Marc E. Rothenberg Division of Allergy and Immunology, Department of Pediatrics Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine Biography Publications Institution JoVE Articles Marc E. Rothenberg has not added a biography. If you are Marc E. Rothenberg and would like to personalize this page please email our Author Liaison for assistance. Publications Resistin-like Molecule Alpha in Allergen-induced Pulmonary Vascular Remodeling American Journal of Respiratory Cell and Molecular Biology. Jan, 2015 | Pubmed ID: 25569618 Making It Big in Allergy The Journal of Allergy and Clinical Immunology. Jan, 2015 | Pubmed ID: 25567041 Transcriptome Analysis of Proton Pump Inhibitor-responsive Esophageal Eosinophilia Reveals Proton Pump Inhibitor-reversible Allergic Inflammation The Journal of Allergy and Clinical Immunology. Jan, 2015 | Pubmed ID: 25441638 Phenome-wide Association Study (PheWAS) in EMR-linked Pediatric Cohorts, Genetically Links PLCL1 to Speech Language Development and IL5-IL13 to Eosinophilic Esophagitis Frontiers in Genetics. 2014 | Pubmed ID: 25477900 Twin and Family Studies Reveal Strong Environmental and Weaker Genetic Cues Explaining Heritability of Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. Nov, 2014 | Pubmed ID: 25258143 Histologic Eosinophilic Gastritis is a Systemic Disorder Associated with Blood and Extragastric Eosinophilia, TH2 Immunity, and a Unique Gastric Transcriptome The Journal of Allergy and Clinical Immunology. Nov, 2014 | Pubmed ID: 25234644 IL-5 Triggers a Cooperative Cytokine Network That Promotes Eosinophil Precursor Maturation Journal of Immunology (Baltimore, Md. : 1950). Oct, 2014 | Pubmed ID: 25230753 Intravenous Anti-IL-13 MAb QAX576 for the Treatment of Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. Sep, 2014 | Pubmed ID: 25226850 Roles and Regulation of Gastrointestinal Eosinophils in Immunity and Disease Journal of Immunology (Baltimore, Md. : 1950). Aug, 2014 | Pubmed ID: 25049430 Genome-wide Association Analysis of Eosinophilic Esophagitis Provides Insight into the Tissue Specificity of This Allergic Disease Nature Genetics. Aug, 2014 | Pubmed ID: 25017104 Murine Models of Eosinophilic Leukemia: a Model of FIP1L1-PDGFRα Initiated Chronic Eosinophilic Leukemia/systemic Mastocytosis Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24986627 Genetic and Epigenetic Underpinnings of Eosinophilic Esophagitis Gastroenterology Clinics of North America. Jun, 2014 | Pubmed ID: 24813515 Carbonic Anhydrase IV is Expressed on IL-5-activated Murine Eosinophils Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014 | Pubmed ID: 24808371 Utility of Neutrophil Fcγ Receptor I (CD64) Index As a Biomarker for Mucosal Inflammation in Pediatric Crohn's Disease Inflammatory Bowel Diseases. Jun, 2014 | Pubmed ID: 24788216 Eosinophils and Cancer Cancer Immunology Research. Jan, 2014 | Pubmed ID: 24778159 Efficacy, Dose Reduction, and Resistance to High-dose Fluticasone in Patients with Eosinophilic Esophagitis Gastroenterology. Aug, 2014 | Pubmed ID: 24768678 Rab5 is a Novel Regulator of Mast Cell Secretory Granules: Impact on Size, Cargo, and Exocytosis Journal of Immunology (Baltimore, Md. : 1950). May, 2014 | Pubmed ID: 24696234 Mendelian Inheritance of Elevated Serum Tryptase Associated with Atopy and Connective Tissue Abnormalities The Journal of Allergy and Clinical Immunology. May, 2014 | Pubmed ID: 24472624 Increased Prevalence of Eosinophilic Gastrointestinal Disorders in Pediatric PTEN Hamartoma Tumor Syndromes Journal of Pediatric Gastroenterology and Nutrition. May, 2014 | Pubmed ID: 24345843 Demethylation of the Human Eotaxin-3 Gene Promoter Leads to the Elevated Expression of Eotaxin-3 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2014 | Pubmed ID: 24323578 Correlation of Increased PARP14 and CCL26 Expression in Biopsies from Children with Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. Feb, 2014 | Pubmed ID: 24238647 Paired Immunoglobulin-like Receptor A is an Intrinsic, Self-limiting Suppressor of IL-5-induced Eosinophil Development Nature Immunology. Jan, 2014 | Pubmed ID: 24212998 The Management of Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. In Practice. Jul-Aug, 2013 | Pubmed ID: 24565538 Eosinophilic Asthma: Insights into the Effects of Reducing IL-5 Receptor-positive Cell Levels The Journal of Allergy and Clinical Immunology. Nov, 2013 | Pubmed ID: 24094543 IL-33 Markedly Activates Murine Eosinophils by an NF-κB-dependent Mechanism Differentially Dependent Upon an IL-4-driven Autoinflammatory Loop Journal of Immunology (Baltimore, Md. : 1950). Oct, 2013 | Pubmed ID: 24043894 Molecular Diagnosis of Eosinophilic Esophagitis by Gene Expression Profiling Gastroenterology. Dec, 2013 | Pubmed ID: 23978633 Rank-based Genome-wide Analysis Reveals the Association of Ryanodine Receptor-2 Gene Variants with Childhood Asthma Among Human Populations Human Genomics. 2013 | Pubmed ID: 23829686 Diagnostic, Functional, and Therapeutic Roles of MicroRNA in Allergic Diseases The Journal of Allergy and Clinical Immunology. Jul, 2013 | Pubmed ID: 23735656 Expanding the Paradigm of Eosinophilic Esophagitis: Mast Cells and IL-9 The Journal of Allergy and Clinical Immunology. Jun, 2013 | Pubmed ID: 23726533 High Prevalence of Eosinophilic Esophagitis in Patients with Inherited Connective Tissue Disorders The Journal of Allergy and Clinical Immunology. Aug, 2013 | Pubmed ID: 23608731 Emerging Concepts of Dietary Therapy for Pediatric and Adult Eosinophilic Esophagitis Expert Review of Clinical Immunology. Apr, 2013 | Pubmed ID: 23557262 Eosinophil Adoptive Transfer System to Directly Evaluate Pulmonary Eosinophil Trafficking in Vivo Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23536294 Targeted Ablation of MiR-21 Decreases Murine Eosinophil Progenitor Cell Growth PloS One. 2013 | Pubmed ID: 23533623 PedsQL Eosinophilic Esophagitis Module: Feasibility, Reliability, and Validity Journal of Pediatric Gastroenterology and Nutrition. Jul, 2013 | Pubmed ID: 23478422 Advances in Mechanisms of Allergy and Clinical Immunology in 2012 The Journal of Allergy and Clinical Immunology. Mar, 2013 | Pubmed ID: 23352632 The E3 Ubiquitin Ligase Midline 1 Promotes Allergen and Rhinovirus-induced Asthma by Inhibiting Protein Phosphatase 2A Activity Nature Medicine. Feb, 2013 | Pubmed ID: 23334847 Targeting Eosinophils in Allergy, Inflammation and Beyond Nature Reviews. Drug Discovery. Feb, 2013 | Pubmed ID: 23334207 MiR-223 Deficiency Increases Eosinophil Progenitor Proliferation Journal of Immunology (Baltimore, Md. : 1950). Feb, 2013 | Pubmed ID: 23325891 Reply: To PMID 22541246 The Journal of Allergy and Clinical Immunology. Jan, 2013 | Pubmed ID: 23127828 Long-term Safety of Mepolizumab for the Treatment of Hypereosinophilic Syndromes The Journal of Allergy and Clinical Immunology. Feb, 2013 | Pubmed ID: 23040887 ICON: Eosinophil Disorders The World Allergy Organization Journal. Dec, 2012 | Pubmed ID: 23282419 The Child Health Research Centers: Twenty-one Years of Promoting the Development of Pediatrician Scientists from 1990-2011 The Journal of Pediatrics. Dec, 2012 | Pubmed ID: 23171484 Commentary on "Markers of Antigen Presentation And Activation On Eosinophils And T-Cells in the Esophageal Tissue of Patients With Eosinophilic Esophagitis" Journal of Pediatric Gastroenterology and Nutrition. Nov, 2012 | Pubmed ID: 23132165 Development of the Pediatric Quality of Life Inventory™ Eosinophilic Esophagitis Module Items: Qualitative Methods BMC Gastroenterology. 2012 | Pubmed ID: 23009120 Working with the US Food and Drug Administration: Progress and Timelines in Understanding and Treating Patients with Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. Sep, 2012 | Pubmed ID: 22935588 Workshop Report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD) The Journal of Allergy and Clinical Immunology. Sep, 2012 | Pubmed ID: 22935587 Novel Targeted Therapies for Eosinophilic Disorders The Journal of Allergy and Clinical Immunology. Sep, 2012 | Pubmed ID: 22935585 Behavioral Feeding Problems and Parenting Stress in Eosinophilic Gastrointestinal Disorders in Children Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology. Dec, 2012 | Pubmed ID: 22882380 The Greater