Johannes Loffing Institute of Anatomy, Swiss National Centre of Competence in Research Kidney University of Zürich Biography Publications Institution JoVE Articles Johannes Loffing has not added a biography. If you are Johannes Loffing and would like to personalize this page please email our Author Liaison for assistance. Publications Extracellular K(+) Rapidly Controls NaCl Cotransporter Phosphorylation in the Native Distal Convoluted Tubule by Cl(-) -dependent and Independent Mechanisms The Journal of Physiology. Nov, 2016 | Pubmed ID: 27457700 TRPV4 is Associated with Central Rather Than Nephrogenic Osmoregulation Pflugers Archiv : European Journal of Physiology. Sep, 2016 | Pubmed ID: 27364478 The Authors Reply Kidney International. May, 2016 | Pubmed ID: 27083290 Renal Tubular SGK1 Deficiency Causes Impaired K+ Excretion Via Loss of Regulation of NEDD4-2/WNK1 and ENaC American Journal of Physiology. Renal Physiology. Aug, 2016 | Pubmed ID: 27009335 The Mineralocorticoid Receptor (MR) Regulates ENaC but Not NCC in Mice with Random MR Deletion Pflugers Archiv : European Journal of Physiology. May, 2016 | Pubmed ID: 26898302 Adult Nephron-specific MR-deficient Mice Develop a Severe Renal PHA-1 Phenotype Pflugers Archiv : European Journal of Physiology. May, 2016 | Pubmed ID: 26762397 Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit Journal of the American Society of Nephrology : JASN. Aug, 2016 | Pubmed ID: 26701978 Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus Journal of the American Society of Nephrology : JASN. Jul, 2016 | Pubmed ID: 26574046 An Integrated View of Potassium Homeostasis The New England Journal of Medicine. Oct, 2015 | Pubmed ID: 26510040 Rab-GAP TBC1D4 (AS160) is Dispensable for the Renal Control of Sodium and Water Homeostasis but Regulates GLUT4 in Mouse Kidney American Journal of Physiology. Renal Physiology. Nov, 2015 | Pubmed ID: 26336159 The Rho-GTPase Binding Protein IQGAP2 is Required for the Glomerular Filtration Barrier Kidney International. Nov, 2015 | Pubmed ID: 26154927 ENaC Activity in Collecting Ducts Modulates NCC in Cirrhotic Mice Pflugers Archiv : European Journal of Physiology. Dec, 2015 | Pubmed ID: 26055235 Deletion of Both Rab-GTPase-activating Proteins TBC14KO and TBC1D4 in Mice Eliminates Insulin- and AICAR-stimulated Glucose Transport. Diabetes 2015;64:746-759 Diabetes. Apr, 2015 | Pubmed ID: 25805765 Akt Substrate of 160 KD Regulates Na+,K+-ATPase Trafficking in Response to Energy Depletion and Renal Ischemia Journal of the American Society of Nephrology : JASN. Nov, 2015 | Pubmed ID: 25788531 Dietary Potassium and the Renal Control of Salt Balance and Blood Pressure Pflugers Archiv : European Journal of Physiology. Mar, 2015 | Pubmed ID: 25559844 “Deletion of Both Rab-GTPase–activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-stimulated Glucose Transport [corrected] Diabetes. Mar, 2015 | Pubmed ID: 25249576 Mechanisms of Renal Control of Potassium Homeostasis in Complete Aldosterone Deficiency Journal of the American Society of Nephrology : JASN. Feb, 2015 | Pubmed ID: 25071088 Gitelman Syndrome and Glomerular Proteinuria: a Link Between Loss of Sodium-chloride Cotransporter and Podocyte Dysfunction? Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Sep, 2014 | Pubmed ID: 25165177 Sympathetic Stimulation of Thiazide-sensitive Sodium Chloride Cotransport in the Generation of Salt-sensitive Hypertension Hypertension (Dallas, Tex. : 1979). Jul, 2014 | Pubmed ID: 24799612 Common Variants in UMOD Associate with Urinary Uromodulin Levels: a Meta-analysis Journal of the American Society of Nephrology : JASN. Aug, 2014 | Pubmed ID: 24578125 Hydrochlorothiazide Attenuates Lithium-induced Nephrogenic Diabetes Insipidus Independently of the Sodium-chloride Cotransporter American Journal of Physiology. Renal Physiology. Mar, 2014 | Pubmed ID: 24352504 The Sodium Chloride Cotransporter SLC12A3: New Roles in Sodium, Potassium, and Blood Pressure Regulation Pflugers Archiv : European Journal of Physiology. Jan, 2014 | Pubmed ID: 24310820 Protein Phosphatase 1 Inhibitor-1 Deficiency Reduces Phosphorylation of Renal NaCl Cotransporter and Causes Arterial Hypotension Journal of the American Society of Nephrology : JASN. Mar, 2014 | Pubmed ID: 24231659 Common Noncoding UMOD Gene Variants Induce Salt-sensitive Hypertension and Kidney Damage by Increasing Uromodulin Expression Nature Medicine. Dec, 2013 | Pubmed ID: 24185693 Mice Carrying Ubiquitin-specific Protease 2 (Usp2) Gene Inactivation Maintain Normal Sodium Balance and Blood Pressure American Journal of Physiology. Renal Physiology. Jul, 2013 | Pubmed ID: 23552861 Rapid Dephosphorylation of the Renal Sodium Chloride Cotransporter in Response to Oral Potassium Intake in Mice Kidney International. May, 2013 | Pubmed ID: 23447069 Renal Tubular NEDD4-2 Deficiency Causes NCC-mediated Salt-dependent Hypertension The Journal of Clinical Investigation. Feb, 2013 | Pubmed ID: 23348737 Parvalbumin: Calcium and Magnesium Buffering in the Distal Nephron Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Nov, 2012 | Pubmed ID: 23144069 Low-dose Oral Sirolimus and the Risk of Menstrual-cycle Disturbances and Ovarian Cysts: Analysis of the Randomized Controlled SUISSE ADPKD Trial PloS One. 2012 | Pubmed ID: 23071528 Aldosterone Deficiency Adversely Affects Pregnancy Outcome in Mice Pflugers Archiv : European Journal of Physiology. Oct, 2012 | Pubmed ID: 22941338 Aldosterone-dependent and -independent Regulation of the Epithelial Sodium Channel (ENaC) in Mouse Distal Nephron American Journal of Physiology. Renal Physiology. Nov, 2012 | Pubmed ID: 22933298 A Primary Culture of Distal Convoluted Tubules Expressing Functional Thiazide-sensitive NaCl Transport American Journal of Physiology. Renal Physiology. Sep, 2012 | Pubmed ID: 22759396 Immunofluorescent Localization of the Rab-GAP Protein TBC1D4 (AS160) in Mouse Kidney Histochemistry and Cell Biology. Jul, 2012 | Pubmed ID: 22466139 Inducible Renal Principal Cell-specific Mineralocorticoid Receptor Gene Inactivation in Mice American Journal of Physiology. Renal Physiology. Mar, 2011 | Pubmed ID: 21383102 Vasopressin-dependent Coupling Between Sodium Transport and Water Flow in a Mouse Cortical Collecting Duct Cell Line Kidney International. Apr, 2011 | Pubmed ID: 21178974 AlphaENaC-mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus Journal of the American Society of Nephrology : JASN. Feb, 2011 | Pubmed ID: 21051735 Decreased ENaC Expression Compensates the Increased NCC Activity Following Inactivation of the Kidney-specific Isoform of WNK1 and Prevents Hypertension Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010 | Pubmed ID: 20921400 In Vivo Nuclear Translocation of Mineralocorticoid and Glucocorticoid Receptors in Rat Kidney: Differential Effect of Corticosteroids Along the Distal Tubule American Journal of Physiology. Renal Physiology. Dec, 2010 | Pubmed ID: 20861076 Thiazide Effects and Adverse Effects: Insights from Molecular