Schahram Akbarian Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai Biography Publications Institution JoVE Articles Schahram Akbarian has not added a biography. If you are Schahram Akbarian and would like to personalize this page please email our Author Liaison for assistance. Publications Comprehensive Identification of Somatic Nucleotide Variants in Human Brain Tissue Genome Biology. Mar, 2021 | Pubmed ID: 33781308 Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection Stem Cell Reports. 03, 2021 | Pubmed ID: 33636110 Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome Biological Psychiatry. Jan, 2021 | Pubmed ID: 33131715 Common Genetic Variation in Humans Impacts Susceptibility to SARS-CoV-2 Infection BioRxiv : the Preprint Server for Biology. Sep, 2020 | Pubmed ID: 32995783 A Prefrontal-paraventricular Thalamus Circuit Requires Juvenile Social Experience to Regulate Adult Sociability in Mice Nature Neuroscience. 10, 2020 | Pubmed ID: 32868932 Genotype-phenotype Correlation at Codon 1740 of SETD2 American Journal of Medical Genetics. Part A. 09, 2020 | Pubmed ID: 32710489 Epigenetic Clocks in Schizophrenia: Promising Biomarkers, Foggy Clockwork Biological Psychiatry. 08, 2020 | Pubmed ID: 32674842 Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells Advances in Neurobiology. 2020 | Pubmed ID: 32578147 A Computational Tool (H-MAGMA) for Improved Prediction of Brain-disorder Risk Genes by Incorporating Brain Chromatin Interaction Profiles Nature Neuroscience. 04, 2020 | Pubmed ID: 32152537 Prefrontal Parvalbumin Interneurons Require Juvenile Social Experience to Establish Adult Social Behavior Nature Communications. 02, 2020 | Pubmed ID: 32081848 A Chromosomal Connectome for Psychiatric and Metabolic Risk Variants in Adult Dopaminergic Neurons Genome Medicine. 02, 2020 | Pubmed ID: 32075678 Special Volume: The Genomics and Epigenomics of Schizophrenia Schizophrenia Research. 03, 2020 | Pubmed ID: 31813801 CRISPR-based Functional Evaluation of Schizophrenia Risk Variants Schizophrenia Research. 03, 2020 | Pubmed ID: 31277978 Use of the Epigenetic Toolbox to Contextualize Common Variants Associated with Schizophrenia Risk Dialogues in Clinical Neuroscience. 12, 2019 | Pubmed ID: 31949408 Chromatin Profiling of Cortical Neurons Identifies Individual Epigenetic Signatures in Schizophrenia Translational Psychiatry. 10, 2019 | Pubmed ID: 31624234 CommonMind Consortium Provides Transcriptomic and Epigenomic Data for Schizophrenia and Bipolar Disorder Scientific Data. 09, 2019 | Pubmed ID: 31551426 In Vivo Epigenetic Editing of Sema6a Promoter Reverses Transcallosal Dysconnectivity Caused by C11orf46/Arl14ep Risk Gene Nature Communications. 09, 2019 | Pubmed ID: 31511512 Metabolome Signature of Autism in the Human Prefrontal Cortex Communications Biology. 2019 | Pubmed ID: 31263778 Spatial Genome Exploration in the Context of Cognitive and Neurological Disease Current Opinion in Neurobiology. 12, 2019 | Pubmed ID: 31255842 Epigenetic-genetic Chromatin Footprinting Identifies Novel and Subject-specific Genes Active in Prefrontal Cortex Neurons FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 07, 2019 | Pubmed ID: 30970224 Comprehensive Functional Genomic Resource and Integrative Model for the Human Brain Science (New York, N.Y.). 12, 2018 | Pubmed ID: 30545857 Neuron-specific Signatures in the Chromosomal Connectome Associated with Schizophrenia Risk Science (New York, N.Y.). 