Seema Saksena Department of Medicine University of Illinois at Chicago Biography Publications Institution JoVE Articles Seema Saksena has not added a biography. If you are Seema Saksena and would like to personalize this page please email our Author Liaison for assistance. Publications Role of SHP2 Protein Tyrosine Phosphatase in SERT Inhibition by Enteropathogenic E. Coli (EPEC) American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2017 | Pubmed ID: 28209599 GLP-1 Nanomedicine Alleviates Gut Inflammation Nanomedicine : Nanotechnology, Biology, and Medicine. Feb, 2017 | Pubmed ID: 27553076 Lactobacillus Acidophilus Counteracts Inhibition of NHE3 and DRA Expression and Alleviates Diarrheal Phenotype in Mice Infected with Citrobacter Rodentium American Journal of Physiology. Gastrointestinal and Liver Physiology. Nov, 2016 | Pubmed ID: 27634011 Transcriptional Modulation of SLC26A3 (DRA) by Sphingosine-1-phosphate American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2016 | Pubmed ID: 27079615 Lactobacillus Acidophilus Stimulates Intestinal P-glycoprotein Expression Via a C-Fos/c-Jun-dependent Mechanism in Intestinal Epithelial Cells American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2016 | Pubmed ID: 26867563 Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease-Associated Diarrhea Inflammatory Bowel Diseases. Dec, 2015 | Pubmed ID: 26595422 Mechanisms of DRA Recycling in Intestinal Epithelial Cells: Effect of Enteropathogenic E. Coli American Journal of Physiology. Cell Physiology. Dec, 2015 | Pubmed ID: 26447204 Mechanisms of Intestinal Serotonin Transporter (SERT) Upregulation by TGF-β1 Induced Non-Smad Pathways PloS One. 2015 | Pubmed ID: 25954931 All-trans-retinoic Acid Increases SLC26A3 DRA (Down-regulated in Adenoma) Expression in Intestinal Epithelial Cells Via HNF-1β The Journal of Biological Chemistry. Jun, 2015 | Pubmed ID: 25887398 N-glycosylation is Essential for Ileal ASBT Function and Protection Against Proteases American Journal of Physiology. Cell Physiology. Jun, 2015 | Pubmed ID: 25855079 Lactobacillus Acidophilus Attenuates Downregulation of DRA Function and Expression in Inflammatory Models American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2014 | Pubmed ID: 25059823 Epigenetic Modulation of Intestinal Cholesterol Transporter Niemann-Pick C1-like 1 (NPC1L1) Gene Expression by DNA Methylation The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 24904062 Pharmacokinetic Characterization of Mangosteen (Garcinia Mangostana) Fruit Extract Standardized to α-mangostin in C57BL/6 Mice Nutrition Research (New York, N.Y.). Apr, 2014 | Pubmed ID: 24774070 Overactivation of Intestinal SREBP2 in Mice Increases Serum Cholesterol PloS One. 2014 | Pubmed ID: 24465397 Keratinocyte Growth Factor-2 Stimulates P-glycoprotein Expression and Function in Intestinal Epithelial Cells American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2013 | Pubmed ID: 23328208 Regulation of Intestinal Serotonin Transporter Expression Via Epigenetic Mechanisms: Role of HDAC2 American Journal of Physiology. Cell Physiology. Feb, 2013 | Pubmed ID: 23195070 D-Glucose Modulates Intestinal Niemann-Pick C1-like 1 (NPC1L1) Gene Expression Via Transcriptional Regulation American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2013 | Pubmed ID: 23139223 Enteropathogenic Escherichia Coli Inhibits Ileal Sodium-dependent Bile Acid Transporter ASBT American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2012 | Pubmed ID: 22403793 LPA Stimulates Intestinal DRA Gene Transcription Via LPA2 Receptor, PI3K/AKT, and C-Fos-dependent Pathway American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2012 | Pubmed ID: 22159277 Transcriptional Regulation of the Intestinal Luminal Na⁺ and Cl⁻ Transporters The Biochemical Journal. Apr, 2011 | Pubmed ID: 21726200 SREBP2 Mediates the Modulation of Intestinal NPC1L1 Expression by Curcumin American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2011 | Pubmed ID: 21527728 Upregulation of P-glycoprotein by Probiotics in Intestinal Epithelial Cells and in the Dextran Sulfate Sodium Model of Colitis in Mice American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2011 | Pubmed ID: 21350189 Epidermal Growth Factor Upregulates Serotonin Transporter in Human Intestinal Epithelial Cells Via Transcriptional Mechanisms American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2011 | Pubmed ID: 21273531 Stimulation of Apical Cl⁻/HCO₃⁻(OH⁻) Exchanger, SLC26A3 by Neuropeptide Y is Lipid Raft Dependent American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2010 | Pubmed ID: 20884887 Ileal Apical Na+-dependent Bile Acid Transporter ASBT is Upregulated in Rats with Diabetes Mellitus Induced by Low Doses of Streptozotocin American Journal of Physiology. Gastrointestinal and Liver Physiology. Oct, 2010 | Pubmed ID: 20651004 Green Tea Catechin EGCG Inhibits Ileal Apical Sodium Bile Acid Transporter ASBT American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2010 | Pubmed ID: 20056894 Lactobacillus Acidophilus Stimulates