Immune Responses Against Cancer in Humans and Mice The Journal of Clinical Investigation. Aug, 2011 | Pubmed ID: 21765211 Cancer Patients Treated with Sunitinib or Sorafenib Have Sufficient Antibody and Cellular Immune Responses to Warrant Influenza Vaccination Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2011 | Pubmed ID: 21712444 DEC-205 Mediates Antigen Uptake and Presentation by Both Resting and Activated Human Plasmacytoid Dendritic Cells European Journal of Immunology. Apr, 2011 | Pubmed ID: 21413003 Multimodal Imaging of Nanovaccine Carriers Targeted to Human Dendritic Cells Molecular Pharmaceutics. Apr, 2011 | Pubmed ID: 21381651 Prophylactic Vaccines Mimic Synthetic CpG Oligonucleotides in Their Ability to Modulate Immune Responses Molecular Immunology. Mar, 2011 | Pubmed ID: 21257206 IL-4 and IL-13 Alter Plasmacytoid Dendritic Cell Responsiveness to CpG DNA and Herpes Simplex Virus-1 The Journal of Investigative Dermatology. Apr, 2011 | Pubmed ID: 21191414 Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-depleting Agents Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2011 | Pubmed ID: 21177412 Wild-type and Modified Gp100 Peptide-pulsed Dendritic Cell Vaccination of Advanced Melanoma Patients Can Lead to Long-term Clinical Responses Independent of the Peptide Used Cancer Immunology, Immunotherapy : CII. Feb, 2011 | Pubmed ID: 21069321 A Novel (19)F Agent for Detection and Quantification of Human Dendritic Cells Using Magnetic Resonance Imaging International Journal of Cancer. Journal International Du Cancer. Jul, 2011 | Pubmed ID: 20839261 Sorafenib Reduces the Percentage of Tumour Infiltrating Regulatory T Cells in Renal Cell Carcinoma Patients International Journal of Cancer. Journal International Du Cancer. Jul, 2011 | Pubmed ID: 20839259 The Lymphoid Chemokine CCL21 Triggers LFA-1 Adhesive Properties on Human Dendritic Cells Immunology and Cell Biology. Mar, 2011 | Pubmed ID: 20805842 Immunogenicity of Dendritic Cells Pulsed with CEA Peptide or Transfected with CEA MRNA for Vaccination of Colorectal Cancer Patients Anticancer Research. Dec, 2010 | Pubmed ID: 21187495 Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: a Phase I/II Study in Metastatic Melanoma Patients Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2010 | Pubmed ID: 20736326 Induction of Complete and Molecular Remissions in Acute Myeloid Leukemia by Wilms' Tumor 1 Antigen-targeted Dendritic Cell Vaccination Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20631300 Customizable, Multi-functional Fluorocarbon Nanoparticles for Quantitative in Vivo Imaging Using 19F MRI and Optical Imaging Biomaterials. Sep, 2010 | Pubmed ID: 20566214 Prognostic Significance and Mechanism of Treg Infiltration in Human Brain Tumors Journal of Neuroimmunology. Aug, 2010 | Pubmed ID: 20537408 (19)F MRI for Quantitative in Vivo Cell Tracking Trends in Biotechnology. Jul, 2010 | Pubmed ID: 20427096 Commonly Used Prophylactic Vaccines As an Alternative for Synthetically Produced TLR Ligands to Mature Monocyte-derived Dendritic Cells Blood. Jul, 2010 | Pubmed ID: 20424184 Cross-talk Between Human Dendritic Cell Subsets Influences Expression of RNA Sensors and Inhibits Picornavirus Infection Journal of Innate Immunity. 