Michael J. Mitchell Department of Bioengineering University of Pennsylvania Biography Publications Institution JoVE Articles Michael J. Mitchell has not added a biography. If you are Michael J. Mitchell and would like to personalize this page please email our Author Liaison for assistance. Publications Nanoparticle Protein Corona: from Structure and Function to Therapeutic Targeting Lab on a Chip. Jan, 2023 | Pubmed ID: 36655824 Ligand-tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis Nature Communications. Jan, 2023 | Pubmed ID: 36650129 Platelet-Mimicking Nanosponges for Functional Reversal of Antiplatelet Agents Circulation Research. Jan, 2023 | Pubmed ID: 36625267 RGD Peptide-based Lipids for Targeted MRNA Delivery and Gene Editing Applications RSC Advances. Sep, 2022 | Pubmed ID: 36199352 A (Controlled) Spill of IL2 for Localized Treatment of Mesothelioma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2022 | Pubmed ID: 36190329 Drug Delivery Technologies for Fetal, Neonatal, and Maternal Therapy Advanced Drug Delivery Reviews. Oct, 2022 | Pubmed ID: 36030020 Nanotechnology-based Strategies Against SARS-CoV-2 Variants Nature Nanotechnology. Oct, 2022 | Pubmed ID: 35982317 Ionizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes International Journal of Nanomedicine. 2022 | Pubmed ID: 35795081 Rational Design of Bisphosphonate Lipid-like Materials for MRNA Delivery to the Bone Microenvironment Journal of the American Chemical Society. Jun, 2022 | Pubmed ID: 35616998 Lipid Nanodiscs Give Cancer a STING Nature Materials. Jun, 2022 | Pubmed ID: 35606430 Endothelial Plasticity Drives Aberrant Vascularization and Impedes Cardiac Repair After Myocardial Infarction Nature Cardiovascular Research. Apr, 2022 | Pubmed ID: 35571674 Hydroxycholesterol Substitution in Ionizable Lipid Nanoparticles for MRNA Delivery to T Cells Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2022 | Pubmed ID: 35569584 Cytosolic Delivery of Small Protein Scaffolds Enables Efficient Inhibition of Ras and Myc Molecular Pharmaceutics. Apr, 2022 | Pubmed ID: 35225618 Lighting the Way to Personalized MRNA Immune Cell Therapies Science Advances. Feb, 2022 | Pubmed ID: 35196095 Rational Design of Anti-inflammatory Lipid Nanoparticles for MRNA Delivery Journal of Biomedical Materials Research. Part A. May, 2022 | Pubmed ID: 35076171 Added to Pre-existing Inflammation, MRNA-lipid Nanoparticles Induce Inflammation Exacerbation (IE) Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2022 | Pubmed ID: 34953981 Amniotic Fluid Stabilized Lipid Nanoparticles for in Utero Intra-amniotic MRNA Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2022 | Pubmed ID: 34742747 Orthogonal Design of Experiments for Optimization of Lipid Nanoparticles for MRNA Engineering of CAR T Cells Nano Letters. Jan, 2022 | Pubmed ID: 34669421 An Ionizable Lipid Toolbox for RNA Delivery Nature Communications. Dec, 2021 | Pubmed ID: 34903741 One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for MRNA Journal of the American Chemical Society. Aug, 2021 | Pubmed ID: 34324336 Scalable MRNA and SiRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device Nano Letters. Jul, 2021 | Pubmed ID: 34189917 Microfluidic Formulation of Nanoparticles for Biomedical Applications Biomaterials. Jul, 2021 | Pubmed ID: 33965797 Delivery Technologies for T Cell Gene Editing: Applications in Cancer Immunotherapy EBioMedicine. May, 2021 | Pubmed ID: 33910123 Delivery Technologies to Engineer Natural Killer Cells for Cancer Immunotherapy Cancer Gene Therapy. Sep, 2021 | Pubmed ID: 33888870 Lipid Nanoparticle-Mediated Delivery of MRNA