Manabu Tokeshi Division of Applied Chemistry, Faculty of Engineering Hokkaido University Biography Publications Institution JoVE Articles Manabu Tokeshi has not added a biography. If you are Manabu Tokeshi and would like to personalize this page please email our Author Liaison for assistance. Publications Dimethoxytriadinylation LC-MS/MS of Novichok A-Series Degradation Products in Human Urine Analytical Chemistry. Mar, 2022 | Pubmed ID: 35253439 Enzyme Kinetics in Confined Geometries at the Single Enzyme Level The Analyst. Mar, 2022 | Pubmed ID: 35230361 Microfluidic Technologies and Devices for Lipid Nanoparticle-based RNA Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2022 | Pubmed ID: 35183654 Electrochemical Enzyme-based Blood ATP and Lactate Sensor for a Rapid and Straightforward Evaluation of Illness Severity Biosensors & Bioelectronics. Feb, 2022 | Pubmed ID: 34856516 Determination of Blood Lithium-ion Concentration Using Digital Microfluidic Whole-blood Separation and Preloaded Paper Sensors Biosensors & Bioelectronics. Jan, 2022 | Pubmed ID: 34571482 One-Step Production Using a Microfluidic Device of Highly Biocompatible Size-Controlled Noncationic Exosome-like Nanoparticles for RNA Delivery ACS Applied Bio Materials. 02, 2021 | Pubmed ID: 35014524 Paper-Based Analytical Device for the On-Site Detection of Nerve Agents ACS Applied Bio Materials. 08, 2021 | Pubmed ID: 35006863 Topology-Dependent Interaction of Cyclic Poly(ethylene Glycol) Complexed with Gold Nanoparticles Against Bovine Serum Albumin for a Colorimetric Change Langmuir : the ACS Journal of Surfaces and Colloids. Dec, 2021 | Pubmed ID: 34878285 Microchip Immunoassays for Monitoring Renal Function: Rapid, Low-Cost, and Highly Sensitive Quantification of Urinary Biomarkers of Diabetic Nephropathy Micromachines. Oct, 2021 | Pubmed ID: 34832765 Facile and Rapid Detection of SARS-CoV-2 Antibody Based on a Noncompetitive Fluorescence Polarization Immunoassay in Human Serum Samples Biosensors & Bioelectronics. Oct, 2021 | Pubmed ID: 34130087 Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material Pharmaceutics. Apr, 2021 | Pubmed ID: 33924589 Simple Approach for Fluorescence Signal Amplification Utilizing a Poly(vinyl Alcohol)-Based Polymer Structure in a Microchannel ACS Omega. Mar, 2021 | Pubmed ID: 33817494 Dip-Type Paper-Based Analytical Device for Straightforward Quantitative Detection Without Precise Sample Introduction ACS Sensors. 03, 2021 | Pubmed ID: 33660502 Non-competitive Fluorescence Polarization Immunoassay for Detection of H5 Avian Influenza Virus Using a Portable Analyzer Analytical and Bioanalytical Chemistry. Jul, 2021 | Pubmed ID: 33547481 Rapid, Sensitive Universal Paper-based Device Enhances Competitive Immunoassays of Small Molecules Analytica Chimica Acta. Feb, 2021 | Pubmed ID: 33453801 Lipid Nanoparticles Loaded with Ribonucleoprotein-oligonucleotide Complexes Synthesized Using a Microfluidic Device Exhibit Robust Genome Editing and Hepatitis B Virus Inhibition Journal of Controlled Release : Official Journal of the Controlled Release Society. 02, 2021 | Pubmed ID: 33333121 Room-temperature Crystallography Using a Microfluidic Protein Crystal Array Device and Its Application to Protein-ligand Complex Structure Analysis Chemical Science. Aug, 2020 | Pubmed ID: 34094189 Enhanced Dispersion Stability of Gold Nanoparticles by the Physisorption of Cyclic Poly(ethylene Glycol) Nature Communications. 11, 2020 | Pubmed ID: 33257670 Development of an Immuno-wall Device for the Rapid and Sensitive Detection of EGFR Mutations in Tumor Tissues Resected from Lung Cancer Patients PloS One. 2020 | Pubmed ID: 33196648 Noncompetitive Fluorescence Polarization Immunoassay for Protein Determination Analytical Chemistry. 11, 2020 | Pubmed ID: 33094615 The Use of Design of Experiments with Multiple Responses to Determine Optimal Formulations for in Vivo Hepatic MRNA Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. 