Stephen A. Duncan Department of Regenerative Medicine and Cell Biology Medical University of South Carolina Biography Publications Institution JoVE Articles Stephen A. Duncan Stephen Duncan received his PhD for working on vaccinia virus from Oxford University in 1992. He then moved to Rockefeller University in New York City to undertake a postdoctoral fellowship in the laboratory of Dr. James Darnell. He relocated to the Medical College of Wisconsin, Milwaukee in 1997 to establish an independent laboratory as an Assistant Professor and moved through the ranks to become the Marcus Professor of Cell Biology, Neurobiology and Anatomy. In 2007, he accepted a position as the founding Director of MCW’s Program in Regenerative Medicine. In 2015, Dr. Duncan relocated to the Medical University of South Carolina in Charleston, where he is currently the Chair of the Department of Regenerative Medicine and Cell Biology.Research in the Duncan Lab focuses on the use of mice and stem cells to understand the contribution of transcription factors to embryonic development and function of the liver. His group has developed technologies to control the differentiation of pluripotent stem cells into cells with hepatocyte characteristics. In addition to using such cells to understand cell differentiation, his group has exploited them to model inborn errors in hepatic metabolism and as a platform for drug discovery. Publications Modeling Inborn Errors of Hepatic Metabolism Using Induced Pluripotent Stem Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2017 | Pubmed ID: 28818857 GATA6 is Essential for Endoderm Formation from Human Pluripotent Stem Cells Biology Open. Jul, 2017 | Pubmed ID: 28606935 Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes ApoB Secretion and Increases Cell Stress Cell Reports. 05, 2017 | Pubmed ID: 28514664 Large, Diverse Population Cohorts of HiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci Cell Stem Cell. 04, 2017 | Pubmed ID: 28388432 A Drug Screen Using Human IPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides As a Potential Treatment for Hypercholesterolemia Cell Stem Cell. 04, 2017 | Pubmed ID: 28388428 A Small-molecule Screen Reveals That HSP90β Promotes the Conversion of Induced Pluripotent Stem Cell-derived Endoderm to a Hepatic Fate and Regulates HNF4A Turnover Development (Cambridge, England). 05, 2017 | Pubmed ID: 28360131 ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion EBioMedicine. Apr, 2017 | Pubmed ID: 28330813 N-glycoprotein Surfaceome of Human Induced Pluripotent Stem Cell Derived Hepatic Endoderm Proteomics. Mar, 2017 | Pubmed ID: 27966262 Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of IPSC-Derived Hepatocytes Stem Cell Reports. 09, 2016 | Pubmed ID: 27569060 Liver Capsule: Multipotent Stem Cells and Their Lineage Restriction to Hepatocytes Hepatology (Baltimore, Md.). 10, 2016 | Pubmed ID: 27405444 FGF2 Mediates Hepatic Progenitor Cell Formation During Human Pluripotent Stem Cell Differentiation by Inducing the WNT Antagonist NKD1 Genes & Development. Dec, 2015 | Pubmed ID: 26637527 С помощью человека индуцированных плюрипотентных стволовых клеток получены гепатоцито как клетки для обнаружения наркотиков Jui-Tung Liu1, Mary Paige Lamprecht1, Stephen A. Duncan1 1Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina JoVE 57194 Biologie du développement
С помощью человека индуцированных плюрипотентных стволовых клеток получены гепатоцито как клетки для обнаружения наркотиков Jui-Tung Liu1, Mary Paige Lamprecht1, Stephen A. Duncan1 1Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina JoVE 57194 Biologie du développement