Genetics Hypertension (Dallas, Tex. : 1979). Aug, 2009 | Pubmed ID: 19564550 Regulated Sodium Transport in the Renal Connecting Tubule (CNT) Via the Epithelial Sodium Channel (ENaC) Pflügers Archiv : European Journal of Physiology. May, 2009 | Pubmed ID: 19277701 Upregulation of Apical Sodium-chloride Cotransporter and Basolateral Chloride Channels is Responsible for the Maintenance of Salt-sensitive Hypertension American Journal of Physiology. Renal Physiology. Aug, 2008 | Pubmed ID: 18480177 Mouse Model of Type II Bartter's Syndrome. II. Altered Expression of Renal Sodium- and Water-transporting Proteins American Journal of Physiology. Renal Physiology. Jun, 2008 | Pubmed ID: 18322017 Renal Expression of Parvalbumin is Critical for NaCl Handling and Response to Diuretics Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17804801 Impairment of Sodium Balance in Mice Deficient in Renal Principal Cell Mineralocorticoid Receptor Journal of the American Society of Nephrology : JASN. Jun, 2007 | Pubmed ID: 17475815 Replication of Segment-specific and Intercalated Cells in the Mouse Renal Collecting System Histochemistry and Cell Biology. Apr, 2007 | Pubmed ID: 17186265 Pendrin Regulation in Mouse Kidney Primarily is Chloride-dependent Journal of the American Society of Nephrology : JASN. Aug, 2006 | Pubmed ID: 16825334 Dietary Sodium Intake Regulates the Ubiquitin-protein Ligase Nedd4-2 in the Renal Collecting System Journal of the American Society of Nephrology : JASN. May, 2006 | Pubmed ID: 16571785 Sgk Kinases and Their Role in Epithelial Transport Annual Review of Physiology. 2006 | Pubmed ID: 16460280 Luminal Kidney and Intestine SLC6 Amino Acid Transporters of B0AT-cluster and Their Tissue Distribution in Mus Musculus American Journal of Physiology. Renal Physiology. Feb, 2006 | Pubmed ID: 16174864 Hyperaldosteronemia and Activation of the Epithelial Sodium Channel Are Not Required for Sodium Retention in Puromycin-induced Nephrosis Journal of the American Society of Nephrology : JASN. Dec, 2005 | Pubmed ID: 16267158 Tissue Kallikrein-deficient Mice Display a Defect in Renal Tubular Calcium Absorption Journal of the American Society of Nephrology : JASN. Dec, 2005 | Pubmed ID: 16251243 Functional Domains of the Epithelial Sodium Channel Journal of the American Society of Nephrology : JASN. Nov, 2005 | Pubmed ID: 16192417 Progesterone Down-regulates the Open Probability of the Amiloride-sensitive Epithelial Sodium Channel Via a Nedd4-2-dependent Mechanism The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16172119 Aldosterone-induced Serum and Glucocorticoid-induced Kinase 1 Expression is Accompanied by Nedd4-2 Phosphorylation and Increased Na+ Transport in Cortical Collecting Duct Cells Journal of the American Society of Nephrology : JASN. Aug, 2005 | Pubmed ID: 15958725 Sodium Retention in Rats with Liver Cirrhosis is Associated with Increased Renal Abundance of NaCl Cotransporter (NCC) Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Sep, 2005 | Pubmed ID: 15956070 Enhanced Passive Ca2+ Reabsorption and Reduced Mg2+ Channel Abundance Explains Thiazide-induced Hypocalciuria and Hypomagnesemia The Journal of Clinical Investigation. Jun, 2005 | Pubmed ID: 15902302 Characterization of Renal Interstitial Fibroblast-specific Protein 1/S100A4-positive Cells in Healthy and Inflamed Rodent Kidneys Histochemistry and Cell Biology. Jun, 2005 | Pubmed ID: 15856273 Mineralocorticoid Versus Glucocorticoid Receptor Occupancy Mediating Aldosterone-stimulated