James W. Fawcett Cambridge Centre for Brain Repair, Department of Clinical Neurosciences University of Cambridge Biography Publications Institution JoVE Articles James W. Fawcett has not added a biography. If you are James W. Fawcett and would like to personalize this page please email our Author Liaison for assistance. Publications Assembly of a New Growth Cone After Axotomy: the Precursor to Axon Regeneration Nature Reviews. Neuroscience. Feb, 2012 | Pubmed ID: 22334213 High Sensitivity Recording of Afferent Nerve Activity Using Ultra-compliant Microchannel Electrodes: an Acute in Vivo Validation Journal of Neural Engineering. Feb, 2012 | Pubmed ID: 22328617 Chondroitin Sulfates in the Developing Rat Hindbrain Confine Commissural Projections of Vestibular Nuclear Neurons Neural Development. Feb, 2012 | Pubmed ID: 22305371 A Regenerative Microchannel Neural Interface for Recording from and Stimulating Peripheral Axons in Vivo Journal of Neural Engineering. Feb, 2012 | Pubmed ID: 22258138 An in Vitro Assay to Examine Oligodendrocyte Precursor Cell Migration on Astrocytes Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22144321 Astrocyte-Schwann-cell Coculture Systems Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22144320 Activated Retinal Glia Mediated Axon Regeneration in Experimental Glaucoma Neurobiology of Disease. Jan, 2012 | Pubmed ID: 21867754 Chondroitinase ABC Combined with Neurotrophin NT-3 Secretion and NR2D Expression Promotes Axonal Plasticity and Functional Recovery in Rats with Lateral Hemisection of the Spinal Cord The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2011 | Pubmed ID: 22159095 Training and Anti-CSPG Combination Therapy for Spinal Cord Injury Experimental Neurology. Sep, 2011 | Pubmed ID: 21946272 Extracellular Matrix and Perineuronal Nets in CNS Repair Developmental Neurobiology. Nov, 2011 | Pubmed ID: 21898855 Lentiviral Vectors Express Chondroitinase ABC in Cortical Projections and Promote Sprouting of Injured Corticospinal Axons Journal of Neuroscience Methods. Sep, 2011 | Pubmed ID: 21855577 NG2 Expression in Glioblastoma Identifies an Actively Proliferating Population with an Aggressive Molecular Signature Neuro-oncology. Aug, 2011 | Pubmed ID: 21798846 6-Sulphated Chondroitins Have a Positive Influence on Axonal Regeneration PloS One. 2011 | Pubmed ID: 21747937 Chondroitinase Combined with Rehabilitation Promotes Recovery of Forelimb Function in Rats with Chronic Spinal Cord Injury The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21697383 Integrin Activation Promotes Axon Growth on Inhibitory Chondroitin Sulfate Proteoglycans by Enhancing Integrin Signaling The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2011 | Pubmed ID: 21525268 Transcriptome Analysis of Embryonic and Adult Sensory Axons Reveals Changes in MRNA Repertoire Localization RNA (New York, N.Y.). Jan, 2011 | Pubmed ID: 21098654 Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone MRNAs The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2010 | Pubmed ID: 21084603 Rab11 and Its Effector Rab Coupling Protein Contribute to the Trafficking of Beta 1 Integrins During Axon Growth in Adult Dorsal Root Ganglion Neurons and PC12 Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2010 | Pubmed ID: 20810886 Controlled Release of Chondroitinase ABC from Fibrin Gel Reduces the Level of Inhibitory Glycosaminoglycan Chains in Lesioned Spinal Cord Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2010 | Pubmed ID: 20620180 In Vitro Modeling of Perineuronal Nets: Hyaluronan Synthase and Link Protein Are Necessary for Their Formation and Integrity Journal of Neurochemistry. Sep, 2010 | Pubmed ID: 20584105 