John C. Schimenti Department of Biomedical Sciences Cornell University Biography Publications Institution JoVE Articles John C. Schimenti has not added a biography. If you are John C. Schimenti and would like to personalize this page please email our Author Liaison for assistance. Publications The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure Molecular Cell. Sep, 2017 | Pubmed ID: 28844861 Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death Genetics. 08, 2017 | Pubmed ID: 28576861 Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog Genetics. 02, 2017 | Pubmed ID: 27986806 The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice Genetics. 08, 2016 | Pubmed ID: 27280691 L. C. Dunn and Donald Charles on Quantitative Traits in the Mouse Genetics. Mar, 2016 | Pubmed ID: 26953264 Transcriptional Profiling of Cortical Versus Cancellous Bone from Mechanically-loaded Murine Tibiae Reveals Differential Gene Expression Bone. May, 2016 | Pubmed ID: 26876048 Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, MicroRNA-Assisted MCM2-7 Downregulation PLoS Genetics. Jan, 2016 | Pubmed ID: 26765334 MCM9 Deficiency Delays Primordial Germ Cell Proliferation Independent of the ATM Pathway Genesis (New York, N.Y. : 2000). Nov, 2015 | Pubmed ID: 26388201 The Genetics of Human Infertility by Functional Interrogation of SNPs in Mice Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26240362 Mechanism and Regulation of Rapid Telomere Prophase Movements in Mouse Meiotic Chromosomes Cell Reports. Apr, 2015 | Pubmed ID: 25892231 Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male Mice Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Aug, 2015 | Pubmed ID: 25707500 Mouse BRWD1 is Critical for Spermatid Postmeiotic Transcription and Female Meiotic Chromosome Stability The Journal of Cell Biology. Jan, 2015 | Pubmed ID: 25547156 A Mouse Geneticist's Practical Guide to CRISPR Applications Genetics. Jan, 2015 | Pubmed ID: 25271304 A Method for Isolating High Quality RNA from Mouse Cortical and Cancellous Bone Bone. Nov, 2014 | Pubmed ID: 25073031 Hypersensitivity of Primordial Germ Cells to Compromised Replication-associated DNA Repair Involves ATM-p53-p21 Signaling PLoS Genetics. Jul, 2014 | Pubmed ID: 25010009 Applying "gold Standards" to In-vitro-derived Germ Cells Cell. Jun, 2014 | Pubmed ID: 24906145 Induced Pluripotent Stem Cells Have Similar Immunogenic and More Potent Immunomodulatory Properties Compared with Bone Marrow-derived Stromal Cells in Vitro Regenerative Medicine. 2014 | Pubmed ID: 24773530 MiR-34 Cooperates with P53 in Suppression of Prostate Cancer by Joint Regulation of Stem Cell Compartment Cell Reports. Mar, 2014 | Pubmed ID: 24630988 STAG3 is a Strong Candidate Gene for Male Infertility Human Molecular Genetics. Jul, 2014 | Pubmed ID: 24608227 Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway Science (New York, N.Y.). Jan, 2014 | Pubmed ID: 24482479 IQ Motif-containing G (Iqcg) is Required for Mouse Spermiogenesis G3 (Bethesda, Md.). Feb, 2014 | Pubmed ID: 24362311 Female Mice Lacking Estrogen Receptor-alpha in Osteoblasts Have Compromised Bone Mass and Strength Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Feb, 2014 | Pubmed ID: 24038209 Role of DNA Damage Response Pathways in Preventing Carcinogenesis Caused by Intrinsic Replication Stress Oncogene. Jul, 2014 | Pubmed ID: 23975433 AKAP9 is Essential for Spermatogenesis and Sertoli Cell Maturation in Mice Genetics. Jun, 2013 | Pubmed ID: 23608191 Un Fattore Di Trascrizione Antica Inizia La Raffica Di PiRNA Produzione Durante La Meiosi Precoce Nei Testicoli Del Mouse Molecular Cell. Apr, 2013 | Pubmed ID: 23523368 The MCM8-MCM9 Complex Promotes RAD51 Recruitment at DNA Damage Sites to Facilitate Homologous Recombination Molecular and Cellular Biology. Apr, 2013 | Pubmed ID: 23401855 Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility PLoS Genetics. 2012 | Pubmed ID: 23133405 Meiosis Arrest Female 1 (MARF1) Has Nuage-like Function in Mammalian Oocytes Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23090997 Tissue-specific Functional Networks for Prioritizing Phenotype and Disease Genes PLoS Computational Biology. 2012 | Pubmed ID: 23028291 Using Genetic Networks and Homology to Understand the Evolution of Phenotypic Traits Current Genomics. Mar, 2012 | Pubmed ID: 22942677 Genetics of Meiosis and Recombination in Mice International Review of Cell and Molecular Biology. 