Sodium Transport in a Novel Renal Cell Line Journal of the American Society of Nephrology : JASN. Apr, 2005 | Pubmed ID: 15743993 Role of Sgk1 in Salt and Potassium Homeostasis American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jan, 2005 | Pubmed ID: 15590995 Paradoxical Antidiuretic Effect of Thiazides in Diabetes Insipidus: Another Piece in the Puzzle Journal of the American Society of Nephrology : JASN. Nov, 2004 | Pubmed ID: 15504949 Sodium and Potassium Handling by the Aldosterone-sensitive Distal Nephron: the Pivotal Role of the Distal and Connecting Tubule American Journal of Physiology. Renal Physiology. Oct, 2004 | Pubmed ID: 15345493 Altered Renal Distal Tubule Structure and Renal Na(+) and Ca(2+) Handling in a Mouse Model for Gitelman's Syndrome Journal of the American Society of Nephrology : JASN. Sep, 2004 | Pubmed ID: 15339977 Loss-of-function Mutations of the K(+) Channel Gene KCNJ2 Constitute a Rare Cause of Long QT Syndrome Journal of Molecular and Cellular Cardiology. Aug, 2004 | Pubmed ID: 15276028 A Naturally Occurring Human Nedd4-2 Variant Displays Impaired ENaC Regulation in Xenopus Laevis Oocytes American Journal of Physiology. Renal Physiology. Sep, 2004 | Pubmed ID: 15140763 Impaired Regulation of Renal K+ Elimination in the Sgk1-knockout Mouse Journal of the American Society of Nephrology : JASN. Apr, 2004 | Pubmed ID: 15034090 Dysfunction of the Epithelial Sodium Channel Expressed in the Kidney of a Mouse Model for Liddle Syndrome Journal of the American Society of Nephrology : JASN. Sep, 2003 | Pubmed ID: 12937297 Collecting Duct-specific Gene Inactivation of AlphaENaC in the Mouse Kidney Does Not Impair Sodium and Potassium Balance The Journal of Clinical Investigation. Aug, 2003 | Pubmed ID: 12925696 Thiazide-induced Hypocalciuria is Accompanied by a Decreased Expression of Ca2+ Transport Proteins in Kidney Kidney International. Aug, 2003 | Pubmed ID: 12846750 SGK1: Aldosterone-induced Relay of Na+ Transport Regulation in Distal Kidney Nephron Cells Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2003 | Pubmed ID: 12649599 Sodium and Calcium Transport Pathways Along the Mammalian Distal Nephron: from Rabbit to Human American Journal of Physiology. Renal Physiology. Apr, 2003 | Pubmed ID: 12620920 Impaired Renal Na(+) Retention in the Sgk1-knockout Mouse The Journal of Clinical Investigation. Nov, 2002 | Pubmed ID: 12417564 Human Cortical Distal Nephron: Distribution of Electrolyte and Water Transport Pathways Journal of the American Society of Nephrology : JASN. Apr, 2002 | Pubmed ID: 11912242 Cell-surface Expression of the Channel Activating Protease XCAP-1 is Required for Activation of ENaC in the Xenopus Oocyte Journal of the American Society of Nephrology : JASN. Mar, 2002 | Pubmed ID: 11856761 A Golgi-associated PDZ Domain Protein Modulates Cystic Fibrosis Transmembrane Regulator Plasma Membrane Expression The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11707463 The Mouse Isolated Perfused Kidney Technique Jan Czogalla1, Frank Schweda2, Johannes Loffing1 1Institute of Anatomy, Swiss National Centre of Competence in Research Kidney, University of Zürich, 2Department of Physiology, University of Regensburg JoVE 54712 Biologie
The Mouse Isolated Perfused Kidney Technique Jan Czogalla1, Frank Schweda2, Johannes Loffing1 1Institute of Anatomy, Swiss National Centre of Competence in Research Kidney, University of Zürich, 2Department of Physiology, University of Regensburg JoVE 54712 Biologie