Marcus Groettrup Division of Immunology, Department of Biology University of Konstanz Biography Publications Institution JoVE Articles Marcus Groettrup has not added a biography. If you are Marcus Groettrup and would like to personalize this page please email our Author Liaison for assistance. Publications On the Role of the Immunoproteasome in Protein Homeostasis Cells. 11, 2021 | Pubmed ID: 34831438 PLGA-particle Vaccine Carrying TLR3/RIG-I Ligand Riboxxim Synergizes with Immune Checkpoint Blockade for Effective Anti-cancer Immunotherapy Nature Communications. 05, 2021 | Pubmed ID: 34006895 Silencing of the Proteasome and Oxidative Stress Impair Endoplasmic Reticulum Targeting and Signal Cleavage of a Prostate Carcinoma Antigen Biochemical and Biophysical Research Communications. 05, 2021 | Pubmed ID: 33774280 Immunoproteasome Upregulation Is Not Required to Control Protein Homeostasis During Viral Infection Journal of Immunology (Baltimore, Md. : 1950). 04, 2021 | Pubmed ID: 33731337 Parkin is an E3 Ligase for the Ubiquitin-like Modifier FAT10, Which Inhibits Parkin Activation and Mitophagy Cell Reports. 03, 2021 | Pubmed ID: 33730565 Evidence for an Involvement of the Ubiquitin-like Modifier ISG15 in MHC Class I Antigen Presentation European Journal of Immunology. 01, 2021 | Pubmed ID: 32686110 Recent Insights How Combined Inhibition of Immuno/proteasome Subunits Enables Therapeutic Efficacy Genes and Immunity. 11, 2020 | Pubmed ID: 32839530 The Ubiquitin-like Modifier FAT10 Inhibits Retinal PDE6 Activity and Mediates Its Proteasomal Degradation The Journal of Biological Chemistry. 10, 2020 | Pubmed ID: 32817338 The Ubiquitin-like Modifier FAT10 - Much More Than a Proteasome-targeting Signal Journal of Cell Science. 07, 2020 | Pubmed ID: 32719056 Regulation of Interferon Induction by the Ubiquitin-Like Modifier FAT10 Biomolecules. 06, 2020 | Pubmed ID: 32586037 FAT10 Localises in Dendritic Cell Aggresome-like Induced Structures and Contributes to Their Disassembly Journal of Cell Science. 07, 2020 | Pubmed ID: 32546531 Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome ACS Central Science. Feb, 2020 | Pubmed ID: 32123742 The Ubiquitin-like Modifier FAT10 Interferes with SUMO Activation Nature Communications. 10, 2019 | Pubmed ID: 31575873 Immunoproteasome Inhibition Selectively Kills Human CD14 Monocytes and As a Result Dampens IL-23 Secretion Journal of Immunology (Baltimore, Md. : 1950). 10, 2019 | Pubmed ID: 31484727 Testing the Impact of Protease Inhibitors in Antigen Presentation Assays Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31147932 Harnessing Dendritic Cells for Poly (D,L-lactide--glycolide) Microspheres (PLGA MS)-Mediated Anti-tumor Therapy Frontiers in Immunology. 2019 | Pubmed ID: 31024545 Analysis of Modification and Proteolytic Targeting by the Ubiquitin-like Modifier FAT10 Methods in Enzymology. 2019 | Pubmed ID: 30850054 The Ubiquitin-like Modifier FAT10 is Required for Normal IFN-γ Production by Activated CD8 T Cells Molecular Immunology. 04, 2019 | Pubmed ID: 30818228 The Ubiquitin-like Modifier FAT10 Stimulates the Activity of Deubiquitylating Enzyme OTUB1 The Journal of Biological Chemistry. 03, 2019 | Pubmed ID: 30718280 Immunoproteasome Inhibition Induces Plasma Cell Apoptosis and Preserves Kidney Allografts by Activating the Unfolded Protein Response and Suppressing Plasma Cell Survival Factors Kidney International. 03, 2019 | Pubmed ID: 30685098 On the Role of the Immunoproteasome in Transplant Rejection Immunogenetics. 