Linda M Pilarski Department of Oncology University of Alberta Biography Publications Institution JoVE Articles Linda M Pilarski has not added a biography. If you are Linda M Pilarski and would like to personalize this page please email our Author Liaison for assistance. Publications A Novel Method for Sample Delivery and Testing of Whole Blood: Gel Strip PCR for Point of Care (POC) Molecular Diagnostics Lab on a Chip. Oct, 2013 | Pubmed ID: 23966268 Storing Self-contained Gel Capillary Cassettes for POC Medical Diagnostics Lab on a Chip. Oct, 2013 | Pubmed ID: 23966212 Frequent Occurrence of Highly Expanded but Unrelated B-cell Clones in Patients with Multiple Myeloma PloS One. 2013 | Pubmed ID: 23724106 The Systemic Cytokine Environment is Permanently Altered in Multiple Myeloma PloS One. 2013 | Pubmed ID: 23544044 Aberrant Splicing, Hyaluronan Synthases and Intracellular Hyaluronan As Drivers of Oncogenesis and Potential Drug Targets Current Cancer Drug Targets. May, 2013 | Pubmed ID: 23517594 An Enclosed In-gel PCR Amplification Cassette with Multi-target, Multi-sample Detection for Platform Molecular Diagnostics Lab on a Chip. Jul, 2013 | Pubmed ID: 23471315 Differential Nuclear Organization of Translocation-prone Genes in Nonmalignant B Cells from Patients with T(14;16) As Compared with T(4;14) or T(11;14) Myeloma Genes, Chromosomes & Cancer. Jun, 2013 | Pubmed ID: 23460268 Alteration of Introns in a Hyaluronan Synthase 1 (HAS1) Minigene Convert Pre-mRNA [corrected] Splicing to the Aberrant Pattern in Multiple Myeloma (MM): MM Patients Harbor Similar Changes PloS One. 2013 | Pubmed ID: 23301075 In Non-transplant Patients with Multiple Myeloma, the Pre-treatment Level of Clonotypic Cells Predicts Event-free Survival Molecular Cancer. 2012 | Pubmed ID: 23083101 In Multiple Myeloma, Bone-marrow Lymphocytes Harboring the Same Chromosomal Abnormalities As Autologous Plasma Cells Predict Poor Survival American Journal of Hematology. Jun, 2012 | Pubmed ID: 22495885 Differential Positioning and Close Spatial Proximity of Translocation-prone Genes in Nonmalignant B-cells from Multiple Myeloma Patients Genes, Chromosomes & Cancer. Aug, 2012 | Pubmed ID: 22489023 A Miniaturized and Integrated Gel Post Platform for Multiparameter PCR Detection of Herpes Simplex Viruses from Raw Genital Swabs Lab on a Chip. May, 2012 | Pubmed ID: 22426784 Expression, Adverse Prognostic Significance and Therapeutic Small Molecule Inhibition of Polo-like Kinase 1 in Multiple Myeloma Leukemia Research. Dec, 2011 | Pubmed ID: 21816470 In a Patient with Biclonal Waldenstrom Macroglobulinemia Only One Clone Expands in Three-dimensional Culture and Includes Putative Cancer Stem Cells Leukemia & Lymphoma. Feb, 2011 | Pubmed ID: 21133724 In-gel Technology for PCR Genotyping and Pathogen Detection Analytical Chemistry. Oct, 2010 | Pubmed ID: 20809605 Multiple Myeloma May Include Microvessel Endothelial Cells of Malignant Origin Leukemia & Lymphoma. Apr, 2010 | Pubmed ID: 20233053 Promiscuity of Translocation Partners in Multiple Myeloma Journal of Cellular Biochemistry. Apr, 2010 | Pubmed ID: 20127714 Aberrant Splice Variants of HAS1 (Hyaluronan Synthase 1) Multimerize with and Modulate Normally Spliced HAS1 Protein: a Potential Mechanism Promoting Human Cancer The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19451652 Genetic Abnormalities in Waldenström's Macroglobulinemia Clinical Lymphoma & Myeloma. Mar, 2009 | Pubmed ID: 19362966 The Relationships Among Physiologic Variables, Quality of Life, and Fatigue in Patients with Multiple Myeloma Oncology Nursing Forum. Mar, 2009 | Pubmed ID: 19273410 Altered Expression of Fibronectin and Collagens I and IV in Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Mar, 2009 | Pubmed ID: 19001640 Multiple Myeloma Includes Phenotypically Defined Subsets of Clonotypic CD20+ B Cells That Persist During Treatment with Rituximab Clinical Medicine. Oncology. 