Kezhong Zhang Center for Molecular Medicine and Genetics Wayne State University Biography Publications Institution JoVE Articles Kezhong Zhang has not added a biography. If you are Kezhong Zhang and would like to personalize this page please email our Author Liaison for assistance. Publications ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis Journal of Clinical & Cellular Immunology. Oct, 2016 | Pubmed ID: 27942420 Relationship Between the Plasma Levels of Neurodegenerative Proteins and Motor Subtypes of Parkinson's Disease Journal of Neural Transmission (Vienna, Austria : 1996). Nov, 2016 | Pubmed ID: 27878377 Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin The Journal of Biological Chemistry. Oct, 2016 | Pubmed ID: 27637329 Inositol Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs Diabetes. Sep, 2016 | Pubmed ID: 27634225 Glucagon Regulates Hepatic Lipid Metabolism Via CAMP and Insig-2 Signaling: Implication for the Pathogenesis of Hypertriglyceridemia and Hepatic Steatosis Scientific Reports. Sep, 2016 | Pubmed ID: 27582413 Endoplasmic Reticulum-resident E3 Ubiquitin Ligase Hrd1 Controls B-cell Immunity Through Degradation of the Death Receptor CD95/Fas Proceedings of the National Academy of Sciences of the United States of America. Sep, 2016 | Pubmed ID: 27573825 COX7AR is a Stress-inducible Mitochondrial COX Subunit That Promotes Breast Cancer Malignancy Scientific Reports. Aug, 2016 | Pubmed ID: 27550821 CREBH Couples Circadian Clock With Hepatic Lipid Metabolism Diabetes. Nov, 2016 | Pubmed ID: 27507854 Nogo-B Receptor Deficiency Increases Liver X Receptor Alpha Nuclear Translocation and Hepatic Lipogenesis Through an Adenosine Monophosphate-activated Protein Kinase Alpha-dependent Pathway Hepatology (Baltimore, Md.). Nov, 2016 | Pubmed ID: 27480224 Alterations of Functional and Structural Connectivity of Freezing of Gait in Parkinson's Disease Journal of Neurology. Aug, 2016 | Pubmed ID: 27230857 Microarray Analysis of MicroRNA Expression in Bone Marrow-derived Progenitor Cells from Mice with Type 2 Diabetes Genomics Data. Mar, 2016 | Pubmed ID: 26981370 Regional Homogeneity Alterations Differentiate Between Tremor Dominant and Postural Instability Gait Difficulty Subtypes of Parkinson's Disease Journal of Neural Transmission (Vienna, Austria : 1996). Mar, 2016 | Pubmed ID: 26666253 Plasma Antioxidant Status and Motor Features in De Novo Chinese Parkinson's Disease Patients The International Journal of Neuroscience. 2016 | Pubmed ID: 26010212 Reduced Plasma Taurine Level in Parkinson's Disease: Association with Motor Severity and Levodopa Treatment The International Journal of Neuroscience. 2016 | Pubmed ID: 26004911 A Novel ER-microtubule-binding Protein, ERLIN2, Stabilizes Cyclin B1 and Regulates Cell Cycle Progression Cell Discovery. 2015 | Pubmed ID: 27462423 [Study on Changes of Plasma Levels of Oxidative Stress Biomarkers and Its Relation with Cognition Function in Patients with Parkinson's Disease] Zhonghua Yi Xue Za Zhi. Nov, 2015 | Pubmed ID: 26812976 Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism Molecular and Cellular Biology. Dec, 2015 | Pubmed ID: 26438600 Exposure to Fine Airborne Particulate Matters Induces Hepatic Fibrosis in Murine Models Journal of Hepatology. Dec, 2015 | Pubmed ID: 26220751 COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis Molecular Endocrinology (Baltimore, Md.). Aug, 2015 | Pubmed ID: 26083833 Petroleum Coke in the Urban Environment: a Review of Potential Health Effects International Journal of Environmental Research and Public Health. May, 2015 | Pubmed ID: 26035666 Reduced Plasma Serotonin and 5-hydroxyindoleacetic Acid Levels in Parkinson's Disease Are Associated with Nonmotor Symptoms Parkinsonism & Related Disorders. Aug, 2015 | Pubmed ID: 26028271 SMAD3 Deficiency Promotes Vessel Wall Remodeling, Collagen Fiber Reorganization and Leukocyte Infiltration in an Inflammatory Abdominal Aortic Aneurysm Mouse Model Scientific Reports. May, 2015 | Pubmed ID: 25985281 Genome-wide Identification, Evolutionary, and Expression Analyses of Histone H3 Variants in Plants BioMed Research International. 