Kevin Eggan Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Biography Publications Institution JoVE Articles Kevin Eggan has not added a biography. If you are Kevin Eggan and would like to personalize this page please email our Author Liaison for assistance. Publications A Multiplexed GRNA PiggyBac Transposon System Facilitates Efficient Induction of CRISPRi and CRISPRa in Human Pluripotent Stem Cells Scientific Reports. Jan, 2020 | Pubmed ID: 31959800 Publisher Correction: Exome Sequencing in Amyotrophic Lateral Sclerosis Implicates a Novel Gene, DNAJC7, Encoding a Heat-shock Protein Nature Neuroscience. Feb, 2020 | Pubmed ID: 31857710 Herpesviral Lytic Gene Functions Render the Viral Genome Susceptible to Novel Editing by CRISPR/Cas9 ELife. 12, 2019 | Pubmed ID: 31789594 Exome Sequencing in Amyotrophic Lateral Sclerosis Implicates a Novel Gene, DNAJC7, Encoding a Heat-shock Protein Nature Neuroscience. 12, 2019 | Pubmed ID: 31768050 RNA-seq As a Tool for Evaluating Human Embryo Competence Genome Research. 10, 2019 | Pubmed ID: 31548358 Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells Cell Stem Cell. Oct, 2019 | Pubmed ID: 31543368 A High-Content Screen Identifies TPP1 and Aurora B As Regulators of Axonal Mitochondrial Transport Cell Reports. Sep, 2019 | Pubmed ID: 31533043 Comparison of Three Congruent Patient-specific Cell Types for the Modelling of a Human Genetic Schwann-cell Disorder Nature Biomedical Engineering. 07, 2019 | Pubmed ID: 30962586 Dysregulated Protocadherin-pathway Activity As an Intrinsic Defect in Induced Pluripotent Stem Cell-derived Cortical Interneurons from Subjects with Schizophrenia Nature Neuroscience. 02, 2019 | Pubmed ID: 30664768 ALS-implicated Protein TDP-43 Sustains Levels of STMN2, a Mediator of Motor Neuron Growth and Repair Nature Neuroscience. 02, 2019 | Pubmed ID: 30643292 A Stem Cell-Based Screening Platform Identifies Compounds That Desensitize Motor Neurons to Endoplasmic Reticulum Stress Molecular Therapy : the Journal of the American Society of Gene Therapy. 01, 2019 | Pubmed ID: 30446391 Convergence of Independent DISC1 Mutations on Impaired Neurite Growth Via Decreased UNC5D Expression Translational Psychiatry. 11, 2018 | Pubmed ID: 30410030 Oligodendrocyte Differentiation of Induced Pluripotent Stem Cells Derived from Subjects with Schizophrenias Implicate Abnormalities in Development Translational Psychiatry. 10, 2018 | Pubmed ID: 30352993 Comparative Genomic Analysis of Embryonic, Lineage-converted and Stem Cell-derived Motor Neurons Development (Cambridge, England). 11, 2018 | Pubmed ID: 30337375 All-optical Synaptic Electrophysiology Probes Mechanism of Ketamine-induced Disinhibition Nature Methods. 10, 2018 | Pubmed ID: 30275587 Hippo Signaling in the Ovary and Polycystic Ovarian Syndrome Journal of Assisted Reproduction and Genetics. Oct, 2018 | Pubmed ID: 30120633 Dipeptide Repeat Proteins Activate a Heat Shock Response Found in C9ORF72-ALS/FTLD Patients Acta Neuropathologica Communications. 07, 2018 | Pubmed ID: 29973287 The C9orf72-interacting Protein Smcr8 is a Negative Regulator of Autoimmunity and Lysosomal Exocytosis Genes & Development. 