Jianxin Lyu School of Laboratory Medicine and Life Sciences Wenzhou Medical University Biography Publications Institution JoVE Articles Jianxin Lyu has not added a biography. If you are Jianxin Lyu and would like to personalize this page please email our Author Liaison for assistance. Publications Protein Interacting with C-kinase 1 is Involved in Epithelial-mesenchymal Transformation and Suppresses Progress of Gastric Cancer Medical Oncology (Northwood, London, England). Mar, 2021 | Pubmed ID: 33660148 Gut Microbiome Analysis As a Predictive Marker for the Gastric Cancer Patients Applied Microbiology and Biotechnology. Jan, 2021 | Pubmed ID: 33404833 HMGA2 Promotes Breast Cancer Metastasis by Modulating Hippo-YAP Signaling Pathway Cancer Biology & Therapy. Jan, 2021 | Pubmed ID: 33307962 4-Hydroxyphenylpyruvate Dioxygenase-Like Protein Promotes Pancreatic Cancer Cell Progression and Is Associated With Glutamine-Mediated Redox Balance Frontiers in Oncology. 2020 | Pubmed ID: 33537239 PRRG4 Promotes Breast Cancer Metastasis Through the Recruitment of NEDD4 and Downregulation of Robo1 Oncogene. 12, 2020 | Pubmed ID: 33037408 β-Catenin Induces Transcriptional Expression of PD-L1 to Promote Glioblastoma Immune Evasion The Journal of Experimental Medicine. 11, 2020 | Pubmed ID: 32860047 Assessment of Mitochondrial Function in Metabolic Dysfunction-associated Fatty Liver Disease Using Obese Mouse Models Zoological Research. Sep, 2020 | Pubmed ID: 32786176 [Analysis of TWNK Variant in a Family Affected with Perrault Syndrome] Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. Jul, 2020 | Pubmed ID: 32619254 Islet-cell Autoantigen 69 Accelerates Liver Regeneration by Downregulating Tgfbr1 and Attenuating Tgfβ Signaling in Mice FEBS Letters. Sep, 2020 | Pubmed ID: 32531799 Strict Assembly Restriction of Peptides from Rabbit Hemorrhagic Disease Virus Presented by Rabbit Major Histocompatibility Complex Class I Molecule RLA-A1 Journal of Virology. 08, 2020 | Pubmed ID: 32522857 A Novel Mitochondrial M.14430A>G (MT-ND6, P.W82R) Variant Causes Complex I Deficiency and Mitochondrial Leigh Syndrome Clinical Chemistry and Laboratory Medicine. Oct, 2020 | Pubmed ID: 32432562 COX6B2 Drives Metabolic Reprogramming Toward Oxidative Phosphorylation to Promote Metastasis in Pancreatic Ductal Cancer Cells Oncogenesis. May, 2020 | Pubmed ID: 32415061 Association Between Mitochondrial DNA Haplogroup Variation and Coronary Artery Disease Nutrition, Metabolism, and Cardiovascular Diseases : NMCD. 06, 2020 | Pubmed ID: 32402592 A Simple and Rapid Protein Purification Method Based on Cell-surface Display of SUMO-fused Recombinant Protein and Ulp1 Protease AMB Express. Apr, 2020 | Pubmed ID: 32266507 Removal of Chromium (VI) by Cells Expressing Cytoplasmic or Surface-Displayed ChrB: a Comparative Study Journal of Microbiology and Biotechnology. Jul, 2020 | Pubmed ID: 32238765 Systematic Analysis of a Mitochondrial Disease-causing ND6 Mutation in Mitochondrial Deficiency Molecular Genetics & Genomic Medicine. 05, 2020 | Pubmed ID: 32162843 Primaquine Phosphate Induces the Apoptosis of ATRA-resistant Acute Promyelocytic Leukemia Cells by Inhibition of the NF-κB Pathway Journal of Leukocyte Biology. 04, 2020 | Pubmed ID: 32125014 Comparison of Paired Cerebrospinal Fluid and Serum Cell-free Mitochondrial and Nuclear DNA with Copy Number and Fragment Length Journal of Clinical Laboratory Analysis. Jun, 2020 | Pubmed ID: 32052892 Mutations in FASTKD2 Are Associated with Mitochondrial Disease with Multi-OXPHOS Deficiency Human Mutation. 