Mercedes Gonzalez-Juarrero Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology Colorado State University Biography Publications Institution JoVE Articles Mercedes Gonzalez-Juarrero has not added a biography. If you are Mercedes Gonzalez-Juarrero and would like to personalize this page please email our Author Liaison for assistance. Publications Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics Pharmaceutics. Jun, 2023 | Pubmed ID: 37376207 Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium Abscessus Burden Antimicrobial Agents and Chemotherapy. Jun, 2023 | Pubmed ID: 37154689 Characterization of Spectinamide 1599 Efficacy Against Different Mycobacterial Phenotypes Tuberculosis (Edinburgh, Scotland). May, 2023 | Pubmed ID: 37120915 Spray Dried Tigecycline Dry Powder Aerosols for the Treatment of Nontuberculous Mycobacterial Pulmonary Infections Tuberculosis (Edinburgh, Scotland). Mar, 2023 | Pubmed ID: 36716525 Microbiological Profile, Preclinical Pharmacokinetics and Efficacy of CRS0393, a Novel Antimycobacterial Agent Targeting MmpL3 Tuberculosis (Edinburgh, Scotland). Jan, 2023 | Pubmed ID: 36470124 Mucosal Exposure to Non-tuberculous Mycobacteria Elicits B Cell-mediated Immunity Against Pulmonary Tuberculosis Cell Reports. Dec, 2022 | Pubmed ID: 36516760 Development of a Mucoadhesive Liquid Crystal System for the Administration of Rifampicin Applicable in Tuberculosis Therapy Life (Basel, Switzerland). Jul, 2022 | Pubmed ID: 36013317 Mycobacterium Leprae Infection in a Wild Nine-Banded Armadillo, Nuevo León, Mexico Emerging Infectious Diseases. Mar, 2022 | Pubmed ID: 35202538 Therapeutic Efficacy of Antimalarial Drugs Targeting DosRS Signaling in Science Translational Medicine. Feb, 2022 | Pubmed ID: 35196022 Unique Features of Biofilms Formed in Synthetic Cystic Fibrosis Medium Frontiers in Microbiology. 2021 | Pubmed ID: 34777289 Lipid Nanoparticle Formulation of Niclosamide (nano NCM) Effectively Inhibits SARS-CoV-2 Replication Precision Nanomedicine. Apr, 2021 | Pubmed ID: 34676370 Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy Against Tuberculosis ACS Infectious Diseases. Oct, 2021 | Pubmed ID: 34546724 Neonatal and Infant Immunity for Tuberculosis Vaccine Development: Importance of Age-matched Animal Models Disease Models & Mechanisms. Sep, 2020 | Pubmed ID: 32988990 Inhaled Tigecycline is Effective Against Mycobacterium Abscessus in Vitro and in Vivo The Journal of Antimicrobial Chemotherapy. Jul, 2020 | Pubmed ID: 32294173 Minipigs As a Neonatal Animal Model for Tuberculosis Vaccine Efficacy Testing Veterinary Immunology and Immunopathology. Sep, 2019 | Pubmed ID: 31420066 Sterilization of Mycobacterium Tuberculosis Infected Samples Using Methanol Preserves Anti-tuberculosis Drugs for Subsequent Pharmacological Testing Studies Tuberculosis (Edinburgh, Scotland). Jul, 2019 | Pubmed ID: 31378268 Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599 Pharmaceutical Research. Jul, 2019 | Pubmed ID: 31321552 Direct Inhibition of