12, 2018 | Pubmed ID: 30545851 Lipidome Alterations in Human Prefrontal Cortex During Development, Aging, and Cognitive Disorders Molecular Psychiatry. Aug, 2018 | Pubmed ID: 30089790 Evaluation of Chromatin Accessibility in Prefrontal Cortex of Individuals with Schizophrenia Nature Communications. 08, 2018 | Pubmed ID: 30087329 Cell-specific Histone Modification Maps in the Human Frontal Lobe Link Schizophrenia Risk to the Neuronal Epigenome Nature Neuroscience. 08, 2018 | Pubmed ID: 30038276 Chromosomal Conformations and Epigenomic Regulation in Schizophrenia Progress in Molecular Biology and Translational Science. 2018 | Pubmed ID: 29933951 Activity-Induced Regulation of Synaptic Strength Through the Chromatin Reader L3mbtl1 Cell Reports. 06, 2018 | Pubmed ID: 29898393 Landscape of Conditional EQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS American Journal of Human Genetics. 06, 2018 | Pubmed ID: 29805045 Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells Frontiers in Pediatrics. 2018 | Pubmed ID: 29666786 Allele-specific Expression in a Family Quartet with Autism Reveals Mono-to-biallelic Switch and Novel Transcriptional Processes of Autism Susceptibility Genes Scientific Reports. 03, 2018 | Pubmed ID: 29523860 MEF2C Transcription Factor is Associated with the Genetic and Epigenetic Risk Architecture of Schizophrenia and Improves Cognition in Mice Molecular Psychiatry. 01, 2018 | Pubmed ID: 28115742 Antipsychotic-induced Hdac2 Transcription Via NF-κB Leads to Synaptic and Cognitive Side Effects Nature Neuroscience. Sep, 2017 | Pubmed ID: 28783139 Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in HiPSC-Derived NPCs, Neurons, and Astrocytes Stem Cell Reports. 08, 2017 | Pubmed ID: 28757163 The Epigenomics of Schizophrenia, in the Mouse American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. Sep, 2017 | Pubmed ID: 28699694 The Methyltransferase SETDB1 Regulates a Large Neuron-specific Topological Chromatin Domain Nature Genetics. Aug, 2017 | Pubmed ID: 28671686 Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2 Biological Psychiatry. Dec, 2017 | Pubmed ID: 28577753 Phf8 Loss Confers Resistance to Depression-like and Anxiety-like Behaviors in Mice Nature Communications. 05, 2017 | Pubmed ID: 28485378 Intersection of Diverse Neuronal Genomes and Neuropsychiatric Disease: The Brain Somatic Mosaicism Network Science (New York, N.Y.). 04, 2017 | Pubmed ID: 28450582 Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue Biological Psychiatry. 01, 2017 | Pubmed ID: 27113501 Spatial Genome Organization and Cognition Nature Reviews. Neuroscience. 11, 2016 | Pubmed ID: 27708356 Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism PLoS Biology. Sep, 2016 | Pubmed ID: 27685936 Longitudinal Assessment of Neuronal 3D Genomes in Mouse Prefrontal Cortex Nature Communications. 09, 2016 | Pubmed ID: 27597321 Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 12, 2016 | Pubmed ID: 27485686 Insulin-like Growth Factor 1 for Healthy Spines and Healthy Minds? Biological Psychiatry. 08, 2016 | Pubmed ID: 27468627 Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research Biological Psychiatry. 07, 2016 | Pubmed ID: 27346079 DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition Biological Psychiatry. 11, 2016 | Pubmed ID: 27184921 Understanding the Genetic Liability to Schizophrenia Through the Neuroepigenome Schizophrenia Research. 