Motoyuki Otsuka Department of Gastroenterology, Graduate School of Medicine The University of Tokyo Biography Publications Institution JoVE Articles Motoyuki Otsuka has not added a biography. If you are Motoyuki Otsuka and would like to personalize this page please email our Author Liaison for assistance. Publications Detection of Circulating Colorectal Cancer Cells by a Custom Microfluid System Before and After Endoscopic Metallic Stent Placement Oncology Letters. Dec, 2019 | Pubmed ID: 31807163 Expression of Circular RNA CDR1‑AS in Colon Cancer Cells Increases Cell Surface PD‑L1 Protein Levels Oncology Reports. Oct, 2019 | Pubmed ID: 31322270 Inhibition of HBV Transcription From CccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction Cellular and Molecular Gastroenterology and Hepatology. 2019 | Pubmed ID: 30704981 Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus Hepatology (Baltimore, Md.). May, 2019 | Pubmed ID: 30586159 Liver Stiffness Measurements in Chronic Hepatitis C: Treatment Evaluation and Risk Assessment Journal of Gastroenterology and Hepatology. May, 2019 | Pubmed ID: 30393960 Inflammation and De-differentiation in Pancreatic Carcinogenesis World Journal of Clinical Cases. Dec, 2018 | Pubmed ID: 30568942 ISGF3 with Reduced Phosphorylation is Associated with Constitutive Expression of Interferon-induced Genes in Aging Cells NPJ Aging and Mechanisms of Disease. 2018 | Pubmed ID: 30455980 Hepatitis B Virus Pathogenesis: Fresh Insights into Hepatitis B Virus RNA World Journal of Gastroenterology. Jun, 2018 | Pubmed ID: 29881235 DHX9 Regulates Production of Hepatitis B Virus-derived Circular RNA and Viral Protein Levels Oncotarget. Apr, 2018 | Pubmed ID: 29765512 Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer Molecular Cancer Research : MCR. 08, 2018 | Pubmed ID: 29748382 CPT2 Downregulation Adapts HCC to Lipid-rich Environment and Promotes Carcinogenesis Via Acylcarnitine Accumulation in Obesity Gut. 08, 2018 | Pubmed ID: 29437870 RASAL1 is a Potent Regulator of Hepatic Stellate Cell Activity and Liver Fibrosis Oncotarget. Sep, 2017 | Pubmed ID: 29029395 Biliary Epithelial Injury-induced Regenerative Response by IL-33 Promotes Cholangiocarcinogenesis from Peribiliary Glands Proceedings of the National Academy of Sciences of the United States of America. 05, 2017 | Pubmed ID: 28439013 Transcriptional Activation of the MICA Gene with an Engineered CRISPR-Cas9 System Biochemical and Biophysical Research Communications. 04, 2017 | Pubmed ID: 28322797 Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis Gastroenterology. 02, 2017 | Pubmed ID: 27825961 MicroRNAs and Liver Disease Journal of Human Genetics. Jan, 2017 | Pubmed ID: 27225852 Quantitation of Circulating Satellite RNAs in Pancreatic Cancer Patients JCI Insight. 06, 2016 | Pubmed ID: 27699267 Satellite RNAs Promote Pancreatic Oncogenic Processes Via the Dysfunction of YBX1 Nature Communications. Sep, 2016 | Pubmed ID: 27667193 Mutual Antagonism Between Hepatitis B Viral MRNA and Host MicroRNA Let-7 Scientific Reports. Mar, 2016 | Pubmed ID: 26979389 Development of a Screening Method to Identify Regulators of MICA Shedding Biochemical and Biophysical Research Communications. Oct, 2015 | Pubmed ID: 26299929 Circulating RNAs As New Biomarkers for Detecting Pancreatic Cancer World Journal of Gastroenterology. Jul, 2015 | Pubmed ID: 26229396 ROCK Inhibition Enhances MicroRNA Function by Promoting Deadenylation of Targeted MRNAs Via Increasing PAIP2 Expression Nucleic Acids Research. Sep, 2015 | Pubmed ID: 26187994 Novel Therapeutic Approaches for Hepatitis B Virus Covalently Closed Circular DNA World Journal of Gastroenterology. Jun, 2015 | Pubmed ID: 26109795 Decreased MiR122 in Hepatocellular Carcinoma Leads to Chemoresistance with Increased Arginine Oncotarget. Apr, 2015 | Pubmed ID: 25826076 Diagnostic and Therapeutic Application of Noncoding RNAs for Hepatocellular Carcinoma World Journal of Hepatology. Jan, 2015 | Pubmed ID: 25624991 The Flavonoid Apigenin Inhibits Hepatitis C Virus Replication by Decreasing Mature MicroRNA122 Levels Virology. Aug, 2014 | Pubmed ID: 25092460 Specific Delivery of MicroRNA93 into HBV-replicating Hepatocytes Downregulates Protein Expression of Liver Cancer Susceptible Gene MICA