MmpL3 by Novel Antitubercular Compounds ACS Infectious Diseases. Jun, 2019 | Pubmed ID: 30882198 Comparative Pharmacokinetics of Spectinamide 1599 After Subcutaneous and Intrapulmonary Aerosol Administration in Mice Tuberculosis (Edinburgh, Scotland). Jan, 2019 | Pubmed ID: 30711150 Host Directed Therapy for Chronic Tuberculosis Via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway Scientific Reports. Nov, 2018 | Pubmed ID: 30413750 Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent Frontiers in Microbiology. 2018 | Pubmed ID: 30294313 Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular Frontiers in Microbiology. 2018 | Pubmed ID: 30186246 Interactions of Free-living Amoebae with Rice Bacterial Pathogens Xanthomonas Oryzae Pathovars Oryzae and Oryzicola PloS One. 2018 | Pubmed ID: 30142182 Cell Mediated Immune Response in Goats After Experimental Challenge with the Virulent Brucella Melitensis Strain 16M and the Reduced Virulence Strain Rev. 1 Veterinary Immunology and Immunopathology. Aug, 2018 | Pubmed ID: 30078602 Evidence of Zoonotic Leprosy in Pará, Brazilian Amazon, and Risks Associated with Human Contact or Consumption of Armadillos PLoS Neglected Tropical Diseases. Jun, 2018 | Pubmed ID: 29953440 Yersinia Pestis Survival and Replication in Potential Ameba Reservoir Emerging Infectious Diseases. Feb, 2018 | Pubmed ID: 29350155 Evaluation of Shedding, Tissue Burdens, and Humoral Immune Response in Goats After Experimental Challenge with the Virulent Brucella Melitensis Strain 16M and the Reduced Virulence Vaccine Strain Rev. 1 PloS One. 2017 | Pubmed ID: 29028813 The Minipig As an Animal Model to Study Mycobacterium Tuberculosis Infection and Natural Transmission Tuberculosis (Edinburgh, Scotland). Sep, 2017 | Pubmed ID: 28802411 Mycobacterium Bovis Hosted by Free-living-amoebae Permits Their Long-term Persistence Survival Outside of Host Mammalian Cells and Remain Capable of Transmitting Disease to Mice Environmental Microbiology. Oct, 2017 | Pubmed ID: 28585299 Therapeutic Potential of the Mycobacterium Tuberculosis Mycolic Acid Transporter, MmpL3 Antimicrobial Agents and Chemotherapy. Sep, 2016 | Pubmed ID: 27297488 Potential and Development of Inhaled RNAi Therapeutics for the Treatment of Pulmonary Tuberculosis Advanced Drug Delivery Reviews. 07, 2016 | Pubmed ID: 27108702 Partial Saturation of Menaquinone in : Function and Essentiality of a Novel Reductase, MenJ ACS Central Science. Sep, 2015 | Pubmed ID: 26436137 Presence of Multiple Lesion Types with Vastly Different Microenvironments in C3HeB/FeJ Mice Following Aerosol Infection with Mycobacterium Tuberculosis Disease Models & Mechanisms. Jun, 2015 | Pubmed ID: 26035867 Extended Culture of Macrophages from Different Sources and Maturation Results in a Common M2 Phenotype Journal of Biomedical Materials Research. Part A. Sep, 2015 | Pubmed ID: 25684281 Long-term Survival and Virulence of Mycobacterium Leprae in Amoebal Cysts PLoS Neglected Tropical Diseases. Dec, 2014 | Pubmed ID: 