Cincinnati Pediatric Clinic Repository: A Novel Framework for Childhood Asthma and Allergy Research Pediatric Allergy, Immunology, and Pulmonology. Jun, 2012 | Pubmed ID: 22768387 Comparative Dietary Therapy Effectiveness in Remission of Pediatric Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. Jun, 2012 | Pubmed ID: 22541246 Behavioral Functioning and Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology. Aug, 2012 | Pubmed ID: 22435992 MicroRNA Signature in Patients with Eosinophilic Esophagitis, Reversibility with Glucocorticoids, and Assessment As Disease Biomarkers The Journal of Allergy and Clinical Immunology. Apr, 2012 | Pubmed ID: 22391115 Advances in Mechanisms of Asthma, Allergy, and Immunology in 2011 The Journal of Allergy and Clinical Immunology. Feb, 2012 | Pubmed ID: 22284930 Resistin-like Molecule-α Regulates IL-13-induced Chemokine Production but Not Allergen-induced Airway Responses American Journal of Respiratory Cell and Molecular Biology. May, 2012 | Pubmed ID: 22246861 Reslizumab in Children and Adolescents with Eosinophilic Esophagitis: Results of a Double-blind, Randomized, Placebo-controlled Trial The Journal of Allergy and Clinical Immunology. Feb, 2012 | Pubmed ID: 22206777 The Pan-B Cell Marker CD22 is Expressed on Gastrointestinal Eosinophils and Negatively Regulates Tissue Eosinophilia Journal of Immunology (Baltimore, Md. : 1950). Feb, 2012 | Pubmed ID: 22190185 Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders Journal of Pediatric Psychology. Jun, 2012 | Pubmed ID: 22080457 Eosinophilic Esophagitis: Rapidly Advancing Insights Annual Review of Medicine. 2012 | Pubmed ID: 22034864 Development of a Validated Patient-reported Symptom Metric for Pediatric Eosinophilic Esophagitis: Qualitative Methods BMC Gastroenterology. 2011 | Pubmed ID: 22099448 IL-13 Receptor α1 Differentially Regulates Aeroallergen-induced Lung Responses Journal of Immunology (Baltimore, Md. : 1950). Nov, 2011 | Pubmed ID: 21957151 MicroRNA-21 Limits in Vivo Immune Response-mediated Activation of the IL-12/IFN-gamma Pathway, Th1 Polarization, and the Severity of Delayed-type Hypersensitivity Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21849676 Long-term Outcomes in Pediatric-onset Esophageal Eosinophilia The Journal of Allergy and Clinical Immunology. Jul, 2011 | Pubmed ID: 21636117 Agonist Activation of F-actin-mediated Eosinophil Shape Change and Mediator Release is Dependent on Rac2 International Archives of Allergy and Immunology. 2011 | Pubmed ID: 21576984 Genetic Dissection of Eosinophilic Esophagitis Provides Insight into Disease Pathogenesis and Treatment Strategies The Journal of Allergy and Clinical Immunology. Jul, 2011 | Pubmed ID: 21570716 Colonic Eosinophilic Inflammation in Experimental Colitis is Mediated by Ly6C(high) CCR2(+) Inflammatory Monocyte/macrophage-derived CCL11 Journal of Immunology (Baltimore, Md. : 1950). May, 2011 | Pubmed ID: 21498668 Eosinophilic Esophagitis: Updated Consensus Recommendations for Children and Adults The Journal of Allergy and Clinical Immunology. Jul, 2011 | Pubmed ID: 21477849 Differences in Candidate Gene Association Between European Ancestry and African American Asthmatic Children PloS One. 2011 | Pubmed ID: 21387019 Advances in Mechanisms of Asthma, Allergy, and Immunology in 2010 The Journal of Allergy and Clinical Immunology. Mar, 2011 | Pubmed ID: 21377038 Epigenetic Regulation of the IL-13-induced Human Eotaxin-3 Gene by CREB-binding Protein-mediated Histone 3 Acetylation The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21325281 Interleukin-13 (IL-13)/IL-13 Receptor Alpha1 (IL-13Ralpha1) Signaling Regulates Intestinal Epithelial Cystic Fibrosis Transmembrane Conductance Regulator Channel-dependent Cl- Secretion The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21303908 A Striking Local Esophageal Cytokine Expression Profile in Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. Jan, 2011 | Pubmed ID: 21211656 The Role of Neuropeptide S and Neuropeptide S Receptor 1 in Regulation of Respiratory Function in Mice Peptides. Apr, 2011 | Pubmed ID: 21167892 Acquired Coenzyme Q10 