Matthew S. Macauley Department of Chemistry University of Alberta Biography Publications Institution JoVE Articles Matthew S. Macauley has not added a biography. If you are Matthew S. Macauley and would like to personalize this page please email our Author Liaison for assistance. Publications Hypersialylation in Cancer: Modulation of Inflammation and Therapeutic Opportunities Cancers. Jun, 2018 | Pubmed ID: 29912148 Cell-based Glycan Arrays for Probing Glycan-glycan Binding Protein Interactions Nature Communications. 02, 2018 | Pubmed ID: 29491407 Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model Journal of Immunology (Baltimore, Md. : 1950). 11, 2017 | Pubmed ID: 28972089 Exploiting CD22 on Antigen-specific B cells to Prevent Allergy to the Major Peanut Allergen Ara H 2 The Journal of Allergy and Clinical Immunology. Aug, 2016 | Pubmed ID: 27554819 Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies Cell Reports. Aug, 2016 | Pubmed ID: 27545891 Siglec-F is a Novel Intestinal M Cell Marker Biochemical and Biophysical Research Communications. Oct, 2016 | Pubmed ID: 27524237 Reproducing SIVΔnef Vaccine Correlates of Protection: Trimeric Gp41 Antibody Concentrated at Mucosal Front Lines AIDS (London, England). Jul, 2016 | Pubmed ID: 27428745 Targeting Selectins and Their Ligands in Cancer Frontiers in Oncology. 2016 | Pubmed ID: 27148485 Transfection of MicroRNA Mimics Should Be Used with Caution Frontiers in Genetics. 2015 | Pubmed ID: 26697058 Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man The Journal of Biological Chemistry. Dec, 2015 | Pubmed ID: 26507663 Therapeutic Targeting of Siglecs Using Antibody- and Glycan-Based Approaches Trends in Pharmacological Sciences. Oct, 2015 | Pubmed ID: 26435210 Systemic Blockade of Sialylation in Mice with a Global Inhibitor of Sialyltransferases The Journal of Biological Chemistry. Dec, 2014 | Pubmed ID: 25368325 Siglecs Induce Tolerance to Cell Surface Antigens by BIM-dependent Deletion of the Antigen-reactive B Cells Journal of Immunology (Baltimore, Md. : 1950). Nov, 2014 | Pubmed ID: 25252961 Siglec-mediated Regulation of Immune Cell Function in Disease Nature Reviews. Immunology. Oct, 2014 | Pubmed ID: 25234143 Transcriptional Programs of Lymphoid Tissue Capillary and High Endothelium Reveal Control Mechanisms for Lymphocyte Homing Nature Immunology. Oct, 2014 | Pubmed ID: 25173345 Targeted Delivery of Mycobacterial Antigens to Human Dendritic Cells Via Siglec-7 Induces Robust T Cell Activation Journal of Immunology (Baltimore, Md. : 1950). Aug, 2014 | Pubmed ID: 25000981 Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas Chemical Science (Royal Society of Chemistry : 2010). Jun, 2014 | Pubmed ID: 24921038 Immunology: Glyco-engineering 'super-self' Nature Chemical Biology. Jan, 2014 | Pubmed ID: 24346034 Copresentation of Antigen and Ligands of Siglec-G Induces B Cell Tolerance Independent of CD22 Journal of Immunology (Baltimore, Md. : 1950). Aug, 2013 | Pubmed ID: 23836061 Antigenic Liposomes Displaying CD22 Ligands Induce Antigen-specific B Cell Apoptosis The Journal of Clinical Investigation. Jul, 2013 | Pubmed ID: 23722906 Metabolism of Vertebrate Amino Sugars with N-glycolyl Groups: Intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the Biochemical and Structural Rationale for the Substrate Tolerance of β-O-linked β-N-acetylglucosaminidase The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22692202 Increasing O-GlcNAc Slows Neurodegeneration and Stabilizes Tau Against Aggregation Nature Chemical Biology. Apr, 2012 | Pubmed ID: 22366723 Siglecs As Sensors of Self in Innate and Adaptive Immune Responses Annals of the New York Academy of Sciences. Apr, 2012 | Pubmed ID: 22288608 Elevation of Global O-GlcNAc in Rodents Using a Selective O-GlcNAcase Inhibitor Does Not Cause Insulin Resistance or Perturb Glucohomeostasis Chemistry & Biology. Sep, 2010 | Pubmed ID: 20851344 Inhibition of O-GlcNAcase Using a Potent and Cell-permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes Chemistry & Biology. Sep, 2010 | Pubmed ID: 20851343 Visualizing the Reaction Coordinate of an O-GlcNAc Hydrolase Journal of the American Chemical Society. Feb, 2010 | Pubmed ID: 20067256 Increasing O-GlcNAc Levels: An Overview of Small-molecule Inhibitors of O-GlcNAcase Biochimica Et Biophysica Acta. Feb, 2010 | Pubmed ID: 19664691 Probing Synergy Between Two Catalytic Strategies in the Glycoside Hydrolase O-GlcNAcase Using Multiple Linear Free Energy Relationships Journal of the American Chemical Society. Sep, 2009 | Pubmed ID: 19715310 Drosophila O-GlcNAc Transferase (OGT) is