25521850 Microhemorrhage is an Early Event in the Pulmonary Fibrotic Disease of PECAM-1 Deficient FVB/n Mice Experimental and Molecular Pathology. Aug, 2014 | Pubmed ID: 24972347 Spectinamides: a New Class of Semisynthetic Antituberculosis Agents That Overcome Native Drug Efflux Nature Medicine. Feb, 2014 | Pubmed ID: 24464186 GM-CSF Knockout Mice for Preclinical Testing of Agents with Antimicrobial Activity Against Mycobacterium Abscessus The Journal of Antimicrobial Chemotherapy. Apr, 2014 | Pubmed ID: 24222613 Polar Lipids of Burkholderia Pseudomallei Induce Different Host Immune Responses PloS One. 2013 | Pubmed ID: 24260378 Correlates of Immune Protection Following Cutaneous Immunization with an Attenuated Burkholderia Pseudomallei Vaccine Infection and Immunity. Dec, 2013 | Pubmed ID: 24101688 Experimental Aerosol Mycobacterium Bovis Model of Infection in Goats Tuberculosis (Edinburgh, Scotland). Sep, 2013 | Pubmed ID: 23850102 Exposure to a Cutinase-like Serine Esterase Triggers Rapid Lysis of Multiple Mycobacterial Species The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23155047 Mouse Model for Efficacy Testing of Antituberculosis Agents Via Intrapulmonary Delivery Antimicrobial Agents and Chemotherapy. Jul, 2012 | Pubmed ID: 22547626 Immunity to TB and Targets for Immunotherapy Immunotherapy. Feb, 2012 | Pubmed ID: 22339461 结核分枝杆菌肺结核果糖-1,6-二磷酸醛缩酶的糖酵解和非糖酵解职能、 产生的复制必需的酶和非复制的杆菌。 The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21949126 针对 TGFβ1 的 SiRNA 与局部肺免疫增强了结核分枝杆菌感染结核小鼠的抗菌能力。 Tuberculosis (Edinburgh, Scotland). Jan, 2011 | Pubmed ID: 21195670 优化的吸入治疗肺结核: 巨噬细胞和树突状细胞的作用。 Tuberculosis (Edinburgh, Scotland). Jan, 2011 | Pubmed ID: 20888298 由双染色方法发现鼠标和豚鼠肺组织中有多个 M.结核病表型。 PloS One. 2010 | Pubmed ID: 20559431 肺泡巨噬细胞和骨髓单核细胞化学后和病原体所致的慢性肺炎症反应的微分极化。 Journal of Leukocyte Biology. Jul, 2010 | Pubmed ID: 20360403 本地化的免疫抑制环境中异物回应植入生物材料。 The American Journal of Pathology. Jul, 2009 | Pubmed ID: 19528351 缺乏白细胞介素-10 在肺部结核分枝杆菌感染期间改变炎症和免疫反应。 Tuberculosis (Edinburgh, Scotland). Mar, 2009 | Pubmed ID: 19213603 XCL1 针对小干扰 RNA 对小鼠慢性感染结核分枝杆菌肺内交付。 American Journal of Respiratory Cell and Molecular Biology. Aug, 2009 | Pubmed ID: 19097989 结核分枝杆菌和鉴定的分子标记的疾病的免疫反应。 American Journal of Respiratory Cell and Molecular Biology. Apr, 2009 | Pubmed ID: 18787176 表型非等价性小鼠 (单核细胞-) 巨噬细胞细胞在生物材料和炎症模型。 Journal of Biomedical Materials Research. Part A. Mar, 2009 | Pubmed ID: 18357567 白细胞介素-10 促进 CBA/J 小鼠结核分枝杆菌肺结核病情发展。 Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18832712 M 脑脊液和 GM-CSF 的相对水平影响中结核分枝杆菌感染特定生成的巨噬细胞的人口。 Journal of Immunology (Baltimore, Md. : 1950). Apr, 2008 | Pubmed ID: 18354213 结核分枝杆菌感染的动物模型。 Current Protocols in Microbiology. Nov, 2007 | Pubmed ID: 18770606 XCL1 (趋) 趋化因子产生的活化 CD8 T 细胞与结核分枝杆菌感染慢性阶段产生负面影响生产的干扰素 γ 的 CD4 T 细胞,并参与肉芽肿稳定。 Journal of Leukocyte Biology. Nov, 2007 | Pubmed ID: 17699612 交叉反应的抗人 CD 单克隆抗体对豚鼠细胞: 豚鼠科 HLDA8 动物同系物数据的摘要。 Veterinary Immunology and Immunopathology. Sep, 2007 | Pubmed ID: 17658620 加强肉芽肿病变的质疑与结核分枝杆菌的免疫小鼠的巨噬细胞活性。 