11, 2020 | Pubmed ID: 32853732 Real-Time Measurement of Protein Crystal Growth Rates Within the Microfluidic Device to Understand the Microspace Effect ACS Omega. Jul, 2020 | Pubmed ID: 32715205 Development of a Microfluidic-Based Post-Treatment Process for Size-Controlled Lipid Nanoparticles and Application to SiRNA Delivery ACS Applied Materials & Interfaces. Jul, 2020 | Pubmed ID: 32667806 Observation of Ethanol-Induced Condensation and Decondensation Processes at a Single-DNA Molecular Level in Microfluidic Devices Equipped with a Rapid Solution Exchange System Analytical Chemistry. 07, 2020 | Pubmed ID: 32483963 Rapid Detection of Anti-H5 Avian Influenza Virus Antibody by Fluorescence Polarization Immunoassay Using a Portable Fluorescence Polarization Analyzer Sensors and Actuators. B, Chemical. Aug, 2020 | Pubmed ID: 32322135 Paper-Based Device for the Facile Colorimetric Determination of Lithium Ions in Human Whole Blood ACS Sensors. 05, 2020 | Pubmed ID: 32283919 The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution Molecular Pharmaceutics. 03, 2020 | Pubmed ID: 31990567 Hydrophobic Scaffolds of PH-sensitive Cationic Lipids Contribute to Miscibility with Phospholipids and Improve the Efficiency of Delivering Short Interfering RNA by Small-sized Lipid Nanoparticles Acta Biomaterialia. 01, 2020 | Pubmed ID: 31733331 Rapid, Sensitive, and Selective Detection of H5 Hemagglutinin from Avian Influenza Virus Using an Immunowall Device ACS Omega. Oct, 2019 | Pubmed ID: 31616851 A Paper-based Analytical Device Coupled with Electrochemical Detection for the Determination of Dexamethasone and Prednisolone in Adulterated Traditional Medicines Analytica Chimica Acta. Oct, 2019 | Pubmed ID: 31358214 An Electrochemical Sensor Based on Structure Switching of Dithiol-modified Aptamer for Simple Detection of Ochratoxin A Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry. Nov, 2019 | Pubmed ID: 31327816 High-throughput Fluorescence Polarization Immunoassay by Using a Portable Fluorescence Polarization Imaging Analyzer Lab on a Chip. 08, 2019 | Pubmed ID: 31250849 Ultrasensitive Detection of Disease Biomarkers Using an Immuno-wall Device with Enzymatic Amplification The Analyst. Aug, 2019 | Pubmed ID: 31237262 The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria Journal of Pharmaceutical Sciences. 08, 2019 | Pubmed ID: 30959057 Understanding Structure-activity Relationships of PH-sensitive Cationic Lipids Facilitates the Rational Identification of Promising Lipid Nanoparticles for Delivering SiRNAs in Vivo Journal of Controlled Release : Official Journal of the Controlled Release Society. 02, 2019 | Pubmed ID: 30610950 Development of a Microdevice for Facile Analysis of Theophylline in Whole Blood by a Cloned Enzyme Donor Immunoassay Lab on a Chip. 01, 2019 | Pubmed ID: 30547178 Development of the ILiNP Device: Fine Tuning the Lipid Nanoparticle Size Within 10 Nm for Drug Delivery ACS Omega. May, 2018 | Pubmed ID: 31458718 Recent Microdevice-Based Aptamer Sensors Micromachines. Apr, 2018 | Pubmed ID: 30424135 Microfluidic Devices for Drug Delivery Systems Advanced Drug Delivery Reviews. 03, 2018 | Pubmed ID: 29908612 Advances in Microfluidics for Lipid Nanoparticles and Extracellular Vesicles and Applications in Drug Delivery Systems Advanced Drug Delivery Reviews. 03, 2018 | Pubmed ID: 29567396 A Compact Fluorescence Polarization Analyzer with High-transmittance Liquid Crystal Layer The Review of Scientific Instruments. Feb, 2018 | Pubmed ID: 29495833 Characteristics of Microfluidic Paper-based Analytical Devices Fabricated by Four Different Methods Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry. 2018 | Pubmed ID: 29321455 Understanding the Formation Mechanism of Lipid Nanoparticles in Microfluidic Devices with Chaotic Micromixers PloS One. 2017 | Pubmed ID: 29182626 Using Laser Interference Lithography in the Fabrication of a Simplified Micro- and Nanofluidic Device for Label-free Detection Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry. 2017 | Pubmed ID: 28993597 A Millisecond Micro-RNA Separation Technique by a Hybrid Structure of Nanopillars and Nanoslits Scientific Reports. 