2008 | Pubmed ID: 21892289 Strategies for Enhancing the Speed and Integration of Microchip Genetic Amplification Electrophoresis. Dec, 2008 | Pubmed ID: 19053066 An Integrated Microfluidic Chip for Chromosome Enumeration Using Fluorescence in Situ Hybridization Lab on a Chip. Dec, 2008 | Pubmed ID: 19023479 Inherited and Acquired Variations in the Hyaluronan Synthase 1 (HAS1) Gene May Contribute to Disease Progression in Multiple Myeloma and Waldenstrom Macroglobulinemia Blood. Dec, 2008 | Pubmed ID: 18815290 Analysis of Clonotypic Switch Junctions Reveals Multiple Myeloma Originates from a Single Class Switch Event with Ongoing Mutation in the Isotype-switched Progeny Blood. Sep, 2008 | Pubmed ID: 18577707 A Unique Three-dimensional Model for Evaluating the Impact of Therapy on Multiple Myeloma Blood. Oct, 2008 | Pubmed ID: 18535198 An Inexpensive and Portable Microchip-based Platform for Integrated RT-PCR and Capillary Electrophoresis The Analyst. Mar, 2008 | Pubmed ID: 18299747 The Selective Aurora B Kinase Inhibitor AZD1152 is a Potential New Treatment for Multiple Myeloma British Journal of Haematology. Feb, 2008 | Pubmed ID: 18076711 Establishment of BCWM.1 Cell Line for Waldenström's Macroglobulinemia with Productive in Vivo Engraftment in SCID-hu Mice Experimental Hematology. Sep, 2007 | Pubmed ID: 17761288 Microfluidic Platform for Single Nucleotide Polymorphism Genotyping of the Thiopurine S-methyltransferase Gene to Evaluate Risk for Adverse Drug Events The Journal of Molecular Diagnostics : JMD. Sep, 2007 | Pubmed ID: 17690215 Microfluidic Chips for Detecting the T(4;14) Translocation and Monitoring Disease During Treatment Using Reverse Transcriptase-polymerase Chain Reaction Analysis of IgH-MMSET Hybrid Transcripts The Journal of Molecular Diagnostics : JMD. Jul, 2007 | Pubmed ID: 17591936 Molecular Characterization of Waldenstrom's Macroglobulinemia Reveals Frequent Occurrence of Two B-cell Clones Having Distinct IgH VDJ Sequences Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2007 | Pubmed ID: 17404080 Ten Years and Counting: So What Do We Know About T(4;14)(p16;q32) Multiple Myeloma Leukemia & Lymphoma. Nov, 2006 | Pubmed ID: 17107900 Automated Screening Using Microfluidic Chip-based PCR and Product Detection to Assess Risk of BK Virus-associated Nephropathy in Renal Transplant Recipients Electrophoresis. Oct, 2006 | Pubmed ID: 16960845 Impaired Class Switch Recombination (CSR) in Waldenstrom Macroglobulinemia (WM) Despite Apparently Normal CSR Machinery Blood. Apr, 2006 | Pubmed ID: 16317092 SSX Cancer Testis Antigens Are Expressed in Most Multiple Myeloma Patients: Co-expression of SSX1, 2, 4, and 5 Correlates with Adverse Prognosis and High Frequencies of SSX-positive PCs Journal of Immunotherapy (Hagerstown, Md. : 1997). Nov-Dec, 2005 | Pubmed ID: 16224274 Sensitive Detection Using Microfluidics Technology of Single Cell PCR Products from High and Low Abundance IgH VDJ Templates in Multiple Myeloma Journal of Immunological Methods. Oct, 2005 | Pubmed ID: 16150455 A Potential Role for Centrosomal Deregulation Within IgH Translocation-positive Myeloma Medical Hypotheses. 2005 | Pubmed ID: 16023302 Identification of Clonotypic IgH VDJ Sequences in Multiple Myeloma Methods in Molecular Medicine. 