Lei Fang Jiangsu Key Laboratory of Molecular Medicine Medical School of Nanjing University Biography Publications Institution JoVE Articles Lei Fang has not added a biography. If you are Lei Fang and would like to personalize this page please email our Author Liaison for assistance. Publications Global Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice Journal of Proteome Research. Apr, 2020 | Pubmed ID: 32105074 Liver Governs Adipose Remodelling Via Extracellular Vesicles in Response to Lipid Overload Nature Communications. 02, 2020 | Pubmed ID: 32024826 FAM134B Oligomerization Drives Endoplasmic Reticulum Membrane Scission for ER-phagy The EMBO Journal. Mar, 2020 | Pubmed ID: 31930741 Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination Frontiers in Immunology. 2019 | Pubmed ID: 31866999 CENP-A Ubiquitylation Is Indispensable to Cell Viability Developmental Cell. 09, 2019 | Pubmed ID: 31550462 The Transferrin Receptor CD71 Regulates Type II CD38, Revealing Tight Topological Compartmentalization of Intracellular Cyclic ADP-ribose Production The Journal of Biological Chemistry. 10, 2019 | Pubmed ID: 31434741 Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion Journal of Proteome Research. 05, 2019 | Pubmed ID: 30901224 Evidence for a Role of Geranylgeranylation in Renal Angiomyolipoma and Renal Epithelioid Angiomyolipoma Oncology Letters. Feb, 2019 | Pubmed ID: 30675208 A Cytosolic Chaperone Complex Controls Folding and Degradation of Type III CD38 The Journal of Biological Chemistry. 03, 2019 | Pubmed ID: 30670591 HSPA12A is a Novel Player in Nonalcoholic Steatohepatitis Via Promoting Nuclear PKM2-mediated M1 Macrophage Polarization Diabetes. Nov, 2018 | Pubmed ID: 30455376 Author Correction: PTEN-L is a Novel Protein Phosphatase for Ubiquitin Dephosphorylation to Inhibit PINK1-Parkin-mediated Mitophagy Cell Research. 08, 2018 | Pubmed ID: 30038297 PTEN-L is a Novel Protein Phosphatase for Ubiquitin Dephosphorylation to Inhibit PINK1-Parkin-mediated Mitophagy Cell Research. 08, 2018 | Pubmed ID: 29934616 The Effects of Acetaldehyde Exposure on Histone Modifications and Chromatin Structure in Human Lung Bronchial Epithelial Cells Environmental and Molecular Mutagenesis. 06, 2018 | Pubmed ID: 29569274 Mechanisms Underlying Acrolein-Mediated Inhibition of Chromatin Assembly Molecular and Cellular Biology. 12, 2016 | Pubmed ID: 27669733 Shuang-huang-lian Attenuates Lipopolysaccharide-induced Acute Lung Injury in Mice Involving Anti-inflammatory and Antioxidative Activities Evidence-based Complementary and Alternative Medicine : ECAM. 2015 | Pubmed ID: 25945107 Sequencing of Allotetraploid Cotton (Gossypium Hirsutum L. Acc. TM-1) Provides a Resource for Fiber Improvement Nature Biotechnology. May, 2015 | Pubmed ID: 25893781 A Potential New Mechanism of Arsenic Carcinogenesis: Depletion of Stem-Loop Binding Protein and Increase in Polyadenylated Canonical Histone H3.1 MRNA Biological Trace Element Research. Apr, 2015 | Pubmed ID: 25893362 Erratum for Wire Et Al., Lack of Clinically Significant Pharmacokinetic Interaction Between the Thrombopoietin Receptor Agonist Eltrombopag and Hepatitis C Virus Protease Inhibitors Boceprevir and Telaprevir Antimicrobial Agents and Chemotherapy. May, 2015 | Pubmed ID: 25862822 HOTAIR is a Potential Target for the Treatment of Cisplatin‑resistant Ovarian Cancer Molecular Medicine Reports. Mar, 2015 | Pubmed ID: 25824616 