Stephen C. Harrison Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Biography Publications Institution JoVE Articles Stephen C. Harrison has not added a biography. If you are Stephen C. Harrison and would like to personalize this page please email our Author Liaison for assistance. Publications RWD Domain: a Recurring Module in Kinetochore Architecture Shown by a Ctf19-Mcm21 Complex Structure EMBO Reports. Feb, 2012 | Pubmed ID: 22322944 Ndc10 is a Platform for Inner Kinetochore Assembly in Budding Yeast Nature Structural & Molecular Biology. Jan, 2012 | Pubmed ID: 22139014 Cross-linking of Rotavirus Outer Capsid Protein VP7 by Antibodies or Disulfides Inhibits Viral Entry Journal of Virology. Oct, 2011 | Pubmed ID: 21849465 Broadly Neutralizing Human Antibody That Recognizes the Receptor-binding Pocket of Influenza Virus Hemagglutinin Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21825125 Mitochondrial Uncoupling Protein 2 Structure Determined by NMR Molecular Fragment Searching Nature. Aug, 2011 | Pubmed ID: 21785437 Recognition of the Centromere-specific Histone Cse4 by the Chaperone Scm3 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606327 Near-atomic Resolution Reconstructions of Icosahedral Viruses from Electron Cryo-microscopy Current Opinion in Structural Biology. Apr, 2011 | Pubmed ID: 21333526 Single-molecule Analysis of a Molecular Disassemblase Reveals the Mechanism of Hsc70-driven Clathrin Uncoating Nature Structural & Molecular Biology. Mar, 2011 | Pubmed ID: 21278753 Atomic Model of an Infectious Rotavirus Particle The EMBO Journal. Jan, 2011 | Pubmed ID: 21157433 Mechanistic Biology in the Next Quarter Century Molecular Biology of the Cell. Nov, 2010 | Pubmed ID: 21079017 Structural Analysis of the Interaction Between Dishevelled2 and Clathrin AP-2 Adaptor, a Critical Step in Noncanonical Wnt Signaling Structure (London, England : 1993). Oct, 2010 | Pubmed ID: 20947020 Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem Journal of Virology. Dec, 2010 | Pubmed ID: 20881042 Structure of the PTEN-like Region of Auxilin, a Detector of Clathrin-coated Vesicle Budding Structure (London, England : 1993). Sep, 2010 | Pubmed ID: 20826345 Virology. Looking Inside Adenovirus Science (New York, N.Y.). Aug, 2010 | Pubmed ID: 20798308 Structural Biology: Conservation in Vesicle Coats Nature. Aug, 2010 | Pubmed ID: 20739998 The Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-microtubule Attachments Cell. Aug, 2010 | Pubmed ID: 20723757 CLASP Promotes Microtubule Rescue by Recruiting Tubulin Dimers to the Microtubule Developmental Cell. Aug, 2010 | Pubmed ID: 20708587 Analysis of Kinetic Intermediates in Single-particle Dwell-time Distributions Biophysical Journal. Jul, 2010 | Pubmed ID: 20643053 Peptide Inhibitors of Dengue-virus Entry Target a Late-stage Fusion Intermediate PLoS Pathogens. Apr, 2010 | Pubmed ID: 20386713 Effect of Mutations in VP5 Hydrophobic Loops on Rotavirus Cell Entry Journal of Virology. Jun, 2010 | Pubmed ID: 20375171 Subunit Interactions in Bovine Papillomavirus Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20308582 Structural Basis for Receptor Recognition by New World Hemorrhagic Fever Arenaviruses Nature Structural & Molecular Biology. Apr, 2010 | Pubmed ID: 20208545 X-ray Crystal Structure of the Rotavirus Inner Capsid Particle at 3.8 A Resolution Journal of Molecular Biology. Mar, 2010 | Pubmed ID: 20122940 Structure of Clathrin Coat with Bound Hsc70 and Auxilin: Mechanism of Hsc70-facilitated Disassembly The EMBO Journal. Feb, 2010 | Pubmed ID: 20033059 A Rotavirus Spike Protein Conformational Intermediate Binds Lipid Bilayers Journal of Virology. Feb, 2010 | Pubmed ID: 20007281 Role of HIV Membrane in Neutralization by Two Broadly Neutralizing