07, 2018 | Pubmed ID: 29950492 TDP-43 Induces P53-mediated Cell Death of Cortical Progenitors and Immature Neurons Scientific Reports. 05, 2018 | Pubmed ID: 29802307 Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission Cell Reports. 05, 2018 | Pubmed ID: 29791859 All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human IPSC-Derived Motor Neuron Model of ALS Stem Cell Reports. 06, 2018 | Pubmed ID: 29779896 Publisher Correction: Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium Nature Neuroscience. Jul, 2018 | Pubmed ID: 29549319 Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium Nature Neuroscience. 12, 2017 | Pubmed ID: 29184211 Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons Stem Cell Reports. 11, 2017 | Pubmed ID: 29107592 A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease Stem Cell Reports. 10, 2017 | Pubmed ID: 29020615 Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy Through TGF-β1 Stem Cell Reports. Aug, 2017 | Pubmed ID: 28712846 Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications Stem Cell Reports. Jul, 2017 | Pubmed ID: 28700896 Human Pluripotent Stem Cells Recurrently Acquire and Expand Dominant Negative P53 Mutations Nature. 05, 2017 | Pubmed ID: 28445466 Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection Cell Stem Cell. Dec, 2016 | Pubmed ID: 27912091 Generation of a TLE3 Heterozygous Knockout Human Embryonic Stem Cell Line Using CRISPR-Cas9 Stem Cell Research. Sep, 2016 | Pubmed ID: 27879221 Generation of a TLE1 Homozygous Knockout Human Embryonic Stem Cell Line Using CRISPR-Cas9 Stem Cell Research. Sep, 2016 | Pubmed ID: 27879218 Two Familial ALS Proteins Function in Prevention/repair of Transcription-associated DNA Damage Proceedings of the National Academy of Sciences of the United States of America. Nov, 2016 | Pubmed ID: 27849576 Monitoring Peripheral Nerve Degeneration in ALS by Label-free Stimulated Raman Scattering Imaging Nature Communications. Oct, 2016 | Pubmed ID: 27796305 Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. Aug, 2016 | Pubmed ID: 27532820 Loss-of-function Mutations in the C9ORF72 Mouse Ortholog Cause Fatal Autoimmune Disease Science Translational Medicine. Jul, 2016 | Pubmed ID: 27412785 CAT7 and Cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function During Human and Zebrafish Development The Journal of Biological Chemistry. Sep, 2016 | Pubmed ID: 27405765 Modeling ALS with Motor Neurons Derived from Human Induced Pluripotent Stem Cells Nature Neuroscience. Apr, 2016 | Pubmed ID: 27021939 SLC52A3, A Brown-Vialetto-van Laere Syndrome Candidate Gene is Essential for Mouse Development, but Dispensable for Motor Neuron Differentiation Human Molecular Genetics. May, 2016 | Pubmed ID: 26976849 A Perspective on Stem Cell Modeling of Amyotrophic Lateral Sclerosis Cell Cycle (Georgetown, Tex.). 