05, 2020 | Pubmed ID: 31944455 Mutations in TOMM70 Lead to Multi-OXPHOS Deficiencies and Cause Severe Anemia, Lactic Acidosis, and Developmental Delay Journal of Human Genetics. Mar, 2020 | Pubmed ID: 31907385 Development of a Sensitive Bioreporter Without Antibiotic Markers for Detecting Bioavailable Copper in Water Environments Frontiers in Microbiology. 2019 | Pubmed ID: 32038525 Divergent Peptide Presentations of HLA-A30 Alleles Revealed by Structures With Pathogen Peptides Frontiers in Immunology. 2019 | Pubmed ID: 31396224 Biodetection and Bioremediation of Copper Ions in Environmental Water Samples Using a Temperature-controlled, Dual-functional Escherichia Coli Cell Applied Microbiology and Biotechnology. Aug, 2019 | Pubmed ID: 31240366 An Eight-year Epidemiologic Study of Head and Neck Tuberculosis in Texas, USA Tuberculosis (Edinburgh, Scotland). 05, 2019 | Pubmed ID: 31060959 The Protein Kinase Activity of Fructokinase A Specifies the Antioxidant Responses of Tumor Cells by Phosphorylating P62 Science Advances. 04, 2019 | Pubmed ID: 31032410 Upregulation of MicroRNA-21 Promotes Tumorigenesis of Prostate Cancer Cells by Targeting KLF5 Cancer Biology & Therapy. 2019 | Pubmed ID: 31002531 Zinc Toxicity and Iron-Sulfur Cluster Biogenesis in Applied and Environmental Microbiology. 05, 2019 | Pubmed ID: 30824435 Lipase Member H is a Downstream Molecular Target of Hypoxia Inducible Factor-1α and Promotes Papillary Thyroid Carcinoma Cell Migration in BCPAP and KTC-1 Cell Lines Cancer Management and Research. 2019 | Pubmed ID: 30774423 [Variant Analysis for a Pedigree Affected with Limb-girdle Muscular Dystrophy Type 2D] Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. Feb, 2019 | Pubmed ID: 30703231 GALNT6 Promotes Tumorigenicity and Metastasis of Breast Cancer Cell Via β-catenin/MUC1-C Signaling Pathway International Journal of Biological Sciences. 2019 | Pubmed ID: 30662357 The Age-related Changes and Differences in Energy Metabolism and Glutamate-glutamine Recycling in the D-gal-induced and Naturally Occurring Senescent Astrocytes in Vitro Experimental Gerontology. 04, 2019 | Pubmed ID: 30610899 Profiling and Targeting of Cellular Mitochondrial Bioenergetics: Inhibition of Human Gastric Cancer Cell Growth by Carnosine Acta Pharmacologica Sinica. Jul, 2019 | Pubmed ID: 30560903 Oncocytic Tumors Are Marked by Enhanced Mitochondrial Content and MtDNA Mutations of Complex I in Chinese Patients Mitochondrion. 03, 2019 | Pubmed ID: 29386142 Correction: A Novel NDUFS3 Mutation in a Chinese Patient with Severe Leigh Syndrome Journal of Human Genetics. 12, 2018 | Pubmed ID: 30266949 A Novel NDUFS3 Mutation in a Chinese Patient with Severe Leigh Syndrome Journal of Human Genetics. Dec, 2018 | Pubmed ID: 30140060 TIMMDC1 Knockdown Inhibits Growth and Metastasis of Gastric Cancer Cells Through Metabolic Inhibition and AKT/GSK3β/β-Catenin Signaling Pathway International Journal of Biological Sciences. 2018 | Pubmed ID: 30123074 Enhanced ROS Production Leads to Excessive Fat Accumulation Through DAF-16 in Caenorhabditis Elegans Experimental Gerontology. 10, 2018 | Pubmed ID: 30120932 Nicking-enhanced Rolling Circle Amplification for Sensitive Fluorescent Detection of Cancer-related MicroRNAs Analytical and Bioanalytical Chemistry. Oct, 2018 | Pubmed ID: 30066196 Fucosyltransferase 2 Induced Epithelial-mesenchymal Transition Via TGF-β/Smad Signaling Pathway in Lung Adenocarcinaoma Experimental Cell Research. 09, 2018 | Pubmed ID: 30031128 SURF1 Mutations in Chinese Patients with Leigh Syndrome: Novel Mutations, Mutation Spectrum, and the Functional Consequences Gene. Oct, 2018 | Pubmed ID: 29933018 Exploration of DNA Methylation Markers for Diagnosis and Prognosis of Patients with Endometrial Cancer Epigenetics. 