Deficiency in Children with Recurrent Food Intolerance and Allergies Mitochondrion. Jan, 2011 | Pubmed ID: 20817046 Psychological Functioning of Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders Children's Health Care : Journal of the Association for the Care of Children's Health. Oct, 2010 | Pubmed ID: 21532963 TGF-β1: Mediator of a Feedback Loop in Eosinophilic Esophagitis--or Should We Really Say Mastocytic Esophagitis? The Journal of Allergy and Clinical Immunology. Dec, 2010 | Pubmed ID: 21134572 IL-13Rα2 Has a Protective Role in a Mouse Model of Cutaneous Inflammation Journal of Immunology (Baltimore, Md. : 1950). Dec, 2010 | Pubmed ID: 20971924 Innate Sensing of Nickel Nature Immunology. Sep, 2010 | Pubmed ID: 20720584 Refining the Definition of Hypereosinophilic Syndrome The Journal of Allergy and Clinical Immunology. Jul, 2010 | Pubmed ID: 20639008 Variants of Thymic Stromal Lymphopoietin and Its Receptor Associate with Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. Jul, 2010 | Pubmed ID: 20620568 Identification, Epidemiology, and Chronicity of Pediatric Esophageal Eosinophilia, 1982-1999 The Journal of Allergy and Clinical Immunology. Jul, 2010 | Pubmed ID: 20620567 The Cationic Amino Acid Transporter 2 is Induced in Inflammatory Lung Models and Regulates Lung Fibrosis Respiratory Research. 2010 | Pubmed ID: 20576117 IL-13 Induces Esophageal Remodeling and Gene Expression by an Eosinophil-independent, IL-13R Alpha 2-inhibited Pathway Journal of Immunology (Baltimore, Md. : 1950). Jul, 2010 | Pubmed ID: 20543112 Involvement of Mast Cells in Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. Jul, 2010 | Pubmed ID: 20538331 IL-5 Pathway Inhibition in the Treatment of Asthma and Churg-Strauss Syndrome The Journal of Allergy and Clinical Immunology. Jun, 2010 | Pubmed ID: 20513522 Arginase I Suppresses IL-12/IL-23p40-driven Intestinal Inflammation During Acute Schistosomiasis Journal of Immunology (Baltimore, Md. : 1950). Jun, 2010 | Pubmed ID: 20483789 Indoor Insect Allergens Are Potent Inducers of Experimental Eosinophilic Esophagitis in Mice Journal of Leukocyte Biology. Aug, 2010 | Pubmed ID: 20413729 Paired Immunoglobulin-like Receptor B (PIR-B) Negatively Regulates Macrophage Activation in Experimental Colitis Gastroenterology. Aug, 2010 | Pubmed ID: 20398663 Organ-specific Eosinophilic Disorders of the Skin, Lung, and Gastrointestinal Tract The Journal of Allergy and Clinical Immunology. Jul, 2010 | Pubmed ID: 20392477 Interleukin-15 Expression is Increased in Human Eosinophilic Esophagitis and Mediates Pathogenesis in Mice Gastroenterology. Jul, 2010 | Pubmed ID: 20381491 Glucocorticoid-regulated Genes in Eosinophilic Esophagitis: a Role for FKBP51 The Journal of Allergy and Clinical Immunology. Apr, 2010 | Pubmed ID: 20371398 Common Variants at 5q22 Associate with Pediatric Eosinophilic Esophagitis Nature Genetics. Apr, 2010 | Pubmed ID: 20208534 Coordinate Interaction Between IL-13 and Epithelial Differentiation Cluster Genes in Eosinophilic Esophagitis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2010 | Pubmed ID: 20208004 Abnormal Response to Stress and Impaired NPS-induced Hyperlocomotion, Anxiolytic Effect and Corticosterone Increase in Mice Lacking NPSR1 Psychoneuroendocrinology. Sep, 2010 | Pubmed ID: 20171785 Key Advances in Mechanisms of Asthma, Allergy, and Immunology in 2009 The Journal of Allergy and Clinical Immunology. Feb, 2010 | Pubmed ID: 20159240 Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma Journal of Immunology (Baltimore, Md. : 1950). Feb, 2010 | Pubmed ID: 20130218 Health-related Quality of Life Across Pediatric Chronic Conditions The Journal of Pediatrics. Apr, 2010 | Pubmed ID: 20117793 Persistent Rotavirus Vaccine Shedding in a New Case of Severe Combined Immunodeficiency: A Reason to Screen The Journal of Allergy and Clinical Immunology. Jan, 2010 | Pubmed ID: 20109754 Polymorphisms in the Sialic Acid-binding Immunoglobulin-like Lectin-8 (Siglec-8) Gene Are Associated with Susceptibility to Asthma European Journal of Human Genetics : EJHG. Jun, 2010 | Pubmed ID: 20087405 Intestinal Epithelial