Journal of Immunology (Baltimore, Md. : 1950). Apr, 2006 | Pubmed ID: 16585589 毒临床分离株结核分枝杆菌的快速增长和诱导细胞坏死,但最少在小鼠巨噬细胞凋亡。 Journal of Leukocyte Biology. Jan, 2006 | Pubmed ID: 16275894 泡沫巨噬细胞内的结核分枝杆菌肺结核快递分子特性的树突状细胞和凋亡标记的肿瘤坏死因子受体相关因子家族感染小鼠肺肉芽肿。 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148133 接种 Hsp65 DNA 产生耐药性的结核分枝杆菌感染结核病的小鼠肺炎肉芽肿相关的因素。 Infection and Immunity. Aug, 2005 | Pubmed ID: 16041037 结核分枝杆菌感染的肺在 CBA Xid 基因突变小鼠的巨噬细胞白细胞介素-10 生产。 Immunology. Jun, 2005 | Pubmed ID: 15885131 中断的粒细胞巨噬细胞集落刺激因子生产在肺部严重影响控制结核分枝杆菌感染小鼠的能力。 Journal of Leukocyte Biology. Jun, 2005 | Pubmed ID: 15767289 稳定表达效应细胞表面表型在肺部的慢性感染结核分枝杆菌的小鼠 T 细胞人口。 Infection and Immunity. Jan, 2004 | Pubmed ID: 14688138 NK 细胞响应肺感染结核分枝杆菌,但在保护中发挥作用很小。 Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14634116 种群动态的巨噬细胞在小鼠肺结核。 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003 | Pubmed ID: 12960339 华丽肺炎症反应与接种疫苗的小鼠抗原 85 脉冲树突状细胞和气溶胶与结核分枝杆菌的质疑。 Cellular Immunology. Nov, 2002 | Pubmed ID: 12718935 体内白细胞介素-10 生产重新激活 C57BL/6 小鼠慢性肺结核。 Journal of Immunology (Baltimore, Md. : 1950). Dec, 2002 | Pubmed ID: 12444141 Temporal and Spatial Arrangement of Lymphocytes Within Lung Granulomas Induced by Aerosol Infection with Mycobacterium Tuberculosis Infection and Immunity. Mar, 2001 | Pubmed ID: 11179349 Characterization of Murine Lung Dendritic Cells Infected with Mycobacterium Tuberculosis Infection and Immunity. Feb, 2001 | Pubmed ID: 11160010 Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models (Video) | JoVE Sara E. Maloney1, Ian E. Stewart1, Jeffrey B. Mecham1, Mercedes Gonzalez-Juarrero2, Bernd Meibohm3, Anthony J. Hickey1 1Technology Advancement and Commercialization, RTI International, 2Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center JoVE 65756 Médecine 非手术治疗的小鼠气管内滴入肺和肺淋巴结流式细胞仪分析 Manira Rayamajhi1, Elizabeth F. Redente2, Tracy V. Condon1, Mercedes Gonzalez-Juarrero3, David W.H. Riches1,2,4, Laurel L. Lenz1,4 1Department of Immunology, University of Colorado School of Medicine, 2Division of Cell Biology, Department of Pediatrics, National Jewish Health, 3Department of Microbiology, Immunology, and Pathology, Colorado State University, 4Department of Immunology, National Jewish Health JoVE 2702 Immunologie et Infection
Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models (Video) | JoVE Sara E. Maloney1, Ian E. Stewart1, Jeffrey B. Mecham1, Mercedes Gonzalez-Juarrero2, Bernd Meibohm3, Anthony J. Hickey1 1Technology Advancement and Commercialization, RTI International, 2Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center JoVE 65756 Médecine
非手术治疗的小鼠气管内滴入肺和肺淋巴结流式细胞仪分析 Manira Rayamajhi1, Elizabeth F. Redente2, Tracy V. Condon1, Mercedes Gonzalez-Juarrero3, David W.H. Riches1,2,4, Laurel L. Lenz1,4 1Department of Immunology, University of Colorado School of Medicine, 2Division of Cell Biology, Department of Pediatrics, National Jewish Health, 3Department of Microbiology, Immunology, and Pathology, Colorado State University, 4Department of Immunology, National Jewish Health JoVE 2702 Immunologie et Infection