2015 | Pubmed ID: 26505672 Automated, High-throughput Derivation, Characterization and Differentiation of Induced Pluripotent Stem Cells Nature Methods. Sep, 2015 | Pubmed ID: 26237226 From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial Cell Stem Cell. Jul, 2015 | Pubmed ID: 26140603 Efficient CRISPR-Cas9-mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus Cell Reports. May, 2015 | Pubmed ID: 25937281 Focus on Induced Pluripotency and Cellular Reprogramming The EMBO Journal. Jun, 2015 | Pubmed ID: 25916828 Generation of Neuropeptidergic Hypothalamic Neurons from Human Pluripotent Stem Cells Development (Cambridge, England). Feb, 2015 | Pubmed ID: 25670790 ALS-causative Mutations in FUS/TLS Confer Gain and Loss of Function by Altered Association with SMN and U1-snRNP Nature Communications. 2015 | Pubmed ID: 25625564 Motoneurons Derived from Induced Pluripotent Stem Cells Develop Mature Phenotypes Typical of Endogenous Spinal Motoneurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2015 | Pubmed ID: 25609642 Modeling Pain in Vitro Using Nociceptor Neurons Reprogrammed from Fibroblasts Nature Neuroscience. Jan, 2015 | Pubmed ID: 25420066 IPSC-derived Dopamine Neurons Reveal Differences Between Monozygotic Twins Discordant for Parkinson's Disease Cell Reports. Nov, 2014 | Pubmed ID: 25456120 Genetic Variation in Human DNA Replication Timing Cell. Nov, 2014 | Pubmed ID: 25416942 The Role of Maternal-specific H3K9me3 Modification in Establishing Imprinted X-chromosome Inactivation and Embryogenesis in Mice Nature Communications. 2014 | Pubmed ID: 25394724 Genetic Validation of a Therapeutic Target in a Mouse Model of ALS Science Translational Medicine. Aug, 2014 | Pubmed ID: 25100738 DNA Methylation Dynamics of the Human Preimplantation Embryo Nature. Jul, 2014 | Pubmed ID: 25079558 FUS is Sequestered in Nuclear Aggregates in ALS Patient Fibroblasts Molecular Biology of the Cell. Sep, 2014 | Pubmed ID: 25009283 Notch Inhibition Allows Oncogene-independent Generation of IPS Cells Nature Chemical Biology. Aug, 2014 | Pubmed ID: 24952596 Ketamine Exposure in Early Development Impairs Specification of the Primary Germ Cell Layers Neurotoxicology and Teratology. May-Jun, 2014 | Pubmed ID: 24746641 Pathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1 Cell Stem Cell. Jun, 2014 | Pubmed ID: 24704492 Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-derived Motor Neurons Cell Reports. Apr, 2014 | Pubmed ID: 24703839 Gene Profiling of Human Induced Pluripotent Stem Cell-derived Astrocyte Progenitors Following Spinal Cord Engraftment Stem Cells Translational Medicine. May, 2014 | Pubmed ID: 24604284 Nanog-independent Reprogramming to IPSCs with Canonical Factors Stem Cell Reports. Feb, 2014 | Pubmed ID: 24527385 Axonal Transport of TDP-43 MRNA Granules is Impaired by ALS-causing Mutations Neuron. Feb, 2014 | Pubmed ID: 24507191 How to Make Spinal Motor Neurons Development (Cambridge, England). Feb, 2014 | Pubmed ID: 24449832 Picking the Lock on Pluripotency The New England Journal of Medicine. Nov, 2013 | Pubmed ID: 24283230 The Mouse C9ORF72 Ortholog is Enriched in Neurons Known to Degenerate in ALS and FTD Nature Neuroscience. Dec, 2013 | Pubmed ID: 24185425 Derivation of Induced Pluripotent Stem Cells from the Baboon: a Nonhuman Primate Model for Preclinical Testing of Stem Cell Therapies Cellular Reprogramming. Dec, 2013 | Pubmed ID: 24182315 Opportunities