11, 2016 | Pubmed ID: 26827128 NeuN+ Neuronal Nuclei in Non-human Primate Prefrontal Cortex and Subcortical White Matter After Clozapine Exposure Schizophrenia Research. Feb, 2016 | Pubmed ID: 26776227 Back to the Past in Schizophrenia Genomics Nature Neuroscience. Jan, 2016 | Pubmed ID: 26713739 Pharmacological Modulation of Astrocytes and the Role of Cell Type-specific Histone Modifications for the Treatment of Mood Disorders Current Opinion in Pharmacology. Feb, 2016 | Pubmed ID: 26515273 Epigenetic Basis of Mental Illness The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10, 2016 | Pubmed ID: 26450593 Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2016 | Pubmed ID: 26224620 RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression PloS One. 2015 | Pubmed ID: 26636579 Prefrontal Cortex and Social Cognition in Mouse and Man Frontiers in Psychology. 2015 | Pubmed ID: 26635701 The PsychENCODE Project Nature Neuroscience. Dec, 2015 | Pubmed ID: 26605881 CHRNA7 and CHRFAM7A: Psychosis and Smoking? Blame the Neighbors! The American Journal of Psychiatry. Nov, 2015 | Pubmed ID: 26575444 DNA Methylation Levels of α-synuclein Intron 1 in the Aging Brain Neurobiology of Aging. Dec, 2015 | Pubmed ID: 26422361 Critical Role of Histone Turnover in Neuronal Transcription and Plasticity Neuron. Jul, 2015 | Pubmed ID: 26139371 Quantifying Polymorphism and Divergence from Epigenetic Data: a Framework for Inferring the Action of Selection Frontiers in Genetics. 2015 | Pubmed ID: 26074949 MiR-10b-5p Expression in Huntington's Disease Brain Relates to Age of Onset and the Extent of Striatal Involvement BMC Medical Genomics. Mar, 2015 | Pubmed ID: 25889241 Cognition and Mood-related Behaviors in L3mbtl1 Null Mutant Mice PloS One. 2015 | Pubmed ID: 25849281 Interneuron Epigenomes During the Critical Period of Cortical Plasticity: Implications for Schizophrenia Neurobiology of Learning and Memory. Oct, 2015 | Pubmed ID: 25849095 Neuronal Kmt2a/Mll1 Histone Methyltransferase is Essential for Prefrontal Synaptic Plasticity and Working Memory The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2015 | Pubmed ID: 25834037 Transcriptional Regulation of GAD1 GABA Synthesis Gene in the Prefrontal Cortex of Subjects with Schizophrenia Schizophrenia Research. Sep, 2015 | Pubmed ID: 25458568 Epigenetics and Sex Differences in the Brain: A Genome-wide Comparison of Histone-3 Lysine-4 Trimethylation (H3K4me3) in Male and Female Mice Experimental Neurology. Jun, 2015 | Pubmed ID: 25131640 Conserved Higher-order Chromatin Regulates NMDA Receptor Gene Expression and Cognition Neuron. Dec, 2014 | Pubmed ID: 25467983 A Role for Noncoding Variation in Schizophrenia Cell Reports. Nov, 2014 | Pubmed ID: 25453756 The Future of Neuroepigenetics in the Human Brain Progress in Molecular Biology and Translational Science. 2014 | Pubmed ID: 25410546 Epigenetic Mechanisms in Schizophrenia Dialogues in Clinical Neuroscience. Sep, 2014 | Pubmed ID: 25364289 Analytical Tools and Current Challenges in the Modern Era of Neuroepigenomics Nature Neuroscience. Nov, 2014 | Pubmed ID: 25349914 Regulation of Histone H3K4 Methylation in Brain Development and Disease Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Sep, 2014 | Pubmed ID: 25135975 Chromatin-bound RNA and the Neurobiology of Psychiatric Disease Neuroscience. Apr, 2014 | Pubmed ID: 23831425 The Genome in Three Dimensions: A New Frontier