Margaret H.L. Ng Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital The Chinese University of Hong Kong Biography Publications Institution JoVE Articles Margaret H.L. Ng has not added a biography. If you are Margaret H.L. Ng and would like to personalize this page please email our Author Liaison for assistance. Publications Distinct Mutation Spectrum, Clinical Outcome and Therapeutic Responses of Typical Complex/monosomy Karyotype Acute Myeloid Leukemia Carrying TP53 Mutations American Journal of Hematology. Jun, 2019 | Pubmed ID: 30900772 Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma Cancers. Jan, 2019 | Pubmed ID: 30658414 RUNX1 Upregulation Via Disruption of Long-range Transcriptional Control by a Novel T(5;21)(q13;q22) Translocation in Acute Myeloid Leukemia Molecular Cancer. 08, 2018 | Pubmed ID: 30157851 Prevalence and Clinicopathologic Significance of BRAF V600E Mutation in Chinese Multiple Myeloma Patients Clinical Lymphoma, Myeloma & Leukemia. 07, 2018 | Pubmed ID: 29807803 Distinctive Regional-specific PROS1 Mutation Spectrum in Southern China Journal of Thrombosis and Thrombolysis. Jul, 2018 | Pubmed ID: 29748776 Outcome of Children with Newly Diagnosed Acute Lymphoblastic Leukemia Treated with CCLG-ALL 2008: The First Nation-wide Prospective Multicenter Study in China American Journal of Hematology. 07, 2018 | Pubmed ID: 29675840 Next-generation Sequencing and Molecular Cytogenetic Characterization of ETV6-LYN Fusion Due to Chromosomes 1, 8 and 12 Rearrangement in Acute Myeloid Leukemia Cancer Genetics. Dec, 2017 | Pubmed ID: 29153093 First Report of Hb Kent [β37(C3)Trp→Cys (TGG>TGC) HBB: C.114G>C] in a Chinese Family Hemoglobin. Jul - Nov, 2017 | Pubmed ID: 29043885 FNDC3B is Another Novel Partner Fused to RARA in the T(3;17)(q26;q21) Variant of Acute Promyelocytic Leukemia Blood. 05, 2017 | Pubmed ID: 28314734 Chromosome Recognition Methods in Molecular Biology (Clifton, N.J.). Month, 2017 | Pubmed ID: 27910015 Chromosome Preparation for Myeloid Malignancies Methods in Molecular Biology (Clifton, N.J.). Month, 2017 | Pubmed ID: 27910010 A Multi-locus Approach to Characterization of Major Quantitative Trait Loci Influencing Hb F Regulation in Chinese β-thalassemia Carriers Hemoglobin. Nov, 2016 | Pubmed ID: 27707011 Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients PloS One. Month, 2016 | Pubmed ID: 27494141 Hb Tarrant [α126(H9)Asp→Asn; HBA2: C.379G > A (or HBA1)] in a Chinese Family As a Cause of Familial Erythrocytosis Hemoglobin. Aug, 2016 | Pubmed ID: 27240426 Helicase-like Transcription Factor is a RUNX1 Target Whose Downregulation Promotes Genomic Instability and Correlates with Complex Cytogenetic Features in Acute Myeloid Leukemia Haematologica. Apr, 2016 | Pubmed ID: 26802049 Minimal Residual Disease-based Risk Stratification in Chinese Childhood Acute Lymphoblastic Leukemia by Flow Cytometry and Plasma DNA Quantitative Polymerase Chain Reaction PloS One. Month, 2013 | Pubmed ID: 23936021 HLA-B Alleles Associated with Severe Cutaneous Reactions to Antiepileptic Drugs in Han Chinese Epilepsia. Jul, 2013 | Pubmed ID: 23692434 A Polymorphism in the 3'-untranslated Region of the NPM1 Gene Causes Illegitimate Regulation by MicroRNA-337-5p and Correlates with Adverse Outcome in Acute Myeloid Leukemia Haematologica. Jun, 2013 | Pubmed ID: 23065518 Platelet Factor 4 Induces Cell Apoptosis by Inhibition of STAT3 Via Up-regulation of SOCS3 Expression in Multiple Myeloma Haematologica. Feb, 2013 | Pubmed ID: 22929979 Association of Polymorphism of Human Leukocyte Antigen Alleles with Development of Hepatocellular Carcinoma in Hong Kong Chinese Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi. Dec, 2012 | Pubmed ID: 23249853 A Novel 19q13 Nucleolar Zinc Finger Protein Suppresses Tumor Cell Growth Through Inhibiting Ribosome Biogenesis and Inducing Apoptosis but is Frequently Silenced in Multiple Carcinomas Molecular Cancer Research : MCR. Jul, 2012 | Pubmed ID: 22679109 A Pale Chinese Boy with Recurrent Painful Digital Swelling Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi. Apr, 2012 | Pubmed ID: 22477743 Familial Aggregation of Narcolepsy Sleep Medicine. Dec, 2011 | Pubmed ID: 22036600 Secreted-frizzled Related Protein 1 is a Transcriptional Repression Target of the T(8;21) Fusion Protein in Acute Myeloid Leukemia Blood. Dec, 2011 | Pubmed ID: 22031861 Sirtuin 1 is Upregulated in a Subset of Hepatocellular Carcinomas Where It is Essential for Telomere Maintenance and Tumor Cell Growth Cancer Research. Jun, 2011 | Pubmed ID: 21527554 Preclinical