N. Joan Abbott Institute of Pharmaceutical Science King's College London Biography Publications Institution JoVE Articles N. Joan Abbott has not added a biography. If you are N. Joan Abbott and would like to personalize this page please email our Author Liaison for assistance. Publications The Blood-brain Barrier in Psychosis The Lancet. Psychiatry. Aug, 2017 | Pubmed ID: 28781208 Uptake and Metabolism of Sulphated Steroids by the Blood-brain Barrier in the Adult Male Rat Journal of Neurochemistry. Sep, 2017 | Pubmed ID: 28665486 Impact of Capillary Flow Hydrodynamics on Carrier-mediated Transport of Opioid Derivatives at the Blood-brain Barrier, Based on PH-dependent Michaelis-Menten and Crone-Renkin Analyses European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Aug, 2017 | Pubmed ID: 28614733 Bidirectional Apical-basal Traffic of the Cation-independent Mannose-6-phosphate Receptor in Brain Endothelial Cells Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jul, 2017 | Pubmed ID: 28337939 In vitro Models of the Blood-brain Barrier: An Overview of Commonly Used Brain Endothelial Cell Culture Models and Guidelines for Their Use Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2016 | Pubmed ID: 26868179 Translocation of LRP1 Targeted Carbon Nanotubes of Different Diameters Across the Blood-brain Barrier in Vitro and in Vivo Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2016 | Pubmed ID: 26809004 LRP-1-mediated Intracellular Antibody Delivery to the Central Nervous System Scientific Reports. Jul, 2015 | Pubmed ID: 26189707 The Interaction of Carbon Nanotubes with an in Vitro Blood-brain Barrier Model and Mouse Brain in Vivo Biomaterials. Jun, 2015 | Pubmed ID: 25890741 Characterization of a Novel Brain Barrier Ex Vivo Insect-based P-glycoprotein Screening Model Pharmacology Research & Perspectives. Aug, 2014 | Pubmed ID: 25505597 Primary Porcine Brain Microvessel Endothelial Cell Isolation and Culture Current Protocols in Neuroscience. Oct, 2014 | Pubmed ID: 25297692 In Vitro Porcine Blood-brain Barrier Model for Permeability Studies: PCEL-X Software PKa(FLUX) Method for Aqueous Boundary Layer Correction and Detailed Data Analysis European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Dec, 2014 | Pubmed ID: 25239510 A High-content Small Molecule Screen Identifies Sensitivity of Glioblastoma Stem Cells to Inhibition of Polo-like Kinase 1 PloS One. 2013 | Pubmed ID: 24204733 A Multi-system Approach Assessing the Interaction of Anticonvulsants with P-gp PloS One. 2013 | Pubmed ID: 23741405 Blood-brain Barrier Structure and Function and the Challenges for CNS Drug Delivery Journal of Inherited Metabolic Disease. May, 2013 | Pubmed ID: 23609350 A Detailed Method for Preparation of a Functional and Flexible Blood-brain Barrier Model Using Porcine Brain Endothelial Cells Brain Research. Jul, 2013 | Pubmed ID: 23603406 Delivery of Paclitaxel Across Cellular Barriers Using a Dendrimer-based Nanocarrier International Journal of Pharmaceutics. Jan, 2013 | Pubmed ID: 23089576 Establishment of a Simplified in Vitro Porcine Blood-brain Barrier Model with High Transendothelial Electrical Resistance Brain Research. Jul, 2013 | Pubmed ID: 22789905 Overview and Introduction: the Blood-brain Barrier in Health and Disease Epilepsia. Nov, 2012 | Pubmed ID: 23134489 An Improved in Vitro Blood-brain Barrier Model: Rat Brain Endothelial Cells Co-cultured with Astrocytes Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22144323 Structure and Function of the Blood-brain Barrier Neurobiology of Disease. Jan, 2010 | Pubmed ID: 19664713 All Vertebrates Started out with a Glial Blood-brain Barrier 4-500 Million Years Ago Glia. May, 2008 | Pubmed ID: 18338790 Strategies to Advance Translational Research into Brain Barriers The Lancet. Neurology. Jan, 2008 | Pubmed ID: 18093565 P-Glycoprotein Expression in Human Retinal Pigment Epithelium Cell Lines Experimental Eye Research. Jul, 2006 | Pubmed ID: 16530756 Astrocyte-endothelial Interactions at the Blood-brain Barrier Nature Reviews. Neuroscience. Jan, 2006 | Pubmed ID: 16371949 Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation Cellular and Molecular Neurobiology. Feb, 2005 | Pubmed ID: 15962506 Induction of Aquaporin 1 but Not Aquaporin 4 Messenger RNA in Rat