James J Moon Department of Pharmaceutical Sciences University of Michigan Biography Publications Institution JoVE Articles James J Moon has not added a biography. If you are James J Moon and would like to personalize this page please email our Author Liaison for assistance. Publications Cationic Liposome-hyaluronic Acid Hybrid Nanoparticles for Intranasal Vaccination with Subunit Antigens Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2015 | Pubmed ID: 25869965 T Cell Receptor Cross-reactivity Between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity Immunity. Jan, 2015 | Pubmed ID: 25601203 Biomaterials for Nanoparticle Vaccine Delivery Systems Pharmaceutical Research. Oct, 2014 | Pubmed ID: 24848341 A Dual TLR Agonist Adjuvant Enhances the Immunogenicity and Protective Efficacy of the Tuberculosis Vaccine Antigen ID93 PloS One. 2014 | Pubmed ID: 24404140 Cutting Edge: Type 1 Diabetes Occurs Despite Robust Anergy Among Endogenous Insulin-specific CD4 T Cells in NOD Mice Journal of Immunology (Baltimore, Md. : 1950). Nov, 2013 | Pubmed ID: 24123682 Generation of Effector Memory T Cell-based Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination Science Translational Medicine. Sep, 2013 | Pubmed ID: 24068737 Adjuvant Formulation Structure and Composition Are Critical for the Development of an Effective Vaccine Against Tuberculosis Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2013 | Pubmed ID: 23933525 Response to Comment on “The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude” Journal of Immunology (Baltimore, Md. : 1950). Mar, 2013 | Pubmed ID: 23544199 CXCR3 Chemokine Receptor-ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation Immunity. Dec, 2012 | Pubmed ID: 23123063 Releasable Layer-by-layer Assembly of Stabilized Lipid Nanocapsules on Microneedles for Enhanced Transcutaneous Vaccine Delivery ACS Nano. Sep, 2012 | Pubmed ID: 22920601 Engineering Nano- and Microparticles to Tune Immunity Advanced Materials (Deerfield Beach, Fla.). Jul, 2012 | Pubmed ID: 22641380 Detection of an Autoreactive T-cell Population Within the Polyclonal Repertoire That Undergoes Distinct Autoimmune Regulator (Aire)-mediated Selection Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22552229 The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude Journal of Immunology (Baltimore, Md. : 1950). May, 2012 | Pubmed ID: 22517866 Antigen-Displaying Lipid-Enveloped PLGA Nanoparticles As Delivery Agents for a Plasmodium Vivax Malaria Vaccine PloS One. 2012 | Pubmed ID: 22328935 Enhancing Humoral Responses to a Malaria Antigen with Nanoparticle Vaccines That Expand Tfh Cells and Promote Germinal Center Induction Proceedings of the National Academy of Sciences of the United States of America. Jan, 2012 | Pubmed ID: 22247289 Immunization Route Dictates Cross-priming Efficiency and Impacts the Optimal Timing of Adjuvant Delivery Frontiers in Immunology. 2011 | Pubmed ID: 22566860 CARMA1 is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma Journal of Immunology (Baltimore, Md. : 1950). Dec, 2011 | Pubmed ID: 22075698 Robust Antigen Specific Th17 T Cell Response to Group A Streptococcus is Dependent on IL-6 and Intranasal Route of Infection PLoS Pathogens. Sep, 2011 | Pubmed ID: 21966268 Quantitative Impact of Thymic Selection on Foxp3+ and Foxp3- Subsets of Self-peptide/MHC Class II-specific CD4+ T Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21873213 Robust IgG Responses to Nanograms of Antigen Using a Biomimetic Lipid-coated Particle Vaccine Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2011 | Pubmed ID: 21820024 Interbilayer-crosslinked Multilamellar Vesicles As Synthetic Vaccines for Potent Humoral and Cellular Immune Responses Nature Materials. Mar, 2011 | Pubmed ID: 21336265 Distinct Functions of Antigen-specific CD4 T Cells During Murine Mycobacterium Tuberculosis Infection Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20962277 Negative Selection and Peptide Chemistry Determine the Size of Naive Foreign Peptide-MHC Class II-specific CD4+ T Cell Populations Journal of Immunology (Baltimore, Md. : 1950). Oct, 2010 | Pubmed ID: 20861357 Therapeutic Cell Engineering with Surface-conjugated Synthetic Nanoparticles Nature Medicine. Sep, 2010 | Pubmed ID: 20711198 CD4+CD25+Foxp3+ Regulatory T Cells Optimize Diversity of the Conventional T Cell Repertoire During Reconstitution from Lymphopenia Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20357265 On the Composition of the Preimmune Repertoire of T Cells Specific for Peptide-major Histocompatibility Complex Ligands Annual Review of Immunology. 