and Challenges of Pluripotent Stem Cell Neurodegenerative Disease Models Nature Neuroscience. Jul, 2013 | Pubmed ID: 23799470 Modeling Human Disease with Pluripotent Stem Cells: from Genome Association to Function Cell Stem Cell. Jun, 2013 | Pubmed ID: 23746975 Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells Cell Stem Cell. May, 2013 | Pubmed ID: 23642365 CLP1 Links TRNA Metabolism to Progressive Motor-neuron Loss Nature. Mar, 2013 | Pubmed ID: 23474986 Analysis of Human Embryos from Zygote to Blastocyst Reveals Distinct Gene Expression Patterns Relative to the Mouse Developmental Biology. Mar, 2013 | Pubmed ID: 23261930 Developmental Bias in Cleavage-stage Mouse Blastomeres Current Biology : CB. Jan, 2013 | Pubmed ID: 23177476 SnapShot: Directed Differentiation of Pluripotent Stem Cells Cell. May, 2012 | Pubmed ID: 22632979 Erosion of Dosage Compensation Impacts Human IPSC Disease Modeling Cell Stem Cell. May, 2012 | Pubmed ID: 22560080 보상의 부재에 계란 기증자 모집의 현실성 Cell Stem Cell. Oct, 2011 | Pubmed ID: 21982228 하지만 인간 Zygotes 마우스에 핵 이전 다음 시간 프로그래밍 Nature Communications. 2011 | Pubmed ID: 21971503 마우스와 인간의 섬유 아 세포의 기능성 척추 운동 뉴런으로 변환 Cell Stem Cell. Sep, 2011 | Pubmed ID: 21852222 건설 및 신경 질환의 줄기 세포 모델 Deconstructing Neuron. May, 2011 | Pubmed ID: 21609821 체세포 코딩 돌연변이 인간 유도 만능 줄기 세포 Nature. Mar, 2011 | Pubmed ID: 21368825 인간의 ES 및 IPS 세포 변형 참조 지도 Pluripotent 셀 라인의 높은 처리량 특성 사용 Cell. Feb, 2011 | Pubmed ID: 21295703 인간 유도 만능 줄기 세포의 기능적 특징이 테스트 집합 Nature Biotechnology. Mar, 2011 | Pubmed ID: 21293464 줄기 세포 분화를 향해 Epigenetic 프리 내려 걸어간 Development (Cambridge, England). Aug, 2010 | Pubmed ID: 20554719 받는 사람 세포 핵 요소는 핵 이식 하 여 프로그래밍 하는 데 필요한 Development (Cambridge, England). Jun, 2010 | Pubmed ID: 20463036 Sox17 직접 Extraembryonic 유전자 발현을 조절 하 고 자기 갱신을 직접 Antagonizing 여 마우스 배아 줄기 세포에서 분화를 촉진 합니다 Genes & Development. Feb, 2010 | Pubmed ID: 20123909 환자 특정 Pluripotent 줄기 세포의 임상 적용에 대 한 진행률 The Journal of Clinical Investigation. Jan, 2010 | Pubmed ID: 20051636 Tgf-베타 시그널링의 작은 분자 억제 물 Sox2 Nanog 유도 재프로그래밍에 대체 합니다 Cell Stem Cell. Nov, 2009 | Pubmed ID: 19818703 마우스 Blastomeres로 염색체 전송 후 프로그래밍 Current Biology : CB. Aug, 2009 | Pubmed ID: 19682906 디지털 RNA Allelotyping 인간의 조직 및 대립 유전자 관련 유전자 발현을 보여준다 Nature Methods. Aug, 2009 | Pubmed ID: 19620972 타겟된 황산 시퀀싱 프로그래밍을 핵과 관련 된 DNA 메 틸 화 변화를 보여준다 Nature Biotechnology. Apr, 2009 | Pubmed ID: 19330000 내부 세포 집단 격리의 최적 타이밍 인간 배아 줄기 세포 유래의 효율성을 증가 하 고 형제 셀 라인의 세대 수 있습니다 Cell Stem Cell. Feb, 2009 | Pubmed ID: 19200798 인간 배아 줄기 세포 유래 모터 뉴런의 루 게 릭 병을 일으키는 돌연변이 들고 Glial 세포 독성 효과에 민감합니다 Cell Stem Cell. Dec, 2008 | Pubmed ID: 19041780 줄기 세포를 사용 하 고 프로그래밍을 질병을 이해 하입니다 Regenerative Medicine. Nov, 2008 | Pubmed ID: 18947303 루 게 릭 병 환자에서 생성 된 유도 만능 줄기 세포 모터 신경 세포로 분화 될 수 있다 Science (New York, N.Y.). Aug, 2008 | Pubmed ID: 18669821 Mediators of Reprogramming: Transcription Factors and Transitions Through Mitosis Nature Reviews. Molecular Cell Biology. Jul, 2008 | Pubmed ID: 18568039 합선 Epiblast 개발 Cell Stem Cell. Aug, 2007 | Pubmed ID: 18371343 발달 Mitotic 마우스 Zygotes로 염색체 전송 후 프로그래밍 Nature. Jun, 2007 | Pubmed ID: 17554301 비 세포 배아 줄기 세포 기반 ALS 모델의 모터 뉴런에 명과의 자치 효과 Nature Neuroscience. May, 2007 | Pubmed ID: 17435754 돌리의 유산: 인간의 핵 이식 및 우리의 아이 들을 위한 더 나은 의약품 Cloning and Stem Cells. 