Kensuke Osada Department of Bioengineering, School of Engineering The University of Tokyo Biography Publications Institution JoVE Articles Kensuke Osada has not added a biography. If you are Kensuke Osada and would like to personalize this page please email our Author Liaison for assistance. Publications Block Copolymer Micellization As a Protection Strategy for DNA Origami Angewandte Chemie (International Ed. in English). Mar, 2017 | Pubmed ID: 28295864 Effect of Shear Stress on Structure and Function of Polyplex Micelles from Poly(ethylene Glycol)-poly(l-lysine) Block Copolymers As Systemic Gene Delivery Carrier Biomaterials. May, 2017 | Pubmed ID: 28254691 Happy Birthday Kataoka-sensei! Macromolecular Bioscience. Jan, 2017 | Pubmed ID: 28079310 Poly(ethylene Glycol) Crowding As Critical Factor To Determine PDNA Packaging Scheme into Polyplex Micelles for Enhanced Gene Expression Biomacromolecules. Jan, 2017 | Pubmed ID: 27990798 Polyplex Micelle Installing Intracellular Self-processing Functionalities Without Free Catiomers for Safe and Efficient Systemic Gene Therapy Through Tumor Vasculature Targeting Biomaterials. Jan, 2017 | Pubmed ID: 27835820 Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers Macromolecular Rapid Communications. Mar, 2016 | Pubmed ID: 26765970 Systemic Delivery of Messenger RNA for the Treatment of Pancreatic Cancer Using Polyplex Nanomicelles with a Cholesterol Moiety Biomaterials. Mar, 2016 | Pubmed ID: 26763736 Polyplex Micelles with Double-Protective Compartments of Hydrophilic Shell and Thermoswitchable Palisade of Poly(oxazoline)-Based Block Copolymers for Promoted Gene Transfection Biomacromolecules. Jan, 2016 | Pubmed ID: 26682466 Enhanced Target Recognition of Nanoparticles by Cocktail PEGylation with Chains of Varying Lengths Chemical Communications (Cambridge, England). Jan, 2016 | Pubmed ID: 26658952 Rod-to-Globule Transition of PDNA/PEG-Poly(l-Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness Small (Weinheim an Der Bergstrasse, Germany). Mar, 2016 | Pubmed ID: 26426541 Toroidal Packaging of PDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression Biomacromolecules. Sep, 2015 | Pubmed ID: 26226080 Ternary Polyplex Micelles with PEG Shells and Intermediate Barrier to Complexed DNA Cores for Efficient Systemic Gene Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2015 | Pubmed ID: 25912408 Feasibility of a Subcutaneously Administered Block/homo-mixed Polyplex Micelle As a Carrier for DNA Vaccination in a Mouse Tumor Model Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2015 | Pubmed ID: 25819159 A Tadpole-shaped Gene Carrier with Distinct Phase Segregation in a Ternary Polymeric Micelle Soft Matter. Apr, 2015 | Pubmed ID: 25711768 Intraperitoneal Administration of a Tumor-associated Antigen SART3, CD40L, and GM-CSF Gene-loaded Polyplex Micelle Elicits a Vaccine Effect in Mouse Tumor Models PloS One. 2014 | Pubmed ID: 25013909 Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency Against Pancreatic Tumor ACS Nano. Jul, 2014 | Pubmed ID: 24927216 Optimized Rod Length of Polyplex Micelles for Maximizing Transfection Efficiency and Their Performance in Systemic Gene Therapy Against Stroma-rich Pancreatic Tumors Biomaterials. Jul, 2014 | Pubmed ID: 24720877 Three-layered Polyplex Micelle As a Multifunctional Nanocarrier Platform for Light-induced Systemic Gene Transfer Nature Communications. Apr, 2014 | Pubmed ID: 24694458 Targeted Gene Delivery by Polyplex Micelles with Crowded PEG Palisade and CRGD Moiety for Systemic Treatment of Pancreatic Tumors Biomaterials. Mar, 2014 | Pubmed ID: 24439417 In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle PloS One. 2013 | Pubmed ID: 23418537 Bioactive Polymeric Metallosomes Self-assembled Through Block Copolymer-metal Complexation Journal of the American Chemical Society. Aug, 2012 | Pubmed ID: 22834643 NanoPARCEL: a Method for Controlling Cellular Behavior with External Light Chemical Communications (Cambridge, England). Aug, 2012 | Pubmed ID: 