2015 | Pubmed ID: 25815311 Cross Talk Between ER Stress, Oxidative Stress, and Inflammation in Health and Disease Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25804758 Proteomics Analysis of Rough Endoplasmic Reticulum in Pancreatic Beta Cells Proteomics. May, 2015 | Pubmed ID: 25546123 Correlations Between Plasma Levels of Amino Acids and Nonmotor Symptoms in Parkinson's Disease Journal of Neural Transmission (Vienna, Austria : 1996). Mar, 2015 | Pubmed ID: 25059457 Endoplasmic Reticulum Stress Response and Transcriptional Reprogramming Frontiers in Genetics. 2014 | Pubmed ID: 25709614 PM2.5 in Beijing - Temporal Pattern and Its Association with Influenza Environmental Health : a Global Access Science Source. Dec, 2014 | Pubmed ID: 25471661 Hepatic Mitochondrial and ER Stress Induced by Defective PPARα Signaling in the Pathogenesis of Hepatic Steatosis American Journal of Physiology. Endocrinology and Metabolism. Jun, 2014 | Pubmed ID: 24735884 Elevated Systemic Expression of ER Stress Related Genes is Associated with Stress-related Mental Disorders in the Detroit Neighborhood Health Study Psychoneuroendocrinology. May, 2014 | Pubmed ID: 24703171 Liver-enriched Transcription Factor CREBH Interacts with Peroxisome Proliferator-activated Receptor α to Regulate Metabolic Hormone FGF21 Endocrinology. Mar, 2014 | Pubmed ID: 24424044 Diabetes Mellitus is Associated with Hepatocellular Carcinoma: a Retrospective Case-control Study in Hepatitis Endemic Area PloS One. 2013 | Pubmed ID: 24386416 The Serine-threonine Kinase Inositol-requiring Enzyme 1 α (IRE1α) Promotes IL-4 Production in T Helper Cells The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24100031 Toll-like Receptor-mediated IRE1α Activation As a Therapeutic Target for Inflammatory Arthritis The EMBO Journal. Sep, 2013 | Pubmed ID: 23942232 The Association Between Glycogen Synthase Kinase 3 Beta (GSK3-β) Polymorphisms and Parkinson's Disease Susceptibility: A Meta-analysis Gene. Apr, 2013 | Pubmed ID: 23628795 Exposure to Fine Airborne Particulate Matter Induces Macrophage Infiltration, Unfolded Protein Response, and Lipid Deposition in White Adipose Tissue American Journal of Translational Research. 2013 | Pubmed ID: 23573366 Aquaporin-assisted and ER-mediated Mitochondrial Fission: a Hypothesis Micron (Oxford, England : 1993). Apr, 2013 | Pubmed ID: 23416165 Exposure to Ambient Particulate Matter Induces a NASH-like Phenotype and Impairs Hepatic Glucose Metabolism in an Animal Model Journal of Hepatology. Jan, 2013 | Pubmed ID: 22902548 Genomic Amplification and a Role in Drug-resistance for the KDM5A Histone Demethylase in Breast Cancer American Journal of Translational Research. 2012 | Pubmed ID: 22937203 Endoplasmic Reticulum Stress and Lipid Metabolism Biochemistry Research International. 2012 | Pubmed ID: 22778961 Endoplasmic Reticulum Factor ERLIN2 Regulates Cytosolic Lipid Content in Cancer Cells The Biochemical Journal. Sep, 2012 | Pubmed ID: 22690709 ERLIN2 Promotes Breast Cancer Cell Survival by Modulating Endoplasmic Reticulum Stress Pathways BMC Cancer. Jun, 2012 | Pubmed ID: 22681620 Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes Biochemistry Research International. 2012 | Pubmed ID: 22506114 Pharmacologic ER Stress Induces Non-alcoholic Steatohepatitis in an Animal Model Toxicology Letters. May, 2012 | Pubmed ID: 22414386 Pharmacological ER Stress Promotes Hepatic Lipogenesis and Lipid Droplet Formation American Journal of Translational Research. 2012 | Pubmed ID: 22347525 Endoplasmic Reticulum-tethered Transcription Factor CAMP Responsive Element-binding Protein, Hepatocyte Specific, Regulates Hepatic Lipogenesis, Fatty Acid Oxidation, and Lipolysis Upon Metabolic Stress in Mice Hepatology (Baltimore, Md.). Nov, 2011 | Pubmed ID: 22095841 The Unfolded Protein Response Transducer IRE1α Prevents ER Stress-induced Hepatic Steatosis The EMBO Journal. Apr, 2011 | Pubmed ID: 21407177 Unfolded Protein Response in Cancer: the Physician's Perspective Journal of Hematology & Oncology. Feb, 2011 | Pubmed ID: 21345215 Measurement of ER Stress Response and Inflammation in the Mouse Model of Nonalcoholic Fatty Liver Disease Methods in Enzymology. 