Jong-Ik Hwang Graduate School of Medicine Korea University Biography Publications Institution JoVE Articles Jong-Ik Hwang has not added a biography. If you are Jong-Ik Hwang and would like to personalize this page please email our Author Liaison for assistance. Publications Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight Frontiers in Neuroscience. 2019 | Pubmed ID: 31057364 SP-8356, a (1S)-(-)-verbenone Derivative, Exerts in Vitro and in Vivo Anti-breast Cancer Effects by Inhibiting NF-κB Signaling Scientific Reports. Apr, 2019 | Pubmed ID: 31036845 Generation by Somatic Cell Nuclear Transfer of GGTA1 Knockout Pigs Expressing Soluble Human TNFRI-Fc and Human HO-1 Transgenic Research. 02, 2019 | Pubmed ID: 30552552 Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction Between Macrophages and Alveolar Epithelial Cells Scientific Reports. Dec, 2018 | Pubmed ID: 30510259 Conformational Signatures in β-arrestin2 Reveal Natural Biased Agonism at a G-protein-coupled Receptor Communications Biology. 2018 | Pubmed ID: 30272007 Nafamostat Mesilate Negatively Regulates the Metastasis of Triple-negative Breast Cancer Cells Archives of Pharmacal Research. Feb, 2018 | Pubmed ID: 29196918 Generation of CMAHKO/GTKO/shTNFRI-Fc/HO-1 Quadruple Gene Modified Pigs Transgenic Research. 08, 2017 | Pubmed ID: 28553699 The Accessory Proteins REEP5 and REEP6 Refine CXCR1-mediated Cellular Responses and Lung Cancer Progression Scientific Reports. 12, 2016 | Pubmed ID: 27966653 Human Antibody Reactivity Against Xenogeneic N-glycolylneuraminic Acid and Galactose-α-1,3-galactose Antigen Xenotransplantation. 07, 2016 | Pubmed ID: 27373998 Ninjurin1 Inhibits Colitis-mediated Colon Cancer Development and Growth by Suppression of Macrophage Infiltration Through Repression of FAK Signaling Oncotarget. May, 2016 | Pubmed ID: 27127177 Characterization of Functional Domains in NME1L Regulation of NF-κB Signaling Molecules and Cells. May, 2016 | Pubmed ID: 27094059 Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice Scientific Reports. Feb, 2016 | Pubmed ID: 26907960 Ninjurin1 Suppresses Metastatic Property of Lung Cancer Cells Through Inhibition of Interleukin 6 Signaling Pathway International Journal of Cancer. 07, 2016 | Pubmed ID: 26815582 Beneficial Effects of the Transgenic Expression of Human STNF-αR-Fc and HO-1 on Pig-to-mouse Islet Xenograft Survival Transplant Immunology. Feb, 2016 | Pubmed ID: 26777482 NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells Journal of Cellular Biochemistry. Jun, 2016 | Pubmed ID: 26565392 Prevertebrate Local Gene Duplication Facilitated Expansion of the Neuropeptide GPCR Superfamily Molecular Biology and Evolution. Nov, 2015 | Pubmed ID: 26337547 Dimer of Arfaptin 2 Regulates NF-κB Signaling by Interacting with IKKβ/NEMO and Inhibiting IKKβ Kinase Activity Cellular Signalling. Nov, 2015 | Pubmed ID: 26296658 Human Thrombomodulin Regulates Complement Activation As Well As the Coagulation Cascade in Xeno-immune Response Xenotransplantation. Jul-Aug, 2015 | Pubmed ID: 26179123 Ligand Binding Pocket Formed by Evolutionarily Conserved Residues in the Glucagon-like Peptide-1 (GLP-1) Receptor Core Domain The Journal of Biological Chemistry. Feb, 2015 | Pubmed ID: 25561730 A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth Endocrinology and Metabolism (Seoul, Korea). Sep, 2014 | Pubmed ID: 25309791 Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family? Frontiers in Endocrinology. 2014 | Pubmed ID: 25165463 Apoptotic Death of Prostate Cancer Cells by a Gonadotropin-releasing Hormone-II Antagonist PloS One. 2014 | Pubmed ID: 24926857 A Splicing Variant of NME1 Negatively Regulates NF-κB Signaling and Inhibits Cancer Metastasis by Interacting with IKKβ The Journal of Biological Chemistry. Jun, 2014 | Pubmed ID: 24811176 Coevolution of the Spexin/galanin/kisspeptin Family: Spexin Activates Galanin Receptor Type II and III Endocrinology. May, 2014 | Pubmed ID: 24517231 Local Duplication of Gonadotropin-releasing Hormone (GnRH) Receptor Before Two Rounds of Whole Genome Duplication and Origin of the Mammalian GnRH Receptor PloS One. 2014 | Pubmed ID: 24498396 Expression Analysis of Combinatorial Genes Using a Bi-cistronic T2A Expression System in Porcine Fibroblasts PloS One. 2013 | Pubmed ID: 23922997 A Novel Glucagon-related Peptide (GCRP) and Its Receptor GCRPR Account for Coevolution of Their Family Members in Vertebrates PloS One. 2013 | Pubmed ID: 23776481 Expansion of Secretin-like G Protein-coupled Receptors and Their Peptide Ligands Via Local Duplications Before and After Two Rounds of Whole-genome Duplication Molecular Biology and Evolution. May, 2013 | Pubmed ID: 23427277 CXCL14 Enhances Proliferation and Migration of NCI-H460 Human Lung Cancer Cells Overexpressing the Glycoproteins Containing Heparan Sulfate or Sialic Acid Journal of Cellular Biochemistry. May, 2013 | Pubmed ID: 23161284 Structural and Molecular Conservation of Glucagon-like Peptide-1 and Its Receptor Confers Selective Ligand-receptor Interaction Frontiers in Endocrinology. 