Evaluation of Sunitinib As Single Agent or in Combination with Chemotherapy in Nasopharyngeal Carcinoma Investigational New Drugs. Dec, 2011 | Pubmed ID: 20467883 Hypoxia-targeting by Tirapazamine (TPZ) Induces Preferential Growth Inhibition of Nasopharyngeal Carcinoma Cells with Chk1/2 Activation Investigational New Drugs. Jun, 2011 | Pubmed ID: 20013349 Immunogenetics in SARS: a Case-control Study Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi. Month, 2010 | Pubmed ID: 20864745 Reverse Phase Protein Array Identifies Novel Anti-invasion Mechanisms of YC-1 Biochemical Pharmacology. Mar, 2010 | Pubmed ID: 19879857 New Testing Approach in HLA Genotyping Helps Overcome Barriers in Effective Clinical Practice Clinical Chemistry. Aug, 2009 | Pubmed ID: 19556444 Transcriptional Repression of the RUNX3/AML2 Gene by the T(8;21) and Inv(16) Fusion Proteins in Acute Myeloid Leukemia Blood. Oct, 2008 | Pubmed ID: 18663147 The Familial Risk and HLA Susceptibility Among Narcolepsy Patients in Hong Kong Chinese Sleep. Jul, 2007 | Pubmed ID: 17682655 4q Loss is Potentially an Important Genetic Event in MM Tumorigenesis: Identification of a Tumor Suppressor Gene Regulated by Promoter Methylation at 4q13.3, Platelet Factor 4 Blood. Mar, 2007 | Pubmed ID: 17077331 Hematocrit, Independent of Chronic Kidney Disease, Predicts Adverse Cardiovascular Outcomes in Chinese Patients with Type 2 Diabetes Diabetes Care. Nov, 2006 | Pubmed ID: 17065681 HLA-B67 May Be a Male-specific HLA Marker of Susceptibility to Relapsed Childhood ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 Signifies a Higher Presentation Leukocytosis: A Retrospective Analysis on 53 Transplant Candidates (1989-2003) Annals of Hematology. Aug, 2006 | Pubmed ID: 16710717 Thrombocytopenia in Patients with Severe Acute Respiratory Syndrome (review) Hematology (Amsterdam, Netherlands). Apr, 2005 | Pubmed ID: 16019455 Identification of TPO Receptors on Central Nervous System-a Preliminary Report Zhongguo Shi Yan Xue Ye Xue Za Zhi. Aug, 2004 | Pubmed ID: 15363139 Association of Human-leukocyte-antigen Class I (B*0703) and Class II (DRB1*0301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory Syndrome The Journal of Infectious Diseases. Aug, 2004 | Pubmed ID: 15243926 Childhood Acute Myeloid Leukemia with CBFbeta-MYH11 Rearrangement: Study of Incidence, Morphology, Cytogenetics, and Clinical Outcomes of Chinese in Hong Kong American Journal of Hematology. Jul, 2004 | Pubmed ID: 15224374 Alterations of RAS Signalling in Chinese Multiple Myeloma Patients: Absent BRAF and Rare RAS Mutations, but Frequent Inactivation of RASSF1A by Transcriptional Silencing or Expression of a Non-functional Variant Transcript British Journal of Haematology. Nov, 2003 | Pubmed ID: 14616967 A Prospective, Randomized, Placebo-controlled Study of the Dose Effect of Oral Estradiol on Bone Mineral Density in Postmenopausal Chinese Women Maturitas. Jul, 2003 | Pubmed ID: 12818461 Chromosomal Aberrations of Multiple Myeloma in Chinese Patients at Diagnosis: a Study by Combined G-banding and Multicolor Spectral Karyotyping Oncology Reports. May-Jun, 2003 | Pubmed ID: 12684628 A Prospective, Randomized, Placebo-controlled Study of the Dose Effect of Oral Oestradiol on Menopausal Symptoms, Psychological Well Being, and Quality of Life in Postmenopausal Chinese Women Maturitas. Mar, 2003 | Pubmed ID: 12648884 Effect of Stress Hormones on the Expression of Fibrinogen-binding Receptors in Platelets Resuscitation. Dec, 2002 | Pubmed ID: 12458065 Death Associated Protein Kinase: from Regulation of Apoptosis to Tumor Suppressive Functions and B Cell Malignancies Apoptosis : an International Journal on Programmed Cell Death. Jun, 2002 | Pubmed ID: 11997670 Frequent Death-associated Protein Kinase Promoter Hypermethylation in Multiple Myeloma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2001 | Pubmed ID: 11410512 DNA Methylation Changes and Multiple Myeloma Leukemia & Lymphoma. Aug, 1999 | Pubmed ID: 10492069 Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells Chi-Keung Cheng1, Terry H.Y. Wong1, Yuk-Lin Yung1, Nelson C.N. Chan1, Margaret H.L. Ng1,2 1Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, 2State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong JoVE 60130 Génétique
Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells Chi-Keung Cheng1, Terry H.Y. Wong1, Yuk-Lin Yung1, Nelson C.N. Chan1, Margaret H.L. Ng1,2 1Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, 2State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong JoVE 60130 Génétique
