Steven Van Cruchten

Publications

• Species Selection for Nonclinical Safety Assessment of Drug Candidates: Examples of Current Industry Practice
  Regulatory Toxicology and Pharmacology : RTP. Aug, 2021  |   Pubmed ID: 34455009
• Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling
  Frontiers in Pharmacology. 2021  |   Pubmed ID: 33935788
• Low Birth Weight Female Piglets Show Altered Intestinal Development, Gene Expression, and Epigenetic Changes at Key Developmental Loci
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2021  |   Pubmed ID: 33734504
• The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development
  Pharmaceutics. Dec, 2020  |   Pubmed ID: 33396805
• Refinement of the Zebrafish Embryo Developmental Toxicity Assay
  MethodsX. 2020  |   Pubmed ID: 33134094
• A Medium-Throughput System for In Vitro Oxidative Stress Assessment in IPEC-J2 Cells
  International Journal of Molecular Sciences. Oct, 2020  |   Pubmed ID: 33019601
• Short-chain Fructo-oligosaccharides Supplementation to Suckling Piglets: Assessment of Pre- and Post-weaning Performance and Gut Health
  PloS One. 2020  |   Pubmed ID: 32502215
• A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates
  Frontiers in Pharmacology. 2020  |   Pubmed ID: 32477113
• Birthweight Determines Intestinal Microvasculature Development and Alters Endothelial Nitric Oxide Synthase Density in Young Piglets
  Anatomia, Histologia, Embryologia. Sep, 2020  |   Pubmed ID: 31995241
• Use of Zebrafish in Drug Discovery Toxicology
  Chemical Research in Toxicology. 01, 2020  |   Pubmed ID: 31625720
• Glucose and Glycogen Levels in Piglets That Differ in Birth Weight and Vitality
  Heliyon. Sep, 2019  |   Pubmed ID: 31687599
• Does Intrauterine Crowding Affect the Force Generating Capacity and Muscle Composition of the Piglet Front Limb?
  PloS One. 2019  |   Pubmed ID: 31600318
• On the Characterisation of the Porcine Gland-specific Salivary Proteome
  Journal of Proteomics. 03, 2019  |   Pubmed ID: 30707949
• Advancing the Zebrafish Embryo Test for Endocrine Disruptor Screening Using Micro-injection: Ethinyl Estradiol As a Case Study
  Environmental Toxicology and Chemistry. 03, 2019  |   Pubmed ID: 30569562
• How Does Intrauterine Crowding Affect Locomotor Performance in Newborn Pigs? A Study of Force Generating Capacity and Muscle Composition of the Hind Limb
  PloS One. 2018  |   Pubmed ID: 30550550
• From MRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation During Zebrafish Embryonic and Larval Development
  International Journal of Molecular Sciences. Dec, 2018  |   Pubmed ID: 30544719
• The Porcine Tonsils and Peyer's Patches: A Stereological Morphometric Analysis in Conventionally and Artificially Reared Piglets
  Veterinary Immunology and Immunopathology. Dec, 2018  |   Pubmed ID: 30502915
• Editorial ETS 2018
  Reproductive Toxicology (Elmsford, N.Y.). 09, 2018  |   Pubmed ID: 30193665
• Gene Transcription Ontogeny of Hypothalamic-pituitary-thyroid Axis Development in Early-life Stage Fathead Minnow and Zebrafish
  General and Comparative Endocrinology. 09, 2018  |   Pubmed ID: 29733815
• Does Intrauterine Crowding Affect Locomotor Development? A Comparative Study of Motor Performance, Neuromotor Maturation and Gait Variability Among Piglets That Differ in Birth Weight and Vitality
  PloS One. 2018  |   Pubmed ID: 29689084
• UPLC/MS MS Data of Testosterone Metabolites in Human and Zebrafish Liver Microsomes and Whole Zebrafish Larval Microsomes
  Data in Brief. Feb, 2018  |   Pubmed ID: 29541660
• Pre- and Postnatal Development of the Eye: A Species Comparison