2005 | Pubmed ID: 15968099 Potential Impact of a Single Nucleotide Polymorphism in the Hyaluronan Synthase 1 Gene in Waldenstrom's Macroglobulinemia Clinical Lymphoma. Mar, 2005 | Pubmed ID: 15794859 Origins of Waldenstrom's Macroglobulinemia: Does It Arise from an Unusual B-cell Precursor? Clinical Lymphoma. Mar, 2005 | Pubmed ID: 15794851 Intronic Splicing of Hyaluronan Synthase 1 (HAS1): a Biologically Relevant Indicator of Poor Outcome in Multiple Myeloma Blood. Jun, 2005 | Pubmed ID: 15731173 Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer Current Drug Targets. Cardiovascular & Haematological Disorders. Feb, 2005 | Pubmed ID: 15720220 Receptor for Hyaluronan-mediated Motility Correlates with Centrosome Abnormalities in Multiple Myeloma and Maintains Mitotic Integrity Cancer Research. Feb, 2005 | Pubmed ID: 15705883 Overexpression of Transcripts Originating from the MMSET Locus Characterizes All T(4;14)(p16;q32)-positive Multiple Myeloma Patients Blood. May, 2005 | Pubmed ID: 15677557 A Combined Dielectrophoresis, Traveling Wave Dielectrophoresis and Electrorotation Microchip for the Manipulation and Characterization of Human Malignant Cells Journal of Microbiological Methods. Sep, 2004 | Pubmed ID: 15279943 RHAMM Expression and Isoform Balance Predict Aggressive Disease and Poor Survival in Multiple Myeloma Blood. Aug, 2004 | Pubmed ID: 15105292 Genetics and Cytogenetics of Multiple Myeloma: a Workshop Report Cancer Research. Feb, 2004 | Pubmed ID: 14989251 Clonotypic IgM V/D/J Sequence Analysis in Waldenstrom Macroglobulinemia Suggests an Unusual B-cell Origin and an Expansion of Polyclonal B Cells in Peripheral Blood Blood. Oct, 2004 | Pubmed ID: 14764523 Discussion on the Safety of 6-mercaptopurine for Childbearing Patients with Inflammatory Bowel Disease: a Retrospective Cohort Study Gastroenterology. Nov, 2003 | Pubmed ID: 14628819 RHAMM is a Centrosomal Protein That Interacts with Dynein and Maintains Spindle Pole Stability Molecular Biology of the Cell. Jun, 2003 | Pubmed ID: 12808028 Improved Resolution with Microchip-based Enhanced Field Inversion Electrophoresis Electrophoresis. Jun, 2003 | Pubmed ID: 12783455 Abnormal Expression of Hyaluronan Synthases in Patients with Waldenstrom's Macroglobulimenia Seminars in Oncology. Apr, 2003 | Pubmed ID: 12720129 The Malignant Clone in Waldenstrom's Macroglobulinemia Seminars in Oncology. Apr, 2003 | Pubmed ID: 12720122 In Multiple Myeloma, T(4;14)(p16;q32) is an Adverse Prognostic Factor Irrespective of FGFR3 Expression Blood. Feb, 2003 | Pubmed ID: 12393535 Clonotypic Myeloma Cells Able to Xenograft Myeloma to Nonobese Diabetic Severe Combined Immunodeficient Mice Copurify with CD34 (+) Hematopoietic Progenitors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2002 | Pubmed ID: 12374689 CD20-directed Serotherapy in Patients with Multiple Myeloma: Biologic Considerations and Therapeutic Applications Journal of Immunotherapy (Hagerstown, Md. : 1997). Jan-Feb, 2002 | Pubmed ID: 11924912 Leukemic B Cells Clonally Identical to Myeloma Plasma Cells Are Myelomagenic in NOD/SCID Mice Experimental Hematology. Mar, 2002 | Pubmed ID: 11882359 Intraclonal Homogeneity of Clonotypic Immunoglobulin M and Diversity of Nonclinical Post-switch Isotypes in Multiple Myeloma: Insights into the Evolution of the Myeloma Clone Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2002 | Pubmed ID: 11839670 Een Drie-dimensionale Tissue Culture Model om te studeren Primary humaan beenmerg en zijn Malignancies Mukti R. Parikh1, Andrew R. Belch2,3, Linda M Pilarski2,3, Julia Kirshner1 1Department of Biological Sciences, Purdue University, 2Department of Oncology, University of Alberta, 3Cross Cancer Institute JoVE 50947 Médecine
Een Drie-dimensionale Tissue Culture Model om te studeren Primary humaan beenmerg en zijn Malignancies Mukti R. Parikh1, Andrew R. Belch2,3, Linda M Pilarski2,3, Julia Kirshner1 1Department of Biological Sciences, Purdue University, 2Department of Oncology, University of Alberta, 3Cross Cancer Institute JoVE 50947 Médecine