2010 | Pubmed ID: 20307209 Biomimetic Hydrogels with Pro-angiogenic Properties Biomaterials. May, 2010 | Pubmed ID: 20185173 Covalently-immobilized Vascular Endothelial Growth Factor Promotes Endothelial Cell Tubulogenesis in Poly(ethylene Glycol) Diacrylate Hydrogels Journal of Biomaterials Science. Polymer Edition. 2009 | Pubmed ID: 19723440 Positive Selection Optimizes the Number and Function of MHCII-restricted CD4+ T Cell Clones in the Naive Polyclonal Repertoire Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009 | Pubmed ID: 19541603 Tracking the Dynamics of Salmonella Specific T Cell Responses Current Topics in Microbiology and Immunology. 2009 | Pubmed ID: 19521686 Tracking Epitope-specific T Cells Nature Protocols. 2009 | Pubmed ID: 19373228 Cytosolic Delivery Mediated Via Electrostatic Surface Binding of Protein, Virus, or SiRNA Cargos to PH-responsive Core-shell Gel Particles Biomacromolecules. Apr, 2009 | Pubmed ID: 19239276 Dendritic Cell Antigen Presentation Drives Simultaneous Cytokine Production by Effector and Regulatory T Cells in Inflamed Skin Immunity. Feb, 2009 | Pubmed ID: 19200757 Micropatterning of Poly(ethylene Glycol) Diacrylate Hydrogels with Biomolecules to Regulate and Guide Endothelial Morphogenesis Tissue Engineering. Part A. Mar, 2009 | Pubmed ID: 18803481 EphrinA I-targeted Nanoshells for Photothermal Ablation of Prostate Cancer Cells International Journal of Nanomedicine. 2008 | Pubmed ID: 18990944 Antigen Persistence is Required for Dendritic Cell Licensing and CD8+ T Cell Cross-priming Journal of Immunology (Baltimore, Md. : 1950). Sep, 2008 | Pubmed ID: 18713977 Three-dimensional Micropatterning of Bioactive Hydrogels Via Two-photon Laser Scanning Photolithography for Guided 3D Cell Migration Biomaterials. Jul, 2008 | Pubmed ID: 18433863 Vascularization of Engineered Tissues: Approaches to Promote Angio-genesis in Biomaterials Current Topics in Medicinal Chemistry. 2008 | Pubmed ID: 18393893 Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire Immunity. Jan, 2008 | Pubmed ID: 18199418 Naive CD4(+) T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response Magnitude Immunity. Aug, 2007 | Pubmed ID: 17707129 Regulation of NF-kappaB Activation in T Cells Via Association of the Adapter Proteins ADAP and CARMA1 Science (New York, N.Y.). May, 2007 | Pubmed ID: 17478723 Poly(ethylene Glycol) Hydrogels Conjugated with a Collagenase-sensitive Fluorogenic Substrate to Visualize Collagenase Activity During Three-dimensional Cell Migration Biomaterials. Jul, 2007 | Pubmed ID: 17395258 Synthetic Biomimetic Hydrogels Incorporated with Ephrin-A1 for Therapeutic Angiogenesis Biomacromolecules. Jan, 2007 | Pubmed ID: 17206786 Naive and Memory CD4+ T Cell Survival Controlled by Clonal Abundance Science (New York, N.Y.). Apr, 2006 | Pubmed ID: 16513943 Photolithographic Patterning of Polyethylene Glycol Hydrogels Biomaterials. Apr, 2006 | Pubmed ID: 16375965 Proteolytically Degradable Hydrogels with a Fluorogenic Substrate for Studies of Cellular Proteolytic Activity and Migration Biotechnology Progress. Nov-Dec, 2005 | Pubmed ID: 16321059 Transcription-induced Chromatin Remodeling at the C-myc Gene Involves the Local Exchange of Histone H2A.Z The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15878876 Covalently Immobilized Gradients of BFGF on Hydrogel Scaffolds for Directed Cell Migration Biomaterials. Jun, 2005 | Pubmed ID: 15603817 Role of Cell Surface Heparan Sulfate Proteoglycans in Endothelial Cell Migration and Mechanotransduction Journal of Cellular Physiology. Apr, 2005 | Pubmed ID: 15389626 A Permissive Role for Phosphatidylinositol 3-kinase in the Stat5-mediated Expression of Cyclin D2 by the Interleukin-2 Receptor The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14660677 Uncoupling of Promitogenic and Antiapoptotic Functions of IL-2 by Smad-dependent TGF-beta Signaling Journal of Immunology (Baltimore, Md. : 1950). Jun, 2003 | Pubmed ID: 12759434 Differential Regulation of Fcgamma Receptor Isoforms: Implications for Therapeutic Intervention American Journal of Therapeutics. Oct, 1995 | Pubmed ID: 11854786 Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination Lukasz J. Ochyl1,2, James J Moon1,2,3 1Department of Pharmaceutical Sciences, University of Michigan, 2Biointerfaces Institute, University of Michigan, 3Department of Biomedical Engineering, University of Michigan JoVE 52771 Immunologie et Infection
Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination Lukasz J. Ochyl1,2, James J Moon1,2,3 1Department of Pharmaceutical Sciences, University of Michigan, 2Biointerfaces Institute, University of Michigan, 3Department of Biomedical Engineering, University of Michigan JoVE 52771 Immunologie et Infection