Jennifer L. Gommerman Department of Immunology University of Toronto Biography Publications Institution JoVE Articles Jennifer L. Gommerman has not added a biography. If you are Jennifer L. Gommerman and would like to personalize this page please email our Author Liaison for assistance. Publications Comparison of Omicron Breakthrough Infection Versus Monovalent SARS-CoV-2 Intramuscular Booster Reveals Differences in Mucosal and Systemic Humoral Immunity Mucosal Immunology. Jan, 2024 | Pubmed ID: 38278415 Editorial: Environmental Factors in Autoimmunity Frontiers in Immunology. 2023 | Pubmed ID: 38292480 TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses BioRxiv : the Preprint Server for Biology. Sep, 2023 | Pubmed ID: 37790513 Under the Influence: Environmental Factors As Modulators of Neuroinflammation Through the IL-10/IL-10R Axis Frontiers in Immunology. 2023 | Pubmed ID: 37600781 Guardians of the Oral and Nasopharyngeal Galaxy: IgA and Protection Against SARS-CoV-2 Infection Immunological Reviews. Aug, 2022 | Pubmed ID: 35815463 Age-related Changes in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis Seminars in Immunology. Jan, 2022 | Pubmed ID: 35752572 Age-dependent Gray Matter Demyelination is Associated with Leptomeningeal Neutrophil Accumulation JCI Insight. Jun, 2022 | Pubmed ID: 35536649 Systemic and Mucosal IgA Responses Are Variably Induced in Response to SARS-CoV-2 MRNA Vaccination and Are Associated with Protection Against Subsequent Infection Mucosal Immunology. May, 2022 | Pubmed ID: 35468942 Neonatal LTβR Signaling is Required for the Accumulation of Eosinophils in the Inflamed Adult Mesenteric Lymph Node Mucosal Immunology. Mar, 2022 | Pubmed ID: 35181738 Immunoglobulin A Nephropathy is Characterized by Anticommensal Humoral Immune Responses JCI Insight. Mar, 2022 | Pubmed ID: 35133979 Accumulation of Meningeal Lymphocytes Correlates with White Matter Lesion Activity in Progressive Multiple Sclerosis JCI Insight. Mar, 2022 | Pubmed ID: 35104246 Persistence of T Cell and Antibody Responses to SARS-CoV-2 Up to 9 Months After Symptom Onset Journal of Immunology (Baltimore, Md. : 1950). Jan, 2022 | Pubmed ID: 34903642 The Microbiome and IgA Nephropathy Seminars in Immunopathology. Oct, 2021 | Pubmed ID: 34664087 The Impact of IgA and the Microbiota on CNS Disease Frontiers in Immunology. 2021 | Pubmed ID: 34603329 CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein-Induced Experimental Autoimmune Encephalomyelitis Despite an Altered Germinal Center Response Journal of Immunology (Baltimore, Md. : 1950). Sep, 2021 | Pubmed ID: 34400521 Queen's Gambit: B Cell to Follicle Journal of Immunology (Baltimore, Md. : 1950). Aug, 2021 | Pubmed ID: 34321285 Complement-associated Loss of CA2 Inhibitory Synapses in the Demyelinated Hippocampus Impairs Memory Acta Neuropathologica. Oct, 2021 | Pubmed ID: 34170374 Fantastic IgA Plasma Cells and Where to Find Them Immunological Reviews. Sep, 2021 | Pubmed ID: 34046908 The Impact of Migration on the Gut Metagenome of South Asian Canadians Gut Microbes. Jan-Dec, 2021 | Pubmed ID: 33794735 A Totally OSM Gift to Astrocytes Relieves Inflammation Immunity. Mar, 2021 | Pubmed ID: 33691129 The Ins and Outs of Central Nervous System Inflammation-Lessons Learned from Multiple Sclerosis Annual Review of Immunology. Apr, 2021 | Pubmed ID: 33524273 Stromal Cell-Mediated Coordination of Immune Cell Recruitment, Retention, and Function in Brain-Adjacent Regions Journal of Immunology (Baltimore, Md. : 1950). Jan, 2021 | Pubmed ID: 33397742 B Cell Depletion Therapies in Autoimmune Disease: Advances and Mechanistic Insights Nature Reviews. Drug Discovery. Mar, 2021 | Pubmed ID: 33324003 Regulation of Neuroinflammation by B Cells and Plasma Cells Immunological Reviews. Jan, 2021 | Pubmed ID: 33107072 Plasma Cells: From Cytokine Production to Regulation in Experimental Autoimmune Encephalomyelitis Journal of Molecular Biology. Jan, 2021 | Pubmed ID: 32976908 An "Outside-In" and "Inside-Out" Consideration of Complement in the Multiple Sclerosis Brain: Lessons From Development and Neurodegenerative Diseases Frontiers in Cellular Neuroscience. 