2012 | Pubmed ID: 22878107 Genetic Background Affects Induced Pluripotent Stem Cell Generation Stem Cell Research & Therapy. Aug, 2012 | Pubmed ID: 22862934 Comparative Oncogenomics Implicates the Neurofibromin 1 Gene (NF1) As a Breast Cancer Driver Genetics. Oct, 2012 | Pubmed ID: 22851646 MARF1 Regulates Essential Oogenic Processes in Mice Science (New York, N.Y.). Mar, 2012 | Pubmed ID: 22442484 Post-transcriptional Homeostasis and Regulation of MCM2-7 in Mammalian Cells Nucleic Acids Research. Jun, 2012 | Pubmed ID: 22362746 MCM4 Mutation Causes Adrenal Failure, Short Stature, and Natural Killer Cell Deficiency in Humans The Journal of Clinical Investigation. Mar, 2012 | Pubmed ID: 22354170 Phosphorylation of Chromosome Core Components May Serve As Axis Marks for the Status of Chromosomal Events During Mammalian Meiosis PLoS Genetics. Feb, 2012 | Pubmed ID: 22346761 Spata22, a Novel Vertebrate-specific Gene, is Required for Meiotic Progress in Mouse Germ Cells Biology of Reproduction. Feb, 2012 | Pubmed ID: 22011390 Haploid Embryonic Stem Cells and the Dominance of Recessive Traits Cell Stem Cell. Dec, 2011 | Pubmed ID: 22136917 Minichromosome Maintenance Helicase Paralog MCM9 is Dispensible for DNA Replication but Functions in Germ-line Stem Cells and Tumor Suppression Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21987787 Genetic Evidence That Synaptonemal Complex Axial Elements Govern Recombination Pathway Choice in Mice Genetics. Sep, 2011 | Pubmed ID: 21750255 A-MYB (MYBL1) Transcription Factor is a Master Regulator of Male Meiosis Development (Cambridge, England). Aug, 2011 | Pubmed ID: 21750041 A Reduction of Licensed Origins Reveals Strain-specific Replication Dynamics in Mice Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2011 | Pubmed ID: 21611832 Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, As an E3 SUMO Ligase Genes. Dec, 2010 | Pubmed ID: 21779533 High Resolution Mapping and Positional Cloning of ENU-induced Mutations in the Rw Region of Mouse Chromosome 5 BMC Genetics. Nov, 2010 | Pubmed ID: 21118569 Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress PLoS Genetics. Sep, 2010 | Pubmed ID: 20838603 The Full-length Isoform of the Mouse Pleckstrin Homology Domain-interacting Protein (PHIP) is Required for Postnatal Growth FEBS Letters. Sep, 2010 | Pubmed ID: 20816727 PDCD2 is Essential for Inner Cell Mass Development and Embryonic Stem Cell Maintenance Developmental Biology. Nov, 2010 | Pubmed ID: 20813103 An Allele Separating Skeletal Patterning and Spermatogonial Renewal Functions of PLZF BMC Developmental Biology. Mar, 2010 | Pubmed ID: 20338044 Deficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress and Embryonic Lethality The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20197277 SEL1L Deficiency Impairs Growth and Differentiation of Pancreatic Epithelial Cells BMC Developmental Biology. Feb, 2010 | Pubmed ID: 20170518 Aneuploidy and Improved Growth Are Coincident but Not Causal in a Yeast Cancer Model PLoS Biology. Jul, 2009 | Pubmed ID: 19636358 Mouse H6 Homeobox 1 (Hmx1) Mutations Cause Cranial Abnormalities and Reduced Body Mass BMC Developmental Biology. Apr, 2009 | Pubmed ID: 19379485 Development and Use of DNA Archives at Veterinary Teaching Hospitals to Investigate the Genetic Basis of Disease in Dogs Journal of the American Veterinary Medical Association. Jan, 2009 | Pubmed ID: 19119968 The Dual Bromodomain and WD Repeat-containing Mouse Protein BRWD1 is Required for Normal Spermiogenesis and the Oocyte-embryo Transition Developmental Biology. May, 2008 | Pubmed ID: 18353305 Mutation in Mouse Hei10, an E3 Ubiquitin Ligase, Disrupts Meiotic Crossing Over PLoS Genetics. Aug, 2007 | Pubmed ID: 17784788 Mouse Pachytene Checkpoint 2 (trip13) is Required for Completing Meiotic Recombination but Not Synapsis PLoS Genetics. Aug, 2007 | Pubmed ID: 17696610 Different Regulatory Systems Operate in the Midpiece and Principal Piece of the Mammalian Sperm Flagellum Society of Reproduction and Fertility Supplement. 2007 | Pubmed ID: 17644973 A Dominant, Recombination-defective Allele of Dmc1 Causing Male-specific Sterility PLoS Biology. May, 2007 | Pubmed ID: 17425408 Mutation of a Ubiquitously Expressed Mouse Transmembrane Protein (Tapt1) Causes Specific Skeletal Homeotic Transformations Genetics. Feb, 2007 | Pubmed ID: 17151244 The Translesion DNA Polymerase Theta Plays a Dominant Role in Immunoglobulin Gene Somatic Hypermutation The EMBO Journal. Nov, 2005 | Pubmed ID: 16222339 Random Mutagenesis of Proximal Mouse Chromosome 5 Uncovers Predominantly Embryonic Lethal Mutations Genome Research. Aug, 2005 | Pubmed ID: 16024820 The Mouse Genomic Instability Mutation Chaos1 is an Allele of Polq That Exhibits Genetic Interaction with Atm Molecular and Cellular Biology. Dec, 2004 | Pubmed ID: 15542845 Tutta Monte immunofluorescenza e quantificazione del follicolo delle ovaie coltivati del topo Vera D. Rinaldi1, Jordana C. Bloom2, John C. Schimenti1,2 1Department of Biomedical Sciences, Cornell University, 2Department of Molecular Biology and Genetics, Cornell University JoVE 57593 Biologie du développement
Tutta Monte immunofluorescenza e quantificazione del follicolo delle ovaie coltivati del topo Vera D. Rinaldi1, Jordana C. Bloom2, John C. Schimenti1,2 1Department of Biomedical Sciences, Cornell University, 2Department of Molecular Biology and Genetics, Cornell University JoVE 57593 Biologie du développement