Stephen L. Archer Department of Medicine Queen's University Biography Publications Institution JoVE Articles Stephen L. Archer has not added a biography. If you are Stephen L. Archer and would like to personalize this page please email our Author Liaison for assistance. Publications Differentiating COVID-19 Pneumonia from Acute Respiratory Distress Syndrome (ARDS) and High Altitude Pulmonary Edema (HAPE): Therapeutic Implications Circulation. May, 2020 | Pubmed ID: 32369390 Supra-coronary Aortic Banding Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension in Rats by Increasing Systolic Right Coronary Artery Perfusion Acta Physiologica (Oxford, England). Apr, 2020 | Pubmed ID: 32339403 Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis Circulation Research. Jun, 2020 | Pubmed ID: 32216531 Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension Circulation. Mar, 2020 | Pubmed ID: 32192357 Mitochondria in the Pulmonary Vasculature in Health and Disease: Oxygen-Sensing, Metabolism, and Dynamics Comprehensive Physiology. Mar, 2020 | Pubmed ID: 32163206 Hypochloremia Is a Noninvasive Predictor of Mortality in Pulmonary Arterial Hypertension Journal of the American Heart Association. Mar, 2020 | Pubmed ID: 32079477 An Epigenetic Increase in Mitochondrial Fission by MiD49 and MiD51 Regulates the Cell Cycle in Cancer: Diagnostic and Therapeutic Implications FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2020 | Pubmed ID: 32068312 Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes Critical Care Medicine. Feb, 2020 | Pubmed ID: 31939812 Identification of Novel Dynamin-related Protein 1 (Drp1) GTPase Inhibitors: Therapeutic Potential of Drpitor1 and Drpitor1a in Cancer and Cardiac Ischemia-reperfusion Injury FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2020 | Pubmed ID: 31914641 Clinical Value of Non-coding RNAs in Cardiovascular, Pulmonary, and Muscle Diseases American Journal of Physiology. Cell Physiology. 01, 2020 | Pubmed ID: 31483703 Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction" Circulation Research. Sep, 2019 | Pubmed ID: 31557123 Metabolic Syndrome Exacerbates Pulmonary Hypertension Due to Left Heart Disease Circulation Research. 08, 2019 | Pubmed ID: 31154939 Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction Circulation Research. 06, 2019 | Pubmed ID: 30922174 Pathophysiology, Incidence, Management, and Consequences of Cardiac Arrhythmia in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension Pulmonary Circulation. Jan-Mar, 2019 | Pubmed ID: 30747032 Clinical Determinants and Prognostic Implications of Right Ventricular Dysfunction in Pulmonary Hypertension Caused by Chronic Lung Disease Journal of the American Heart Association. 01, 2019 | Pubmed ID: 30646788 Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again Journal of the American Heart Association. 01, 2019 | Pubmed ID: 30590974 Genetic Determinants of Risk in Pulmonary Arterial Hypertension: International Genome-wide Association Studies and Meta-analysis The Lancet. Respiratory Medicine. 03, 2019 | Pubmed ID: 30527956 Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities Frontiers in Cardiovascular Medicine. 2018 | Pubmed ID: 30740395 Survival in Pulmonary Hypertension Due to Chronic Lung Disease: Influence of Low Diffusion Capacity of the Lungs for Carbon Monoxide The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Sep, 2018 | Pubmed ID: 30391191 Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities International Journal of Molecular Sciences. Sep, 2018 | Pubmed ID: 30213070 A Step Closer to Understanding How Riociguat Results in Remodelling of the Right Ventricle in Chronic Thromboembolic Pulmonary Hypertension The Canadian Journal of Cardiology. Sep, 2018 | Pubmed ID: 30170664 Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension Frontiers in Physiology. 2018 | Pubmed ID: 30042687 A Pro-con Debate: Current Controversies in PAH Pathogenesis at the American Thoracic Society International Conference in 2017 American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2018 | Pubmed ID: 29877097 Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research Circulation Research. Mar, 2018 | Pubmed ID: 29599278 Pulmonary Arterial Hypertension: Pathogenesis and Clinical Management BMJ (Clinical Research Ed.). 03, 2018 | Pubmed ID: 29540357 Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension: A Population-Based Cohort Study in Ontario, Canada Circulation. Cardiovascular Quality and Outcomes. Feb, 2018 | Pubmed ID: 29444925 Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications Circulation. Jul, 2018 | Pubmed ID: 29431643 Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension American Journal of Respiratory and Critical Care Medicine. Jun, 2018 | Pubmed ID: 29360393 Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension Hypertension (Dallas, Tex. : 1979). 