A Meta-analysis of the Fusion Rate from Surgical Treatment for Odontoid Factures: Anterior Odontoid Screw Versus Posterior C1-C2 Arthrodesis European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. Mar, 2015 | Pubmed ID: 25805577 Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis Molecular and Cellular Biology. Jun, 2015 | Pubmed ID: 25802280 An Open-Label, Single-Arm, Phase 1 Study to Assess Biomarker Effects, Efficacy, and Safety of Ofatumumab in Patients With Refractory Chronic Lymphocytic Leukemia Leukemia & Lymphoma. Feb, 2015 | Pubmed ID: 25721750 Mitochondrial Function in Neuronal Cells Depends on P97/VCP/Cdc48-mediated Quality Control Frontiers in Cellular Neuroscience. 2015 | Pubmed ID: 25698929 Construction of Stable Polymeric Vesicles Based on Azobenzene and Beta-cyclodextrin Grafted Poly(glycerol Methacrylate)s for Potential Applications in Colon-specific Drug Delivery Chemical Communications (Cambridge, England). Mar, 2015 | Pubmed ID: 25692460 Mapping Functional Group Free Energy Patterns at Protein Occluded Sites: Nuclear Receptors and G-protein Coupled Receptors Journal of Chemical Information and Modeling. Mar, 2015 | Pubmed ID: 25692383 Evaluation of the Intestinal Transport of a Phenylethanoid Glycoside-rich Extract from Cistanche Deserticola Across the Caco-2 Cell Monolayer Model PloS One. 2015 | Pubmed ID: 25646971 Pharmacophore Modeling Using Site-identification by Ligand Competitive Saturation (SILCS) with Multiple Probe Molecules Journal of Chemical Information and Modeling. Feb, 2015 | Pubmed ID: 25622696 Two-dimensional Mineral [Pb2BiS3][AuTe2]: High-mobility Charge Carriers in Single-atom-thick Layers Journal of the American Chemical Society. Feb, 2015 | Pubmed ID: 25612093 Exploring the Association Between Interleukin-1β and Its Interacting Proteins in Alzheimer's Disease Molecular Medicine Reports. May, 2015 | Pubmed ID: 25585621 The BRCA1/2-directed MiRNA Signature Predicts a Good Prognosis in Ovarian Cancer Patients with Wild-type BRCA1/2 Oncotarget. Feb, 2015 | Pubmed ID: 25537514 Repeated Inhalation of Sevoflurane Inhibits Airway Inflammation in an OVA-induced Mouse Model of Allergic Airway Inflammation Respirology (Carlton, Vic.). Feb, 2015 | Pubmed ID: 25399488 Application of Chitosan Microparticles for Reduction of Vibrio Species in Seawater and Live Oysters (Crassostrea Virginica) Applied and Environmental Microbiology. Jan, 2015 | Pubmed ID: 25381244 Assessment of the Effect of Ofatumumab on Cardiac Repolarization Journal of Clinical Pharmacology. Jan, 2015 | Pubmed ID: 25103870 [Study on Secondary Metabolites of Endophytic Fungi Penicillium Polonicum] Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. Oct, 2014 | Pubmed ID: 25751949 [Curative Effects of Kinesitherapy in Combination with Self-made Simple Orthosis in Treatment of Scar Contracture of Burned Hand in Children] Zhonghua Shao Shang Za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns. Dec, 2014 | Pubmed ID: 25608782 Safety and Efficacy of Laparoscopy-assisted Gastrectomy for Advanced Gastric Cancer in the Elderly International Journal of Clinical and Experimental Medicine. 2014 | Pubmed ID: 25419398 Postsynthetic Lanthanide Functionalization of Nanosized Metal-organic Frameworks for Highly Sensitive Ratiometric Luminescent Thermometry Chemical Communications (Cambridge, England). Dec, 2014 | Pubmed ID: 25345472 The Effect of Flammer-syndrome on Retinal Venous Pressure BMC Ophthalmology. 