Radislav Sedlacek Czech Centre for Phenogenomics Institute of Molecular Genetics of the Czech Academy of Sciences Biography Publications Institution JoVE Articles Radislav Sedlacek has not added a biography. If you are Radislav Sedlacek and would like to personalize this page please email our Author Liaison for assistance. Publications Comprehensive ECG Reference Intervals in C57BL/6N Substrains Provide a Generalizable Guide for Cardiac Electrophysiology Studies in Mice Mammalian Genome : Official Journal of the International Mammalian Genome Society. Jun, 2023 | Pubmed ID: 37294348 Spatial Analysis of Nucleotide Metabolism: From CRISPR Knockout Cancer Cells to MALDI Imaging of Tumors Methods in Molecular Biology (Clifton, N.J.). 2023 | Pubmed ID: 37258772 Variation in Mouse Chemical Signals is Genetically Controlled and Environmentally Modulated Scientific Reports. May, 2023 | Pubmed ID: 37237091 A Structural Model of the IRhom-ADAM17 Sheddase Complex Reveals Functional Insights into Its Trafficking and Activity Cellular and Molecular Life Sciences : CMLS. Apr, 2023 | Pubmed ID: 37119365 Genome-wide Screening Reveals the Genetic Basis of Mammalian Embryonic Eye Development BMC Biology. Feb, 2023 | Pubmed ID: 36737727 Human Neutralizing Antibodies to Cold Linear Epitopes and Subdomain 1 of the SARS-CoV-2 Spike Glycoprotein Science Immunology. Mar, 2023 | Pubmed ID: 36701425 LACTB Induces Cancer Cell Death Through the Activation of the Intrinsic Caspase-independent Pathway in Breast Cancer Apoptosis : an International Journal on Programmed Cell Death. Feb, 2023 | Pubmed ID: 36282364 Molecular Interactions of Adaptor Protein PSTPIP2 Control Neutrophil-mediated Responses Leading to Autoinflammation Frontiers in Immunology. 2022 | Pubmed ID: 36605205 Human Neutralizing Antibodies to Cold Linear Epitopes and to Subdomain 1 of SARS-CoV-2 BioRxiv : the Preprint Server for Biology. Nov, 2022 | Pubmed ID: 36482967 Analysis of Genome-wide Knockout Mouse Database Identifies Candidate Ciliopathy Genes Scientific Reports. Dec, 2022 | Pubmed ID: 36456625 Structural and Functional Basis of Mammalian MicroRNA Biogenesis by Dicer Molecular Cell. Nov, 2022 | Pubmed ID: 36332606 Self-reactivity of CD8 T-cell Clones Determines Their Differentiation Status Rather Than Their Responsiveness in Infections Frontiers in Immunology. 2022 | Pubmed ID: 36275704 Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the Gene Cells. Sep, 2022 | Pubmed ID: 36139390 Full Assessment of Lung Mechanics Using Computer-Controlled, Forced Oscillation Technique Current Protocols. Jul, 2022 | Pubmed ID: 35834677 FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 35769260 Batch Alignment Via Retention Orders for Preprocessing Large-scale Multi-batch LC-MS Experiments Bioinformatics (Oxford, England). Aug, 2022 | Pubmed ID: 35748696 Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA Non-coding RNA. May, 2022 | Pubmed ID: 35645339 Genome-wide Association Study Identifies Kallikrein 5 in Type 2 Inflammation-low Asthma The Journal of Allergy and Clinical Immunology. Apr, 2022 | Pubmed ID: 35487308 Semantic Clustering Analysis of E3-ubiquitin Ligases in Gastrointestinal Tract Defines Genes Ontology Clusters with Tissue Expression Patterns BMC Gastroenterology. Apr, 2022 | Pubmed ID: 35413796 Correction To: Plectin Ensures Intestinal Epithelial Integrity and Protects Colon Against Colitis Mucosal Immunology. Mar, 2022 | Pubmed ID: 35301446 Multi-Level Approach for Comprehensive Enamel Phenotyping Current Protocols. Jan, 2022 | Pubmed ID: 35007410 Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies Biological Psychiatry. Jul, 2022 | Pubmed ID: 34865853 Correction: Plectin Ensures Intestinal Epithelial Integrity and Protects Colon Against Colitis Mucosal Immunology. Feb, 2022 | Pubmed ID: 34686840 INFRAFRONTIER Quality Principles in Systemic