01, 2018 | Pubmed ID: 29158355 Interleukin-6 is Independently Associated with Right Ventricular Function in Pulmonary Arterial Hypertension The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Mar, 2018 | Pubmed ID: 28893516 Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension Circulation. Dec, 2017 | Pubmed ID: 29255124 Resistance over Compliance Describes Right Ventricular Afterload Better Than Resistance-compliance Time: a Friendly Amendment Pulmonary Circulation. Mar, 2017 | Pubmed ID: 28680587 Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension Journal of the American Heart Association. May, 2017 | Pubmed ID: 28566298 Abnormal Angiogenesis in Blood Outgrowth Endothelial Cells Derived from Von Willebrand Disease Patients Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis. Mar, 2017 | Pubmed ID: 28362648 Ischemia-induced Drp1 and Fis1-mediated Mitochondrial Fission and Right Ventricular Dysfunction in Pulmonary Hypertension Journal of Molecular Medicine (Berlin, Germany). Apr, 2017 | Pubmed ID: 28265681 MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype American Journal of Respiratory and Critical Care Medicine. Feb, 2017 | Pubmed ID: 27648837 Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine Chest. Jan, 2017 | Pubmed ID: 27645688 Pulmonary Pulse Wave Transit Time is Associated with Right Ventricular-pulmonary Artery Coupling in Pulmonary Arterial Hypertension Pulmonary Circulation. Dec, 2016 | Pubmed ID: 28090301 Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension American Journal of Respiratory and Critical Care Medicine. Oct, 2016 | Pubmed ID: 27689707 The Role of Drp1 Adaptor Proteins MiD49 and MiD51 in Mitochondrial Fission: Implications for Human Disease Clinical Science (London, England : 1979). 11, 2016 | Pubmed ID: 27660309 Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 27343087 Pulmonary Hypertension Begets Pulmonary Hypertension: Mutually Reinforcing Roles for Haemodynamics, Inflammation, and Cancer-like Phenotypes Cardiovascular Research. 07, 2016 | Pubmed ID: 27216865 Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension American Journal of Respiratory and Critical Care Medicine. 08, 2016 | Pubmed ID: 26926454 A Mitochondrial Redox Oxygen Sensor in the Pulmonary Vasculature and Ductus Arteriosus Pflugers Archiv : European Journal of Physiology. Jan, 2016 | Pubmed ID: 26395471 Gone Fission: an Asymptomatic STAT2 Mutation Elongates Mitochondria and Causes Human Disease Following Viral Infection Brain : a Journal of Neurology. Oct, 2015 | Pubmed ID: 26408653 Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension: Part I: Metabolic Plasticity and Mitochondrial Dynamics in the Pulmonary Circulation and Right Ventricle in Pulmonary Arterial Hypertension Circulation. May, 2015 | Pubmed ID: 25964279 Right Ventricular Adaptation and Failure in Pulmonary Arterial Hypertension The Canadian Journal of Cardiology. Apr, 2015 | Pubmed ID: 25840092 Mitochondrial Dynamics in Pulmonary Arterial Hypertension Journal of Molecular Medicine (Berlin, Germany). Mar, 2015 | Pubmed ID: 25672499 Soluble Guanylate Cyclase: a New Therapeutic Target for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension Clinical Pharmacology and Therapeutics. Jan, 2015 | Pubmed ID: 25670386 Mitochondrial Dynamics in Cardiovascular Disease: Fission and Fusion Foretell Form and Function Journal of Molecular Medicine (Berlin, Germany). Mar, 2015 | Pubmed ID: 25669447 Inhibition of the Mitochondrial Fission Protein Dynamin-related Protein 1 Improves Survival in a Murine Cardiac Arrest Model Critical Care Medicine. Feb, 2015 | Pubmed ID: 25599491 Peripheral Blood Signature of Vasodilator-responsive Pulmonary Arterial Hypertension Circulation. Jan, 2015 | Pubmed ID: 25361553 The Right Ventricle in Pulmonary Arterial Hypertension: Disorders of Metabolism, Angiogenesis and Adrenergic Signaling in Right Ventricular Failure Circulation Research. Jun, 2014 | Pubmed ID: 24951766 Activation of the EGFR/p38/JNK Pathway by Mitochondrial-derived Hydrogen Peroxide Contributes to Oxygen-induced Contraction of Ductus Arteriosus Journal of Molecular Medicine (Berlin, Germany). Sep, 2014 | Pubmed ID: 24906456 SIRT3 Deacetylates and Activates OPA1 to Regulate Mitochondrial Dynamics During Stress Molecular and Cellular Biology. Mar, 2014 | Pubmed ID: 24344202 Dynamin-related Protein 1 (Drp1)-mediated Diastolic Dysfunction in Myocardial Ischemia-reperfusion Injury: Therapeutic Benefits of Drp1 Inhibition to Reduce Mitochondrial Fission FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2014 | Pubmed ID: 24076965 Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension Journal of the American College of Cardiology. Dec, 2013 | Pubmed ID: 24355640 Atrioventricular Heart Block and Syncope Coincident with Diagnosis of Systemic Lupus Erythematosus The Canadian Journal of Cardiology. Oct, 2013 | Pubmed ID: 23916739 Cardiac Glutaminolysis: a Maladaptive Cancer Metabolism Pathway in the Right Ventricle in Pulmonary Hypertension Journal of Molecular Medicine (Berlin, Germany). Oct, 2013 | Pubmed ID: 23794090 Metabolism and Bioenergetics in the Right Ventricle and Pulmonary Vasculature in Pulmonary Hypertension Pulmonary Circulation. Jan, 2013 | Pubmed ID: 23662191 The Role of Redox Signaling in Epigenetics and Cardiovascular Disease Antioxidants & Redox Signaling. May, 2013 | Pubmed ID: 23480168 PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension American Journal of Respiratory and Critical Care Medicine. Apr, 2013 | Pubmed ID: 23449689 Role of Dynamin-related Protein 1 (Drp1)-mediated Mitochondrial Fission in Oxygen Sensing and Constriction of the Ductus Arteriosus Circulation Research. Mar, 2013 | Pubmed ID: 23334860 Farelerde Kapalı Göğüs Kateterizasyonu ile Kardiyak Fonksiyon ve Basınç-Hacim Döngülerinin Biventriküler Değerlendirmesi Francois Potus1, Ashley Y Martin1, Brooke Snetsinger1, Stephen L. Archer1 1Department of Medicine, Queen's University JoVE 61088 Médecine
Farelerde Kapalı Göğüs Kateterizasyonu ile Kardiyak Fonksiyon ve Basınç-Hacim Döngülerinin Biventriküler Değerlendirmesi Francois Potus1, Ashley Y Martin1, Brooke Snetsinger1, Stephen L. Archer1 1Department of Medicine, Queen's University JoVE 61088 Médecine