Cell Secretion of RELM-beta Protects Against Gastrointestinal Worm Infection The Journal of Experimental Medicine. Dec, 2009 | Pubmed ID: 19995957 Hypereosinophilic Syndrome: a Multicenter, Retrospective Analysis of Clinical Characteristics and Response to Therapy The Journal of Allergy and Clinical Immunology. Dec, 2009 | Pubmed ID: 19910029 Hypersensitivity and Allergy: from Mice to Men Current Opinion in Immunology. Dec, 2009 | Pubmed ID: 19879743 Eosinophil Viability is Increased by Acidic PH in a CAMP- and GPR65-dependent Manner Blood. Sep, 2009 | Pubmed ID: 19641187 Biology and Treatment of Eosinophilic Esophagitis Gastroenterology. Oct, 2009 | Pubmed ID: 19596009 CCR3 is a Target for Age-related Macular Degeneration Diagnosis and Therapy Nature. Jul, 2009 | Pubmed ID: 19525930 Murine Model of Hypereosinophilic Syndromes/chronic Eosinophilic Leukemia International Archives of Allergy and Immunology. 2009 | Pubmed ID: 19494514 Bone Marrow Cell Derived Arginase I is the Major Source of Allergen-induced Lung Arginase but is Not Required for Airway Hyperresponsiveness, Remodeling and Lung Inflammatory Responses in Mice BMC Immunology. 2009 | Pubmed ID: 19486531 Eosinophilic Esophagitis: Concepts, Controversies, and Evidence Current Gastroenterology Reports. Jun, 2009 | Pubmed ID: 19463222 MicroRNA-21 is Up-regulated in Allergic Airway Inflammation and Regulates IL-12p35 Expression Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009 | Pubmed ID: 19342679 Molecular Diagnostics and Treatment of Patients with the Hypereosinophilic Syndrome Clinical Advances in Hematology & Oncology : H&O. Jan, 2009 | Pubmed ID: 19274040 Biology of the Eosinophil Advances in Immunology. 2009 | Pubmed ID: 19231593 Resistin-like Molecule Alpha Decreases Glucose Tolerance During Intestinal Inflammation Journal of Immunology (Baltimore, Md. : 1950). Feb, 2009 | Pubmed ID: 19201890 Dissociation Between Symptoms and Histological Severity in Pediatric Eosinophilic Esophagitis Journal of Pediatric Gastroenterology and Nutrition. Feb, 2009 | Pubmed ID: 19179876 Ablation of Type I Hypersensitivity in Experimental Allergic Conjunctivitis by Eotaxin-1/CCR3 Blockade International Immunology. Feb, 2009 | Pubmed ID: 19147836 Chemotactic Factors Associated with Eosinophilic Gastrointestinal Diseases Immunology and Allergy Clinics of North America. Feb, 2009 | Pubmed ID: 19141349 Targeting IL-4/IL-13 Signaling to Alleviate Oral Allergen-induced Diarrhea The Journal of Allergy and Clinical Immunology. Jan, 2009 | Pubmed ID: 18996576 Resistin-like Molecule Alpha Enhances Myeloid Cell Activation and Promotes Colitis The Journal of Allergy and Clinical Immunology. Dec, 2008 | Pubmed ID: 19084112 Intestinal Macrophage/epithelial Cell-derived CCL11/eotaxin-1 Mediates Eosinophil Recruitment and Function in Pediatric Ulcerative Colitis Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008 | Pubmed ID: 18981162 Mitochondrial Missile Defense Nature Medicine. Sep, 2008 | Pubmed ID: 18776879 Allergy and Eosinophil-associated Gastrointestinal Disorders (EGID) Current Opinion in Immunology. Dec, 2008 | Pubmed ID: 18721876 FIP1L1/PDGFRalpha Synergizes with SCF to Induce Systemic Mastocytosis in a Murine Model of Chronic Eosinophilic Leukemia/hypereosinophilic Syndrome Blood. Sep, 2008 | Pubmed ID: 18539901 Pulmonary Eosinophilia Requires Interleukin-5, Eotaxin-1, and CD4+ T Cells in Mice Immunized with Respiratory Syncytial Virus G Glycoprotein Journal of Leukocyte Biology. Sep, 2008 | Pubmed ID: 18519743 Origin, Regulation and Physiological Function of Intestinal Oeosinophils Best Practice & Research. Clinical Gastroenterology. 