2014 | Pubmed ID: 25312339 Design and Synthesis of Lapatinib Derivatives Containing a Branched Side Chain As HER1/HER2 Targeting Antitumor Drug Candidates European Journal of Medicinal Chemistry. Nov, 2014 | Pubmed ID: 25305330 [Effects of Plant-derived Smoke Water on Accumulation of Biomass and Active Substance of Salvia Miltiorrhiza F. Alba] Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. Jul, 2014 | Pubmed ID: 25276963 Cotton Fiber Elongation Network Revealed by Expression Profiling of Longer Fiber Lines Introgressed with Different Gossypium Barbadense Chromosome Segments BMC Genomics. 2014 | Pubmed ID: 25273845 Arsenic Induces Polyadenylation of Canonical Histone MRNA by Down-regulating Stem-loop-binding Protein Gene Expression The Journal of Biological Chemistry. Nov, 2014 | Pubmed ID: 25266719 High-quality Draft Genome Sequence of Nematocidal Bacillus Thuringiensis Sbt003 Standards in Genomic Sciences. Jun, 2014 | Pubmed ID: 25197449 Lack of Clinically Significant Pharmacokinetic Interaction Between the Thrombopoietin Receptor Agonist Eltrombopag and Hepatitis C Virus Protease Inhibitors Boceprevir and Telaprevir Antimicrobial Agents and Chemotherapy. Nov, 2014 | Pubmed ID: 25155600 Implementation and Evaluation of the Chronic-disease Self-management Program Among Chinese Immigrant Older Adults in the U.S Geriatric Nursing (New York, N.Y.). Nov-Dec, 2014 | Pubmed ID: 25155476 [Comparison on Surface Ultrastructure Characteristic and Drought Resistance of Different Trichosanthes Kirilowii Strains] Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. May, 2014 | Pubmed ID: 25095361 The New Phase [Tl₄Sb₆Se₁₀][Sn₅Sb₂Se₁₄]: a Naturally Formed Semiconducting Heterostructure with Two-dimensional Conductance Journal of the American Chemical Society. Aug, 2014 | Pubmed ID: 25058471 Environmental-stress-induced Chromatin Regulation and Its Heritability Journal of Carcinogenesis & Mutagenesis. Jan, 2014 | Pubmed ID: 25045581 Comparison of the Endothelial Toxicity Induced by Short-term Amiodarone and Diazepam Exposure in a Human Umbilical Vein Endothelial Cell Line (EVC304) Pharmaceutical Biology. Oct, 2014 | Pubmed ID: 25026356 Loss of EGFR Signaling Regulated MiR-203 Promotes Prostate Cancer Bone Metastasis and Tyrosine Kinase Inhibitors Resistance Oncotarget. Jun, 2014 | Pubmed ID: 25004126 High Fever As an Initial Symptom of Primary Gastric Inflammatory Myofibroblastic Tumor in an Adult Woman International Journal of Clinical and Experimental Medicine. 2014 | Pubmed ID: 24995114 AR-regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis Cancer Research. Aug, 2014 | Pubmed ID: 24970477 Heat Shock Protein 70 from Trichinella Spiralis Induces Protective Immunity in BALB/c Mice by Activating Dendritic Cells Vaccine. Jul, 2014 | Pubmed ID: 24962751 [Mechanism of Signal Molecule High Mobility Group Box Protein 1 Mediated by Toll-like Receptor 2 in Murine Asthma] Zhonghua Yi Xue Za Zhi. Apr, 2014 | Pubmed ID: 24924884 Rational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine Detoxification ACS Chemical Biology. Aug, 2014 | Pubmed ID: 24919140 Expression and Effects of JMJD2A Histone Demethylase in Endometrial Carcinoma Asian Pacific Journal of Cancer Prevention : APJCP. 