Animals Lacking Link Protein Have Attenuated Perineuronal Nets and Persistent Plasticity Brain : a Journal of Neurology. Aug, 2010 | Pubmed ID: 20566484 Role of Chondroitin Sulfate Proteoglycans in Axonal Conduction in Mammalian Spinal Cord The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2010 | Pubmed ID: 20534825 Analysis of Combinatorial Variability Reveals Selective Accumulation of the Fibronectin Type III Domains B and D of Tenascin-C in Injured Brain Experimental Neurology. Sep, 2010 | Pubmed ID: 20451518 Astrocyte-produced Ephrins Inhibit Schwann Cell Migration Via VAV2 Signaling The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2010 | Pubmed ID: 20335460 Integrin Activation or Alpha 9 Expression Allows Retinal Pigmented Epithelial Cell Adhesion on Bruch's Membrane in Wet Age-related Macular Degeneration Brain : a Journal of Neurology. Feb, 2010 | Pubmed ID: 20159768 Schwann Cell Migration is Integrin-dependent and Inhibited by Astrocyte-produced Aggrecan Glia. May, 2010 | Pubmed ID: 20155822 Modification of N-glycosylation Sites Allows Secretion of Bacterial Chondroitinase ABC from Mammalian Cells Journal of Biotechnology. Jan, 2010 | Pubmed ID: 19900493 The Role of Local Protein Synthesis and Degradation in Axon Regeneration Experimental Neurology. May, 2010 | Pubmed ID: 19520073 Extrinsic and Intrinsic Factors Controlling Axonal Regeneration After Spinal Cord Injury Expert Reviews in Molecular Medicine. 2009 | Pubmed ID: 19968910 Chondroitinase ABC Treatment Opens a Window of Opportunity for Task-specific Rehabilitation Nature Neuroscience. Sep, 2009 | Pubmed ID: 19668200 Damage Control in the Nervous System: Rehabilitation in a Plastic Environment Nature Medicine. Jul, 2009 | Pubmed ID: 19584862 Axonal MRNAs: Characterisation and Role in the Growth and Regeneration of Dorsal Root Ganglion Axons and Growth Cones Molecular and Cellular Neurosciences. Oct, 2009 | Pubmed ID: 19520167 Astrocytes and Oligodendrocytes Can Be Generated from NG2+ Progenitors After Acute Brain Injury: Intracellular Localization of Oligodendrocyte Transcription Factor 2 is Associated with Their Fate Choice The European Journal of Neuroscience. May, 2009 | Pubmed ID: 19473238 Recovery from Spinal Cord Injury: Regeneration, Plasticity and Rehabilitation Brain : a Journal of Neurology. Jun, 2009 | Pubmed ID: 19429905 Alpha9 Integrin Promotes Neurite Outgrowth on Tenascin-C and Enhances Sensory Axon Regeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2009 | Pubmed ID: 19403822 Chronic Spinal Hemisection in Rats Induces a Progressive Decline in Transmission in Uninjured Fibers to Motoneurons Experimental Neurology. Apr, 2009 | Pubmed ID: 19320005 Microchannel Electrodes for Recording and Stimulation: in Vitro Evaluation IEEE Transactions on Bio-medical Engineering. May, 2009 | Pubmed ID: 19203882 Recording with Microchannel Electrodes in a Noisy Environment Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2008 | Pubmed ID: 19162587 Bridging Spinal Cord Injuries Journal of Biology. 2008 | Pubmed ID: 18947368 Role of Extracellular Factors in Axon Regeneration in the CNS: Implications for Therapy Regenerative Medicine. Nov, 2008 | Pubmed ID: 18947312 Proteoglycans in the Central Nervous System: Plasticity, Regeneration and Their Stimulation with Chondroitinase ABC Restorative Neurology and Neuroscience. 