Primary Brain Microvessel Endothelial Cells in Culture Journal of Neurochemistry. May, 2005 | Pubmed ID: 15857386 Prediction of Blood-brain Barrier Permeation in Drug Discovery from in Vivo, in Vitro and in Silico Models Drug Discovery Today. Technologies. Dec, 2004 | Pubmed ID: 24981621 Interaction of Nucleoside Analogues with Nucleoside Transporters in Rat Brain Endothelial Cells Journal of Drug Targeting. Jun, 2004 | Pubmed ID: 15512777 Barrera Hemato - Encefálica Abrió Por Estimulación De Los Ganglios Parasimpáticos Esfenopalatino: Un Nuevo Método Para La Entrega De La Macromolécula Al Cerebro Journal of Neurosurgery. Aug, 2004 | Pubmed ID: 15309923 Brain to Blood Efflux Transport of Adenosine: Blood-brain Barrier Studies in the Rat Journal of Neurochemistry. Jul, 2004 | Pubmed ID: 15228584 Evidence for Bulk Flow of Brain Interstitial Fluid: Significance for Physiology and Pathology Neurochemistry International. Sep, 2004 | Pubmed ID: 15186921 Cross Reactivity of Polyclonal GFAP Antiserum: Implications for the In-vitro Characterisation of Brain Endothelium Brain Research. Jun, 2004 | Pubmed ID: 15158176 Flavonoid Permeability Across an in Situ Model of the Blood-brain Barrier Free Radical Biology & Medicine. Mar, 2004 | Pubmed ID: 14980703 In Vitro Trans-monolayer Permeability Calculations: Often Forgotten Assumptions Drug Discovery Today. Nov, 2003 | Pubmed ID: 14643163 An Overview of in Vitro Techniques for Blood-brain Barrier Studies Methods in Molecular Medicine. 2003 | Pubmed ID: 12958429 Functional Characterisation of Nucleoside Transport in Rat Brain Endothelial Cells Neuroreport. May, 2003 | Pubmed ID: 12802208 Vascular and Parenchymal Mechanisms in Multiple Drug Resistance: a Lesson from Human Epilepsy Current Drug Targets. May, 2003 | Pubmed ID: 12699350 Interaction Between Flavonoids and the Blood-brain Barrier: in Vitro Studies Journal of Neurochemistry. Apr, 2003 | Pubmed ID: 12641740 Lipids in Blood-brain Barrier Models in Vitro II: Influence of Glial Cells on Lipid Classes and Lipid Fatty Acids In Vitro Cellular & Developmental Biology. Animal. Nov-Dec, 2002 | Pubmed ID: 12762838 Lipids in Blood-brain Barrier Models in Vitro I: Thin-layer Chromatography and High-performance Liquid Chromatography for the Analysis of Lipid Classes and Long-chain Polyunsaturated Fatty Acids In Vitro Cellular & Developmental Biology. Animal. Nov-Dec, 2002 | Pubmed ID: 12762837 Bradykinin Increases Permeability by Calcium and 5-lipoxygenase in the ECV304/C6 Cell Culture Model of the Blood-brain Barrier Brain Research. Oct, 2002 | Pubmed ID: 12384249 Evaluation of the RBE4 Cell Line to Explore Carrier-mediated Drug Delivery to the CNS Via the L-system Amino Acid Transporter at the Blood-brain Barrier Journal of Drug Targeting. Jun, 2002 | Pubmed ID: 12164376 Astrocyte-endothelial Interactions and Blood-brain Barrier Permeability Journal of Anatomy. Jun, 2002 | Pubmed ID: 12162730 Ionic Currents in Isolated and in Situ Squid Schwann Cells The Journal of Physiology. Jun, 2002 | Pubmed ID: 12068039 Drug Resistance in Epilepsy: the Role of the Blood-brain Barrier Novartis Foundation Symposium. 2002 | Pubmed ID: 11990780 Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. Dec, 1998 | Pubmed ID: 11390805 Mejor método para el establecimiento de un In Vitro Barrera Blood - Brain modelo basado en las células endoteliales de cerebro porcino Simone S. E. Nielsen1, Piotr Siupka1, Ana Georgian2, Jane E. Preston2, Andrea E. Tóth1, Siti R. Yusof2,3, N. Joan Abbott2, Morten S. Nielsen1 1Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Department of Biomedicine, Aarhus University, 2Institute of Pharmaceutical Science, King's College London, 3HICoE Centre for Drug Research, Universiti Sains Malaysia JoVE 56277 Médecine
Mejor método para el establecimiento de un In Vitro Barrera Blood - Brain modelo basado en las células endoteliales de cerebro porcino Simone S. E. Nielsen1, Piotr Siupka1, Ana Georgian2, Jane E. Preston2, Andrea E. Tóth1, Siti R. Yusof2,3, N. Joan Abbott2, Morten S. Nielsen1 1Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Department of Biomedicine, Aarhus University, 2Institute of Pharmaceutical Science, King's College London, 3HICoE Centre for Drug Research, Universiti Sains Malaysia JoVE 56277 Médecine