Phenotyping Mammalian Genome : Official Journal of the International Mammalian Genome Society. Mar, 2022 | Pubmed ID: 34328547 The Receptor-type Protein Tyrosine Phosphatase CD45 Promotes Onset and Severity of IL-1β-mediated Autoinflammatory Osteomyelitis The Journal of Biological Chemistry. Oct, 2021 | Pubmed ID: 34461100 Heterozygous Mutation Affects Glucose Tolerance in Male Rats Genes. Jul, 2021 | Pubmed ID: 34356103 Publisher Correction: Bispecific IgG Neutralizes SARS-CoV-2 Variants and Prevents Escape in Mice Nature. Sep, 2021 | Pubmed ID: 34345019 Retraction Notice to "Fam208a Orchestrates Interaction Protein Network Essential for Early Embryonic Development and Cell Division" [Exp. Cell Res. 382 (1) (2019) 111437] Experimental Cell Research. Aug, 2021 | Pubmed ID: 34272044 Dual Role of Fam208a During Zygotic Cleavage and Early Embryonic Development Experimental Cell Research. Sep, 2021 | Pubmed ID: 34216590 LAMP3 Deficiency Affects Surfactant Homeostasis in Mice PLoS Genetics. Jun, 2021 | Pubmed ID: 34161347 Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 34150743 Deletion of TLR2 Erythro-myeloid Progenitors Leads to Embryonic Lethality in Mice European Journal of Immunology. Sep, 2021 | Pubmed ID: 34107067 ADAM10 and ADAM17 Regulate EGFR, C-Met and TNF RI Signalling in Liver Regeneration and Fibrosis Scientific Reports. 06, 2021 | Pubmed ID: 34075077 CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase During Spermatogenesis and T Cell Activation International Journal of Molecular Sciences. May, 2021 | Pubmed ID: 34065512 Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1 Frontiers in Immunology. 2021 | Pubmed ID: 33986741 The IRhom Homology Domain is Indispensable for ADAM17-mediated TNFα and EGF Receptor Ligand Release Cellular and Molecular Life Sciences : CMLS. Jun, 2021 | Pubmed ID: 33950315 Expression of Human-specific ARHGAP11B in Mice Leads to Neocortex Expansion and Increased Memory Flexibility The EMBO Journal. Jul, 2021 | Pubmed ID: 33938018 Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the Gene International Journal of Molecular Sciences. Apr, 2021 | Pubmed ID: 33916973 Cytoplasmic Polyadenylation by TENT5A is Required for Proper Bone Formation Cell Reports. Apr, 2021 | Pubmed ID: 33882302 A Resource of Targeted Mutant Mouse Lines for 5,061 Genes Nature Genetics. Apr, 2021 | Pubmed ID: 33833456 Response to Correspondence on "Reproducibility of CRISPR-Cas9 Methods for Generation of Conditional Mouse Alleles: a Multi-center Evaluation" Genome Biology. 04, 2021 | Pubmed ID: 33827648 Bispecific IgG Neutralizes SARS-CoV-2 Variants and Prevents Escape in Mice Nature. May, 2021 | Pubmed ID: 33767445 Plectin Ensures Intestinal Epithelial Integrity and Protects Colon Against Colitis Mucosal Immunology. 05, 2021 | Pubmed ID: 33674761 SGIP1 is Involved in Regulation of Emotionality, Mood, and Nociception and Modulates in Vivo Signalling of Cannabinoid CB Receptors British Journal of Pharmacology. Apr, 2021 | Pubmed ID: 33491188 Bardet-Biedl Syndrome Ciliopathy is Linked to Altered Hematopoiesis and Dysregulated Self-tolerance EMBO Reports. Feb, 2021 | Pubmed ID: 33426789 Efficient Allele Conversion in Mouse Zygotes and Primary Cells Based on Electroporation of Cre Protein Methods (San Diego, Calif.). Jul, 2021 | Pubmed ID: 32717290 Mouse Mutant Phenotyping at Scale Reveals Novel Genes Controlling Bone Mineral Density PLoS Genetics. Dec, 2020 | Pubmed ID: 33370286 Intronic Determinants Coordinate Charme LncRNA Nuclear Activity Through the Interaction with MATR3 and PTBP1 Cell Reports. Dec, 2020 | Pubmed ID: 33357424 The IRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner International Journal of Molecular Sciences. Aug, 2020 | Pubmed ID: 32825187 Cytotoxicity of the Effector Protein BteA Was Attenuated In Bordetella Pertussis by Insertion of an Alanine Residue PLoS Pathogens. Aug, 2020 | Pubmed ID: 32776984 Toll-like Receptor Signaling in Thymic Epithelium Controls Monocyte-derived Dendritic Cell Recruitment and Treg Generation Nature Communications. May, 2020 | Pubmed ID: 32398640 Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis Journal of Immunology (Baltimore, Md. : 1950). 