2018 | Pubmed ID: 29912667 Mitoferrin-1 is Involved in the Progression of Alzheimer's Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis Elegans Model of Alzheimer's Disease Neuroscience. 08, 2018 | Pubmed ID: 29908215 [Whole Exome Sequencing Analysis for a Chinese Pedigree Affected with X-Linked Intellectual Disability] Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. Jun, 2018 | Pubmed ID: 29896742 Dataset of Mitochondrial Genome Variants in Oncocytic Tumors Data in Brief. Apr, 2018 | Pubmed ID: 29876471 Risk Factors for Extrapulmonary Dissemination of Tuberculosis and Associated Mortality During Treatment for Extrapulmonary Tuberculosis Emerging Microbes & Infections. Jun, 2018 | Pubmed ID: 29872046 Reverse Strand-displacement Amplification Strategy for Rapid Detection of P53 Gene Talanta. Sep, 2018 | Pubmed ID: 29853060 Mebendazole Exhibits Potent Anti-leukemia Activity on Acute Myeloid Leukemia Experimental Cell Research. 08, 2018 | Pubmed ID: 29750898 MtDNA Haplogroup N9a Increases the Risk of Type 2 Diabetes by Altering Mitochondrial Function and Intracellular Mitochondrial Signals Diabetes. 07, 2018 | Pubmed ID: 29735607 A Novel RNA Sequencing-based MiRNA Signature Predicts with Recurrence and Outcome of Hepatocellular Carcinoma Molecular Oncology. 06, 2018 | Pubmed ID: 29719937 Electron Transfer Kinetics of the Mitochondrial Outer Membrane Protein MitoNEET Free Radical Biology & Medicine. 06, 2018 | Pubmed ID: 29704621 Establishment of a Nine-gene Prognostic Model for Predicting Overall Survival of Patients with Endometrial Carcinoma Cancer Medicine. 06, 2018 | Pubmed ID: 29665298 Combination of in Situ Metathesis Reaction with a Novel "magnetic Effervescent Tablet-assisted Ionic Liquid Dispersive Microextraction" for the Determination of Endogenous Steroids in Human Fluids Analytical and Bioanalytical Chemistry. May, 2018 | Pubmed ID: 29532194 Oncogenic HSP60 Regulates Mitochondrial Oxidative Phosphorylation to Support Erk1/2 Activation During Pancreatic Cancer Cell Growth Cell Death & Disease. 02, 2018 | Pubmed ID: 29415987 Serum MiR-486-5p As a Diagnostic Marker in Cervical Cancer: with Investigation of Potential Mechanisms BMC Cancer. 01, 2018 | Pubmed ID: 29316891 Breast Cancer-associated Mitochondrial DNA Haplogroup Promotes Neoplastic Growth Via ROS-mediated AKT Activation International Journal of Cancer. 05, 2018 | Pubmed ID: 29226320 The Interaction Between Mitochondria and Oncoviruses Biochimica Et Biophysica Acta. Molecular Basis of Disease. Feb, 2018 | Pubmed ID: 28962899 Carnosine Inhibits the Proliferation of Human Cervical Gland Carcinoma Cells Through Inhibiting Both Mitochondrial Bioenergetics and Glycolysis Pathways and Retarding Cell Cycle Progression Integrative Cancer Therapies. 03, 2018 | Pubmed ID: 28008780 KAT2A Coupled with the α-KGDH Complex Acts As a Histone H3 Succinyltransferase Nature. 12, 2017 | Pubmed ID: 29211711 Generation and Bioenergetic Profiles of Cybrids with East Asian MtDNA Haplogroups Oxidative Medicine and Cellular Longevity. 2017 | Pubmed ID: 29093766 Synergistic Inhibition of Colon Cancer Growth by the Combination of Methylglyoxal and Silencing of Glyoxalase I Mediated by the STAT1 Pathway Oncotarget. Aug, 2017 | Pubmed ID: 28903386 Metformin Inhibits Tumorigenesis and Tumor Growth of Breast Cancer Cells by Upregulating MiR-200c but Downregulating AKT2 Expression Journal of Cancer. 