2008 | Pubmed ID: 18492563 Clinical, Pathologic, and Molecular Characterization of Familial Eosinophilic Esophagitis Compared with Sporadic Cases Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Jun, 2008 | Pubmed ID: 18434257 2007 E. Mead Johnson Award: Scientific Pursuit of the Allergy Problem Pediatric Research. Jul, 2008 | Pubmed ID: 18414146 Anti-IL-5 (mepolizumab) Therapy Reduces Eosinophil Activation Ex Vivo and Increases IL-5 and IL-5 Receptor Levels The Journal of Allergy and Clinical Immunology. Jun, 2008 | Pubmed ID: 18410960 Eosinophils: Biological Properties and Role in Health and Disease Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology. May, 2008 | Pubmed ID: 18384431 IL-9- and Mast Cell-mediated Intestinal Permeability Predisposes to Oral Antigen Hypersensitivity The Journal of Experimental Medicine. Apr, 2008 | Pubmed ID: 18378796 Surfactant Protein D Alters Allergic Lung Responses in Mice and Human Subjects The Journal of Allergy and Clinical Immunology. May, 2008 | Pubmed ID: 18355911 IL-4R Alpha Expression by Bone Marrow-derived Cells is Necessary and Sufficient for Host Protection Against Acute Schistosomiasis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2008 | Pubmed ID: 18354220 Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab The New England Journal of Medicine. Mar, 2008 | Pubmed ID: 18344568 A Dual Activation and Inhibition Role for the Paired Immunoglobulin-like Receptor B in Eosinophils Blood. Jun, 2008 | Pubmed ID: 18316626 Esophageal Remodeling Develops As a Consequence of Tissue Specific IL-5-induced Eosinophilia Gastroenterology. Jan, 2008 | Pubmed ID: 18166354 Basic Pathogenesis of Eosinophilic Esophagitis Gastrointestinal Endoscopy Clinics of North America. Jan, 2008 | Pubmed ID: 18061107 IL-13 Involvement in Eosinophilic Esophagitis: Transcriptome Analysis and Reversibility with Glucocorticoids The Journal of Allergy and Clinical Immunology. Dec, 2007 | Pubmed ID: 18073124 Eosinophilic Esophagitis in Children and Adults: a Systematic Review and Consensus Recommendations for Diagnosis and Treatment Gastroenterology. Oct, 2007 | Pubmed ID: 17919504 An Eosinophil Hypothesis for Functional Dyspepsia Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Oct, 2007 | Pubmed ID: 17916543 Summary of the First International Gastrointestinal Eosinophil Research Symposium Journal of Pediatric Gastroenterology and Nutrition. Sep, 2007 | Pubmed ID: 17873754 Gastrointestinal Eosinophilia Immunology and Allergy Clinics of North America. Aug, 2007 | Pubmed ID: 17868858 Interplay of Adaptive Th2 Immunity with Eotaxin-3/c-C Chemokine Receptor 3 in Eosinophilic Esophagitis Journal of Pediatric Gastroenterology and Nutrition. Jul, 2007 | Pubmed ID: 17592361 Resistin-like Molecule-beta is an Allergen-induced Cytokine with Inflammatory and Remodeling Activity in the Murine Lung American Journal of Physiology. Lung Cellular and Molecular Physiology. Aug, 2007 | Pubmed ID: 17545488 Eosinophils in the New Millennium The Journal of Allergy and Clinical Immunology. Jun, 2007 | Pubmed ID: 17451795 Crosstalk Between Gi and Gq/Gs Pathways in Airway Smooth Muscle Regulates Bronchial Contractility and Relaxation The Journal of Clinical Investigation. May, 2007 | Pubmed ID: 17415415 Regulation of Carcinogenesis by IL-5 and CCL11: a Potential Role for Eosinophils in Tumor Immune Surveillance Journal of Immunology (Baltimore, Md. : 1950). Apr, 2007 | Pubmed ID: 17371978 Influence of Cigarette Smoke on the Arginine Pathway in Asthmatic Airways: Increased Expression of Arginase I The Journal of Allergy and Clinical Immunology. Feb, 2007 | Pubmed ID: 17291856 CD48 is Critically Involved in Allergic Eosinophilic Airway Inflammation American Journal of Respiratory and Critical Care Medicine. May, 2007 | Pubmed ID: 17290046 Pediatric Patients with Eosinophilic Esophagitis: an 8-year Follow-up The Journal of Allergy and Clinical Immunology. Mar, 2007 | Pubmed ID: 17258309 Critical Role for Adaptive T Cell Immunity in Experimental Eosinophilic Esophagitis in Mice Journal of Leukocyte Biology. Apr, 2007 | Pubmed ID: 17194734 Current Concepts on the Pathogenesis of the Hypereosinophilic Syndrome/chronic Eosinophilic Leukemia Translational Oncogenomics. 