Therapeutics and Vaccines Trends in Molecular Medicine. Jun, 2021 | Pubmed ID: 33836968 Ionizable Lipid Nanoparticles for in Utero MRNA Delivery Science Advances. Jan, 2021 | Pubmed ID: 33523869 Nanomaterials for T-cell Cancer Immunotherapy Nature Nanotechnology. Jan, 2021 | Pubmed ID: 33437036 Helper Lipid Structure Influences Protein Adsorption and Delivery of Lipid Nanoparticles to Spleen and Liver Biomaterials Science. Feb, 2021 | Pubmed ID: 33404020 Engineering Precision Nanoparticles for Drug Delivery Nature Reviews. Drug Discovery. Feb, 2021 | Pubmed ID: 33277608 Delivery Technologies for in Utero Gene Therapy Advanced Drug Delivery Reviews. Feb, 2021 | Pubmed ID: 33181188 Summary From the First Kidney Cancer Research Summit, September 12-13, 2019: A Focus on Translational Research Journal of the National Cancer Institute. Mar, 2021 | Pubmed ID: 32359162 Proton-driven Transformable Nanovaccine for Cancer Immunotherapy Nature Nanotechnology. Dec, 2020 | Pubmed ID: 33106640 Nanoparticle-encapsulated SiRNAs for Gene Silencing in the Haematopoietic Stem-cell Niche Nature Biomedical Engineering. Nov, 2020 | Pubmed ID: 33020600 Exploiting the Placenta for Nanoparticle-mediated Drug Delivery During Pregnancy Advanced Drug Delivery Reviews. 2020 | Pubmed ID: 32956719 Cyclodextrins in Drug Delivery: Applications in Gene and Combination Therapy Drug Delivery and Translational Research. Jun, 2020 | Pubmed ID: 32077052 Ionizable Lipid Nanoparticle-Mediated MRNA Delivery for Human CAR T Cell Engineering Nano Letters. Mar, 2020 | Pubmed ID: 31951421 Chiral Supraparticles for Controllable Nanomedicine Advanced Materials (Deerfield Beach, Fla.). Jan, 2020 | Pubmed ID: 31686433 Ionizable Lipid Nanoparticles Encapsulating Barcoded MRNA for Accelerated in Vivo Delivery Screening Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2019 | Pubmed ID: 31678653 Nanoparticles for Nucleic Acid Delivery: Applications in Cancer Immunotherapy Cancer Letters. Aug, 2019 | Pubmed ID: 31100411 Delivery Technologies for Cancer Immunotherapy Nature Reviews. Drug Discovery. Mar, 2019 | Pubmed ID: 30622344 Nanomaterial Interactions with Human Neutrophils ACS Biomaterials Science & Engineering. Dec, 2018 | Pubmed ID: 31497639 Publisher Correction: Engineering and Physical Sciences in Oncology: Challenges and Opportunities Nature Reviews. Cancer. Nov, 2018 | Pubmed ID: 30337715 Biomaterials for Vaccine-based Cancer Immunotherapy Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2018 | Pubmed ID: 30312721 Potent in Vivo Lung Cancer Wnt Signaling Inhibition Via Cyclodextrin-LGK974 Inclusion Complexes Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2018 | Pubmed ID: 30290244 Advances in Biomaterials for Drug Delivery Advanced Materials (Deerfield Beach, Fla.). May, 2018 | Pubmed ID: 29736981 Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy ACS Nano. Feb, 2018 | Pubmed ID: 29378114 Engineering and Physical Sciences in Oncology: Challenges and Opportunities Nature Reviews. Cancer. Nov, 2017 | Pubmed ID: 29026204 Nanostructured Fibrous Membranes with Rose Spike-Like Architecture Nano Letters. 10, 2017 | Pubmed ID: 28819978 Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing Rakan El-Mayta1, Marshall S. Padilla1, Margaret M. Billingsley1, Xuexiang Han1, Michael J. Mitchell1 1Department of Bioengineering, University of Pennsylvania JoVE 64810 Bio-ingénierie
Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing Rakan El-Mayta1, Marshall S. Padilla1, Margaret M. Billingsley1, Xuexiang Han1, Michael J. Mitchell1 1Department of Bioengineering, University of Pennsylvania JoVE 64810 Bio-ingénierie