Sang-Jun Ha Department of Biochemistry, College of Life Science & Biotechnology Yonsei University Biography Publications Institution JoVE Articles Sang-Jun Ha has not added a biography. If you are Sang-Jun Ha and would like to personalize this page please email our Author Liaison for assistance. Publications Cell Type Preference of a Novel Human Derived Cell-Permeable Peptide DNP2 and TAT in Murine Splenic Immune Cells PloS One. 2016 | Pubmed ID: 27186978 Cisplatin Induces Tolerogenic Dendritic Cells in Response to TLR Agonists Via the Abundant Production of IL-10, Thereby Promoting Th2- and Tr1-biased T-cell Immunity Oncotarget. May, 2016 | Pubmed ID: 27172902 Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues Immune Network. Apr, 2016 | Pubmed ID: 27162529 Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications Immune Network. Feb, 2016 | Pubmed ID: 26937232 Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments Cancer Research and Treatment : Official Journal of Korean Cancer Association. Apr, 2016 | Pubmed ID: 26323643 Correction: PD-1 Upregulated on Regulatory T Cells During Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response Via the Interaction with PD-L1 Expressed on CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2015 | Pubmed ID: 26637664 A Small Molecule Inhibitor for ATPase Activity of Hsp70 and Hsc70 Enhances the Immune Response to Protein Antigens Scientific Reports. 2015 | Pubmed ID: 26631605 AMIGO2, a Novel Membrane Anchor of PDK1, Controls Cell Survival and Angiogenesis Via Akt Activation The Journal of Cell Biology. Nov, 2015 | Pubmed ID: 26553931 IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection PLoS Pathogens. Oct, 2015 | Pubmed ID: 26452143 PD-1: Dual Guard for Immunopathology Oncotarget. Sep, 2015 | Pubmed ID: 26318040 PD-1 Upregulated on Regulatory T Cells During Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response Via the Interaction with PD-L1 Expressed on CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2015 | Pubmed ID: 25934860 Identification of a Subnuclear Body Involved in Sequence-specific Cytokine RNA Processing Nature Communications. 2015 | Pubmed ID: 25557830 Diagnostic Performance of a Cytokine and IFN-γ-induced Chemokine MRNA Assay After Mycobacterium Tuberculosis-specific Antigen Stimulation in Whole Blood from Infected Individuals The Journal of Molecular Diagnostics : JMD. Jan, 2015 | Pubmed ID: 25528189 Discrimination Between Active and Latent Tuberculosis Based on Ratio of Antigen-specific to Mitogen-induced IP-10 Production Journal of Clinical Microbiology. Feb, 2015 | Pubmed ID: 25428147 Peptidylarginine Deiminase Inhibition Impairs Toll-like Receptor Agonist-induced Functional Maturation of Dendritic Cells, Resulting in the Loss of T Cell-proliferative Capacity: a Partial Mechanism with Therapeutic Potential in Inflammatory Settings Journal of Leukocyte Biology. Feb, 2015 | Pubmed ID: 25420918 Inhibition of IL-17A Suppresses Enhanced-tumor Growth in Low Dose Pre-irradiated Tumor Beds PloS One. 2014 | Pubmed ID: 25181290 Enhancing T Cell Immune Responses by B Cell-based Therapeutic Vaccine Against Chronic Virus Infection Immune Network. Aug, 2014 | Pubmed ID: 25177253 Direct Endothelial Junction Restoration Results in Significant Tumor Vascular Normalization and Metastasis Inhibition in Mice Oncotarget. May, 2014 | Pubmed ID: 24811731 Regulatory T Cells-an Important Target for Cancer Immunotherapy Nature Reviews. Clinical Oncology. Jun, 2014 | Pubmed ID: 24781417 Highly Efficient Gene Knockout in Mice and Zebrafish with RNA-guided Endonucleases Genome Research. Jan, 2014 | Pubmed ID: 24253447 Differentiation of Antigen-specific T Cells with Limited Functional Capacity During Mycobacterium Tuberculosis Infection Infection and Immunity. Jan, 2014 | Pubmed ID: 24126533 Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8⁺ T-cell Exhaustion PLoS Pathogens. 2013 | Pubmed ID: 23874199 Egr2 Induced During DC Development Acts As an Intrinsic Negative Regulator of DC Immunogenicity European Journal of Immunology. Sep, 2013 | Pubmed ID: 23716134 The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma Yonsei Medical Journal. Jul, 2013 | Pubmed ID: 23709419 PD-L1 Blockade Synergizes with IL-2 Therapy in Reinvigorating Exhausted T Cells The Journal of Clinical Investigation. Jun, 2013 | Pubmed ID: 23676462 Interleukin-21 is a Critical Cytokine for the Generation of Virus-specific Long-lived Plasma Cells Journal of Virology. Jul, 2013 | Pubmed ID: 23637417 Recruitment of Monocytes/macrophages in Different Tumor Microenvironments Biochimica Et Biophysica Acta. Apr, 2013 | Pubmed ID: 23287570 A Phase I Trial of Gefitinib and Nimotuzumab in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) Lung Cancer (Amsterdam, Netherlands). Mar, 2013 | Pubmed ID: 23261229 