2014 | Pubmed ID: 24815446 Genkwanin Inhibits Proinflammatory Mediators Mainly Through the Regulation of MiR-101/MKP-1/MAPK Pathway in LPS-activated Macrophages PloS One. 2014 | Pubmed ID: 24800851 Integration of Modeling and Simulation to Support Changes to Ondansetron Dosing Following a Randomized, Double-blind, Placebo-, and Active-controlled Thorough QT Study Journal of Clinical Pharmacology. Nov, 2014 | Pubmed ID: 24782199 Transcriptomic Analysis of Fiber Strength in Upland Cotton Chromosome Introgression Lines Carrying Different Gossypium Barbadense Chromosomal Segments PloS One. 2014 | Pubmed ID: 24762562 Suppressive Effects of Irisflorentin on LPS-induced Inflammatory Responses in RAW 264.7 Macrophages Experimental Biology and Medicine (Maywood, N.J.). Apr, 2014 | Pubmed ID: 24740875 Rhein Exerts Pro- and Anti-inflammatory Actions by Targeting IKKβ Inhibition in LPS-activated Macrophages Free Radical Biology & Medicine. Jul, 2014 | Pubmed ID: 24721152 Transmigration and Phagocytosis of Macrophages in an Airway Infection Model Using Four-dimensional Techniques American Journal of Respiratory Cell and Molecular Biology. Jul, 2014 | Pubmed ID: 24678629 High Performance All-polymer Solar Cell Via Polymer Side-chain Engineering Advanced Materials (Deerfield Beach, Fla.). Jun, 2014 | Pubmed ID: 24664632 DNA Microarray Analysis Reveals That Antibiotic Resistance-gene Diversity in Human Gut Microbiota is Age Related Scientific Reports. 2014 | Pubmed ID: 24618772 Concomitant Oral and Intravenous Pharmacokinetics of Trametinib, a MEK Inhibitor, in Subjects with Solid Tumours British Journal of Clinical Pharmacology. Sep, 2014 | Pubmed ID: 24606567 Design, Synthesis and Biological Evaluation of D-ring Opened Galantamine Analogs As Multifunctional Anti-Alzheimer Agents European Journal of Medicinal Chemistry. Apr, 2014 | Pubmed ID: 24594525 Amino-acid Mutations to Extend the Biological Half-life of a Therapeutically Valuable Mutant of Human Butyrylcholinesterase Chemico-biological Interactions. May, 2014 | Pubmed ID: 24582612 Anti-inflammatory Response Following Uptake of Apoptotic Bodies by Meningothelial Cells Journal of Neuroinflammation. 2014 | Pubmed ID: 24565420 Combination of Amino Acid/dipeptide with Nitric Oxide Donating Oleanolic Acid Derivatives As PepT1 Targeting Antitumor Prodrugs Journal of Medicinal Chemistry. Feb, 2014 | Pubmed ID: 24422538 TLR2 Mediates Phagocytosis and Autophagy Through JNK Signaling Pathway in Staphylococcus Aureus-stimulated RAW264.7 Cells Cellular Signalling. Apr, 2014 | Pubmed ID: 24412754 Design, Synthesis and Anti-Alzheimer Properties of Dimethylaminomethyl-substituted Curcumin Derivatives Bioorganic & Medicinal Chemistry Letters. Jan, 2014 | Pubmed ID: 24342238 Ruthmycin, a New Tetracyclic Polyketide from Streptomyces Sp. RM-4-15 Organic Letters. Jan, 2014 | Pubmed ID: 24341358 A Model of Glycosylated Human Butyrylcholinesterase Molecular BioSystems. Feb, 2014 | Pubmed ID: 24327294 Curcumol Exhibits Anti-inflammatory Properties by Interfering with the JNK-mediated AP-1 Pathway in Lipopolysaccharide-activated RAW264.7 Cells European Journal of Pharmacology. Jan, 2014 | Pubmed ID: 24269960 Shuang-Huang-Lian Exerts Anti-inflammatory and Anti-oxidative Activities in Lipopolysaccharide-stimulated Murine Alveolar Macrophages Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Mar, 2014 | Pubmed ID: 24192210 Comparison of Uv/PDS and UV/H2O2 Processes for the Degradation of Atenolol in Water Journal of Environmental Sciences (China). Aug, 2013 | Pubmed ID: 24520689 Bisindole Alkaloids with Neural Anti-inflammatory Activity from Gelsemium Elegans Journal of Natural Products. Dec, 2013 | Pubmed ID: 24256496 De Novo Transcriptome Profiling Uncovers a Drastic Downregulation of Photosynthesis Upon Nitrogen Deprivation in the Nonmodel Green Alga Botryosphaerella Sudeticus BMC Genomics. 