in Human Brain Research Biological Psychiatry. Aug, 2013 | Pubmed ID: 23958183 Conserved Chromosome 2q31 Conformations Are Associated with Transcriptional Regulation of GAD1 GABA Synthesis Enzyme and Altered in Prefrontal Cortex of Subjects with Schizophrenia The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2013 | Pubmed ID: 23864674 The Neuroepigenetics of Suicide The American Journal of Psychiatry. May, 2013 | Pubmed ID: 23632831 統合失調症および関連疾患における遺伝子発現のエピジェネティックと転写後調節障害 Neurobiology of Disease. Dec, 2011 | Pubmed ID: 22182689 自閉症のエピジェネティックな署名：前頭前野ニューロンのトリメチル化H3K4の風景 Archives of General Psychiatry. Nov, 2011 | Pubmed ID: 22065254 統合失調症のために創薬を推進する Annals of the New York Academy of Sciences. Oct, 2011 | Pubmed ID: 22032400 精神疾患でのヒストンメチル化活動のバランスをとる Trends in Molecular Medicine. Jul, 2011 | Pubmed ID: 21429800 ニューロンのSetdb1媒介ヒストンH3K9メチル化は、MECP2欠損マウスの神経学的表現型を悪化させる Neuropharmacology. Jun, 2011 | Pubmed ID: 20869373 統合失調症と関連疾患における白質ニューロンの改造 International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience. May, 2011 | Pubmed ID: 20691252 統合失調症のエピジェネティクス Current Topics in Behavioral Neurosciences. 2010 | Pubmed ID: 21312415 C末端のTDP-43断片は、ドミナントネガティブなメカニズムによる高凝集傾向とハーム·ニューロンお持ち PloS One. 2010 | Pubmed ID: 21209826 MAPKの "リン"を維持し、ビー·ハッピー Nature Medicine. Nov, 2010 | Pubmed ID: 21052065 統合失調症者におけるエストロゲン感受性のsmall RNAの性別固有の削減、MIR-30B、 Schizophrenia Bulletin. Aug, 2010 | Pubmed ID: 20732949 RPP25は発達前頭前野の規制と自閉症スペクトラム障害の減少レベルで発現しています Autism Research : Official Journal of the International Society for Autism Research. Aug, 2010 | Pubmed ID: 20632321 クロマチンタンパク質L3MBTL1は、マウスの開発と腫瘍抑制のために不要です。 The Journal of Biological Chemistry. Sep, 2010 | Pubmed ID: 20592034 Setdb1ヒストンメチルトランスフェラーゼは、ムードに関連するビヘイビアとNMDA受容体サブユニットNR2Bの発現を調節する The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20505083 抗メチル化ヒストン抗体の特異性を向上させるための簡単な方法 Epigenetics : Official Journal of the DNA Methylation Society. Jul, 2010 | Pubmed ID: 20458167 開発規制と前頭前野の神経H3K4me3とEpigenomesの個人差 Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20421462 RAAV9 - マウス帯状皮質における効率的な導入遺伝子の発現に対するヒト由来のアデノ随伴ウイルスベクター Cold Spring Harbor Protocols. Apr, 2010 | Pubmed ID: 20360371 統合失調症の分子病理 - ヒストンとDNA修飾に焦点を当て Brain Research Bulletin. Sep, 2010 | Pubmed ID: 19729053 皮質辺縁系回路のコカイン誘発性の代謝活性化は、ヒストンデアセチラーゼ阻害剤酪酸ナトリウムへの暴露後に増加する Neuroscience Letters. Nov, 2009 | Pubmed ID: 19638299 Cingulate White Matter Neurons in Schizophrenia and Bipolar Disorder Biological Psychiatry. Sep, 2009 | Pubmed ID: 19559403 統合失調症被験者の前頭前野におけるGABA作動性調節不全の遺伝子発現の分子決定要因 Biological Psychiatry. Jun, 2009 | Pubmed ID: 19121517 ヒストンリジンメチル化で人間の脳フォーカスのエピジェネティック制御 Biological Psychiatry. Feb, 2009 | Pubmed ID: 18814864 GABA作動性シグナリングと統合失調症における神経同期を復元する The American Journal of Psychiatry. Dec, 2008 | Pubmed ID: 19047328 神経系におけるエピジェネティクス The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2008 | Pubmed ID: 19005036 自殺の分子病理学に近づいて Biological Psychiatry. Oct, 2008 | Pubmed ID: 18926170 ミール-30A-5Pを含む、発現差のあるmiRNAは、一連の、前頭前野のBDNFの転写後阻害剤として作用 Human Molecular Genetics. Oct, 2008 | Pubmed ID: 18632683 脳組織から神経クロマチンの単離 BMC Neuroscience. 