03, 2019 | Pubmed ID: 30220008 The 20S Immunoproteasome and Constitutive Proteasome Bind with the Same Affinity to PA28αβ and Equally Degrade FAT10 Molecular Immunology. 09, 2019 | Pubmed ID: 29208314 Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis Frontiers in Immunology. 2018 | Pubmed ID: 30416500 Prevention of Neuronal Apoptosis by Astrocytes Through Thiol-mediated Stress Response Modulation and Accelerated Recovery from Proteotoxic Stress Cell Death and Differentiation. 12, 2018 | Pubmed ID: 30390092 Author Correction: The Structure of the Ubiquitin-like Modifier FAT10 Reveals an Alternative Targeting Mechanism for Proteasomal Degradation Nature Communications. 11, 2018 | Pubmed ID: 30389928 Co-inhibition of Immunoproteasome Subunits LMP2 and LMP7 is Required to Block Autoimmunity EMBO Reports. 12, 2018 | Pubmed ID: 30279279 The Structure of the Ubiquitin-like Modifier FAT10 Reveals an Alternative Targeting Mechanism for Proteasomal Degradation Nature Communications. 08, 2018 | Pubmed ID: 30127417 Defective Immuno- and Thymoproteasome Assembly Causes Severe Immunodeficiency Scientific Reports. 04, 2018 | Pubmed ID: 29654304 The Expression Profile of the Ubiquitin-like Modifier FAT10 in Immune Cells Suggests Cell Type-specific Functions Immunogenetics. 07, 2018 | Pubmed ID: 29508036 Immunoproteasome Inhibition Prevents Chronic Antibody-mediated Allograft Rejection in Renal transplantation Kidney International. 03, 2018 | Pubmed ID: 29229189 The Immunoproteasome Subunit LMP7 is Required in the Murine Thymus for Filling Up a Hole in the T cell Repertoire European Journal of Immunology. 03, 2018 | Pubmed ID: 29067678 Amelioration of Autoimmunity with an Inhibitor Selectively Targeting All Active Centres of the Immunoproteasome British Journal of Pharmacology. 01, 2018 | Pubmed ID: 29034459 Inhibition and Deficiency of the Immunoproteasome Subunit LMP7 Suppress the Development and Progression of Colorectal Carcinoma in Mice Oncotarget. Aug, 2017 | Pubmed ID: 28881611 No Prolongation of Skin Allograft Survival by Immunoproteasome Inhibition in Mice Molecular Immunology. 08, 2017 | Pubmed ID: 28582644 Chronic Stress Suppresses Anti-tumor T Responses and Tumor Regression Following Cancer Immunotherapy in a Mouse Model of Melanoma Brain, Behavior, and Immunity. Oct, 2017 | Pubmed ID: 28457810 Immunoproteasome Subunit Deficiency Has No Influence on the Canonical Pathway of NF-κB Activation Molecular Immunology. 03, 2017 | Pubmed ID: 28157553 Newly Translated Proteins Are Substrates for Ubiquitin, ISG15, and FAT10 FEBS Letters. Jan, 2017 | Pubmed ID: 27926780 Analyzing Structure-function Relationships of Artificial and Cancer-associated PARP1 Variants by Reconstituting TALEN-generated HeLa PARP1 Knock-out Cells Nucleic Acids Research. Dec, 2016 | Pubmed ID: 27694308 The Ubiquitin-like Modifier FAT10 in Cancer Development The International Journal of Biochemistry & Cell Biology. 10, 2016 | Pubmed ID: 27393295 A Cascading Activity-based Probe Sequentially Targets E1-E2-E3 Ubiquitin Enzymes Nature Chemical Biology. 