2012 | Pubmed ID: 23181056 Generation and Characterization of Human Heme Oxygenase-1 Transgenic Pigs PloS One. 2012 | Pubmed ID: 23071605 Anti-cancer Activity of a Novel Small Molecule Compound That Simultaneously Activates P53 and Inhibits NF-κB Signaling PloS One. 2012 | Pubmed ID: 23028510 Spatiotemporal Expression and Functional Implication of CXCL14 in the Developing Mice Cerebellum Molecules and Cells. Sep, 2012 | Pubmed ID: 22843118 Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with Their Cognate G Protein-Coupled Receptors Frontiers in Neuroscience. 2012 | Pubmed ID: 22291614 Evolutionarily Conserved Residues at Glucagon-like Peptide-1 (GLP-1) Receptor Core Confer Ligand-induced Receptor Activation The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22105074 Insulin Contributes to Fine-tuning of the Pancreatic Beta-cell Response to Glucagon-like Peptide-1 Molecules and Cells. Oct, 2011 | Pubmed ID: 21904878 Revisiting the Evolution of Gonadotropin-releasing Hormones and Their Receptors in Vertebrates: Secrets Hidden in Genomes General and Comparative Endocrinology. Jan, 2011 | Pubmed ID: 21036176 Regulation of IκB Kinase by GβL Through Recruitment of the Protein Phosphatases Molecules and Cells. Dec, 2010 | Pubmed ID: 21110129 Tyr1 and Ile7 of Glucose-dependent Insulinotropic Polypeptide (GIP) Confer Differential Ligand Selectivity Toward GIP and Glucagon-like Peptide-1 Receptors Molecules and Cells. Aug, 2010 | Pubmed ID: 20799012 Molecular Coevolution of Kisspeptins and Their Receptors from Fish to Mammals Annals of the New York Academy of Sciences. Jul, 2010 | Pubmed ID: 20633134 Suppression of NF-kappaB Signaling by KEAP1 Regulation of IKKbeta Activity Through Autophagic Degradation and Inhibition of Phosphorylation Cellular Signalling. Nov, 2010 | Pubmed ID: 20600852 Splicing Variants of the Orphan G-protein-coupled Receptor GPR56 Regulate the Activity of Transcription Factors Associated with Tumorigenesis Journal of Cancer Research and Clinical Oncology. Jan, 2010 | Pubmed ID: 19572147 Phylogenetic History, Pharmacological Features, and Signal Transduction of Neurotensin Receptors in Vertebrates Annals of the New York Academy of Sciences. Apr, 2009 | Pubmed ID: 19456337 A Gonadotropin-releasing Hormone-II Antagonist Induces Autophagy of Prostate Cancer Cells Cancer Research. Feb, 2009 | Pubmed ID: 19176390 Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in Vertebrates Endocrinology. Jun, 2009 | Pubmed ID: 19164475 Molecular Cloning of the Bullfrog Kisspeptin Receptor GPR54 with High Sensitivity to Xenopus Kisspeptin Peptides. Jan, 2009 | Pubmed ID: 18550222 Gene Expression Profiling of Light-induced Retinal Degeneration in Phototransduction Gene Knockout Mice Experimental & Molecular Medicine. Oct, 2008 | Pubmed ID: 18985007 GbetaL Regulates TNFalpha-induced NF-kappaB Signaling by Directly Inhibiting the Activation of IkappaB Kinase Cellular Signalling. Nov, 2008 | Pubmed ID: 18755269 Identification of Farnesyl Pyrophosphate and N-arachidonylglycine As Endogenous Ligands for GPR92 The Journal of Biological Chemistry. Jul, 2008 | Pubmed ID: 18499677 Involvement of Amino Acids Flanking Glu7.32 of the Gonadotropin-releasing Hormone Receptor in the Selectivity of Antagonists Molecules and Cells. Feb, 2008 | Pubmed ID: 18319619 Extracellular Loop 3 (ECL3) and ECL3-proximal Transmembrane Domains VI and VII of the Mesotocin and Vasotocin Receptors Confer Differential Ligand Selectivity and Signaling Activity General and Comparative Endocrinology. Mar, 2008 | Pubmed ID: 18158152 Cloning and Activation of the Bullfrog Apelin Receptor: Gi/o Coupling and High Affinity for [Pro1]apelin-13 Molecular and Cellular Endocrinology. Oct, 2007 | Pubmed ID: 17825479 Role of Galpha12 and Galpha13 As Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor Molecular and Cellular Biology. Sep, 2007 | Pubmed ID: 17591699 Molecular Cloning and Characterization of a Novel Phospholipase C, PLC-eta The Biochemical Journal. Jul, 2005 | Pubmed ID: 15702972 Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery Arfaxad Reyes-Alcaraz1, Yoo-Na Lee1, Seongsik Yun1, Jong-Ik Hwang1, Jae Young Seong1 1Graduate School of Medicine, Korea University JoVE 59994 Biochimie
Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery Arfaxad Reyes-Alcaraz1, Yoo-Na Lee1, Seongsik Yun1, Jong-Ik Hwang1, Jae Young Seong1 1Graduate School of Medicine, Korea University JoVE 59994 Biochimie