the Expression of SLC26A3 Via a Transcriptional Mechanism American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2010 | Pubmed ID: 20044511 Mechanisms of Transcriptional Modulation of the Human Anion Exchanger SLC26A3 Gene Expression by IFN-{gamma} American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2010 | Pubmed ID: 19940027 Mechanisms of Lysophosphatidic Acid (LPA) Mediated Stimulation of Intestinal Apical Cl-/OH- Exchange American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2010 | Pubmed ID: 19910524 Mechanisms Underlying Modulation of Monocarboxylate Transporter 1 (MCT1) by Somatostatin in Human Intestinal Epithelial Cells American Journal of Physiology. Gastrointestinal and Liver Physiology. Nov, 2009 | Pubmed ID: 20501436 Enteropathogenic Escherichia Coli Infection Inhibits Intestinal Serotonin Transporter Function and Expression Gastroenterology. Dec, 2009 | Pubmed ID: 19747920 Modulation of Ileal Apical Na+-dependent Bile Acid Transporter ASBT by Protein Kinase C American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2009 | Pubmed ID: 19571234 PKC-dependent Stimulation of the Human MCT1 Promoter Involves Transcription Factor AP2 American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2009 | Pubmed ID: 19033536 Serotonin Modifies Cytoskeleton and Brush-border Membrane Architecture in Human Intestinal Epithelial Cells American Journal of Physiology. Gastrointestinal and Liver Physiology. Oct, 2008 | Pubmed ID: 18669621 Characterization of the 5'-flanking Region and Regulation of Expression of Human Anion Exchanger SLC26A6 Journal of Cellular Biochemistry. Oct, 2008 | Pubmed ID: 18655181 Role of Fyn and PI3K in H2O2-induced Inhibition of Apical Cl-/OH- Exchange Activity in Human Intestinal Epithelial Cells The Biochemical Journal. Nov, 2008 | Pubmed ID: 18564062 Modulation of Ileal Bile Acid Transporter (ASBT) Activity by Depletion of Plasma Membrane Cholesterol: Association with Lipid Rafts American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2008 | Pubmed ID: 18063707 Function, Expression, and Characterization of the Serotonin Transporter in the Native Human Intestine American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2008 | Pubmed ID: 17991706 Regulation of Monocarboxylate Transporter 1 (MCT1) Promoter by Butyrate in Human Intestinal Epithelial Cells: Involvement of NF-kappaB Pathway Journal of Cellular Biochemistry. Apr, 2008 | Pubmed ID: 17786924 Taurodeoxycholate Modulates Apical Cl-/OH- Exchange Activity in Caco2 Cells Digestive Diseases and Sciences. May, 2007 | Pubmed ID: 17387613 Mechanism Underlying Inhibition of Intestinal Apical Cl/OH Exchange Following Infection with Enteropathogenic E. Coli The Journal of Clinical Investigation. Feb, 2007 | Pubmed ID: 17256057 Modulation of Human Niemann-Pick C1-like 1 Gene Expression by Sterol: Role of Sterol Regulatory Element Binding Protein 2 American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2007 | Pubmed ID: 17008555 Expression and Membrane Localization of MCT Isoforms Along the Length of the Human Intestine American Journal of Physiology. Cell Physiology. Oct, 2005 | Pubmed ID: 15901598 Serotonin Inhibits Na+/H+ Exchange Activity Via 5-HT4 Receptors and Activation of PKC Alpha in Human Intestinal Epithelial Cells Gastroenterology. Apr, 2005 | Pubmed ID: 15825078 Involvement of C-Src and Protein Kinase C Delta in the Inhibition of Cl(-)/OH- Exchange Activity in Caco-2 Cells by Serotonin The Journal of Biological Chemistry. Mar, 2005 | Pubmed ID: 15637072 Cholesterol Modulates Human Intestinal Sodium-dependent Bile Acid Transporter American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2005 | Pubmed ID: 15604201 Mechanisms of Calcium Transport in Human Colonic Basolateral Membrane Vesicles Digestive Diseases and Sciences. Oct, 2002 | Pubmed ID: 12395904 Inhibition of Apical Cl-/OH- Exchange Activity in Caco-2 Cells by Phorbol Esters is Mediated by PKCepsilon American Journal of Physiology. Cell Physiology. Nov, 2002 | Pubmed ID: 12372810 Regulation of NHE3 by Nitric Oxide in Caco-2 Cells American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2002 | Pubmed ID: 12181191 Modulation of Cl-/OH- Exchange Activity in Caco-2 Cells by Nitric Oxide American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2002 | Pubmed ID: 12181176 3Dで栽培ネイティブ腸とのCaco-2細胞において上皮輸送タンパク質の機能および発現を研究するための方法 Arivarasu N. Anabazhagan*1, Ishita Chatterjee*1, Shubha Priyamvada1, Anoop Kumar1, Sangeeta Tyagi1, Seema Saksena1,2, Waddah A. Alrefai1,2, Pradeep K. Dudeja1,2, Ravinder K. Gill1 1Department of Medicine, University of Illinois at Chicago, 2Department of Research, Jesse Brown VA Medical Center JoVE 55304 Biologie
3Dで栽培ネイティブ腸とのCaco-2細胞において上皮輸送タンパク質の機能および発現を研究するための方法 Arivarasu N. Anabazhagan*1, Ishita Chatterjee*1, Shubha Priyamvada1, Anoop Kumar1, Sangeeta Tyagi1, Seema Saksena1,2, Waddah A. Alrefai1,2, Pradeep K. Dudeja1,2, Ravinder K. Gill1 1Department of Medicine, University of Illinois at Chicago, 2Department of Research, Jesse Brown VA Medical Center JoVE 55304 Biologie