07, 2016 | Pubmed ID: 27182664 Inhibiting the Immunoproteasome Exacerbates the Pathogenesis of Systemic Candida Albicans Infection in Mice Scientific Reports. Jan, 2016 | Pubmed ID: 26776888 The STEAP1(262-270) Peptide Encapsulated into PLGA Microspheres Elicits Strong Cytotoxic T Cell Immunity in HLA-A*0201 Transgenic Mice--A New Approach to Immunotherapy Against Prostate Carcinoma The Prostate. Apr, 2016 | Pubmed ID: 26715028 Chaperone BAG6 is Dispensable for MHC Class I Antigen Processing and Presentation Molecular Immunology. Jan, 2016 | Pubmed ID: 26598275 Inhibition and Deficiency of the Immunoproteasome Subunit LMP7 Attenuates LCMV-induced Meningitis European Journal of Immunology. Jan, 2016 | Pubmed ID: 26464284 The Immunoproteasome: a Novel Drug Target for Autoimmune Diseases Clinical and Experimental Rheumatology. Jul-Aug, 2015 | Pubmed ID: 26458097 The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection Journal of Immunology (Baltimore, Md. : 1950). Nov, 2015 | Pubmed ID: 26401002 Cytotoxic T Cell Vaccination with PLGA Microspheres Interferes with Influenza A Virus Replication in the Lung and Suppresses the Infectious Disease Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2015 | Pubmed ID: 26276509 The Ubiquitin-specific Protease USP8 is Critical for the Development and Homeostasis of T Cells Nature Immunology. Sep, 2015 | Pubmed ID: 26214742 The Ubiquitin-like Modifier FAT10 in Antigen Processing and Antimicrobial Defense Molecular Immunology. Dec, 2015 | Pubmed ID: 25983082 Analgesia in Mice with Experimental Meningitis Reduces Pain Without Altering Immune Parameters ALTEX. 2015 | Pubmed ID: 25800953 Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-like Modifier FAT10 Targets It for Proteasomal Degradation PloS One. 2015 | Pubmed ID: 25768649 No Evidence for Immunoproteasomes in Chicken Lymphoid Organs and Activated Lymphocytes Immunogenetics. Jan, 2015 | Pubmed ID: 25403261 The Ubiquitin-like Modifier FAT10 Decorates Autophagy-targeted Salmonella and Contributes to Salmonella Resistance in Mice Journal of Cell Science. Nov, 2014 | Pubmed ID: 25271057 Subunit Specific Inhibitors of Proteasomes and Their Potential for Immunomodulation Current Opinion in Chemical Biology. Dec, 2014 | Pubmed ID: 25217863 The Effect of Trauma-focused Therapy on the Altered T Cell Distribution in Individuals with PTSD: Evidence from a Randomized Controlled Trial Journal of Psychiatric Research. Jul, 2014 | Pubmed ID: 24726027 Investigations into the Auto-FAT10ylation of the Bispecific E2 Conjugating Enzyme UBA6-specific E2 Enzyme 1 The FEBS Journal. Apr, 2014 | Pubmed ID: 24528925 Inhibition of the Immunoproteasome Ameliorates Experimental Autoimmune Encephalomyelitis EMBO Molecular Medicine. 02, 2014 | Pubmed ID: 24399752 The Unique Functions of Tissue-specific Proteasomes Trends in Biochemical Sciences. Jan, 2014 | Pubmed ID: 24286712 FAT10ylation As a Signal for Proteasomal Degradation Biochimica Et Biophysica Acta. Jan, 2014 | Pubmed ID: 23333871 Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins Cell. Feb, 2013 | Pubmed ID: 23452861 Posttraumatic Stress Disorder is Associated with an Enhanced Spontaneous Production of Pro-inflammatory Cytokines by Peripheral Blood Mononuclear Cells BMC Psychiatry. Jan, 2013 | Pubmed ID: 23360282 Using Protease Inhibitors in Antigen Presentation Assays Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23329476 The Immunoproteasome in Antigen Processing and Other Immunological Functions Current Opinion in Immunology. Feb, 2013 | Pubmed ID: 23219269 Prostaglandin E2 Inhibits IL-23 and IL-12 Production by Human Monocytes Through Down-regulation of Their Common P40 Subunit Molecular Immunology. Mar, 2013 | Pubmed ID: 22982753 Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation Journal of Immunology (Baltimore, Md. : 1950). Oct, 2012 | Pubmed ID: 22984077 Ubiquitylation of the Chemokine Receptor CCR7 Enables Efficient Receptor Recycling and Cell Migration Journal of Cell