  Birth Defects Research. Nov, 2017  |   Pubmed ID: 28941218
• How Innate is Locomotion in Precocial Animals? A Study on the Early Development of Spatio-temporal Gait Variables and Gait Symmetry in Piglets
  The Journal of Experimental Biology. 08, 2017  |   Pubmed ID: 28768747
• Antioxidants Reduce Reactive Oxygen Species but Not Embryotoxicity in the Metabolic Danio Rerio Test (mDarT)
  Reproductive Toxicology (Elmsford, N.Y.). 09, 2017  |   Pubmed ID: 28663077
• In Vitro CYP-mediated Drug Metabolism in the Zebrafish (embryo) Using Human Reference Compounds
  Toxicology in Vitro : an International Journal Published in Association with BIBRA. Aug, 2017  |   Pubmed ID: 28506817
• Artificial Rearing Influences the Morphology, Permeability and Redox State of the Gastrointestinal Tract of Low and Normal Birth Weight Piglets
  Journal of Animal Science and Biotechnology. 2017  |   Pubmed ID: 28405313
• Evaluating Complex Mixtures in the Zebrafish Embryo by Reconstituting Field Water Samples: A Metal Pollution Case Study
  International Journal of Molecular Sciences. Mar, 2017  |   Pubmed ID: 28257097
• Effect of Artificial Rearing of Piglets on the Volume Densities of M Cells in the Tonsils of the Soft Palate and Ileal Peyer's Patches
  Veterinary Immunology and Immunopathology. Feb, 2017  |   Pubmed ID: 28166927
• In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition During Early Zebrafish Development
  International Journal of Molecular Sciences. Jan, 2017  |   Pubmed ID: 28117738
• In Vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs
  Pharmaceutical Research. 04, 2017  |   Pubmed ID: 28097507
• In Vitro Investigation of Six Antioxidants for Pig Diets
  Antioxidants (Basel, Switzerland). Nov, 2016  |   Pubmed ID: 27845706
• In Vitro CYP1A Activity in the Zebrafish: Temporal but Low Metabolite Levels During Organogenesis and Lack of Gender Differences in the Adult Stage
  Reproductive Toxicology (Elmsford, N.Y.). 09, 2016  |   Pubmed ID: 27046732
• Xenobiotic Metabolism in the Zebrafish: a Review of the Spatiotemporal Distribution, Modulation and Activity of Cytochrome P450 Families 1 to 3
  The Journal of Toxicological Sciences. Feb, 2016  |   Pubmed ID: 26763387
• Organ Data from the Developing Göttingen Minipig: First Steps Towards a Juvenile PBPK Model
  Journal of Pharmacokinetics and Pharmacodynamics. Apr, 2016  |   Pubmed ID: 26687458
• Incubation at 32.5°C and Above Causes Malformations in the Zebrafish Embryo
  Reproductive Toxicology (Elmsford, N.Y.). Aug, 2015  |   Pubmed ID: 26005098
• Age-related Differences in CYP3A Abundance and Activity in the Liver of the Göttingen Minipig
  Basic & Clinical Pharmacology & Toxicology. Nov, 2015  |   Pubmed ID: 25892190
• Ontogeny of CYP3A and P-glycoprotein in the Liver and the Small Intestine of the Göttingen Minipig: an Immunohistochemical Evaluation
  Basic & Clinical Pharmacology & Toxicology. May, 2014  |   Pubmed ID: 24224644
• M Cell Specific Markers in Man and Domestic Animals: Valuable Tools in Vaccine Development
  Comparative Immunology, Microbiology and Infectious Diseases. Jul, 2013  |   Pubmed ID: 23618793
• Alternative Models to Study the Intestinal Barrier Function of Piglets
  Alternatives to Laboratory Animals : ATLA. Dec, 2012  |   Pubmed ID: 23398344
• Osteopontin Alters the Functional Profile of Porcine Microglia in Vitro
  Cell Biology International. 2012  |   Pubmed ID: 22974008
• Interferon-γ Modulates the Functional Profile of In-vitro-cultured Porcine Microglia
  Neuroreport. Jun, 2012  |   Pubmed ID: 22581042