2013 | Pubmed ID: 24138407 MARCH5 Inactivation Supports Mitochondrial Function During Neurodegenerative Stress Frontiers in Cellular Neuroscience. 2013 | Pubmed ID: 24133412 Platinum(II) Complexes with N-monoalkyl 1R,2R-diaminocyclohexane Derivatives As Carrier Ligands and 3-hydroxycyclobutane-1,1-dicarboxylate As a Leaving Group: Potent Cytotoxicity and DNA Binding Ability European Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24121235 Fundamental Reaction Pathway for Peptide Metabolism by Proteasome: Insights from First-principles Quantum Mechanical/molecular Mechanical Free Energy Calculations The Journal of Physical Chemistry. B. Oct, 2013 | Pubmed ID: 24111489 Degradation of Atenolol by UV/peroxymonosulfate: Kinetics, Effect of Operational Parameters and Mechanism Chemosphere. Nov, 2013 | Pubmed ID: 24083900 Substrate Selectivity of High-activity Mutants of Human Butyrylcholinesterase Organic & Biomolecular Chemistry. Nov, 2013 | Pubmed ID: 24077614 Synthesis and Anticancer Activity of Some Novel 2-phenazinamine Derivatives European Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 23995213 Pneumocystis Jiroveci Pneumonia in Patients with Non-Hodgkin's Lymphoma After Rituximab-containing Regimen: Two Cases of Report and Literature Review Journal of Thoracic Disease. Aug, 2013 | Pubmed ID: 23991330 Adult Hirschsprung's Disease: Report of Four Cases International Journal of Clinical and Experimental Pathology. 2013 | Pubmed ID: 23923081 Large-scale Separation of Alkaloids from Gelsemium Elegans by PH-zone-refining Counter-current Chromatography with a New Solvent System Screening Method Journal of Chromatography. A. Sep, 2013 | Pubmed ID: 23915643 Evaluation of the Effects of Food on the Single-dose Pharmacokinetics of Trametinib, a First-in-class MEK Inhibitor, in Patients with Cancer Journal of Clinical Pharmacology. Sep, 2013 | Pubmed ID: 23893461 Preparation and In vivo Characterization of a Cocaine Hydrolase Engineered from Human Butyrylcholinesterase for Metabolizing Cocaine The Biochemical Journal. Aug, 2013 | Pubmed ID: 23849058 Improved Heterologous Erythromycin A Production Through Expression Plasmid Re-design Biotechnology Progress. Jul-Aug, 2013 | Pubmed ID: 23804312 Cigarette Smoke Component Acrolein Modulates Chromatin Assembly by Inhibiting Histone Acetylation The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23770671 A Universal Pedicle Screw and V-rod System for Lumbar Isthmic Spondylolysis: a Retrospective Analysis of 21 Cases PloS One. 2013 | Pubmed ID: 23691090 Meningothelial Cells As Part of the Central Nervous System Host Defense Biology of the Cell / Under the Auspices of the European Cell Biology Organization. May, 2013 | Pubmed ID: 23634770 Secondary Metabolites from the Endophytic Fungi Penicillium Polonicum and Aspergillus Fumigatus Journal of Asian Natural Products Research. 