Kathy Steece-Collier Department of Translational Neuroscience, College of Human Medicine Michigan State University Biography Publications Institution JoVE Articles Kathy Steece-Collier has not added a biography. If you are Kathy Steece-Collier and would like to personalize this page please email our Author Liaison for assistance. Publications α-Synuclein Antisense Oligonucleotides As a Disease-modifying Therapy for Parkinson's Disease JCI Insight. 03, 2021 | Pubmed ID: 33682798 Striatal Afferent BDNF is Disrupted by Synucleinopathy and Partially Restored by STN DBS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2021 | Pubmed ID: 33472823 The BDNF Val66Met Polymorphism (rs6265) Enhances Dopamine Neuron Graft Efficacy and Side-effect Liability in Rs6265 Knock-in Rats Neurobiology of Disease. Jan, 2021 | Pubmed ID: 33188920 Preclinical Evidence in Support of Repurposing Sub-anesthetic Ketamine As a Treatment for L-DOPA-induced Dyskinesia Experimental Neurology. 11, 2020 | Pubmed ID: 32717354 Striatal Nurr1, but Not FosB Expression Links a Levodopa-induced Dyskinesia Phenotype to Genotype in Fisher 344 Vs. Lewis Hemiparkinsonian Rats Experimental Neurology. 08, 2020 | Pubmed ID: 32387398 Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 04, 2020 | Pubmed ID: 32238479 Cell Therapy for Parkinson's Disease: Why It Doesn't Work Every Time Movement Disorders : Official Journal of the Movement Disorder Society. 08, 2019 | Pubmed ID: 31234239 Genetic Silencing of Striatal CaV1.3 Prevents and Ameliorates Levodopa Dyskinesia Movement Disorders : Official Journal of the Movement Disorder Society. 05, 2019 | Pubmed ID: 31002755 Regulation of Dopamine Neurotransmission from Serotonergic Neurons by Ectopic Expression of the Dopamine D2 Autoreceptor Blocks Levodopa-induced Dyskinesia Acta Neuropathologica Communications. 01, 2019 | Pubmed ID: 30646956 Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression Scientific Reports. Nov, 2017 | Pubmed ID: 29180681 Subthalamic Nucleus Deep Brain Stimulation Employs TrkB Signaling for Neuroprotection and Functional Restoration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 07, 2017 | Pubmed ID: 28607168 Repairing the Aged Parkinsonian Striatum: Lessons from the Lab and Clinic Journal of Clinical & Cellular Immunology. Dec, 2016 | Pubmed ID: 28111608 Impact of Age and Vector Construct on Striatal and Nigral Transgene Expression Molecular Therapy. Methods & Clinical Development. 2016 | Pubmed ID: 27933309 Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and L-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2015 | Pubmed ID: 26558771 Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration PloS One. 2015 | Pubmed ID: 26340267 High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine PloS One. 2015 | Pubmed ID: 26222442 Pathophysiology of L-dopa-induced Motor and Non-motor Complications in Parkinson's Disease Progress in Neurobiology. Sep, 2015 | Pubmed ID: 26209473 Intrastriatal Injection of Pre-formed Mouse α-synuclein Fibrils into Rats Triggers α-synuclein Pathology and Bilateral Nigrostriatal Degeneration Neurobiology of Disease. Oct, 2015 | Pubmed ID: 26093169 The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-hydroxydopamine Reveals Significant Upregulation of Regeneration-associated Genes PloS One. 2015 | Pubmed ID: 25992874 Interrogating the Aged Striatum: Robust Survival of Grafted Dopamine Neurons in Aging Rats Produces Inferior Behavioral Recovery and Evidence of Impaired Integration Neurobiology of Disease. May, 2015 | Pubmed ID: 25771169 Recombinant Adenoassociated Virus 2/5-mediated Gene Transfer is Reduced in the Aged Rat Midbrain Neurobiology of Aging. Feb, 2015 | Pubmed ID: 25457558 Chronic Amitriptyline Treatment Attenuates Nigrostriatal Degeneration and Significantly Alters Trophic Support in a Rat Model of Parkinsonism Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2015 | Pubmed ID: 25267343 Aberrant Restoration of Spines and Their Synapses in L-DOPA-induced Dyskinesia: Involvement of Corticostriatal but Not Thalamostriatal Synapses The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2013 | Pubmed ID: 23843533 Advances in Thin Tissue Golgi-Cox Impregnation: Fast, Reliable Methods for Multi-assay Analyses in Rodent and Non-human Primate Brain Journal of Neuroscience Methods. Mar, 2013 | Pubmed ID: 23313849 Anatomy of Graft-induced Dyskinesias: Circuit Remodeling in the Parkinsonian Striatum Basal Ganglia. Mar, 2012 | Pubmed ID: 22712056 Subthalamic Nucleus Stimulation Increases Brain Derived Neurotrophic Factor in the Nigrostriatal System and Primary Motor Cortex Journal of Parkinson's Disease. May, 2011 | Pubmed ID: 22328911 Striatal Pleiotrophin Overexpression Provides Functional and Morphological Neuroprotection in the 6-Hydroxydopamine Model Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011 | Pubmed ID: 22008908 Transfer of Host-derived α Synuclein to Grafted Dopaminergic Neurons in Rat Neurobiology of Disease. Sep, 2011 | Pubmed ID: 21600984 Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease Margaret E. Caulfield1, Jennifer A. Stancati1, Kathy Steece-Collier1,2 1Department of Translational Neuroscience, College of Human Medicine, Michigan State University, 2Hauenstein Neuroscience Center, Mercy Health Saint Mary's JoVE 62970 Neurosciences
Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease Margaret E. Caulfield1, Jennifer A. Stancati1, Kathy Steece-Collier1,2 1Department of Translational Neuroscience, College of Human Medicine, Michigan State University, 2Hauenstein Neuroscience Center, Mercy Health Saint Mary's JoVE 62970 Neurosciences