2020 | Pubmed ID: 33488361 Gut Microbiota-specific IgA B Cells Traffic to the CNS in Active Multiple Sclerosis Science Immunology. Nov, 2020 | Pubmed ID: 33219152 The EIF2α Kinase HRI Triggers the Autophagic Clearance of Cytosolic Protein Aggregates The Journal of Biological Chemistry. Nov, 2020 | Pubmed ID: 33168630 Persistence of Serum and Saliva Antibody Responses to SARS-CoV-2 Spike Antigens in COVID-19 Patients Science Immunology. Oct, 2020 | Pubmed ID: 33033173 A Simple Protein-based Surrogate Neutralization Assay for SARS-CoV-2 JCI Insight. Oct, 2020 | Pubmed ID: 32870820 Dendritic Cell Subsets in Intestinal Immunity and Inflammation Journal of Immunology (Baltimore, Md. : 1950). Mar, 2020 | Pubmed ID: 32071090 Intestinal Protection Without T Cell Help Nature Reviews. Immunology. May, 2020 | Pubmed ID: 31996798 Siponimod Therapy Implicates Th17 Cells in a Preclinical Model of Subpial Cortical Injury JCI Insight. Jan, 2020 | Pubmed ID: 31821174 Early-life Programming of Mesenteric Lymph Node Stromal Cell Identity by the Lymphotoxin Pathway Regulates Adult Mucosal Immunity Science Immunology. 12, 2019 | Pubmed ID: 31862865 Activated Leukocyte Cell Adhesion Molecule Regulates B Lymphocyte Migration Across Central Nervous System Barriers Science Translational Medicine. Nov, 2019 | Pubmed ID: 31723036 Aged Hind-limb Clasping Experimental Autoimmune Encephalomyelitis Models Aspects of the Neurodegenerative Process Seen in Multiple Sclerosis Proceedings of the National Academy of Sciences of the United States of America. Nov, 2019 | Pubmed ID: 31641069 Multiplexed Imaging of Immune Cells in Staged Multiple Sclerosis Lesions by Mass Cytometry ELife. Aug, 2019 | Pubmed ID: 31368890 C-Myb Exacerbates Atherosclerosis Through Regulation of Protective IgM-Producing Antibody-Secreting Cells Cell Reports. 05, 2019 | Pubmed ID: 31116977 NLRC5 Deficiency Has a Moderate Impact on Immunodominant CD8 T-cell Responses During Rotavirus Infection of Adult Mice Immunology and Cell Biology. Jul, 2019 | Pubmed ID: 30768806 B-Cell Deficiency Lowers Blood Pressure in Mice Hypertension (Dallas, Tex. : 1979). Mar, 2019 | Pubmed ID: 30636551 Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation Via IL-10 Cell. Jan, 2019 | Pubmed ID: 30612739 Generational Patterns of Asthma Incidence Among Immigrants to Canada over Two Decades. A Population-based Cohort Study Annals of the American Thoracic Society. Feb, 2019 | Pubmed ID: 30395726 Isotype-Switched Autoantibodies Are Necessary To Facilitate Central Nervous System Autoimmune Disease in and Mice Journal of Immunology (Baltimore, Md. : 1950). Aug, 2018 | Pubmed ID: 29980612 The H2B Deubiquitinase Usp22 Promotes Antibody Class Switch Recombination by Facilitating Non-homologous End Joining Nature Communications. Mar, 2018 | Pubmed ID: 29520062 Three-Dimensional Imaging of Transparent Tissues Via Metal Nanoparticle Labeling Journal of the American Chemical Society. Jul, 2017 | Pubmed ID: 28641018 Antibody-Independent Function of Human B Cells Contributes to Antifungal T Cell Responses Journal of Immunology (Baltimore, Md. : 1950). Apr, 2017 | Pubmed ID: 28275140 Stromal Cell Niches in the Inflamed Central Nervous System Journal of Immunology (Baltimore, Md. : 1950). Mar, 2017 | Pubmed ID: 28223405 The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination Through ATM and DNAPK-Mediated γH2AX Formation Cell Reports. 