03, 2017 | Pubmed ID: 28272420 Fabrication and Evaluation of Microfluidic Immunoassay Devices with Antibody-Immobilized Microbeads Retained in Porous Hydrogel Micropillars Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28044286 Micro/Nano Devices for Chemical Analysis Micromachines. Sep, 2016 | Pubmed ID: 30404336 Microfluidic Autologous Serum Eye-Drops Preparation As a Potential Dry Eye Treatment Micromachines. Jul, 2016 | Pubmed ID: 30404287 Advances in Microfluidic Paper-Based Analytical Devices for Food and Water Analysis Micromachines. May, 2016 | Pubmed ID: 30404261 Rapid Detection of Cat Cystatin C (cCys-C) Using Immuno-Pillar Chips Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry. 2016 | Pubmed ID: 27941268 An Immuno-wall Microdevice Exhibits Rapid and Sensitive Detection of IDH1-R132H Mutation Specific to Grade II and III Gliomas Science and Technology of Advanced Materials. 2016 | Pubmed ID: 27877908 A Competitive Immunoassay System for Microfluidic Paper-based Analytical Detection of Small Size Molecules The Analyst. Nov, 2016 | Pubmed ID: 27858015 Image Analysis for a Microfluidic Paper-based Analytical Device Using the CIE L*a*b* Color System The Analyst. Nov, 2016 | Pubmed ID: 27830841 Novel Concept of Washing for Microfluidic Paper-based Analytical Devices Based on Capillary Force of Paper Substrates Analytical and Bioanalytical Chemistry. Nov, 2016 | Pubmed ID: 27544520 Label-free Detection of Real-time DNA Amplification Using a Nanofluidic Diffraction Grating Scientific Reports. 08, 2016 | Pubmed ID: 27531471 3,3',5,5'-Tetramethylbenzidine Oxidation on Paper Devices for Horseradish Peroxidase-based Assays Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry. 2016 | Pubmed ID: 27506705 Elucidation of the Physicochemical Properties and Potency of SiRNA-loaded Small-sized Lipid Nanoparticles for SiRNA Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. 05, 2016 | Pubmed ID: 26995758 Microfluidic Approaches for Protein Crystal Structure Analysis Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry. 2016 | Pubmed ID: 26753699 A Portable Liquid Chromatograph with a Battery-operated Compact Electroosmotic Pump and a Microfluidic Chip Device with a Reversed Phase Packed Column Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry. 2015 | Pubmed ID: 26561261 Fluorescence Polarization Measurement System Using a Liquid Crystal Layer and an Image Sensor Analytical Chemistry. Oct, 2015 | Pubmed ID: 26352939 An Instrument-free, Screen-printed Paper Microfluidic Device That Enables Bio and Chemical Sensing The Analyst. Oct, 2015 | Pubmed ID: 26207925 A Microfluidic Cell Culture System for Monitoring of Sequential Changes in Endothelial Cells After Heat Stress Thrombosis Research. Aug, 2015 | Pubmed ID: 26044666 Arrangement of a Nanostructure Array to Control Equilibrium and Nonequilibrium Transports of Macromolecules Nano Letters. May, 2015 | Pubmed ID: 25879141 A Method of Cryoprotection for Protein Crystallography by Using a Microfluidic Chip and Its Application for in Situ X-ray Diffraction Measurements Analytical Chemistry. Apr, 2015 | Pubmed ID: 25834918 Fabrication of Functionalized Double-lamellar Multifunctional Envelope-type Nanodevices Using a Microfluidic Chip with a Chaotic Mixer Array PloS One. 2012 | Pubmed ID: 22723929 Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device Masatoshi Maeki1,2, Yuto Okada3, Shuya Uno3, Ayuka Niwa3, Akihiko Ishida1, Hirofumi Tani1, Manabu Tokeshi1 1Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, 2JST PRESTO, 3Graduate School of Chemical Sciences and Engineering, Hokkaido University JoVE 62999 Biochimie
Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device Masatoshi Maeki1,2, Yuto Okada3, Shuya Uno3, Ayuka Niwa3, Akihiko Ishida1, Hirofumi Tani1, Manabu Tokeshi1 1Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, 2JST PRESTO, 3Graduate School of Chemical Sciences and Engineering, Hokkaido University JoVE 62999 Biochimie