Science. Oct, 2012 | Pubmed ID: 22797918 Coencapsulation of Tumor Lysate and CpG-ODN in PLGA-microspheres Enables Successful Immunotherapy of Prostate Carcinoma in TRAMP Mice Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2012 | Pubmed ID: 22709589 Immunoproteasome-specific Inhibitors and Their Application Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22350900 Cross-talk Between TCR and CCR7 Signaling Sets a Temporal Threshold for Enhanced T Lymphocyte Migration Journal of Immunology (Baltimore, Md. : 1950). Dec, 2011 | Pubmed ID: 22043010 USE1 è Un Bispecific Coniugazione Dell'enzima Ubiquitina E FAT10, Che FAT10ylates Stesso in Cis Nature Communications. 2010 | Pubmed ID: 20975683 Substantial Reduction of Naïve and Regulatory T Cells Following Traumatic Stress Brain, Behavior, and Immunity. Nov, 2009 | Pubmed ID: 19619638 Identification of the Molecular Composition of the 20S Proteasome of Mouse Intestine by High-resolution Mass Spectrometric Proteome Analysis Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19544023 Prostaglandin E(2) Enhances T-cell Proliferation by Inducing the Costimulatory Molecules OX40L, CD70, and 4-1BBL on Dendritic Cells Blood. Mar, 2009 | Pubmed ID: 19029446 Quantitative Analysis of Gene Expression Relative to 18S RRNA in Carcinoma Samples Using the LightCycler Instrument and a SYBR GreenI-based Assay: Determining FAT10 MRNA Levels in Hepatocellular Carcinoma Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18695959 Identification of Homozygous Transgenic Mice by Genomic Real-time PCR Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18695958 Distinct Motifs in the Chemokine Receptor CCR7 Regulate Signal Transduction, Receptor Trafficking and Chemotaxis Journal of Cell Science. Aug, 2008 | Pubmed ID: 18664492 A Novel Cytosolic Class I Antigen-processing Pathway for Endoplasmic-reticulum-targeted Proteins EMBO Reports. Oct, 2007 | Pubmed ID: 17853904 Prostaglandin E2 is a Key Factor for Monocyte-derived Dendritic Cell Maturation: Enhanced T Cell Stimulatory Capacity Despite IDO Journal of Leukocyte Biology. Nov, 2007 | Pubmed ID: 17698915 Opposite Fate of Endocytosed CCR7 and Its Ligands: Recycling Versus Degradation Journal of Immunology (Baltimore, Md. : 1950). Aug, 2006 | Pubmed ID: 16887992 I Domini UBA Di NUB1L Sono Necessari Per L'associazione Ma Non Per Accelerata Degradazione Del Modificatore Di Ubiquitin-like FAT10 The Journal of Biological Chemistry. Jul, 2006 | Pubmed ID: 16707496 Un modello di trapianto renale ortotopico di ratto per il rigetto dell'allotrapianto renale Hang You1,2, Xin Mao2, Chenyang Wang2, Gang Huang3, Marcus Groettrup4,5, Jun Li2 1School of Medicine, Chongqing University, 2Department of Urological Oncology Surgery, Chongqing University Cancer Hospital, 3Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Army Medical University, 4Division of Immunology, Department of Biology, University of Konstanz, 5Biotechnology Institute Thurgau, University of Konstanz JoVE 63464 Médecine
Un modello di trapianto renale ortotopico di ratto per il rigetto dell'allotrapianto renale Hang You1,2, Xin Mao2, Chenyang Wang2, Gang Huang3, Marcus Groettrup4,5, Jun Li2 1School of Medicine, Chongqing University, 2Department of Urological Oncology Surgery, Chongqing University Cancer Hospital, 3Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Army Medical University, 4Division of Immunology, Department of Biology, University of Konstanz, 5Biotechnology Institute Thurgau, University of Konstanz JoVE 63464 Médecine