2008 | Pubmed ID: 18820407 An Experimental Model of Secondary Progressive Multiple Sclerosis That Shows Regional Variation in Gliosis, Remyelination, Axonal and Neuronal Loss Journal of Neuroimmunology. Sep, 2008 | Pubmed ID: 18672298 Spinal Cord Repair: Bridging the Divide Neurorehabilitation and Neural Repair. Sep-Oct, 2008 | Pubmed ID: 18487422 Distribution and Synthesis of Extracellular Matrix Proteoglycans, Hyaluronan, Link Proteins and Tenascin-R in the Rat Spinal Cord The European Journal of Neuroscience. Mar, 2008 | Pubmed ID: 18364019 Microchannels As Axonal Amplifiers IEEE Transactions on Bio-medical Engineering. Mar, 2008 | Pubmed ID: 18334406 Heparan Sulphate Proteoglycans in Glia and in the Normal and Injured CNS: Expression of Sulphotransferases and Changes in Sulphation The European Journal of Neuroscience. Feb, 2008 | Pubmed ID: 18279312 Chondroitin Sulfate Proteoglycans and Microglia Prevent Migration and Integration of Grafted Müller Stem Cells into Degenerating Retina Stem Cells (Dayton, Ohio). Apr, 2008 | Pubmed ID: 18218817 Therapeutic Time Window for the Application of Chondroitinase ABC After Spinal Cord Injury Experimental Neurology. Apr, 2008 | Pubmed ID: 18158149 Chondroitinase ABC Has a Long-lasting Effect on Chondroitin Sulphate Glycosaminoglycan Content in the Injured Rat Brain Journal of Neurochemistry. Jan, 2008 | Pubmed ID: 18005340 Inhibiting Glycosaminoglycan Chain Polymerization Decreases the Inhibitory Activity of Astrocyte-derived Chondroitin Sulfate Proteoglycans The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2007 | Pubmed ID: 18160657 A Potential Role for Bone Morphogenetic Protein Signalling in Glial Cell Fate Determination Following Adult Central Nervous System Injury in Vivo The European Journal of Neuroscience. Dec, 2007 | Pubmed ID: 18028109 How Does Chondroitinase Promote Functional Recovery in the Damaged CNS? Experimental Neurology. Aug, 2007 | Pubmed ID: 17572406 Can Experiments in Nonhuman Primates Expedite the Translation of Treatments for Spinal Cord Injury in Humans? Nature Medicine. May, 2007 | Pubmed ID: 17479102 Characterization of Tests of Functional Recovery After Median and Ulnar Nerve Injury and Repair in the Rat Forelimb Journal of the Peripheral Nervous System : JPNS. Mar, 2007 | Pubmed ID: 17374098 Inosine Promotes Recovery of Skilled Motor Function in a Model of Focal Brain Injury Brain : a Journal of Neurology. Apr, 2007 | Pubmed ID: 17293357 Spinally Upregulated Noggin Suppresses Axonal and Dendritic Plasticity Following Dorsal Rhizotomy Experimental Neurology. Mar, 2007 | Pubmed ID: 17258709 Promoting Plasticity in the Spinal Cord with Chondroitinase Improves Functional Recovery After Peripheral Nerve Repair Brain : a Journal of Neurology. Apr, 2007 | Pubmed ID: 17255150 The Role of Chondroitin Sulfate Proteoglycans in Regeneration and Plasticity in the Central Nervous System Brain Research Reviews. Apr, 2007 | Pubmed ID: 17222456 Upregulation of Aggrecan, Link Protein 1, and Hyaluronan Synthases During Formation of Perineuronal Nets in the Rat Cerebellum The Journal of Comparative Neurology. Mar, 2007 | Pubmed ID: 17206619 Novel Strategies for Protection and Repair of the Central Nervous System Clinical Medicine (London, England). Nov-Dec, 2006 | Pubmed ID: 17228561 The Glial Response to Injury and Its Role in the Inhibition of CNS Repair Advances in Experimental Medicine and Biology. 2006 | Pubmed ID: 16955702 Composition of Perineuronal Net Extracellular Matrix in Rat Brain: a Different Disaccharide Composition for the Net-associated Proteoglycans The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16644727 Overcoming Inhibition in the Damaged Spinal Cord Journal of Neurotrauma. Mar-Apr, 2006 | Pubmed ID: 16629623 Composition of Perineuronal Nets in the Adult Rat Cerebellum and the Cellular Origin of Their Components The Journal of Comparative Neurology. Feb, 2006 | Pubmed ID: 16374793 Identification of Unique Reciprocal and Non Reciprocal Cross Packaging Relationships Between HIV-1, HIV-2 and SIV Reveals an Efficient SIV/HIV-2 Lentiviral Vector System with Highly Favourable Features for in Vivo Testing and Clinical Usage Retrovirology. 