2017 | Pubmed ID: 28819383 A Complex Association Between DNA Methylation and Gene Expression in Human Placenta at First and Third Trimesters PloS One. 2017 | Pubmed ID: 28704530 MicroRNA-4530 Promotes Angiogenesis by Targeting VASH1 in Breast Carcinoma Cells Oncology Letters. Jul, 2017 | Pubmed ID: 28693142 Anaerobic Copper Toxicity and Iron-Sulfur Cluster Biogenesis in Escherichia Coli Applied and Environmental Microbiology. 08, 2017 | Pubmed ID: 28576762 Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy Molecular Cell. Jun, 2017 | Pubmed ID: 28552616 Plasma-derived Exosomes Contribute to Inflammation Via the TLR9-NF-κB Pathway in Chronic Heart Failure Patients Molecular Immunology. 07, 2017 | Pubmed ID: 28433888 [Analysis of Genome-wide Copy Number Variations Among Fetuses with Abnormalities Detected by Prenatal Ultrasouography] Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. Apr, 2017 | Pubmed ID: 28397213 MiR-93 Promotes Tumorigenesis and Metastasis of Non-Small Cell Lung Cancer Cells by Activating the PI3K/Akt Pathway Via Inhibition of // Journal of Cancer. 2017 | Pubmed ID: 28382150 Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth Via Upregulation of STAT1, P53, and Bax and Downregulation of C-Myc and Bcl-2 International Journal of Molecular Sciences. Mar, 2017 | Pubmed ID: 28282916 Accurate Quantitation of Circulating Cell-free Mitochondrial DNA in Plasma by Droplet Digital PCR Analytical and Bioanalytical Chemistry. Apr, 2017 | Pubmed ID: 28154880 Carnosine Modulates Glutamine Synthetase Expression in Senescent Astrocytes Exposed to Oxygen-glucose Deprivation/recovery Brain Research Bulletin. 04, 2017 | Pubmed ID: 28115195 Structural Basis of Anti-PD-L1 Monoclonal Antibody Avelumab for Tumor Therapy Cell Research. Jan, 2017 | Pubmed ID: 27573173 Novel Mutation of ND4 Gene Identified by Targeted Next-generation Sequencing in Patient with Leigh Syndrome Journal of Human Genetics. Oct, 2016 | Pubmed ID: 27761019 Predictive Value of Serum Bradykinin and DesArg-bradykinin Levels for Chemotherapeutic Responses in Active Tuberculosis Patients: A Retrospective Case Series Tuberculosis (Edinburgh, Scotland). 12, 2016 | Pubmed ID: 27720377 Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in Vivo Microenvironment of Lung Cancer Metastasis ACS Applied Materials & Interfaces. Oct, 2016 | Pubmed ID: 27606718 MicroRNA-21 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer, and Tumor Growth Associated with Down-regulation of Sec23a Expression BMC Cancer. 08, 2016 | Pubmed ID: 27495250 Upregulation of SQSTM1/p62 Contributes to Nickel-induced Malignant Transformation of Human Bronchial Epithelial Cells Autophagy. 10, 2016 | Pubmed ID: 27467530 Methylglyoxal Suppresses Human Colon Cancer Cell Lines and Tumor Growth in a Mouse Model by Impairing Glycolytic Metabolism of Cancer Cells Associated with Down-regulation of C-Myc Expression Cancer Biology & Therapy. 09, 2016 | Pubmed ID: 27455418 Cell Type-Specific Modulation of Respiratory Chain Supercomplex Organization International Journal of Molecular Sciences. Jun, 2016 | Pubmed ID: 27338358 Decreased IL-17 During Treatment of Sputum smear-positive Pulmonary Tuberculosis due to Increased Regulatory T Cells and IL-10 Journal of Translational Medicine. 06, 2016 | Pubmed ID: 27311307 A Novel Technique to Detect EGFR Mutations in Lung Cancer International Journal of Molecular Sciences. May, 2016 | Pubmed ID: 27223277 Telomerase Reverse Transcriptase Promoter Mutations in Hepatitis B Virus-associated Hepatocellular Carcinoma Oncotarget. May, 2016 | Pubmed ID: 27056898 Carnosine Decreased Neuronal Cell Death Through Targeting Glutamate System and Astrocyte Mitochondrial Bioenergetics in Cultured Neuron/astrocyte Exposed to OGD/recovery Brain Research Bulletin. 