2010 | Pubmed ID: 20375561 Human Plasmacytoid Dendritic Cells Phagocytose, Process, and Present Exogenous Particulate Antigen Journal of Immunology (Baltimore, Md. : 1950). Apr, 2010 | Pubmed ID: 20304825 Toll-like Receptor Expression and Function in Human Dendritic Cell Subsets: Implications for Dendritic Cell-based Anti-cancer Immunotherapy Cancer Immunology, Immunotherapy : CII. Oct, 2010 | Pubmed ID: 20204387 Consolidative Dendritic Cell-based Immunotherapy Elicits Cytotoxicity Against Malignant Mesothelioma American Journal of Respiratory and Critical Care Medicine. Jun, 2010 | Pubmed ID: 20167848 Dominant Processes During Human Dendritic Cell Maturation Revealed by Integration of Proteome and Transcriptome at the Pathway Level Journal of Proteome Research. Apr, 2010 | Pubmed ID: 20131907 Functional Assessment of Human Dendritic Cells Labeled for in Vivo (19)F Magnetic Resonance Imaging Cell Tracking Cytotherapy. Apr, 2010 | Pubmed ID: 20053146 Regulation of MYCN Expression in Human Neuroblastoma Cells BMC Cancer. 2009 | Pubmed ID: 19615087 In Situ Expression of Tumor Antigens by Messenger RNA-electroporated Dendritic Cells in Lymph Nodes of Melanoma Patients Cancer Research. Apr, 2009 | Pubmed ID: 19318559 Limited Amounts of Dendritic Cells Migrate into the T-cell Area of Lymph Nodes but Have High Immune Activating Potential in Melanoma Patients Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009 | Pubmed ID: 19318472 Regulatory T Cells and the PD-L1/PD-1 Pathway Mediate Immune Suppression in Malignant Human Brain Tumors Neuro-oncology. Aug, 2009 | Pubmed ID: 19028999 DCIR is Endocytosed into Human Dendritic Cells and Inhibits TLR8-mediated Cytokine Production Journal of Leukocyte Biology. Mar, 2009 | Pubmed ID: 19028959 Polyinosinic Polycytidylic Acid Prevents Efficient Antigen Expression After MRNA Electroporation of Clinical Grade Dendritic Cells Cancer Immunology, Immunotherapy : CII. Jul, 2009 | Pubmed ID: 19018531 Vaccine-specific Local T Cell Reactivity in Immunotherapy-associated Vitiligo in Melanoma Patients Cancer Immunology, Immunotherapy : CII. Jan, 2009 | Pubmed ID: 18392619 Activation of Human Plasmacytoid Dendritic Cells by TLR9 Impairs Fc GammaRII-mediated Uptake of Immune Complexes and Presentation by MHC Class II Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18832675 Intratumoral RhIL-12 Administration in Head and Neck Squamous Cell Carcinoma Patients Induces B Cell Activation International Journal of Cancer. Journal International Du Cancer. Nov, 2008 | Pubmed ID: 18729197 Maximizing Dendritic Cell Migration in Cancer Immunotherapy Expert Opinion on Biological Therapy. Jul, 2008 | Pubmed ID: 18549318 Toll-like Receptor Signalling on Tregs: to Suppress or Not to Suppress? Immunology. Aug, 2008 | Pubmed ID: 18540962 Selective Cancer-germline Gene Expression in Pediatric Brain Tumors Journal of Neuro-oncology. Jul, 2008 | Pubmed ID: 18398575 Maturation of Monocyte-derived Dendritic Cells with Toll-like Receptor 3 and 7/8 Ligands Combined with Prostaglandin E2 Results in High Interleukin-12 Production and Cell Migration Cancer Immunology, Immunotherapy : CII. Nov, 2008 | Pubmed ID: 18322684 Targeting DCIR on Human Plasmacytoid Dendritic Cells Results in Antigen Presentation and Inhibits IFN-alpha Production Blood. Apr, 2008 | Pubmed ID: 18258799 Dendritic-cell Immunotherapy: from Ex Vivo Loading to in Vivo Targeting Nature Reviews. Immunology. Oct, 2007 | Pubmed ID: 17853902 Phenotypic and Functional Characterization of Mature Dendritic Cells from Pediatric Cancer Patients Pediatric Blood & Cancer. Dec, 2007 | Pubmed ID: 17486645 Sensitivity of Magnetic Resonance Imaging of Dendritic Cells for in Vivo Tracking of Cellular Cancer Vaccines International Journal of Cancer. Journal International Du Cancer. Mar, 2007 | Pubmed ID: 17163419 Relevance of DC-SIGN in DC-induced T Cell Proliferation Journal of Leukocyte Biology. Mar, 2007 | Pubmed ID: 17135574 