Shaun R. Coughlin Cardiovascular Research Institute University of California, San Francisco Biography Publications Institution JoVE Articles Shaun R. Coughlin has not added a biography. If you are Shaun R. Coughlin and would like to personalize this page please email our Author Liaison for assistance. Publications Gαi/o-coupled Receptor Signaling Restricts Pancreatic β-cell Expansion Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015 | Pubmed ID: 25695968 Redundancy and Interaction of Thrombin- and Collagen-mediated Platelet Activation in Tail Bleeding and Carotid Thrombosis in Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2014 | Pubmed ID: 25278288 Podoplanin Maintains High Endothelial Venule Integrity by Interacting with Platelet CLEC-2 Nature. Oct, 2013 | Pubmed ID: 23995678 IL-7 Production in Murine Lymphatic Endothelial Cells and Induction in the Setting of Peripheral Lymphopenia International Immunology. Aug, 2013 | Pubmed ID: 23657000 PAR1 Contributes to Influenza A Virus Pathogenicity in Mice The Journal of Clinical Investigation. Jan, 2013 | Pubmed ID: 23202729 High-resolution Crystal Structure of Human Protease-activated Receptor 1 Nature. Dec, 2012 | Pubmed ID: 23222541 TMEM16F Forms a Ca2+-activated Cation Channel Required for Lipid Scrambling in Platelets During Blood Coagulation Cell. Sep, 2012 | Pubmed ID: 23021219 Wnt/β-catenin Signaling is Differentially Regulated by Gα Proteins and Contributes to Fibrous Dysplasia Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22106277 Carcinoma Mucins Trigger Reciprocal Activation of Platelets and Neutrophils in a Murine Model of Trousseau Syndrome Blood. Oct, 2011 | Pubmed ID: 21860019 The Sphingosine 1-phosphate Receptor S1P₂ Maintains the Homeostasis of Germinal Center B Cells and Promotes Niche Confinement Nature Immunology. Jul, 2011 | Pubmed ID: 21642988 PAR2 Absence Completely Rescues Inflammation and Ichthyosis Caused by Altered CAP1/Prss8 Expression in Mouse Skin Nature Communications. Jan, 2011 | Pubmed ID: 21245842 Roles and Interactions Among Protease-activated Receptors and P2ry12 in Hemostasis and Thrombosis Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010 | Pubmed ID: 20930120 Identifying Patients at High Risk of a Cardiovascular Event in the Near Future: Current Status and Future Directions: Report of a National Heart, Lung, and Blood Institute Working Group Circulation. Mar, 2010 | Pubmed ID: 20351302 Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo Developmental Cell. Jan, 2010 | Pubmed ID: 20152175 Lymphatic Endothelial Cell Sphingosine Kinase Activity is Required for Lymphocyte Egress and Lymphatic Patterning The Journal of Experimental Medicine. Jan, 2010 | Pubmed ID: 20026661 Sphingosine-1-phosphate in the Plasma Compartment Regulates Basal and Inflammation-induced Vascular Leak in Mice The Journal of Clinical Investigation. Jul, 2009 | Pubmed ID: 19603543 Identification of a Transient Subpial Neurogenic Zone in the Developing Dentate Gyrus and Its Regulation by Cxcl12 and Reelin Signaling Development (Cambridge, England). Jan, 2009 | Pubmed ID: 19103804 Anatomical Profiling of G Protein-coupled Receptor Expression Cell. Oct, 2008 | Pubmed ID: 18984166 Maternal Par4 and Platelets Contribute to Defective Placenta Formation in Mouse Embryos Lacking Thrombomodulin Blood. Aug, 2008 | Pubmed ID: 18490515 A Critical Role for Extracellular Protein Disulfide Isomerase During Thrombus Formation in Mice The Journal of Clinical Investigation. Mar, 2008 | Pubmed ID: 18292814 Probing Cell Type-specific Functions of Gi in Vivo Identifies GPCR Regulators of Insulin Secretion The Journal of Clinical Investigation. Dec, 2007 | Pubmed ID: 17992256 Protease-activated Receptor 2, Dipeptidyl Peptidase I, and Proteases Mediate Clostridium Difficile Toxin A Enteritis Gastroenterology. Jun, 2007 | Pubmed ID: 17570216 Fetal Gene Defects Precipitate Platelet-mediated Pregnancy Failure in Factor V Leiden Mothers The Journal of Experimental Medicine. May, 2007 | Pubmed ID: 17438064 Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-phosphate Science (New York, N.Y.). Apr, 2007 | Pubmed ID: 17363629 Par4 is Required for Platelet Thrombus Propagation but Not Fibrin Generation in a Mouse Model of Thrombosis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17190826 Roles of Protease-activated Receptors in a Mouse Model of Endotoxemia Blood. May, 2006 | Pubmed ID: 16434493 Protease-activated Receptor-2 Activation Induces Acute Lung Inflammation by Neuropeptide-dependent Mechanisms Journal of Immunology (Baltimore, Md. : 1950). Aug, 2005 | Pubmed ID: 16081834 Essential Role for Galpha13 in Endothelial Cells During Embryonic Development Proceedings of the National Academy of Sciences of the United States of America. Jun, 2005 | Pubmed ID: 15919816 PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15665002 Platelets, Protease-activated Receptors, and Fibrinogen in Hematogenous Metastasis Blood. Jul, 2004 | Pubmed ID: 15031212 Regulated Shedding of PAR1 N-terminal Exodomain from Endothelial Cells The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14982936 Combined Deficiency of Protease-activated Receptor-4 and Fibrinogen Recapitulates the Hemostatic Defect but Not the Embryonic Lethality of Prothrombin Deficiency Blood. Jan, 2004 | Pubmed ID: 14504091 Protease-activated Receptors 1 and 4 Mediate Thrombin Signaling in Endothelial Cells Blood. Nov, 2003 | Pubmed ID: 12869501 The Rho Guanine Nucleotide Exchange Factor Lsc Homo-oligomerizes and is Negatively Regulated Through Domains in Its Carboxyl Terminus That Are Absent in Novel Splenic Isoforms The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12773540 PARticipation in Inflammation The Journal of Clinical Investigation. Jan, 2003 | Pubmed ID: 12511583 Overview of the Alliance for Cellular Signaling Nature. Dec, 2002 | Pubmed ID: 12478301 Protection Against Thrombosis in Mice Lacking PAR3 Blood. Nov, 2002 | Pubmed ID: 12384423 Genetic Evidence That Protease-activated Receptors Mediate Factor Xa Signaling in Endothelial Cells The Journal of Biological Chemistry. May, 2002 | Pubmed ID: 11850418 Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart Lisa D. Wilsbacher1,2, Shaun R. Coughlin2 1Feinberg Cardiovascular Research Institute, Northwestern University, 2Cardiovascular Research Institute, University of California, San Francisco JoVE 52644 Biologie du développement Mechanical Vessel Injury in Zebrafish Embryos Hilary Clay1, Shaun R. Coughlin1 1Cardiovascular Research Institute, University of California JoVE 52460 Biologie du développement
Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart Lisa D. Wilsbacher1,2, Shaun R. Coughlin2 1Feinberg Cardiovascular Research Institute, Northwestern University, 2Cardiovascular Research Institute, University of California, San Francisco JoVE 52644 Biologie du développement
Mechanical Vessel Injury in Zebrafish Embryos Hilary Clay1, Shaun R. Coughlin1 1Cardiovascular Research Institute, University of California JoVE 52460 Biologie du développement