05, 2016 | Pubmed ID: 27160905 Hematopoietic LTβR Deficiency Results in Skewed T Cell Cytokine Profiles During a Mucosal Viral Infection Journal of Leukocyte Biology. Jul, 2016 | Pubmed ID: 26657790 Meningeal Tertiary Lymphoid Tissues and Multiple Sclerosis: A Gathering Place for Diverse Types of Immune Cells During CNS Autoimmunity Frontiers in Immunology. 2015 | Pubmed ID: 26793195 Cytokine-Defined B Cell Responses As Therapeutic Targets in Multiple Sclerosis Frontiers in Immunology. 2015 | Pubmed ID: 26779181 B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation Frontiers in Immunology. 2015 | Pubmed ID: 26732544 Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation Immunity. Dec, 2015 | Pubmed ID: 26682987 Proinflammatory GM-CSF-producing B Cells in Multiple Sclerosis and B Cell Depletion Therapy Science Translational Medicine. Oct, 2015 | Pubmed ID: 26491076 A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology Journal of Immunology (Baltimore, Md. : 1950). Nov, 2015 | Pubmed ID: 26459352 Asthma, Type 1 and Type 2 Diabetes Mellitus, and Inflammatory Bowel Disease Amongst South Asian Immigrants to Canada and Their Children: a Population-based Cohort Study PloS One. 2015 | Pubmed ID: 25849480 Re-thinking the Functions of IgA(+) Plasma Cells Gut Microbes. 2014 | Pubmed ID: 25483334 HIV Acquisition is Associated with Increased Antimicrobial Peptides and Reduced HIV Neutralizing IgA in the Foreskin Prepuce of Uncircumcised Men PLoS Pathogens. Oct, 2014 | Pubmed ID: 25275513 The 14th International TNF Conference, Québec City, Canada - Des Progrės Récents Aux Défis Futurs (Recent Advances Toward Future Challenges) Cytokine & Growth Factor Reviews. Apr, 2014 | Pubmed ID: 24698109 The Lymphotoxin Network: Orchestrating a Type I Interferon Response to Optimize Adaptive Immunity Cytokine & Growth Factor Reviews. Apr, 2014 | Pubmed ID: 24698108 AID and Caspase 8 Shape the Germinal Center Response Through Apoptosis Journal of Immunology (Baltimore, Md. : 1950). Dec, 2013 | Pubmed ID: 24244021 AID-expressing Germinal Center B Cells Cluster Normally Within Lymph Node Follicles in the Absence of FDC-M1+ CD35+ Follicular Dendritic Cells but Dissipate Prematurely Journal of Immunology (Baltimore, Md. : 1950). Nov, 2013 | Pubmed ID: 24068672 Notch2-dependent Classical Dendritic Cells Orchestrate Intestinal Immunity to Attaching-and-effacing Bacterial Pathogens Nature Immunology. Sep, 2013 | Pubmed ID: 23913046 The Regulation of Immune Responses by DC Derived Type I IFN Frontiers in Immunology. 2013 | Pubmed ID: 23626590 Secondary B Cell Receptor Diversification is Necessary for T Cell Mediated Neuro-inflammation During Experimental Autoimmune Encephalomyelitis PloS One. 2013 | Pubmed ID: 23613859 B Cells in MS: Why, Where and How? Multiple Sclerosis and Related Disorders. Jul, 2012 | Pubmed ID: 25877077 A Sphingosine-1-phosphate Receptor 1-directed Agonist Reduces Central Nervous System Inflammation in a Plasmacytoid Dendritic Cell-dependent Manner Journal of Immunology (Baltimore, Md. : 1950). Oct, 2012 | Pubmed ID: 22933630 Lymphotoxin-sensitive Microenvironments in Homeostasis and Inflammation Frontiers in Immunology. 2012 | Pubmed ID: 22866054 Homeodomain-interacting Protein Kinase (HIPK)-1 is Required for Splenic B Cell Homeostasis and Optimal T-independent Type 2 Humoral Response PloS One. 2012 | Pubmed ID: 22545114 Fine-tuning of Dendritic Cell Biology by the TNF Superfamily Nature Reviews. Immunology. Apr, 2012 | Pubmed ID: 22487654 Unusual Timing of CD127 Expression by Mouse Uterine Natural Killer Cells Journal of Leukocyte Biology. Mar, 2012 | Pubmed ID: 22227963 Erwerb Der Einen Multifunktionalen IgA + Plasma-Zell-Phänotyp Im Darm Nature. Jan, 2012 | Pubmed ID: 22158124 Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine Immunity. Nov, 