2005 | Pubmed ID: 16168051 Delivery of a Lentiviral Vector in a Pluronic F127 Gel to Cells of the Central Nervous System European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Oct, 2005 | Pubmed ID: 16154331 The Ability of Axons to Regenerate Their Growth Cones Depends on Axonal Type and Age, and is Regulated by Calcium, CAMP and ERK The European Journal of Neuroscience. Apr, 2005 | Pubmed ID: 15869501 Two Separate Metalloproteinase Activities Are Responsible for the Shedding and Processing of the NG2 Proteoglycan in Vitro Molecular and Cellular Neurosciences. May, 2005 | Pubmed ID: 15866049 Chondroitin Sulfate Proteoglycans in Neural Development and Regeneration Current Opinion in Neurobiology. Feb, 2005 | Pubmed ID: 15721753 Chondroitin 6-sulphate Synthesis is Up-regulated in Injured CNS, Induced by Injury-related Cytokines and Enhanced in Axon-growth Inhibitory Glia The European Journal of Neuroscience. Jan, 2005 | Pubmed ID: 15673437 Axonal Protein Synthesis and Degradation Are Necessary for Efficient Growth Cone Regeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2005 | Pubmed ID: 15647476 Axon Behaviour at Schwann Cell - Astrocyte Boundaries: Manipulation of Axon Signalling Pathways and the Neural Adhesion Molecule L1 Can Enable Axons to Cross The European Journal of Neuroscience. Sep, 2004 | Pubmed ID: 15355310 Proteoglycans and Brain Repair News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. Feb, 2004 | Pubmed ID: 14739401 Transplantation of Schwann Cell Line Clones Secreting GDNF or BDNF into the Retinas of Dystrophic Royal College of Surgeons Rats Investigative Ophthalmology & Visual Science. Jan, 2004 | Pubmed ID: 14691183 Regulation of RPTPbeta/phosphacan Expression and Glycosaminoglycan Epitopes in Injured Brain and Cytokine-treated Glia Molecular and Cellular Neurosciences. Dec, 2003 | Pubmed ID: 14697661 The Astrocyte/meningeal Cell Interface is a Barrier to Neurite Outgrowth Which Can Be Overcome by Manipulation of Inhibitory Molecules or Axonal Signalling Pathways Molecular and Cellular Neurosciences. Dec, 2003 | Pubmed ID: 14697658 Expression and Glycanation of the NG2 Proteoglycan in Developing, Adult, and Damaged Peripheral Nerve Molecular and Cellular Neurosciences. Nov, 2003 | Pubmed ID: 14664826 A Herpesvirus Vector Can Transduce Axotomized Brain Neurons Experimental Neurology. Oct, 2003 | Pubmed ID: 14552896 Limited Growth of Severed CNS Axons After Treatment of Adult Rat Brain with Hyaluronidase Journal of Neuroscience Research. Jan, 2003 | Pubmed ID: 12478611 Chondroitin Sulphate Proteoglycans in the CNS Injury Response Progress in Brain Research. 2002 | Pubmed ID: 12440375 Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex Science (New York, N.Y.). Nov, 2002 | Pubmed ID: 12424383 Chondroitinase ABC Promotes Functional Recovery After Spinal Cord Injury Nature. Apr, 2002 | Pubmed ID: 11948352 Building a Bridge: Engineering Spinal Cord Repair Experimental Neurology. Apr, 2002 | Pubmed ID: 11922655 Versican is Upregulated in CNS Injury and is a Product of Oligodendrocyte Lineage Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2002 | Pubmed ID: 11896162 تحليل شفان نجمية طريق التفاعلات في المختبر فحوصات Fardad T. Afshari1, Jessica C. Kwok1, James W. Fawcett1 1Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge JoVE 2214 Biologie
تحليل شفان نجمية طريق التفاعلات في المختبر فحوصات Fardad T. Afshari1, Jessica C. Kwok1, James W. Fawcett1 1Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge JoVE 2214 Biologie