2007 | Pubmed ID: 17386009 셀 퓨전 인간 치료의 가능성이 있습니다 Stem Cell Reviews. 2006 | Pubmed ID: 17848721 핵 프로그래밍에 대 한 Transcriptional 논리입니다 Cell. Aug, 2006 | Pubmed ID: 16923385 성인 생쥐 Ovulated Oocytes 비 순환 세균 세포에서 파생 됩니다 Nature. Jun, 2006 | Pubmed ID: 16799565 핵 재프로그래밍 체세포의 인간 배아 줄기 세포와 융합 한 후 Science (New York, N.Y.). Aug, 2005 | Pubmed ID: 16123299 핵 복제, Epigenetic 프로그래밍 및 세포질 감 별 법입니다 Novartis Foundation Symposium. 2005 | Pubmed ID: 16050253 쥐 후 각 감각 신경 세포에서 복제 합니다 Nature. Mar, 2004 | Pubmed ID: 14990966 배아 생식 세포 및 배아 줄기 세포에서 남성 Gametes의 유래 Nature. Jan, 2004 | Pubmed ID: 14668819 Micromanipulating 복용량 보상: 핵 이식 통해 X 염색체 비활성화 이해 Seminars in Cell & Developmental Biology. Dec, 2003 | Pubmed ID: 15015742 Tetraploid 배아 보완성에 의해 실행 가능한 남성과 여성의 쥐로 F1 배아 줄기 세포의 분화 Methods in Enzymology. 2003 | Pubmed ID: 14696335 마우스 배아에서 Oct4 관련 유전자의 불완전 한 재 체세포 핵에서 복제 합니다 Development (Cambridge, England). Apr, 2003 | Pubmed ID: 12620990 핵 복제, 줄기 세포, 그리고 게놈 프로그래밍 Cloning and Stem Cells. 2002 | Pubmed ID: 12630413 비정상적인 유전자 발현 복제 된 쥐에 있는 미 발달 줄기 세포 및 적 운 세포 핵에서 파생 된 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12235366 남성과 여성의 쥐 Tetraploid 배아 보완성으로 동일한 배아 줄기 세포 복제에서 파생 된 Nature Biotechnology. May, 2002 | Pubmed ID: 11981557 Dnmt1 Overexpression 게놈 Hypermethylation, Imprinting, 그리고 배아 치 사 율의 손실 발생 Molecular and Cellular Biology. Apr, 2002 | Pubmed ID: 11884600 Flp Recombinase ROSA26 로커 스에 LacZ 식 규제 Genesis (New York, N.Y. : 2000). Feb, 2002 | Pubmed ID: 11857816 대뇌 Organoids 파생 Zika 바이러스 감염 개발 인간의 두뇌에는 생체 외에서 줄기 세포를 사용 하 여 모델링 Max R Salick*1, Michael F Wells*2,3, Kevin Eggan2,3, Ajamete Kaykas1 1Department of Neuroscience, Novartis Institutes for BioMedical Research, 2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, 3Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University JoVE 56404 Neurosciences 마우스 Oocytes에 핵 전송 Dieter Egli1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 116 Biologie 냉동 세포에서 시작 문화 : 인간 ES 세포 Erin Trish1, John Dimos1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 86 Biologie 트립신과 Passaging 색채 인간의 배아 줄기 세포 - 라인 Erin Trish1, John Dimos1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 49 Biologie 냉동 인간 ES 세포 Erin Trish1, John Dimos1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 50 Biologie
대뇌 Organoids 파생 Zika 바이러스 감염 개발 인간의 두뇌에는 생체 외에서 줄기 세포를 사용 하 여 모델링 Max R Salick*1, Michael F Wells*2,3, Kevin Eggan2,3, Ajamete Kaykas1 1Department of Neuroscience, Novartis Institutes for BioMedical Research, 2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, 3Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University JoVE 56404 Neurosciences
마우스 Oocytes에 핵 전송 Dieter Egli1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 116 Biologie
냉동 세포에서 시작 문화 : 인간 ES 세포 Erin Trish1, John Dimos1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 86 Biologie
트립신과 Passaging 색채 인간의 배아 줄기 세포 - 라인 Erin Trish1, John Dimos1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 49 Biologie
냉동 인간 ES 세포 Erin Trish1, John Dimos1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 50 Biologie