22798992 Pancreatic Cancer Therapy by Systemic Administration of VEGF SiRNA Contained in Calcium Phosphate/charge-conversional Polymer Hybrid Nanoparticles Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2012 | Pubmed ID: 22580114 Targeted Polymeric Micelles for SiRNA Treatment of Experimental Cancer by Intravenous Injection ACS Nano. Jun, 2012 | Pubmed ID: 22575090 Effective Transgene Expression Without Toxicity by Intraperitoneal Administration of PEG-detachable Polyplex Micelles in Mice with Peritoneal Dissemination Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2012 | Pubmed ID: 22484197 Homo-catiomer Integration into PEGylated Polyplex Micelle from Block-catiomer for Systemic Anti-angiogenic Gene Therapy for Fibrotic Pancreatic Tumors Biomaterials. Jun, 2012 | Pubmed ID: 22444644 PEGylated Polyplex with Optimized PEG Shielding Enhances Gene Introduction in Lungs by Minimizing Inflammatory Responses Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2012 | Pubmed ID: 22334020 Enhanced Gene Expression Promoted by the Quantized Folding of PDNA Within Polyplex Micelles Biomaterials. Jan, 2012 | Pubmed ID: 21993237 Effect of Polymer Structure on Micelles Formed Between SiRNA and Cationic Block Copolymer Comprising Thiols and Amidines Biomacromolecules. Sep, 2011 | Pubmed ID: 21863796 Combination of Chondroitin Sulfate and Polyplex Micelles from Poly(ethylene Glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} Block Copolymer for Prolonged in Vivo Gene Transfection with Reduced Toxicity Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2011 | Pubmed ID: 21571018 Enhanced Endosomal Escape of SiRNA-incorporating Hybrid Nanoparticles from Calcium Phosphate and PEG-block Charge-conversional Polymer for Efficient Gene Knockdown with Negligible Cytotoxicity Biomaterials. Apr, 2011 | Pubmed ID: 21272932 Polyplex Micelles Prepared from ω-cholesteryl PEG-polycation Block Copolymers for Systemic Gene Delivery Biomaterials. Jan, 2011 | Pubmed ID: 20932567 Enhanced in Vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties Macromolecular Rapid Communications. Sep, 2010 | Pubmed ID: 21567561 Quantized Folding of Plasmid DNA Condensed with Block Catiomer into Characteristic Rod Structures Promoting Transgene Efficacy Journal of the American Chemical Society. Sep, 2010 | Pubmed ID: 20712309 Polyplex Nanomicelle Promotes Hydrodynamic Gene Introduction to Skeletal Muscle Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2010 | Pubmed ID: 20043959 Polymeric Micelles from Poly(ethylene Glycol)-poly(amino Acid) Block Copolymer for Drug and Gene Delivery Journal of the Royal Society, Interface. Jun, 2009 | Pubmed ID: 19364722 Charge-conversional Polyionic Complex Micelles-efficient Nanocarriers for Protein Delivery into Cytoplasm Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19294716 Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: a Physiologically Available Oxygen Carrier Angewandte Chemie (International Ed. in English). 2007 | Pubmed ID: 17628476 Semipermeable Polymer Vesicle (PICsome) Self-assembled in Aqueous Medium from a Pair of Oppositely Charged Block Copolymers: Physiologically Stable Micro-/nanocontainers of Water-soluble Macromolecules Journal of the American Chemical Society. May, 2006 | Pubmed ID: 16669639 A Synthetic Block Copolymer Regulates S1 Nuclease Fragmentation of Supercoiled Plasmid DNA Angewandte Chemie (International Ed. in English). Jun, 2005 | Pubmed ID: 15880738 Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface Kosuke Okeyoshi1, Kensuke Osada2, Maiko K. Okajima1, Tatsuo Kaneko1 1Japan Advanced Institute of Science and Technology, 2Department of Bioengineering, School of Engineering, The University of Tokyo JoVE 55274 Bio-ingénierie
Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface Kosuke Okeyoshi1, Kensuke Osada2, Maiko K. Okajima1, Tatsuo Kaneko1 1Japan Advanced Institute of Science and Technology, 2Department of Bioengineering, School of Engineering, The University of Tokyo JoVE 55274 Bio-ingénierie