Oncotarget. Jul, 2014 | Pubmed ID: 25026299 The Role of MicroRNAs in Hepatocarcinogenesis: Current Knowledge and Future Prospects Journal of Gastroenterology. Feb, 2014 | Pubmed ID: 24258409 Impact of PNPLA3 Polymorphisms on the Development of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C Virus Infection Hepatology Research : the Official Journal of the Japan Society of Hepatology. Oct, 2014 | Pubmed ID: 24125181 IL28B Minor Allele is Associated with a Younger Age of Onset of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C Virus Infection Journal of Gastroenterology. Apr, 2014 | Pubmed ID: 23689989 Transdifferentiation of Human Fibroblasts into Hepatocyte-like Cells by Defined Transcriptional Factors Hepatology International. Jul, 2013 | Pubmed ID: 26201932 Current Status of MiRNA-targeting Therapeutics and Preclinical Studies Against Gastroenterological Carcinoma Molecular and Cellular Therapies. 2013 | Pubmed ID: 26056570 Regulation of the Expression of the Liver Cancer Susceptibility Gene MICA by MicroRNAs Scientific Reports. 2013 | Pubmed ID: 24061441 Unique Haploinsufficient Role of the MicroRNA-processing Molecule Dicer1 in a Murine Colitis-associated Tumorigenesis Model PloS One. 2013 | Pubmed ID: 24023722 The Flavonoid Apigenin Improves Glucose Tolerance Through Inhibition of MicroRNA Maturation in MiRNA103 Transgenic Mice Scientific Reports. 2013 | Pubmed ID: 23989853 Inhibition of MicroRNA122 Decreases SREBP1 Expression by Modulating Suppressor of Cytokine Signaling 3 Expression Biochemical and Biophysical Research Communications. Aug, 2013 | Pubmed ID: 23891753 MicroRNAs and Liver Function Minerva Gastroenterologica E Dietologica. Jun, 2013 | Pubmed ID: 23831909 Histone Demethylase KDM4C Regulates Sphere Formation by Mediating the Cross Talk Between Wnt and Notch Pathways in Colonic Cancer Cells Carcinogenesis. Oct, 2013 | Pubmed ID: 23698634 A Genome-wide Association Study of HCV-induced Liver Cirrhosis in the Japanese Population Identifies Novel Susceptibility Loci at the MHC Region Journal of Hepatology. May, 2013 | Pubmed ID: 23321320 MicroRNA-140 Acts As a Liver Tumor Suppressor by Controlling NF-κB Activity by Directly Targeting DNA Methyltransferase 1 (Dnmt1) Expression Hepatology (Baltimore, Md.). Jan, 2013 | Pubmed ID: 22898998 Silencing of MicroRNA-122 Enhances Interferon-α Signaling in the Liver Through Regulating SOCS3 Promoter Methylation Scientific Reports. 2012 | Pubmed ID: 22957141 A MiRNA Machinery Component DDX20 Controls NF-κB Via MicroRNA-140 Function Biochemical and Biophysical Research Communications. Apr, 2012 | Pubmed ID: 22445758 Receptor for Activated Protein Kinase C: Requirement for Efficient MicroRNA Function and Reduced Expression in Hepatocellular Carcinoma PloS One. 2011 | Pubmed ID: 21935400 MicroRNA-22 and MicroRNA-140 Suppress NF-κB Activity by Regulating the Expression of NF-κB Coactivators Biochemical and Biophysical Research Communications. Aug, 2011 | Pubmed ID: 21798241 Altered Composition of Fatty Acids Exacerbates Hepatotumorigenesis During Activation of the Phosphatidylinositol 3-kinase Pathway Journal of Hepatology. Dec, 2011 | Pubmed ID: 21703185 MicroRNA122 is a Key Regulator of α-fetoprotein Expression and Influences the Aggressiveness of Hepatocellular Carcinoma Nature Communications. Jun, 2011 | Pubmed ID: 21654638 Direct Differentiation of Hepatic Cells from Human Induced Pluripotent Stem Cells Using a Limited Number of Cytokines Hepatology International. Dec, 2011 | Pubmed ID: 21484132 Reduced Expression of RAS Protein Activator Like-1 in Gastric Cancer International Journal of Cancer. Mar, 2011 | Pubmed ID: 20473946 Smad4-independent Regulation of P21/WAF1 by Transforming Growth Factor-beta Oncogene. Feb, 2004 | Pubmed ID: 14762439 Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System Kazuma Sekiba1,2, Motoyuki Otsuka1, Kazuhiko Koike1 1Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 2Research Fellow of Japan Society for the Promotion of Science JoVE 60652 Médecine
Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System Kazuma Sekiba1,2, Motoyuki Otsuka1, Kazuhiko Koike1 1Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 2Research Fellow of Japan Society for the Promotion of Science JoVE 60652 Médecine