Cancer-germline Gene Expression in Pediatric Solid Tumors Using Quantitative Real-time PCR International Journal of Cancer. Journal International Du Cancer. Jan, 2007 | Pubmed ID: 17019710 Plasmacytoid Dendritic Cells of Melanoma Patients Present Exogenous Proteins to CD4+ T Cells After Fc Gamma RII-mediated Uptake The Journal of Experimental Medicine. Jul, 2006 | Pubmed ID: 16785312 Development of 111In-labeled Tumor-associated Antigen Peptides for Monitoring Dendritic-cell-based Vaccination Nuclear Medicine and Biology. May, 2006 | Pubmed ID: 16720236 Magnetic Resonance Tracking of Dendritic Cells in Melanoma Patients for Monitoring of Cellular Therapy Nature Biotechnology. Nov, 2005 | Pubmed ID: 16258544 Immunomonitoring Tumor-specific T Cells in Delayed-type Hypersensitivity Skin Biopsies After Dendritic Cell Vaccination Correlates with Clinical Outcome Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Aug, 2005 | Pubmed ID: 16110035 Effective Induction of Naive and Recall T-cell Responses by Targeting Antigen to Human Dendritic Cells Via a Humanized Anti-DC-SIGN Antibody Blood. Aug, 2005 | Pubmed ID: 15878980 Migration of Dendritic Cell Based Cancer Vaccines: in Vivo Veritas? Current Opinion in Immunology. Apr, 2005 | Pubmed ID: 15766677 Intratumoral Recombinant Human Interleukin-12 Administration in Head and Neck Squamous Cell Carcinoma Patients Modifies Locoregional Lymph Node Architecture and Induces Natural Killer Cell Infiltration in the Primary Tumor Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2005 | Pubmed ID: 15756016 Phenotypical and Functional Characterization of Clinical-grade Dendritic Cells Methods in Molecular Medicine. 2005 | Pubmed ID: 15585917 Dendritic Cell Immunotherapy: Mapping the Way Nature Medicine. May, 2004 | Pubmed ID: 15122249 Maturation of Dendritic Cells is a Prerequisite for Inducing Immune Responses in Advanced Melanoma Patients Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2003 | Pubmed ID: 14613986 Effective Migration of Antigen-pulsed Dendritic Cells to Lymph Nodes in Melanoma Patients is Determined by Their Maturation State Cancer Research. Jan, 2003 | Pubmed ID: 12517769 Vaccination of Patients with Metastatic Renal Cell Carcinoma with Autologous Dendritic Cells Pulsed with Autologous Tumor Antigens in Combination with Interleukin-2: a Phase 1 Study Journal of Immunotherapy (Hagerstown, Md. : 1997). Nov-Dec, 2002 | Pubmed ID: 12439347 Phenotypical and Functional Characterization of Clinical Grade Dendritic Cells Journal of Immunotherapy (Hagerstown, Md. : 1997). Sep-Oct, 2002 | Pubmed ID: 12218781 Renal Cell Carcinoma-associated Antigen G250 Encodes a Naturally Processed Epitope Presented by Human Leukocyte Antigen-DR Molecules to CD4(+) T Lymphocytes International Journal of Cancer. Journal International Du Cancer. Aug, 2002 | Pubmed ID: 12115527 In vivo 19 F MRI voor mobiele Tracking Mangala Srinivas1, Philipp Boehm-Sturm2, Markus Aswendt2, Eberhard D. Pracht2,3, Carl G. Figdor1, I. Jolanda de Vries1, Mathias Hoehn2 1Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, 2In-Vivo-NMR Laboratory, Max Planck Institute for Neurological Research, 3German Center for Neurodegenerative Diseases (DZNE) JoVE 50802 Médecine
In vivo 19 F MRI voor mobiele Tracking Mangala Srinivas1, Philipp Boehm-Sturm2, Markus Aswendt2, Eberhard D. Pracht2,3, Carl G. Figdor1, I. Jolanda de Vries1, Mathias Hoehn2 1Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, 2In-Vivo-NMR Laboratory, Max Planck Institute for Neurological Research, 3German Center for Neurodegenerative Diseases (DZNE) JoVE 50802 Médecine