2008 | Pubmed ID: 18442397 統合失調症と双極性障害におけるDNAメチル化の変化 Epigenetics : Official Journal of the DNA Methylation Society. Mar-Apr, 2008 | Pubmed ID: 18398310 ドーパミンDの薬物誘発性アクティベーション（1）受容体のシグナル伝達およびClass I / IIヒストンデアセチラーゼの阻害は、報酬回路におけるクロマチンリモデリングを誘導し、コカインに関連した行動を変調 Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Nov, 2008 | Pubmed ID: 18288092 Prefrontal Dysfunction in Schizophrenia Involves Mixed-lineage Leukemia 1-regulated Histone Methylation at GABAergic Gene Promoters The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2007 | Pubmed ID: 17942719 ヒト大脳皮質におけるDNAメチル化は、動的寿命を通しての安定化と分化したニューロンが含まれる場合など PloS One. 2007 | Pubmed ID: 17878930 統合失調症被験者の前頭前野におけるGAD1 MRNAの発現とDNAメチル化 PloS One. 2007 | Pubmed ID: 17726539 マウスのヒストンデアセチラーゼ阻害剤酪酸ナトリウムの抗うつ薬のような効果 Biological Psychiatry. Jul, 2007 | Pubmed ID: 16945350 レット症候群の分子病理：概要とアップデート Neuromolecular Medicine. 2006 | Pubmed ID: 17028371 統合失調症と関連疾患に代替GAD1/GAD67発現の分子·細胞メカニズム Brain Research Reviews. Sep, 2006 | Pubmed ID: 16759710 NT-3は、神経発生を調節することにより、海馬の可塑性と記憶·学習を促進 Learning & Memory (Cold Spring Harbor, N.Y.). May-Jun, 2006 | Pubmed ID: 16705139 死後脳におけるクロマチン免疫沈降 Journal of Neuroscience Methods. Sep, 2006 | Pubmed ID: 16574239 BDNF条件変異マウスにおける5-HT2A介在神経伝達における深刻な赤字 Journal of Neurobiology. Mar, 2006 | Pubmed ID: 16408297 統合失調症被験者の前頭前野でダウンレギュレート代謝遺伝子の発現と関連するクロマチンの改造 Archives of General Psychiatry. Aug, 2005 | Pubmed ID: 16061760 遺伝子のプロモーターにおけるヒストンメチル化は、発達規制と地域固有のイオンチャネルの発現とヒトの脳における代謝型グルタミン酸受容体に関係している Journal of Neurochemistry. Jul, 2005 | Pubmed ID: 15998284 ドーパミンD2様アンタゴニストとNMDA受容体シグナリングのサイクリックAMPプロテインキナーゼを介して線条体ニューロンにおけるクロマチンリモデリングを誘導する Journal of Neurochemistry. Sep, 2004 | Pubmed ID: 15312167 レット症候群の神経生物学 The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Feb, 2003 | Pubmed ID: 12580340 レット障害の臨床専門家 Pediatric Rehabilitation. Apr-Jun, 2002 | Pubmed ID: 12596822 レット症候群のマウスモデルの転写プロファイリングは、脳内の微妙な転写の変更を明らかに Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12432090 心と脳の疾患：レット症候群、パートII The American Journal of Psychiatry. Aug, 2002 | Pubmed ID: 12153818 減少DARPP-32統合失調症患者の前頭前野の証拠 Archives of General Psychiatry. Aug, 2002 | Pubmed ID: 12150646 心と脳の疾患：レット症候群 The American Journal of Psychiatry. Jul, 2002 | Pubmed ID: 12091185 脳由来神経栄養因子は、ノルアドレナリン作動性ニューロンのアヘン誘起塑性のために不可欠である The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2002 | Pubmed ID: 12019333 ニューロトロフィン3は、脳虚血、酸素 - グルコース欠乏、酸化ストレスで誘導される細胞死を促進する：酸素フリーラジカルの関与の可能性を Neurobiology of Disease. Feb, 2002 | Pubmed ID: 11848682 蛍光活性化核選別を用いた新鮮凍結皮質からの成人ヒトアストロサイト集団の単離 Zarmeen Mussa1,2, Jessica Tome-Garcia1,2, Yan Jiang3, Schahram Akbarian2,4, Nadejda M. Tsankova1,2 1Department of Pathology, Icahn School of Medicine at Mount Sinai, 2Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 3Institutes of Brian Science, Fudan University, 4Department of Psychiatry, Icahn School of Medicine at Mount Sinai JoVE 62405 Neurosciences 人間の死後の脳組織から神経細胞核の単離 Anouch Matevossian1, Schahram Akbarian1 1Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School JoVE 914 Biologie 人間の脳組織のためのクロマチンアッセイ Anouch Matevossian1, Schahram Akbarian1 1Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School JoVE 717 Biologie
蛍光活性化核選別を用いた新鮮凍結皮質からの成人ヒトアストロサイト集団の単離 Zarmeen Mussa1,2, Jessica Tome-Garcia1,2, Yan Jiang3, Schahram Akbarian2,4, Nadejda M. Tsankova1,2 1Department of Pathology, Icahn School of Medicine at Mount Sinai, 2Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 3Institutes of Brian Science, Fudan University, 4Department of Psychiatry, Icahn School of Medicine at Mount Sinai JoVE 62405 Neurosciences
人間の死後の脳組織から神経細胞核の単離 Anouch Matevossian1, Schahram Akbarian1 1Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School JoVE 914 Biologie
人間の脳組織のためのクロマチンアッセイ Anouch Matevossian1, Schahram Akbarian1 1Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School JoVE 717 Biologie