06, 2016 | Pubmed ID: 27040711 Metformin Inhibits Prostate Cancer Cell Proliferation, Migration, and Tumor Growth Through Upregulation of PEDF Expression Cancer Biology & Therapy. 05, 2016 | Pubmed ID: 26987032 Optimization of a NH4PF6-enhanced, Non-organic Solvent, Dual Microextraction Method for Determination of Phthalate Metabolites in Urine by High Performance Liquid Chromatography Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Mar, 2016 | Pubmed ID: 26852090 His-87 Ligand in MitoNEET is Crucial for the Transfer of Iron Sulfur Clusters from Mitochondria to Cytosolic Aconitase Biochemical and Biophysical Research Communications. Jan, 2016 | Pubmed ID: 26778000 EGFR Phosphorylates FAM129B to Promote Ras Activation Proceedings of the National Academy of Sciences of the United States of America. Jan, 2016 | Pubmed ID: 26721396 Mitochondrial DNA Haplogroups Modify the Risk of Osteoarthritis by Altering Mitochondrial Function and Intracellular Mitochondrial Signals Biochimica Et Biophysica Acta. 04, 2016 | Pubmed ID: 26705675 Mitochondrial Common Deletion is Elevated in Blood of Breast Cancer Patients Mediated by Oxidative Stress Mitochondrion. Jan, 2016 | Pubmed ID: 26678158 [Effect of Mitochondrial DNA 5178 C/A Polymorphism on Risks for Type 2 Diabetes Mellitus and Its Complications] Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. Dec, 2015 | Pubmed ID: 26663065 An Investigation on the Population Structure of Mixed Infections of Mycobacterium Tuberculosis in Inner Mongolia, China Tuberculosis (Edinburgh, Scotland). Dec, 2015 | Pubmed ID: 26542224 Secreted and O-GlcNAcylated MIF Binds to the Human EGF Receptor and Inhibits Its Activation Nature Cell Biology. Oct, 2015 | Pubmed ID: 26280537 [Investigation of a Family with Kennedy Disease by Genetic Analysis] Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. Dec, 2014 | Pubmed ID: 25449081 [NK4 Growth Inhibition of Human Raji Lymphoma Xenografts by Competitive Interrupting HGF/Met Signal Pathway] Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology. Aug, 2014 | Pubmed ID: 25346127 [Establishment and Application of Quantitative Detection for Heteroplasmic MtDNA Mutation 3243A→G] Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. Aug, 2014 | Pubmed ID: 25119906 Stabiliteit en structuur van Vleermuis Major Histocompatibiliteit Complexe Klasse I met Heterologe β2-Microglobuline Di Zhang*1,2, Kefang Liu*3,4, Dan Lu*2,5, Pengyan Wang1,2, Qingxu Zhang1,2, Peipei Liu2, Yingze Zhao2, Yan Chai4, Jianxin Lyu1, Jianxun Qi4, William J. Liu1,2 1School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 2NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 3Faculty of Health Sciences, University of Macau, 4CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 5Savaid Medical School, University of Chinese Academy of Sciences JoVE 61462 Immunologie et Infection
Stabiliteit en structuur van Vleermuis Major Histocompatibiliteit Complexe Klasse I met Heterologe β2-Microglobuline Di Zhang*1,2, Kefang Liu*3,4, Dan Lu*2,5, Pengyan Wang1,2, Qingxu Zhang1,2, Peipei Liu2, Yingze Zhao2, Yan Chai4, Jianxin Lyu1, Jianxun Qi4, William J. Liu1,2 1School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 2NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 3Faculty of Health Sciences, University of Macau, 4CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 5Savaid Medical School, University of Chinese Academy of Sciences JoVE 61462 Immunologie et Infection