Antibodies Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19906992 VP5* Rearranges when Rotavirus Uncoats Journal of Virology. Nov, 2009 | Pubmed ID: 19692464 Structure of Rotavirus Outer-layer Protein VP7 Bound with a Neutralizing Fab Science (New York, N.Y.). Jun, 2009 | Pubmed ID: 19520960 Molecular Interactions in Rotavirus Assembly and Uncoating Seen by High-resolution Cryo-EM Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19487668 Requirements for the Formation of Membrane Pores by the Reovirus Myristoylated Micro1N Peptide Journal of Virology. Jul, 2009 | Pubmed ID: 19439475 Mechanism for Coordinated RNA Packaging and Genome Replication by Rotavirus Polymerase VP1 Structure (London, England : 1993). Nov, 2008 | Pubmed ID: 19000820 The PH Sensor for Flavivirus Membrane Fusion The Journal of Cell Biology. Oct, 2008 | Pubmed ID: 18936246 Single-particle Kinetics of Influenza Virus Membrane Fusion Proceedings of the National Academy of Sciences of the United States of America. Oct, 2008 | Pubmed ID: 18829437 Viral Membrane Fusion Nature Structural & Molecular Biology. Jul, 2008 | Pubmed ID: 18596815 Peptides Released from Reovirus Outer Capsid Form Membrane Pores That Recruit Virus Particles The EMBO Journal. Apr, 2008 | Pubmed ID: 18369316 Near-atomic Resolution Using Electron Cryomicroscopy and Single-particle Reconstruction Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18238898 XMAP215 is a Processive Microtubule Polymerase Cell. Jan, 2008 | Pubmed ID: 18191222 Interactions of Lipids with Aquaporin-0 and Other Membrane Proteins Pflügers Archiv : European Journal of Physiology. Jul, 2008 | Pubmed ID: 17932686 Three-dimensional Intricacies in Protein-DNA Recognition and Transcriptional Control Nature Structural & Molecular Biology. Dec, 2007 | Pubmed ID: 18059448 Crystal Structure of the Yeast Inner Kinetochore Subunit Cep3p Structure (London, England : 1993). Nov, 2007 | Pubmed ID: 17997968 Comments on the NIGMS PSI Structure (London, England : 1993). Nov, 2007 | Pubmed ID: 17997957 Structure and Function of an Essential Component of the Outer Membrane Protein Assembly Machine Science (New York, N.Y.). Aug, 2007 | Pubmed ID: 17702946 An Atomic Model of the Interferon-beta Enhanceosome Cell. Jun, 2007 | Pubmed ID: 17574024 Interferon Regulatory Factor 3 is Regulated by a Dual Phosphorylation-dependent Switch The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17526488 Structure of Calcineurin in Complex with PVIVIT Peptide: Portrait of a Low-affinity Signalling Interaction Journal of Molecular Biology. Jun, 2007 | Pubmed ID: 17498738 Protein Arms in the Kinetochore-microtubule Interface of the Yeast DASH Complex Molecular Biology of the Cell. Jul, 2007 | Pubmed ID: 17460120 Crystal Structure of a TOG Domain: Conserved Features of XMAP215/Dis1-family TOG Domains and Implications for Tubulin Binding Structure (London, England : 1993). Mar, 2007 | Pubmed ID: 17355870 Structural Analysis of Bub3 Interactions in the Mitotic Spindle Checkpoint Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17227844 The Ndc80/HEC1 Complex is a Contact Point for Kinetochore-microtubule Attachment Nature Structural & Molecular Biology. Jan, 2007 | Pubmed ID: 17195848 Cryo-electron Tomography of Clathrin-coated Vesicles: Structural Implications for Coat Assembly Journal of Molecular Biology. Jan, 2007 | Pubmed ID: 17095010 Interactions Between SARS Coronavirus and Its Receptor Advances in Experimental Medicine and Biology. 