Fibroblast Growth Factor Receptor 1 Gene Amplification is Associated with Poor Survival and Cigarette Smoking Dosage in Patients with Resected Squamous Cell Lung Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2013 | Pubmed ID: 23182986 Tumor-infiltrating Regulatory T Cells Delineated by Upregulation of PD-1 and Inhibitory Receptors Cellular Immunology. Jul-Aug, 2012 | Pubmed ID: 23121978 Activation of IL-6R/JAK1/STAT3 Signaling Induces De Novo Resistance to Irreversible EGFR Inhibitors in Non-small Cell Lung Cancer with T790M Resistance Mutation Molecular Cancer Therapeutics. Oct, 2012 | Pubmed ID: 22891040 Mind Bomb-1 in Dendritic Cells is Specifically Required for Notch-mediated T Helper Type 2 Differentiation PloS One. 2012 | Pubmed ID: 22558446 High EGFR Gene Copy Number and Skin Rash As Predictive Markers for EGFR Tyrosine Kinase Inhibitors in Patients with Advanced Squamous Cell Lung Carcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2012 | Pubmed ID: 22271877 Distinct Clinical Features and Outcomes in Never-smokers with Nonsmall Cell Lung Cancer Who Harbor EGFR or KRAS Mutations or ALK Rearrangement Cancer. Feb, 2012 | Pubmed ID: 21720997 Antigen-specific CD4 T-cell Help Rescues Exhausted CD8 T Cells During Chronic Viral Infection Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22160724 Co-immunization of Plasmid DNA Encoding IL-12 and IL-18 with Bacillus Calmette-Guérin Vaccine Against Progressive Tuberculosis Yonsei Medical Journal. Nov, 2011 | Pubmed ID: 22028167 Chronic Virus Infection Enforces Demethylation of the Locus That Encodes PD-1 in Antigen-specific CD8(+) T Cells Immunity. Sep, 2011 | Pubmed ID: 21943489 4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade to Augment CD8 T Cell Responses During Chronic Viral Infection Journal of Immunology (Baltimore, Md. : 1950). Aug, 2011 | Pubmed ID: 21742975 Mechanism of T Cell Exhaustion in a Chronic Environment BMB Reports. Apr, 2011 | Pubmed ID: 21524346 Lung Cancer in Never Smokers: Change of a Mindset in the Molecular Era Lung Cancer (Amsterdam, Netherlands). Apr, 2011 | Pubmed ID: 21272954 Cooperation of Tim-3 and PD-1 in CD8 T-cell Exhaustion During Chronic Viral Infection Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20679213 PD-L1 Has Distinct Functions in Hematopoietic and Nonhematopoietic Cells in Regulating T Cell Responses During Chronic Infection in Mice The Journal of Clinical Investigation. Jul, 2010 | Pubmed ID: 20551512 Visualizing Antigen-specific and Infected Cells in Situ Predicts Outcomes in Early Viral Infection Science (New York, N.Y.). Mar, 2009 | Pubmed ID: 19325114 Impact of Epitope Escape on PD-1 Expression and CD8 T-cell Exhaustion During Chronic Infection Journal of Virology. May, 2009 | Pubmed ID: 19211743 IL-10 and PD-L1 Operate Through Distinct Pathways to Suppress T-cell Activity During Persistent Viral Infection Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19075244 Manipulating Both the Inhibitory and Stimulatory Immune System Towards the Success of Therapeutic Vaccination Against Chronic Viral Infections Immunological Reviews. Jun, 2008 | Pubmed ID: 18613845 Enhancing Therapeutic Vaccination by Blocking PD-1-mediated Inhibitory Signals During Chronic Infection The Journal of Experimental Medicine. Mar, 2008 | Pubmed ID: 18332181 Molecular Signature of CD8+ T Cell Exhaustion During Chronic Viral Infection Immunity. Oct, 2007 | Pubmed ID: 17950003 Enhanced Immunogenicity and Protective Efficacy with the Use of Interleukin-12-encapsulated Microspheres Plus AS01B in Tuberculosis Subunit Vaccination Infection and Immunity. Aug, 2006 | Pubmed ID: 16861689 Stimulation History Dictates Memory CD8 T Cell Phenotype: Implications for Prime-boost Vaccination Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16818737 Enhancement of Interleukin-12 Gene-based Tumor Immunotherapy by the Reduced Secretion of P40 Subunit and the Combination with Farnesyltransferase Inhibitor Human Gene Therapy. Mar, 2005 | Pubmed ID: 15812228 IL-12 Priming During in Vitro Antigenic Stimulation Changes Properties of CD8 T Cells and Increases Generation of Effector and Memory Cells Journal of Immunology (Baltimore, Md. : 1950). Mar, 2004 | Pubmed ID: 14978082 IL-23 Induces Stronger Sustained CTL and Th1 Immune Responses Than IL-12 in Hepatitis C Virus Envelope Protein 2 DNA Immunization Journal of Immunology (Baltimore, Md. : 1950). Jan, 2004 | Pubmed ID: 14688363 Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice Hyo Jin Park1, Ji Hoon Oh1, Sang-Jun Ha1 1Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University JoVE 54138 Immunologie et Infection
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice Hyo Jin Park1, Ji Hoon Oh1, Sang-Jun Ha1 1Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University JoVE 54138 Immunologie et Infection