2011 | Pubmed ID: 21266239 Real-world Exposure of Airborne Particulate Matter Triggers Oxidative Stress in an Animal Model International Journal of Physiology, Pathophysiology and Pharmacology. Mar, 2010 | Pubmed ID: 21383899 Role of Unfolded Protein Response in Lipogenesis World Journal of Hepatology. Jun, 2010 | Pubmed ID: 21160998 Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues American Journal of Physiology. Cell Physiology. Oct, 2010 | Pubmed ID: 20554909 The Comparison of Clonidine, Arginine and Both Combined: a Growth Hormone Stimulation Test to Differentiate Multiple System Atrophy from Idiopathic Parkinson's Disease Journal of Neurology. Sep, 2010 | Pubmed ID: 20405138 Integration of ER Stress, Oxidative Stress and the Inflammatory Response in Health and Disease International Journal of Clinical and Experimental Medicine. Jan, 2010 | Pubmed ID: 20369038 Endoplasmic Reticulum Stress Response in Cancer: Molecular Mechanism and Therapeutic Potential American Journal of Translational Research. Jan, 2010 | Pubmed ID: 20182583 ER Stress Controls Iron Metabolism Through Induction of Hepcidin Science (New York, N.Y.). Aug, 2009 | Pubmed ID: 19679815 Regulation of Apoptosis by the Unfolded Protein Response Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19609758 An Age-related Homeostasis Mechanism is Essential for Spontaneous Amelioration of Hemophilia B Leyden Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19416882 Antioxidants Reduce Endoplasmic Reticulum Stress and Improve Protein Secretion Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008 | Pubmed ID: 19011102 Association Study of Semaphorin 5A with Risk of Parkinson's Disease in a Chinese Han Population Brain Research. Dec, 2008 | Pubmed ID: 18950607 Hepatocyte Nuclear Factor 4alpha is Implicated in Endoplasmic Reticulum Stress-induced Acute Phase Response by Regulating Expression of Cyclic Adenosine Monophosphate Responsive Element Binding Protein H Hepatology (Baltimore, Md.). Oct, 2008 | Pubmed ID: 18704925 Identification and Characterization of Endoplasmic Reticulum Stress-induced Apoptosis in Vivo Methods in Enzymology. 2008 | Pubmed ID: 18662581 From Endoplasmic-reticulum Stress to the Inflammatory Response Nature. Jul, 2008 | Pubmed ID: 18650916 Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response Cell. Feb, 2006 | Pubmed ID: 16469704 The Unfolded Protein Response: a Stress Signaling Pathway Critical for Health and Disease Neurology. Jan, 2006 | Pubmed ID: 16432136 ER Stress Signaling by Regulated Splicing: IRE1/HAC1/XBP1 Methods (San Diego, Calif.). Apr, 2005 | Pubmed ID: 15804613 The Unfolded Protein Response Sensor IRE1alpha is Required at 2 Distinct Steps in B Cell Lymphopoiesis The Journal of Clinical Investigation. Feb, 2005 | Pubmed ID: 15690081 The Unfolded Protein Response--a Stress Signaling Pathway of the Endoplasmic Reticulum Journal of Chemical Neuroanatomy. Sep, 2004 | Pubmed ID: 15363493 Signaling the Unfolded Protein Response from the Endoplasmic Reticulum The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 15070890 The Protein Kinase PKR is Required for Macrophage Apoptosis After Activation of Toll-like Receptor 4 Nature. Mar, 2004 | Pubmed ID: 15029200 Unfolding the Toxicity of Cholesterol Nature Cell Biology. Sep, 2003 | Pubmed ID: 12951604 TDAG51 is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Cevelopment of Atherosclerosis in Hyperhomocysteinemia The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12738777 Bone Marrow Stromal Cells As a Genetic Platform for Systemic Delivery of Therapeutic Proteins in Vivo: Human Factor IX Model The Journal of Gene Medicine. Jan, 2003 | Pubmed ID: 12516047 Limitation in Use of Heterologous Reporter Genes for Gene Promoter Analysis. Silencer Activity Associated with the Cloramphenicol Acetyltransferase Reporter Gene The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12473656 New Function for Age-related Stability Element in Conferring Strict Tissue-specific Expression of Human Factor IX and Protein C Genes Thrombosis and Haemostasis. Sep, 2002 | Pubmed ID: 12353089 Genetic Mechanisms of Age Regulation of Protein C and Blood Coagulation The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11719515 Isolation and Primary Culture of Mouse Aortic Endothelial Cells Jie-Mei Wang1, Alex F. Chen2, Kezhong Zhang1 1Center for Molecular Medicine and Genetics, Wayne State University, 2Third Xiangya Hospital and the Institute of Vascular Disease and Translational Medicine, Central South University JoVE 52965 Biologie
Isolation and Primary Culture of Mouse Aortic Endothelial Cells Jie-Mei Wang1, Alex F. Chen2, Kezhong Zhang1 1Center for Molecular Medicine and Genetics, Wayne State University, 2Third Xiangya Hospital and the Institute of Vascular Disease and Translational Medicine, Central South University JoVE 52965 Biologie