2006 | Pubmed ID: 17037534 Restraining the Conformation of HIV-1 Gp120 by Removing a Flexible Loop The EMBO Journal. Oct, 2006 | Pubmed ID: 17006538 Reovirus Mu1 Structural Rearrangements That Mediate Membrane Penetration Journal of Virology. Dec, 2006 | Pubmed ID: 17005655 Small Molecules That Bind the Inner Core of Gp41 and Inhibit HIV Envelope-mediated Fusion Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006 | Pubmed ID: 16963566 Structure Determination of Clathrin Coats to Subnanometer Resolution by Single Particle Cryo-electron Microscopy Journal of Structural Biology. Dec, 2006 | Pubmed ID: 16908193 Crystal Structure of Glycoprotein B from Herpes Simplex Virus 1 Science (New York, N.Y.). Jul, 2006 | Pubmed ID: 16840698 Conformational States of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Ectodomain Journal of Virology. Jul, 2006 | Pubmed ID: 16809285 Structure of a Central Component of the Yeast Kinetochore: the Spc24p/Spc25p Globular Domain Structure (London, England : 1993). Jun, 2006 | Pubmed ID: 16765893 Stu2p Binds Tubulin and Undergoes an Open-to-closed Conformational Change The Journal of Cell Biology. Mar, 2006 | Pubmed ID: 16567500 Single Particle Reconstructions of the Transferrin-transferrin Receptor Complex Obtained with Different Specimen Preparation Techniques Journal of Molecular Biology. Feb, 2006 | Pubmed ID: 16343539 SARS Coronavirus, but Not Human Coronavirus NL63, Utilizes Cathepsin L to Infect ACE2-expressing Cells The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16339146 Single Particle Reconstruction of the Human Apo-transferrin-transferrin Receptor Complex Journal of Structural Biology. Dec, 2005 | Pubmed ID: 16343946 Lipid-protein Interactions in Double-layered Two-dimensional AQP0 Crystals Nature. Dec, 2005 | Pubmed ID: 16319884 Features of Reovirus Outer Capsid Protein Mu1 Revealed by Electron Cryomicroscopy and Image Reconstruction of the Virion at 7.0 Angstrom Resolution Structure (London, England : 1993). Oct, 2005 | Pubmed ID: 16216585 Structure of SARS Coronavirus Spike Receptor-binding Domain Complexed with Receptor Science (New York, N.Y.). Sep, 2005 | Pubmed ID: 16166518 Mechanism of Membrane Fusion by Viral Envelope Proteins Advances in Virus Research. 2005 | Pubmed ID: 16139596 The Active Conformation of the PAK1 Kinase Domain Structure (London, England : 1993). May, 2005 | Pubmed ID: 15893667 Molecular Organization of the Ndc80 Complex, an Essential Kinetochore Component Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005 | Pubmed ID: 15809444 Structure of an Unliganded Simian Immunodeficiency Virus Gp120 Core Nature. Feb, 2005 | Pubmed ID: 15729334 Determining the Structure of an Unliganded and Fully Glycosylated SIV Gp120 Envelope Glycoprotein Structure (London, England : 1993). Feb, 2005 | Pubmed ID: 15698564 The Yeast DASH Complex Forms Closed Rings on Microtubules Nature Structural & Molecular Biology. Feb, 2005 | Pubmed ID: 15640796 Variable Surface Epitopes in the Crystal Structure of Dengue Virus Type 3 Envelope Glycoprotein Journal of Virology. Jan, 2005 | Pubmed ID: 15613349 Crystal Structure of the Spindle Assembly Checkpoint Protein Bub3 Journal of Molecular Biology. Dec, 2004 | Pubmed ID: 15544799 Crystal Structure of a Human CD3-epsilon/delta Dimer in Complex with a UCHT1 Single-chain Antibody Fragment Proceedings of the National Academy of Sciences of the United States of America. Nov, 2004 | Pubmed ID: 15534202 Crystal Structure of ATF-2/c-Jun and IRF-3 Bound to the Interferon-beta Enhancer The EMBO Journal. Nov, 2004 | Pubmed ID: 15510218 Structure of an Auxilin-bound Clathrin Coat and Its Implications for the Mechanism of Uncoating Nature. Dec, 2004 | Pubmed ID: 15502813 Molecular Model for a Complete Clathrin Lattice from Electron Cryomicroscopy Nature. Dec, 2004 | Pubmed ID: 15502812 Crystal Structure of the Clathrin Adaptor Protein 1 Core Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15377783 Structural Rearrangements in the Membrane Penetration Protein of a Non-enveloped Virus Nature. Aug, 2004 | Pubmed ID: 15329727 