03, 2020 | Pubmed ID: 32024700 The Deep Genome Project Genome Biology. Feb, 2020 | Pubmed ID: 32008577 Human and Mouse Essentiality Screens As a Resource for Disease Gene Discovery Nature Communications. Jan, 2020 | Pubmed ID: 32005800 High-throughput Discovery of Genetic Determinants of Circadian Misalignment PLoS Genetics. Jan, 2020 | Pubmed ID: 31929527 CRMP2 Mediates Sema3F-dependent Axon Pruning and Dendritic Spine Remodeling EMBO Reports. Mar, 2020 | Pubmed ID: 31919978 The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach Journal of Diabetes Research. 2019 | Pubmed ID: 31886287 Toll-like Receptor 2 Expression on C-kit Cells Tracks the Emergence of Embryonic Definitive Hematopoietic Progenitors Nature Communications. Nov, 2019 | Pubmed ID: 31729371 Truncated PPM1D Impairs Stem Cell Response to Genotoxic Stress and Promotes Growth of APC-deficient Tumors in the Mouse Colon Cell Death & Disease. Oct, 2019 | Pubmed ID: 31659152 Reproducibility of CRISPR-Cas9 Methods for Generation of Conditional Mouse Alleles: a Multi-center Evaluation Genome Biology. 08, 2019 | Pubmed ID: 31446895 Histone Methyltransferase PRDM9 is Not Essential for Meiosis in Male Mice Genome Research. Jul, 2019 | Pubmed ID: 31186301 Fam208a Orchestrates Interaction Protein Network Essential for Early Embryonic Development and Cell Division Experimental Cell Research. Sep, 2019 | Pubmed ID: 31112734 C-Myb Regulates Tumorigenic Potential of Embryonal Rhabdomyosarcoma Cells Scientific Reports. Apr, 2019 | Pubmed ID: 31004084 Aire-expressing ILC3-like Cells in the Lymph Node Display Potent APC Features The Journal of Experimental Medicine. May, 2019 | Pubmed ID: 30918005 Role of in Maternal MRNA Turnover Life Science Alliance. Aug, 2018 | Pubmed ID: 30456367 The Role of Immune Cell Subpopulations in the Growth and Rejection of TC-1/A9 Tumors in Novel Mouse Strains Differing in the H2-D Haplotype and NKC Domain Oncology Letters. Mar, 2018 | Pubmed ID: 29467880 Plectin Controls Biliary Tree Architecture and Stability in Cholestasis Journal of Hepatology. 05, 2018 | Pubmed ID: 29273475 Intrinsically Disordered Proteins Drive Enamel Formation Via an Evolutionarily Conserved Self-assembly Motif Proceedings of the National Academy of Sciences of the United States of America. Feb, 2017 | Pubmed ID: 28196895 KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype PLoS Genetics. Jan, 2017 | Pubmed ID: 28095415 Knockout of Tmem70 Alters Biogenesis of ATP Synthase and Leads to Embryonal Lethality in Mice Human Molecular Genetics. Nov, 2016 | Pubmed ID: 28173120 Transgenic Reporter Mice with Promoter Region of Murine LRAT Specifically Marks Lens and Meiosis Spermatocytes Physiological Research. 2015 | Pubmed ID: 25317684 Efficient Gene Targeting of the Rosa26 Locus in Mouse Zygotes Using TALE Nucleases FEBS Letters. Nov, 2014 | Pubmed ID: 25241166 Liver Protective Effect of Ursodeoxycholic Acid Includes Regulation of ADAM17 Activity BMC Gastroenterology. Oct, 2013 | Pubmed ID: 24172289 A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model (Video) | JoVE Agnieszka Kubik-Zahorodna1, Jan Prochazka1,2, Radislav Sedlacek1,2 1Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, 2Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences JoVE 65182 Comportement
A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model (Video) | JoVE Agnieszka Kubik-Zahorodna1, Jan Prochazka1,2, Radislav Sedlacek1,2 1Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, 2Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences JoVE 65182 Comportement