Nissi M. Varki Department of Cellular and Molecular Medicine University of California, San Diego Biography Publications Institution JoVE Articles Nissi M. Varki has not added a biography. If you are Nissi M. Varki and would like to personalize this page please email our Author Liaison for assistance. Publications Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: MECHANISMS UNDERLYING GASTROINTESTINAL INCORPORATION OF THE NON-HUMAN SIALIC ACID XENO-AUTOANTIGEN N-GLYCOLYLNEURAMINIC ACID The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22692204 Ptpn11/Shp2 Acts As a Tumor Suppressor in Hepatocellular Carcinogenesis Cancer Cell. May, 2011 | Pubmed ID: 21575863 Biomedical Differences Between Human and Nonhuman Hominids: Potential Roles for Uniquely Human Aspects of Sialic Acid Biology Annual Review of Pathology. 2011 | Pubmed ID: 21073341 The ROCK Inhibitor Y-27632 Improves Recovery of Human Embryonic Stem Cells After Fluorescence-activated Cell Sorting with Multiple Cell Surface Markers PloS One. 2010 | Pubmed ID: 20730054 Evidence for a Novel Human-specific Xeno-auto-antibody Response Against Vascular Endothelium Blood. Dec, 2009 | Pubmed ID: 19828701 A Dietary Non-human Sialic Acid May Facilitate Hemolytic-uremic Syndrome Kidney International. Jul, 2009 | Pubmed ID: 19387473 Molecular Basis of Metastasis The New England Journal of Medicine. Apr, 2009 | Pubmed ID: 19369678 Sensitive and Specific Detection of the Non-human Sialic Acid N-glycolylneuraminic Acid in Human Tissues and Biotherapeutic Products PloS One. 2009 | Pubmed ID: 19156207 Evidence for a Human-specific Mechanism for Diet and Antibody-mediated Inflammation in Carcinoma Progression Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19017806 Incorporation of a Non-human Glycan Mediates Human Susceptibility to a Bacterial Toxin Nature. Dec, 2008 | Pubmed ID: 18971931 Alpha 2-6-Linked Sialic Acids on N-glycans Modulate Carcinoma Differentiation in Vivo Cancer Research. Jan, 2008 | Pubmed ID: 18199532 Diversity in Cell Surface Sialic Acid Presentations: Implications for Biology and Disease Laboratory Investigation; a Journal of Technical Methods and Pathology. Sep, 2007 | Pubmed ID: 17632542 Expression of the Human Copper Influx Transporter 1 in Normal and Malignant Human Tissues The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Sep, 2006 | Pubmed ID: 16709730 L-selectin Facilitation of Metastasis Involves Temporal Induction of Fut7-dependent Ligands at Sites of Tumor Cell Arrest Cancer Research. Feb, 2006 | Pubmed ID: 16452210 A Human-specific Gene in Microglia Science (New York, N.Y.). Sep, 2005 | Pubmed ID: 16151003 Combining Parenting and a Science Career Science (New York, N.Y.). Mar, 2005 | Pubmed ID: 15779114 Combining Parenting and a Science Career Science (New York, N.Y.). Mar, 2005 | Pubmed ID: 15778202 A Fluorescent Orthotopic Mouse Model for Reliable Measurement and Genetic Modulation of Human Neuroblastoma Metastasis Clinical & Experimental Metastasis. 2004 | Pubmed ID: 15679054 Clearance of Citrobacter Rodentium Requires B Cells but Not Secretory Immunoglobulin A (IgA) or IgM Antibodies Infection and Immunity. Jun, 2004 | Pubmed ID: 15155635 Disruption of Forkhead Transcription Factor (FOXO) Family Members in Mice Reveals Their Functional Diversification Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14978268 Increase in Expression of the Copper Transporter ATP7A During Platinum Drug-based Treatment is Associated with Poor Survival in Ovarian Cancer Patients Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2003 | Pubmed ID: 14676106 Human-specific Regulation of Alpha 2-6-linked Sialic Acids The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 14500706 Genetically Altered Mice with Different Sialyltransferase Deficiencies Show Tissue-specific Alterations in Sialylation and Sialic Acid 9-O-acetylation The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12068010 Cloning and Characterization of Human Siglec-11. A Recently Evolved Signaling Molecule That Can Interact with SHP-1 and SHP-2 and is Expressed by Tissue Macrophages, Including Brain Microglia The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 11986327 Heparin Inhibition of Selectin-mediated Interactions During the Hematogenous Phase of Carcinoma Metastasis: Rationale for Clinical Studies in Humans Seminars in Thrombosis and Hemostasis. Feb, 2002 | Pubmed ID: 11885026 Synergistic Effects of L- and P-selectin in Facilitating Tumor Metastasis Can Involve Non-mucin Ligands and Implicate Leukocytes As Enhancers of Metastasis Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11854515 Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution Miriam Cohen1, Nissi M. Varki1, Mark D. Jankowski2, Pascal Gagneux1 1Department of Cellular and Molecular Medicine, University of California, San Diego, 2Biosecurity and Public Health, Los Alamos National Laboratory JoVE 3928 Biologie
Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution Miriam Cohen1, Nissi M. Varki1, Mark D. Jankowski2, Pascal Gagneux1 1Department of Cellular and Molecular Medicine, University of California, San Diego, 2Biosecurity and Public Health, Los Alamos National Laboratory JoVE 3928 Biologie