Structure of Heptameric Protective Antigen Bound to an Anthrax Toxin Receptor: a Role for Receptor in PH-dependent Pore Formation Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15326297 Discovery of Antivirals Against Smallpox Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15249657 Full-length Influenza Hemagglutinin HA2 Refolds into the Trimeric Low-pH-induced Conformation Biochemistry. May, 2004 | Pubmed ID: 15134464 A Chimeric Protein of Simian Immunodeficiency Virus Envelope Glycoprotein Gp140 and Escherichia Coli Aspartate Transcarbamoylase Journal of Virology. May, 2004 | Pubmed ID: 15078931 Orthoreovirus and Aquareovirus Core Proteins: Conserved Enzymatic Surfaces, but Not Protein-protein Interfaces Virus Research. Apr, 2004 | Pubmed ID: 15010214 Structure of the Human Transferrin Receptor-transferrin Complex Cell. Feb, 2004 | Pubmed ID: 14980223 Structure of the Dengue Virus Envelope Protein After Membrane Fusion Nature. Jan, 2004 | Pubmed ID: 14737159 Whither Structural Biology? Nature Structural & Molecular Biology. Jan, 2004 | Pubmed ID: 14718917 X-ray Structure of a Protein-conducting Channel Nature. Jan, 2004 | Pubmed ID: 14661030 Two Distinct Size Classes of Immature and Mature Subviral Particles from Tick-borne Encephalitis Virus Journal of Virology. Nov, 2003 | Pubmed ID: 14557621 Binding of the Essential Saccharomyces Cerevisiae Kinetochore Protein Ndc10p to CDEII Molecular Biology of the Cell. Nov, 2003 | Pubmed ID: 13679521 An Asymmetric NFAT1 Dimer on a Pseudo-palindromic Kappa B-like DNA Site Nature Structural Biology. Oct, 2003 | Pubmed ID: 12949491 A Ligand-binding Pocket in the Dengue Virus Envelope Glycoprotein Proceedings of the National Academy of Sciences of the United States of America. Jun, 2003 | Pubmed ID: 12759475 Disulfide Bonding Among Micro 1 Trimers in Mammalian Reovirus Outer Capsid: a Late and Reversible Step in Virion Morphogenesis Journal of Virology. May, 2003 | Pubmed ID: 12692241 Variation on an Src-like Theme Cell. Mar, 2003 | Pubmed ID: 12654240 How Does Radiation Damage in Protein Crystals Depend on X-ray Dose? Structure (London, England : 1993). Jan, 2003 | Pubmed ID: 12517336 RNA Synthesis in a Cage--structural Studies of Reovirus Polymerase Lambda3 Cell. Nov, 2002 | Pubmed ID: 12464184 Crystal Structure of Human Calcineurin Complexed with Cyclosporin A and Human Cyclophilin Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12357034 Specificity and Affinity of Sialic Acid Binding by the Rhesus Rotavirus VP8* Core Journal of Virology. Oct, 2002 | Pubmed ID: 12239329 Atomic Model of the Papillomavirus Capsid The EMBO Journal. Sep, 2002 | Pubmed ID: 12234916 The Rhesus Rotavirus VP4 Sialic Acid Binding Domain Has a Galectin Fold with a Novel Carbohydrate Binding Site The EMBO Journal. Mar, 2002 | Pubmed ID: 11867517 Don C. Wiley (1944--2001) Molecular Cell. Feb, 2002 | Pubmed ID: 11864596 Don C. Wiley (1944-2001) Cell. Feb, 2002 | Pubmed ID: 11853666 Structure of the Reovirus Membrane-penetration Protein, Mu1, in a Complex with is Protector Protein, Sigma3 Cell. Jan, 2002 | Pubmed ID: 11832217 Pak1 Kinase Homodimers Are Autoinhibited in Trans and Dissociated Upon Activation by Cdc42 and Rac1 Molecular Cell. Jan, 2002 | Pubmed ID: 11804587 Método para Medição da Cinética de Fusão Viral no Nível única partícula Daniel L. Floyd1, Stephen C. Harrison1,2, Antoine M. van Oijen1 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 2Howard Hughes Medical Institute, Harvard Medical School JoVE 1484 Biologie
Método para Medição da Cinética de Fusão Viral no Nível única partícula Daniel L. Floyd1, Stephen C. Harrison1,2, Antoine M. van Oijen1 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 2Howard Hughes Medical Institute, Harvard Medical School JoVE 1484 Biologie