2011 | Pubmed ID: 22018469 LTβR and CD40: Working Together in Dendritic Cells to Optimize Immune Responses Immunological Reviews. Nov, 2011 | Pubmed ID: 22017433 Mice Overexpressing BAFF Develop a Commensal Flora-dependent, IgA-associated Nephropathy The Journal of Clinical Investigation. Oct, 2011 | Pubmed ID: 21881212 LTβR Signaling in Dendritic Cells Induces a Type I IFN Response That is Required for Optimal Clonal Expansion of CD8+ T Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21245292 The Lymphotoxin Pathway As a Novel Regulator of Dendritic Cell Function Advances in Experimental Medicine and Biology. 2011 | Pubmed ID: 21153340 Cytokine/stromal Cell Networks and Lymphoid Tissue Environments Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Mar, 2011 | Pubmed ID: 21133813 Substrain Unterschiede Zeigen Neuartige Krankheitsmodifizierende Gen Kandidaten, Die Den Verlauf Eines Nagetier-Modells Der Multiplen Sklerose Zu ändern Journal of Immunology (Baltimore, Md. : 1950). Mar, 2010 | Pubmed ID: 20173032 Differential Requirement of MALT1 for BAFF-induced Outcomes in B Cell Subsets The Journal of Experimental Medicine. Nov, 2009 | Pubmed ID: 19917778 Dynamic Accumulation of Plasmacytoid Dendritic Cells in Lymph Nodes is Regulated by Interferon-beta Blood. Sep, 2009 | Pubmed ID: 19652204 Hilfe Schränkt Germinal Mitte Größe Durch Wiedergabe B Zellen Anfällig Für Apoptosis Blood. Jul, 2009 | Pubmed ID: 19478044 Nod2-dependent Th2 Polarization of Antigen-specific Immunity Journal of Immunology (Baltimore, Md. : 1950). Dec, 2008 | Pubmed ID: 19017983 ICOS, CD40, and Lymphotoxin Beta Receptors Signal Sequentially and Interdependently to Initiate a Germinal Center Reaction Journal of Immunology (Baltimore, Md. : 1950). Feb, 2008 | Pubmed ID: 18250437 Expression of Lymphotoxin-alphabeta on Antigen-specific T Cells is Required for DC Function The Journal of Experimental Medicine. May, 2007 | Pubmed ID: 17452522 Hilfe Mutiert Eine Nicht-Immunoglobulin-Transgene Unabhängige Chromosomalen Position Molecular Immunology. Jan, 2007 | Pubmed ID: 16542725 The Lymphotoxin Pathway: Beyond Lymph Node Development Immunologic Research. 2006 | Pubmed ID: 17003508 BAFF Induces a Hyper-IgA Syndrome in the Intestinal Lamina Propria Concomitant with IgA Deposition in the Kidney Independent of LIGHT Cellular Immunology. Jun, 2006 | Pubmed ID: 16987502 LIGHT is Dispensable for CD4+ and CD8+ T Cell and Antibody Responses to Influenza A Virus in Mice International Immunology. May, 2006 | Pubmed ID: 16569673 The LIGHT and DARC Sides of Herpesvirus Entry Mediator Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16159963 Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis (Video) | JoVE Carmen C. Ucciferri1, Annette Gower2, Nuria Alvarez-Sanchez1,2, Heather Whetstone3, Valeria Ramaglia1, Jennifer L. Gommerman1, Koroboshka Brand-Arzamendi2, Raphael Schneider2,4, Shannon E Dunn1,2,5 1Department of Immunology, University of Toronto, 2Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, 3Sickkids Research Institute, The Hospital for Sick Children, 4BARLO MS Centre, St. Michael’s Hospital, 5Women’s College Research Institute, Women’s College Hospital JoVE 65738 Immunologie et Infection
Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis (Video) | JoVE Carmen C. Ucciferri1, Annette Gower2, Nuria Alvarez-Sanchez1,2, Heather Whetstone3, Valeria Ramaglia1, Jennifer L. Gommerman1, Koroboshka Brand-Arzamendi2, Raphael Schneider2,4, Shannon E Dunn1,2,5 1Department of Immunology, University of Toronto, 2Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, 3Sickkids Research Institute, The Hospital for Sick Children, 4BARLO MS Centre, St. Michael’s Hospital, 5Women’s College Research Institute, Women’s College Hospital JoVE 65738 Immunologie et Infection