2013 | Pubmed ID: 23600807 Continual Production of Glycerol from Carbon Dioxide by Dunaliella Tertiolecta Bioresource Technology. May, 2013 | Pubmed ID: 23567730 Integrated Materials Design of Organic Semiconductors for Field-effect Transistors Journal of the American Chemical Society. May, 2013 | Pubmed ID: 23557391 Scalable and Selective Dispersion of Semiconducting Arc-discharged Carbon Nanotubes by Dithiafulvalene/thiophene Copolymers for Thin Film Transistors ACS Nano. Mar, 2013 | Pubmed ID: 23402644 Phosphorylation of FOXP3 Controls Regulatory T Cell Function and is Inhibited by TNF-α in Rheumatoid Arthritis Nature Medicine. Mar, 2013 | Pubmed ID: 23396208 Design and Synthesis of Dimethylaminomethyl-substituted Curcumin Derivatives/analogues: Potent Antitumor and Antioxidant Activity, Improved Stability and Aqueous Solubility Compared with Curcumin Bioorganic & Medicinal Chemistry Letters. Mar, 2013 | Pubmed ID: 23357628 Synthesis of Cationic Polylactides with Tunable Charge Densities As Nanocarriers for Effective Gene Delivery Molecular Pharmaceutics. Mar, 2013 | Pubmed ID: 23339525 Propylene Glycol-linked Amino Acid/dipeptide Diester Prodrugs of Oleanolic Acid for PepT1-mediated Transport: Synthesis, Intestinal Permeability, and Pharmacokinetics Molecular Pharmaceutics. Apr, 2013 | Pubmed ID: 23339520 Current Progresses of Novel Natural Products and Their Derivatives/ Analogs As Anti-Alzheimer Candidates: an Update Mini Reviews in Medicinal Chemistry. May, 2013 | Pubmed ID: 23305400 Occurrence of Glycerol Uptake in Dunaliella Tertiolecta Under Hyperosmotic Stress The FEBS Journal. Feb, 2013 | Pubmed ID: 23279806 TNF-α Impairs Differentiation and Function of TGF-β-induced Treg Cells in Autoimmune Diseases Through Akt and Smad3 Signaling Pathway Journal of Molecular Cell Biology. Apr, 2013 | Pubmed ID: 23243069 Inactivation of MARCH5 Prevents Mitochondrial Fragmentation and Interferes with Cell Death in a Neuronal Cell Model PloS One. 2012 | Pubmed ID: 23285122 [A Fast Non-local Means Algorithm for Denoising of Computed Tomography Images] Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University. Nov, 2012 | Pubmed ID: 23174586 Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]. Sep, 2012 | Pubmed ID: 23157949 Mass Spectrometry Analysis to Identify Ubiquitylation of EYFP-tagged CENP-A (EYFP-CENP-A) Yohei Niikura*1, Lei Fang*2, Risa Kitagawa*3, Peizhao Li1, Yao Xi1, Ju You1, Yan Guo2, Katsumi Kitagawa3 1MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 2Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, 3Greehey Children's Cancer Institute, Department of Molecular Medicine, UT Health Science Center San Antonio JoVE 61138 Biologie Comet Assay as an Indirect Measure of Systemic Oxidative Stress Lei Fang1,2, Albert Neutzner1,2, Stephanie Turtschi1, Josef Flammer1, Maneli Mozaffarieh1 1Department of Ophthalmology, University of Basel, 2Department of Biomedicine, University of Basel JoVE 52763 Biologie
Mass Spectrometry Analysis to Identify Ubiquitylation of EYFP-tagged CENP-A (EYFP-CENP-A) Yohei Niikura*1, Lei Fang*2, Risa Kitagawa*3, Peizhao Li1, Yao Xi1, Ju You1, Yan Guo2, Katsumi Kitagawa3 1MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 2Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, 3Greehey Children's Cancer Institute, Department of Molecular Medicine, UT Health Science Center San Antonio JoVE 61138 Biologie
Comet Assay as an Indirect Measure of Systemic Oxidative Stress Lei Fang1,2, Albert Neutzner1,2, Stephanie Turtschi1, Josef Flammer1, Maneli Mozaffarieh1 1Department of Ophthalmology, University of Basel, 2Department of Biomedicine, University of Basel JoVE 52763 Biologie