2006 | Pubmed ID: 23662039 Allergen Induced TFF2 is Expressed by Mucus-producing Airway Epithelial Cells but is Not a Major Regulator of Inflammatory Responses in the Murine Lung Experimental Lung Research. Nov-Dec, 2006 | Pubmed ID: 17169855 Anti-IL-5 (mepolizumab) Therapy for Eosinophilic Esophagitis The Journal of Allergy and Clinical Immunology. Dec, 2006 | Pubmed ID: 17157662 Eosinophils and CCR3 Regulate Interleukin-13 Transgene-induced Pulmonary Remodeling The American Journal of Pathology. Dec, 2006 | Pubmed ID: 17148674 A Randomized, Double-blind, Placebo-controlled Trial of Fluticasone Propionate for Pediatric Eosinophilic Esophagitis Gastroenterology. Nov, 2006 | Pubmed ID: 17101314 Eosinophilic Esophagitis: Pathogenesis, Genetics, and Therapy The Journal of Allergy and Clinical Immunology. Nov, 2006 | Pubmed ID: 17088129 A Central Regulatory Role for Eosinophils and the Eotaxin/CCR3 Axis in Chronic Experimental Allergic Airway Inflammation Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17060636 Potential of Blood Eosinophils, Eosinophil-derived Neurotoxin, and Eotaxin-3 As Biomarkers of Eosinophilic Esophagitis Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Nov, 2006 | Pubmed ID: 17059896 Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-induced Airways Hyperresponsiveness Journal of Immunology (Baltimore, Md. : 1950). Oct, 2006 | Pubmed ID: 17015747 Cationic Amino Acid Transporter 2 Regulates Inflammatory Homeostasis in the Lung Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17003120 Quantity and Distribution of Eosinophils in the Gastrointestinal Tract of Children Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. May-Jun, 2006 | Pubmed ID: 16944979 Experimental Gastrointestinal Allergy Enhances Pulmonary Responses to Specific and Unrelated Allergens The Journal of Allergy and Clinical Immunology. Aug, 2006 | Pubmed ID: 16890767 Resistin-like Molecule Beta Regulates Innate Colonic Function: Barrier Integrity and Inflammation Susceptibility The Journal of Allergy and Clinical Immunology. Jul, 2006 | Pubmed ID: 16815164 Epicutaneous Aeroallergen Exposure Induces Systemic TH2 Immunity That Predisposes to Allergic Nasal Responses The Journal of Allergy and Clinical Immunology. Jul, 2006 | Pubmed ID: 16815139 CD48 is an Allergen and IL-3-induced Activation Molecule on Eosinophils Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16785501 The Role of Th2 Cytokines, Chemokines and Parasite Products in Eosinophil Recruitment to the Gastrointestinal Mucosa During Helminth Infection European Journal of Immunology. Jul, 2006 | Pubmed ID: 16783848 Approaches to the Treatment of Hypereosinophilic Syndromes: a Workshop Summary Report The Journal of Allergy and Clinical Immunology. Jun, 2006 | Pubmed ID: 16750989 ICAM-1-dependent Pathways Regulate Colonic Eosinophilic Inflammation Journal of Leukocyte Biology. Aug, 2006 | Pubmed ID: 16731772 Modulatory Calcineurin-interacting Proteins 1 and 2 Function As Calcineurin Facilitators in Vivo Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16648267 Persistent Effects Induced by IL-13 in the Lung American Journal of Respiratory Cell and Molecular Biology. Sep, 2006 | Pubmed ID: 16645178 The Eosinophil Annual Review of Immunology. 2006 | Pubmed ID: 16551246 IL-17E Upregulates the Expression of Proinflammatory Cytokines in Lung Fibroblasts The Journal of Allergy and Clinical Immunology. Mar, 2006 | Pubmed ID: 16522458 Eosinophil Function in Eosinophil-associated Gastrointestinal Disorders Current Allergy and Asthma Reports. Feb, 2006 | Pubmed ID: 16476198 The Arginine-arginase Balance in Asthma and Lung Inflammation European Journal of Pharmacology. Mar, 2006 | Pubmed ID: 16458291 Eotaxin-3 and a Uniquely Conserved Gene-expression Profile in Eosinophilic Esophagitis The Journal of Clinical Investigation. Feb, 2006 | Pubmed ID: 16453027 The FIP1L1-PDGFRA Fusion Gene Cooperates with IL-5 to Induce Murine Hypereosinophilic Syndrome (HES)/chronic Eosinophilic Leukemia (CEL)-like Disease Blood. May, 2006 | Pubmed ID: 16418325 Hypereosinophilic Syndromes and New Therapeutic Approaches Including Anti-IL-5 Expert Review of Clinical Immunology. Nov, 2005 | Pubmed ID: 20477604 Eosinophilic Esophagitis Current Opinion in Pediatrics. Dec, 2005 | Pubmed ID: 16282772 Transgenic Expression of Bean Alpha-amylase Inhibitor in Peas Results in Altered Structure and Immunogenicity Journal of Agricultural and Food Chemistry. Nov, 2005 | Pubmed ID: 16277398 The Eotaxin Chemokines and CCR3 Are