Encoded by the Polycomb Group (PcG) Gene, Super Sex Combs (sxc) Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19666537 Enzymatic Characterization and Inhibition of the Nuclear Variant of Human O-GlcNAcase Carbohydrate Research. Jun, 2009 | Pubmed ID: 19423084 Streptococcus Pneumoniae Endohexosaminidase D, Structural and Mechanistic Insight into Substrate-assisted Catalysis in Family 85 Glycoside Hydrolases The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19181667 A Selective Inhibitor Gal-PUGNAc of Human Lysosomal Beta-hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19130519 Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18842583 A Potent Mechanism-inspired O-GlcNAcase Inhibitor That Blocks Phosphorylation of Tau in Vivo Nature Chemical Biology. Aug, 2008 | Pubmed ID: 18587388 Structure of an O-GlcNAc Transferase Homolog Provides Insight into Intracellular Glycosylation Nature Structural & Molecular Biology. Jul, 2008 | Pubmed ID: 18536723 Analysis of PUGNAc and NAG-thiazoline As Transition State Analogues for Human O-GlcNAcase: Mechanistic and Structural Insights into Inhibitor Selectivity and Transition State Poise Journal of the American Chemical Society. Jan, 2007 | Pubmed ID: 17227027 Functional Analysis of a Group A Streptococcal Glycoside Hydrolase Spy1600 from Family 84 Reveals It is a Beta-N-acetylglucosaminidase and Not a Hyaluronidase The Biochemical Journal. Oct, 2006 | Pubmed ID: 16822234 Structure and Mechanism of a Bacterial Beta-glucosaminidase Having O-GlcNAcase Activity Nature Structural & Molecular Biology. Apr, 2006 | Pubmed ID: 16565725 Identification of Asp174 and Asp175 As the Key Catalytic Residues of Human O-GlcNAcase by Functional Analysis of Site-directed Mutants Biochemistry. Mar, 2006 | Pubmed ID: 16533067 A Highly Concise Preparation of O-deacetylated Arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl Chloride and Aryl Thiols or Disulfides Carbohydrate Research. Jul, 2006 | Pubmed ID: 16472788 Beads-on-a-string, Characterization of ETS-1 Sumoylated Within Its Flexible N-terminal Sequence The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16319071 O-GlcNAcase Catalyzes Cleavage of Thioglycosides Without General Acid Catalysis Journal of the American Chemical Society. Dec, 2005 | Pubmed ID: 16332065 O-GlcNAcase Uses Substrate-assisted Catalysis: Kinetic Analysis and Development of Highly Selective Mechanism-inspired Inhibitors The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15795231 Structural and Dynamic Independence of Isopeptide-linked RanGAP1 and SUMO-1 The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15355965 प्रतिजनी रोग-विशिष्ट एंटीबॉडी के उत्पादन के लिए Liposomes Kyle J. Bednar*1, Lakeya Hardy*2,3, Johanna Smeekens*3,4, Dharmendra Raghuwanshi5, Shiteng Duan6, Mike D. Kulis3,4, Matthew S. Macauley5,7 1Janssen R&D, 2Department of Microbiology and Immunology, University of North Carolina, 3UNC Food Allergy Initiative, University of North Carolina, 4Department of Pediatrics, University of North Carolina, 5Department of Chemistry, University of Alberta, 6Department of Molecular Medicine, Scripps Research Institute, 7Department of Medical Microbiology and Immunology, University of Alberta JoVE 58285 Immunologie et Infection आकलन रेटिना microglial phagocytic समारोह Salome Murinello1, Stacey K. Moreno1, Matthew S. Macauley2, Susumu Sakimoto1, Peter D. Westenskow1,3, Martin Friedlander1 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Department of Chemical Physiology, The Scripps Research Institute, 3The Lowy Medical Research Institute JoVE 54677 Immunologie et Infection
प्रतिजनी रोग-विशिष्ट एंटीबॉडी के उत्पादन के लिए Liposomes Kyle J. Bednar*1, Lakeya Hardy*2,3, Johanna Smeekens*3,4, Dharmendra Raghuwanshi5, Shiteng Duan6, Mike D. Kulis3,4, Matthew S. Macauley5,7 1Janssen R&D, 2Department of Microbiology and Immunology, University of North Carolina, 3UNC Food Allergy Initiative, University of North Carolina, 4Department of Pediatrics, University of North Carolina, 5Department of Chemistry, University of Alberta, 6Department of Molecular Medicine, Scripps Research Institute, 7Department of Medical Microbiology and Immunology, University of Alberta JoVE 58285 Immunologie et Infection
आकलन रेटिना microglial phagocytic समारोह Salome Murinello1, Stacey K. Moreno1, Matthew S. Macauley2, Susumu Sakimoto1, Peter D. Westenskow1,3, Martin Friedlander1 1Department of Cell and Molecular Biology, The Scripps Research Institute, 2Department of Chemical Physiology, The Scripps Research Institute, 3The Lowy Medical Research Institute JoVE 54677 Immunologie et Infection