John B. Bruning School of Biological Sciences The University of Adelaide Biography Publications Institution JoVE Articles John B. Bruning has not added a biography. If you are John B. Bruning and would like to personalize this page please email our Author Liaison for assistance. Publications Vanishing White Matter: Eukaryotic Initiation Factor 2B Model and the Impact of Missense Mutations Molecular Genetics & Genomic Medicine. Jan, 2021 | Pubmed ID: 33432707 Nucleoside Selectivity of Aspergillus Fumigatus Nucleoside-diphosphate Kinase The FEBS Journal. Oct, 2020 | Pubmed ID: 33089641 D-Alanine-d-alanine Ligase As a Model for the Activation of ATP-grasp Enzymes by Monovalent Cations The Journal of Biological Chemistry. 06, 2020 | Pubmed ID: 32335509 An Aldo-keto Reductase with 2-keto-l-gulonate Reductase Activity Functions in L-tartaric Acid Biosynthesis from Vitamin C in The Journal of Biological Chemistry. 11, 2019 | Pubmed ID: 31488549 Combining Random Microseed Matrix Screening and the Magic Triangle for the Efficient Structure Solution of a Potential Lysin from Bacteriophage P68 Acta Crystallographica. Section D, Structural Biology. Jul, 2019 | Pubmed ID: 31282476 Obtaining Crystals of PPARγ Ligand Binding Domain Bound to Small Molecules Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31041754 Shooting Three Inflammatory Targets with a Single Bullet: Novel Multi-targeting Anti-inflammatory Glitazones European Journal of Medicinal Chemistry. Apr, 2019 | Pubmed ID: 30818268 Structure, Mechanism, and Inhibition of Thioredoxin Reductase Antimicrobial Agents and Chemotherapy. 03, 2019 | Pubmed ID: 30642940 Structural and Dynamic Elucidation of a Non-acid PPAR Partial Agonist: SR1988 Nuclear Receptor Research. 2018 | Pubmed ID: 30906767 Precipitant-ligand Exchange Technique Reveals the ADP Binding Mode in Mycobacterium Tuberculosis Dethiobiotin Synthetase Acta Crystallographica. Section D, Structural Biology. Oct, 2018 | Pubmed ID: 30289406 Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism Structure (London, England : 1993). 11, 2018 | Pubmed ID: 30146169 PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix IScience. Feb, 2018 | Pubmed ID: 30123887 Rational Design of a 3 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2018 | Pubmed ID: 29917264 HDX Reveals the Conformational Dynamics of DNA Sequence Specific VDR Co-activator Interactions Nature Communications. 10, 2017 | Pubmed ID: 29030554 X-ray Crystal Structure of Rivoglitazone Bound to PPARγ and PPAR Subtype Selectivity of TZDs Biochimica Et Biophysica Acta. General Subjects. Aug, 2017 | Pubmed ID: 28499821 Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics Journal of Medicinal Chemistry. 06, 2017 | Pubmed ID: 28485590 Structure of the Sliding Clamp from the Fungal Pathogen Aspergillus Fumigatus (AfumPCNA) and Interactions with Human P21 The FEBS Journal. 03, 2017 | Pubmed ID: 28165677 SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism ACS Chemical Biology. Jan, 2016 | Pubmed ID: 26579553 Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism PPAR Research. 2015 | Pubmed ID: 26435709 Structural Mechanism for Signal Transduction in RXR Nuclear Receptor Heterodimers Nature Communications. Aug, 2015 | Pubmed ID: 26289479 Pharmacological Repression of PPARγ Promotes Osteogenesis Nature Communications. Jun, 2015 | Pubmed ID: 26068133 New Insights into the Evolutionary History of Plant Sorbitol Dehydrogenase BMC Plant Biology. Apr, 2015 | Pubmed ID: 25879735 Macrocyclic Protease Inhibitors with Reduced Peptide Character Angewandte Chemie (International Ed. in English). Jul, 2014 | Pubmed ID: 24903745 Human Variants in the Neuronal Basic Helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function PloS One. 2014 | Pubmed ID: 24465693 Derivatization af Protein Krystaller med I3C ved hjælp af Random Microseed Matrix Screening Jia Quyen Truong*1, Stephanie Nguyen*1,2, John B. Bruning1,2, Keith E. Shearwin1 1School of Biological Sciences, The University of Adelaide, 2Institute of Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide JoVE 61894 Biochimie
Derivatization af Protein Krystaller med I3C ved hjælp af Random Microseed Matrix Screening Jia Quyen Truong*1, Stephanie Nguyen*1,2, John B. Bruning1,2, Keith E. Shearwin1 1School of Biological Sciences, The University of Adelaide, 2Institute of Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide JoVE 61894 Biochimie