Fundamental Regulators of Allergen-induced Pulmonary Eosinophilia Journal of Immunology (Baltimore, Md. : 1950). Oct, 2005 | Pubmed ID: 16210640 Epicutaneous Antigen Exposure Primes for Experimental Eosinophilic Esophagitis in Mice Gastroenterology. Sep, 2005 | Pubmed ID: 16143136 Prevalence and Outcome of Allergic Colitis in Healthy Infants with Rectal Bleeding: a Prospective Cohort Study Journal of Pediatric Gastroenterology and Nutrition. Jul, 2005 | Pubmed ID: 15990624 Eliminating Eosinophilic Esophagitis Clinical Immunology (Orlando, Fla.). May, 2005 | Pubmed ID: 15885634 Anti-IL-5 and Hypereosinophilic Syndromes Clinical Immunology (Orlando, Fla.). Apr, 2005 | Pubmed ID: 15870021 Suppressive Effect of IL-4 on IL-13-induced Genes in Mouse Lung Journal of Immunology (Baltimore, Md. : 1950). Apr, 2005 | Pubmed ID: 15814686 Analysis of the CCR3 Promoter Reveals a Regulatory Region in Exon 1 That Binds GATA-1 BMC Immunology. 2005 | Pubmed ID: 15807893 CXCL9 Inhibits Eosinophil Responses by a CCR3- and Rac2-dependent Mechanism Blood. Jul, 2005 | Pubmed ID: 15802529 Molecular Mechanisms of Anaphylaxis: Lessons from Studies with Murine Models The Journal of Allergy and Clinical Immunology. Mar, 2005 | Pubmed ID: 15753886 Expression and Regulation of Small Proline-rich Protein 2 in Allergic Inflammation American Journal of Respiratory Cell and Molecular Biology. May, 2005 | Pubmed ID: 15731505 Identification of a Cooperative Mechanism Involving Interleukin-13 and Eotaxin-2 in Experimental Allergic Lung Inflammation The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15647285 Eotaxin-1-regulated Eosinophils Have a Critical Role in Innate Immunity Against Experimental Brugia Malayi Infection European Journal of Immunology. Jan, 2005 | Pubmed ID: 15593125 Pulmonary Chemokine Expression is Coordinately Regulated by STAT1, STAT6, and IFN-gamma Journal of Immunology (Baltimore, Md. : 1950). Dec, 2004 | Pubmed ID: 15585884 Arginine in Asthma and Lung Inflammation The Journal of Nutrition. Oct, 2004 | Pubmed ID: 15465795 VEGF Obstructs the Lungs Nature Medicine. Oct, 2004 | Pubmed ID: 15459700 Eosinophilic Esophagitis The New England Journal of Medicine. Aug, 2004 | Pubmed ID: 15329438 T Helper-2 Immunity Regulates Bronchial Hyperresponsiveness in Eosinophil-associated Gastrointestinal Disease in Mice Gastroenterology. Jul, 2004 | Pubmed ID: 15236177 Clinical and Immunopathologic Effects of Swallowed Fluticasone for Eosinophilic Esophagitis Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Jul, 2004 | Pubmed ID: 15224281 Expression and Regulation of a Disintegrin and Metalloproteinase (ADAM) 8 in Experimental Asthma American Journal of Respiratory Cell and Molecular Biology. Sep, 2004 | Pubmed ID: 15087305 Negative Regulation of Eosinophil Recruitment to the Lung by the Chemokine Monokine Induced by IFN-gamma (Mig, CXCL9) Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14769916 Foxa2 Regulates Alveolarization and Goblet Cell Hyperplasia Development (Cambridge, England). Feb, 2004 | Pubmed ID: 14757645 Transcript Signatures in Experimental Asthma: Identification of STAT6-dependent and -independent Pathways Journal of Immunology (Baltimore, Md. : 1950). Feb, 2004 | Pubmed ID: 14734765 Eosinophilic Gastrointestinal Disorders (EGID) The Journal of Allergy and Clinical Immunology. Jan, 2004 | Pubmed ID: 14713902 Anti-interleukin-5 (mepolizumab) Therapy for Hypereosinophilic Syndromes The Journal of Allergy and Clinical Immunology. Jan, 2004 | Pubmed ID: 14699394 Investigando Mastócito Secretory grânulos; de Biossíntese de Exocytosis Nurit P. Azouz1,2, Mitsunori Fukuda3, Marc E. Rothenberg2, Ronit Sagi-Eisenberg1 1Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, 2Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University JoVE 52505 Immunologie et Infection
Investigando Mastócito Secretory grânulos; de Biossíntese de Exocytosis Nurit P. Azouz1,2, Mitsunori Fukuda3, Marc E. Rothenberg2, Ronit Sagi-Eisenberg1 1Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, 2Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University JoVE 52505 Immunologie et Infection